TGF-β type II receptor expression in thymic epithelial cells inhibits the development of hassall's corpuscles in mice

International Immunology

Volumn 25, Issue 11, 2013, Pages 633-642

  Odaka, Chikako ^a   Hauri Hohl, Mathias ^b,f   Takizawa, Kazuya ^a   Nishikawa, Yomiko ^d   Yano, Masashi ^d   Matsumoto, Mitsuru ^d   Boyd, Richard ^e   Holländer, Georg A ^b,c  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e MONASH UNIVERSITY   (Australia)

^f BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

Epithelial cells; Hassall's corpuscle; Mts24; TGF type II receptor; thymus

Indexed keywords

LECTIN; MITOGEN ACTIVATED PROTEIN KINASE; STROMAL CELL DERIVED FACTOR 1; THYMIC STROMAL LYMPHOPOIETIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HASSALL BODY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STELLATE CELL; T LYMPHOCYTE; THYMUS;

EPITHELIAL CELLS; HASSALL'S CORPUSCLE; MTS24; TGF-Β TYPE II RECEPTOR; THYMUS;

ANIMALS; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; THYMUS GLAND;

EID: 84886430543     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt026     Document Type: Article

References (39)

1. van Ewijk, W., Wang, B., Hollander, G. et al. 1999. Thymic microenvironments, 3-D versus 2-D? Semin. Immunol. 11:57.
2. Farr, A. G., Dooley, U. L. and Erickson, M. 2002. Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol. Rev. 189:20.
3. Blackburn, C. C. and Manley, N. R. 2004. Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. 4:278.
4. Bennett, A. R, Farley, A., Blairm, N. F., Gordon, J., Sharp, L. and Blackburn, C. C. 2002. Identification and characterization of thymic epithelial progenitor cells. Immunity 16:803.
5. Gill, J., Malin, M., Holländer, G. A. and Boyd, R. 2002. Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells. Nat. Immunol. 3:635.
6. Rossi, S. W., Jenkinson, W. E., Anderson, G. and Jenkinson, E. J. 2006. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441:988.
7. Bleul, C. C., Corbeaux, T., Reuter, A., Fisch, P., Mönting, J. S. and Boehm, T. 2006. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441:992.
8. Lobach, D. F., Scearce, R. M. and Haynes, B. F. 1985. The human thymic microenvironment: phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies. J. Immunol. 134:250.
9. Lobach, D. F., Itoh, T., Singer, K. H. and Haynes, B. F. 1987. The thymic microenvironment: characterization of in vitro differentiation of the IT26R21 rat thymic epithelial cell line. Differentiation 34:50.
10. Patel, D. D., Whichard, L. P., Radcliff, G., Denning, S. M. and Haynes, B. F. 1995. Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes. J. Clin. Immunol. 15:80.
11. Blau, J. N. 1967. Antigen and antibody localization in Hassall's corpuscles. Nature 215:1073.
12. Blau, J. N. and Veall, N. 1967. The uptake and localization of proteins, Evans Blue and carbon black in the normal and pathological thymus of the guinea-pig. Immunology 12:363.
13. Senelar, R., Escola, M. J., Escola, R., Serrou, B. and Serre. A. 1976. Relationship between Hassall's corpuscles and thymocytes fate in guinea-pig fetus. Biomedicine 24:112.
14. -) human thymocytes. Comparative analysis of the effects of IL-4 and IL-7. J. Immunol. 154:3726.
15. Romagnani, P., Annunziato, F., Manetti, R. et al. 1998. High CD30 ligand expression by epithelial cells and Hassall's corpuscles in the medulla of human thymus. Blood 91:3323.
16. Annunziato, F., Romagnani, P., Cosmi, L. et al. 2000. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. J. Immunol. 165:238.
17. Zaitseva, M., Kawamura, T., Loomis, R., Goldstein, H., Blauvelt, A. and Golding, H. 2002. Stromal-derived factor 1 expression in the human thymus. J. Immunol. 168:2609.
18. +regulatory T cells in human thymus. Nature 436:1181.
19. Massagué, J. and Chen, Y. G. 2000. Controlling TGF-beta signaling. Genes Dev. 14:627.
20. Derynck, R. and Zhang, Y. E. 2003. Smad-dependent and Smadindependent pathways in TGF-beta family signalling. Nature 425:577.
21. Hauri-Hohl, M. M., Zuklys, S., Keller M. P. et al. 2008. TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution. Blood 112:626.
22. Nishikawa, Y., Hirota, F., Yano, M. et al. 2010. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J. Exp. Med. 207:963.
23. Odaka, C. 2009. Localization of mesenchymal cells in adult mouse thymus: their abnormal distribution in mice with disorganization of thymic medullary epithelium. J. Histochem. Cytochem. 57:373.
24. Bravo-Nuevo, A., O'Donnell, R., Rosendahl, A., Chung, J. H., Benjamin, L. E. and Odaka, C. 2011. RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy. Int. Immunol. 23:593.
25. Farr, A. G. and Anderson, S. K. 1985. Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells. J. Immunol. 134:2971.
26. Hale, L. P. and Markert, M. L. 2004. Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. J. Immunol. 172:617.
27. Henry, L. and Anderson, G. 1990. Immunoglobulins in Hassall's corpuscles of the human thymus. J. Anat. 168:185.
28. Lee, M. G., Sharrow, S. O., Farr, A. G., Singer, A. and Udey, M. C. 1994. Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. J. Immunol. 152:5653.
29. Anderson, M. S., Venanzi, E. S., Klein, L. et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298:1395.
30. Kekäläinen, E., Tuovinen, H., Joensuu, J. et al. 2007. A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Immunol. 178:1208.
31. Kim, C. H., Pelus, L. M., White, J. R. and Broxmeyer, H. E. 1998. Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood 91:4434.
32. Friend, S. L., Hosier, S., Nelson, A., Foxworthe, D., Williams, D. E. and Farr, A. 1994. A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp. Hematol. 22:321.
33. Soumelis, V., Reche, P. A., Kanzler, H. et al. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3:673.
34. Nishio, H, Matsui, K., Tsuji, H., Tamura, A. and Suzuki, K. 2001. Immunolocalization of the mitogen-activated protein kinase signalling pathway in Hassall's corpuscles of the human thymus. Acta Histochem. 103:89.
35. Hale, L. P., Buckley, R. H., Puck, J. M. and Patel, D. D. 2004. Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiency syndrome. Clin. Immunol. 110:63.
36. Gosseye, S., Diebold, N., Griscelli, C. and Nezelof, C. 1983. Severe combined immunodeficiency disease: a pathological analysis of 26 cases. Clin. Immunol. Immunopathol. 29:58.
37. Neuhaus, T. J. and Briner, J. 1986. Morphology of original and transplanted thymuses in severe combined immunodeficiency. Pediatr. Pathol. 5:251.
38. Jiang, Q., Coffield, V. M., Kondo, M. and Su, L. 2007. TSLP is involved in expansion of early thymocyte progenitors. BMC Immunol. 8:11.
39. Jensen, C. T., Böiers, C., Kharazi, S. et al. 2008. Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development. Blood 111:2083.