Synthesis and anticancer potential of certain novel 2-oxo-N'-(2-oxoindolin- 3-ylidene)-2H-chromene-3-carbohydrazides

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 358-363

  Abdel Aziz, Hatem A ^a,b   Elsaman, Tilal ^a   Al Dhfyan, Abdullah ^c   Attia, Mohamed I ^a,b   Al Rashood, Khalid A ^a   Al Obaid, Abdul Rahman M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

Chromene 2 ones; Colorectal cancer; Hydrazides hydrazones; Indoline 2,3 dione; Ring opening; Side population (SP) cells

Indexed keywords

2 OXO N' (2 OXOINDOLIN 3 YLIDENE) 2H CHROMENE 3 CARBOHYDRAZIDE; 2 OXO N' (2 OXOINDOLIN 3 YLIDENE) 2H CHROMENE 3 CARBOHYDRAZIDE DERIVATIVE; 6 BROMO 2 OXO N' (2 OXOINDOLIN 3 YLIDENE) 2H CHROMENE 3 CARBOHYDRAZIDE; 6 BROMO N' (5 FLUORO 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; ANTINEOPLASTIC AGENT; CHROMENE DERIVATIVE; HYDRAZONE DERIVATIVE; N' (5 BROMO 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' (5 CHLORO 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' (5 FLUORO 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' (5 METHOXY 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' (5 METHYL 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' (5 NITRO 2 OXOINDOLIN 3 YLIDENE) 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; UNCLASSIFIED DRUG; VERAPAMIL;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER STEM CELL; CELL POPULATION; CELL STRAIN HT29; CONTROLLED STUDY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LEUKEMIA CELL;

CHROMENE-2-ONES; COLORECTAL CANCER; HYDRAZIDES/HYDRAZONES; INDOLINE-2,3-DIONE; RING-OPENING; SIDE POPULATION (SP) CELLS;

ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; HYDRAZINES; K562 CELLS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886457414     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.060     Document Type: Article

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