메뉴 건너뛰기




Volumn 20, Issue 5, 2013, Pages

Thyroid dysfunction and tyrosine kinase inhibitors in renal cell carcinoma

Author keywords

Carcinoma; Hypothyroidism; Metastatic renal cell; Tyrosine kinase inhibitors; VEGF

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; AXITINIB; BEVACIZUMAB; EVEROLIMUS; LIOTHYRONINE; PAZOPANIB; PROTEIN TYROSINE KINASE; RADIOACTIVE IODINE; SORAFENIB; SUNITINIB; TEMSIROLIMUS; THYROID HORMONE; THYROTROPIN; THYROXINE;

EID: 84886424099     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-13-0201     Document Type: Review
Times cited : (35)

References (115)
  • 2
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibit KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ, Prjer NK & Cherrington JM 2003 SU11248 inhibit KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Molecular Cancer Therapeutics 2 471-478.
    • (2003) Molecular Cancer Therapeutics , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Prjer, N.K.4    Cherrington, J.M.5
  • 3
    • 47549084773 scopus 로고    scopus 로고
    • Sunitinib associated lymphocytic thyroiditis without circulating antithyroid antibodies
    • (doi:10.1089/ thy.2007.0349)
    • Alexandrescu DT, Popoveniuc G, Farzanmehr H, Dasanu CA, Dawson N & Wartofsky L 2008 Sunitinib associated lymphocytic thyroiditis without circulating antithyroid antibodies. Thyroid 18 809-812. (doi:10.1089/ thy.2007.0349)
    • (2008) Thyroid , vol.18 , pp. 809-812
    • Alexandrescu, D.T.1    Popoveniuc, G.2    Farzanmehr, H.3    Dasanu, C.A.4    Dawson, N.5    Wartofsky, L.6
  • 4
    • 84880725911 scopus 로고    scopus 로고
    • American Cancer Society: Cancer Facts and Figures 2012. Atlanta, GA, USA: American Cancer Society
    • American Cancer Society: Cancer Facts and Figures 2012. Atlanta GACS, 2012. Atlanta, GA, USA: American Cancer Society.
    • (2012) Atlanta GACS
  • 5
    • 36849067520 scopus 로고    scopus 로고
    • Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: Conclusions and recommendations of the Technical Consultation
    • (doi:10.1017/S1368980007000092)
    • Andersson M, de Benoist B, Delange F & Zupan J 2007 Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation. Public Health Nutrition 10 1606-1611. (doi:10.1017/ S1368980007000092)
    • (2007) Public Health Nutrition , vol.10 , pp. 1606-1611
    • Andersson, M.1    De Benoist, B.2    Delange, F.3    Zupan, J.4
  • 8
    • 84866746182 scopus 로고    scopus 로고
    • The impact of sunitinib-induced hypothyroidism on progression-free survival of metastatic renal cancer patients: A prospective singlecenter study
    • (doi:10.1016/j.urolonc. 2010.07.015)
    • Baldazzi V, Tassi R, Lapini A, Santomaggio C, Carini M & Mazzanti R 2012 The impact of sunitinib-induced hypothyroidism on progression-free survival of metastatic renal cancer patients: a prospective singlecenter study. Urologic Oncology 30 704-710. (doi:10.1016/j.urolonc. 2010.07.015)
    • (2012) Urologic Oncology , vol.30 , pp. 704-710
    • Baldazzi, V.1    Tassi, R.2    Lapini, A.3    Santomaggio, C.4    Carini, M.5    Mazzanti, R.6
  • 9
    • 0021928235 scopus 로고
    • Decreased receptor binding of bio-logically inactive thyrotropin in central hypothyroidism. Effect of treatment with thyrotropin-releasing hormone
    • (doi:10.1056/NEJM198504253121703)
    • Beck-Peccoz P, Amr S, Menezes-Ferreira MM, Faglia G& Weintraub BD 1985 Decreased receptor binding of bio-logically inactive thyrotropin in central hypothyroidism. Effect of treatment with thyrotropin-releasing hormone. New England Journal of Medicine 312 1085-1090. (doi:10.1056/NEJM198504253121703)
    • (1985) New England Journal of Medicine , vol.312 , pp. 1085-1090
    • Beck-Peccoz, P.1    Amr, S.2    Menezes-Ferreira, M.M.3    Faglia, G.4    Weintraub, B.D.5
  • 12
    • 84873986363 scopus 로고    scopus 로고
    • Therapy management with sunitinib in patients with metastatic renal cell carcinoma: Key concepts and the impact of clinical biomarkers
    • (doi:10.1016/j.ctrv.2012.04.009)
    • Castellano D, Ravaud A, Schmidinger M, De Velasco G & Vazquez F 2013 Therapy management with sunitinib in patients with metastatic renal cell carcinoma: key concepts and the impact of clinical biomarkers. Cancer Treatment Reviews 39 230-240. (doi:10.1016/j.ctrv.2012.04.009)
    • (2013) Cancer Treatment Reviews , vol.39 , pp. 230-240
    • Castellano, D.1    Ravaud, A.2    Schmidinger, M.3    De Velasco, G.4    Vazquez, F.5
  • 14
  • 17
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • (doi:10.1016/S0140-6736(06) 69446-4)
    • Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA et al. 2006 Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368 1329-1338. (doi:10.1016/S0140-6736(06) 69446-4)
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    Van Oosterom, A.T.2    Garrett, C.R.3    Blackstein, M.E.4    Shah, M.H.5    Verweij, J.6    McArthur, G.7    Judson, I.R.8    Heinrich, M.C.9    Morgan, J.A.10
  • 22
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of antitumour activity
    • (doi:10.1038/ nrc2403)
    • Ellis LM & Hicklin DJ 2008 VEGF-targeted therapy: mechanisms of antitumour activity. Nature Reviews. Cancer 8 579-591. (doi:10.1038/ nrc2403)
    • (2008) Nature Reviews. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 24
    • 37349080670 scopus 로고    scopus 로고
    • B Bevacizumab plus interferon a-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • (doi:10.1016/S0140-6736(07) 61904-7)
    • Escudier B, Pluzanska A, Koralewski P, Ravaud A, Bracarda S, Szczylik C, Chevreau C, Filipek M, Melichar B & Bajetta E 2007b Bevacizumab plus interferon a-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 370 2103-2111. (doi:10.1016/S0140-6736(07) 61904-7)
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3    Ravaud, A.4    Bracarda, S.5    Szczylik, C.6    Chevreau, C.7    Filipek, M.8    Melichar, B.9    Bajetta, E.10
  • 25
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • (doi:10.1200/JCO.2008.19.5511)
    • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, Negrier S, Chevreau C, Desai AA, Rolland F et al. 2009 Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. Journal of Clinical Oncology 27 3312-3318. (doi:10.1200/JCO.2008.19.5511)
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6    Negrier, S.7    Chevreau, C.8    Desai, A.A.9    Rolland, F.10
  • 26
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • (doi:10.1038/nrd2380)
    • Faivre S, Demetri G, Sargent W & Raymond E 2007 Molecular basis for sunitinib efficacy and future clinical development. Nature Reviews. Drug Discovery 6 734-745. (doi:10.1038/nrd2380)
    • (2007) Nature Reviews. Drug Discovery , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 27
    • 76049128595 scopus 로고    scopus 로고
    • Estimates of cancer incidence and mortality in Europe in 2008
    • (doi:10.1016/j.ejca.2009.12.014)
    • Ferlay J, Parkin DM & Steliarova-Foucher E 2010 Estimates of cancer incidence and mortality in Europe in 2008. European Journal of Cancer 46 765-781. (doi:10.1016/j.ejca.2009.12.014)
    • (2010) European Journal of Cancer , vol.46 , pp. 765-781
    • Ferlay, J.1    Parkin, D.M.2    Steliarova-Foucher, E.3
  • 29
    • 84864351085 scopus 로고    scopus 로고
    • Management of axitinib (AG-013736) -induced fatigue and thyroid dysfunction, and predictive biomarkers of axitinib exposure: Results from phase i studies in Japanese patients
    • (doi:10.1007/s10637-011-9637-1)
    • Fujiwara Y, Kiyota N, Chayahara N, Suzuki A, Umeyama Y, Mukohara T & Minami H 2012 Management of axitinib (AG-013736) -induced fatigue and thyroid dysfunction, and predictive biomarkers of axitinib exposure: results from phase I studies in Japanese patients. Investigational New Drugs 30 1055-1064. (doi:10.1007/s10637-011-9637-1)
    • (2012) Investigational New Drugs , vol.30 , pp. 1055-1064
    • Fujiwara, Y.1    Kiyota, N.2    Chayahara, N.3    Suzuki, A.4    Umeyama, Y.5    Mukohara, T.6    Minami, H.7
  • 30
    • 84871382539 scopus 로고    scopus 로고
    • Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
    • Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack R, Singer PA & Woeber KA 2012 Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine Practice 18 988-1028.
    • (2012) Endocrine Practice , vol.18 , pp. 988-1028
    • Garber, J.R.1    Cobin, R.H.2    Gharib, H.3    Hennessey, J.V.4    Klein, I.5    Mechanick, J.I.6    Pessah-Pollack, R.7    Singer, P.A.8    Woeber, K.A.9
  • 31
    • 34347268452 scopus 로고    scopus 로고
    • Re: Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib
    • (doi:10.1093/jnci/djm008)
    • Garfield D, Hercbergs A & Davis P 2007 Re: hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. Journal of the National Cancer Institute 99 975-976. (doi:10.1093/jnci/djm008)
    • (2007) Journal of the National Cancer Institute , vol.99 , pp. 975-976
    • Garfield, D.1    Hercbergs, A.2    Davis, P.3
  • 33
    • 33947423448 scopus 로고    scopus 로고
    • Approval summary: Sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma
    • (doi:10.1158/ 1078-0432.CCR-06-2328)
    • Goodman VL, Rock EP, Dagher R, Ramchandani RP, Abraham S, Gobburu JV, Booth BP, Verbois SL, Morse DE, Liang CY et al. 2007 Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clinical Cancer Research 13 1367-1373. (doi:10.1158/ 1078-0432.CCR-06-2328)
    • (2007) Clinical Cancer Research , vol.13 , pp. 1367-1373
    • Goodman, V.L.1    Rock, E.P.2    Dagher, R.3    Ramchandani, R.P.4    Abraham, S.5    Gobburu, J.V.6    Booth, B.P.7    Verbois, S.L.8    Morse, D.E.9    Liang, C.Y.10
  • 34
    • 70350772288 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors - A review on pharmacology, metabolism and side effects
    • (doi:10.2174/138920009788897975)
    • Hartmann JT, Haap M, Kopp HG & Lipp HP 2009 Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects. Current Drug Metabolism 10 470-481. (doi:10.2174/138920009788897975)
    • (2009) Current Drug Metabolism , vol.10 , pp. 470-481
    • Hartmann, J.T.1    Haap, M.2    Kopp, H.G.3    Lipp, H.P.4
  • 37
    • 77953033291 scopus 로고    scopus 로고
    • Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of pharmacokinetic/- pharmacodynamic meta-analysis
    • (doi:10.1007/s00280-009-1170-y)
    • Houk BE, Bello CL, Poland B, Rosen LS, Demetri GD & Motzer RJ 2010 Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of pharmacokinetic/- pharmacodynamic meta-analysis. Cancer Chemotherapy and Pharmacology 66 357-371. (doi:10.1007/s00280-009-1170-y)
    • (2010) Cancer Chemotherapy and Pharmacology , vol.66 , pp. 357-371
    • Houk, B.E.1    Bello, C.L.2    Poland, B.3    Rosen, L.S.4    Demetri, G.D.5    Motzer, R.J.6
  • 40
    • 55349124241 scopus 로고    scopus 로고
    • A Predictive and prognostic factors in phase II renal cell carcinoma trial with pazopanib (GW786034) , a multi-kinase angiogenesis inhibitor
    • (suppl 8; abstr 5780) . (doi:10.1093/annonc/mdn510)
    • Hutson TE, Davis ID, Machiels JH, de Souza PL, Baker K, Bordogna W, Westlund R, Crofts T, Pandite L & Figlin RA 2008a Predictive and prognostic factors in phase II renal cell carcinoma trial with pazopanib (GW786034) , a multi-kinase angiogenesis inhibitor. Annals of Oncology 19 viii187 (suppl 8; abstr 5780) . (doi:10.1093/annonc/mdn510)
    • (2008) Annals of Oncology , vol.19
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.H.3    De Souza, P.L.4    Baker, K.5    Bordogna, W.6    Westlund, R.7    Crofts, T.8    Pandite, L.9    Figlin, R.A.10
  • 42
    • 62649174250 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and modifications of thyroid function tests: A review
    • (doi:10.1530/EJE-08- 0648)
    • Illouz F, Laboureau-Soares S, Dubois S, Rohmer V & Rodien P 2009 Tyrosine kinase inhibitors and modifications of thyroid function tests: a review. European Journal of Endocrinology 160 331-336. (doi:10.1530/EJE-08- 0648)
    • (2009) European Journal of Endocrinology , vol.160 , pp. 331-336
    • Illouz, F.1    Laboureau-Soares, S.2    Dubois, S.3    Rohmer, V.4    Rodien, P.5
  • 45
    • 0033756198 scopus 로고    scopus 로고
    • The selenoenzyme family of deiodinase isozymes controls local thyroid hormone availability
    • (doi:10.1023/A:1010012419869)
    • Kohrle J 2000 The selenoenzyme family of deiodinase isozymes controls local thyroid hormone availability. Reviews in Endocrine & Metabolic Disorders 1 49-58. (doi:10.1023/A:1010012419869)
    • (2000) Reviews in Endocrine & Metabolic Disorders , vol.1 , pp. 49-58
    • Kohrle, J.1
  • 47
    • 77952928989 scopus 로고    scopus 로고
    • Pazopanib: An oral multitargeted tyrosine kinase inhibitor for use in renal cell carcinoma
    • (doi:10.1345/aph.1M251)
    • La Plant KD & Louzon PD 2010 Pazopanib: an oral multitargeted tyrosine kinase inhibitor for use in renal cell carcinoma. Annals of Pharmacotherapy 44 1054-1060. (doi:10.1345/aph.1M251)
    • (2010) Annals of Pharmacotherapy , vol.44 , pp. 1054-1060
    • La Plant, K.D.1    Louzon, P.D.2
  • 48
    • 38049126179 scopus 로고    scopus 로고
    • Increasing prevalence and incidence of thyroid disease in Tayside. Scotland: The Thyroid Epidemiology Audit and Research Study (TEARS)
    • Leese GP, Flynn RV, Jung RT, Macdonald TM, Murphy MJ & Morris AD 2008 Increasing prevalence and incidence of thyroid disease in Tayside. Scotland: the Thyroid Epidemiology Audit and Research Study (TEARS) Clinical Endocrinology 68 311-316.
    • (2008) Clinical Endocrinology , vol.68 , pp. 311-316
    • Leese, G.P.1    Flynn, R.V.2    Jung, R.T.3    Macdonald, T.M.4    Murphy, M.J.5    Morris, A.D.6
  • 49
    • 38649129787 scopus 로고    scopus 로고
    • New developments in multitargeted therapy for patients with solid tumours
    • (doi:10.1016/j.ctrv.2007.09.003)
    • Le Tourneau C, Faivre S & Raymond E 2008 New developments in multitargeted therapy for patients with solid tumours. Cancer Treatment Reviews 34 37-48. (doi:10.1016/j.ctrv.2007.09.003)
    • (2008) Cancer Treatment Reviews , vol.34 , pp. 37-48
    • Le Tourneau, C.1    Faivre, S.2    Raymond, E.3
  • 53
    • 84873650357 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor-induced thyroid disorders: A review and hypothesis
    • (doi:10.1089/thy.2012.0456)
    • Makita N & Iiri T 2013 Tyrosine kinase inhibitor-induced thyroid disorders: a review and hypothesis. Thyroid 23 151-159. (doi:10.1089/thy.2012. 0456)
    • (2013) Thyroid , vol.23 , pp. 151-159
    • Makita, N.1    Iiri, T.2
  • 54
    • 77649310826 scopus 로고    scopus 로고
    • Sunitinib induces hypothyroidism with a markedly reduced vascularity
    • (doi:10.1089/thy.2009.0414)
    • Makita N, Miyakawa M, Fujita T & Iiri T 2010 Sunitinib induces hypothyroidism with a markedly reduced vascularity. Thyroid 20 323-326. (doi:10.1089/thy.2009.0414)
    • (2010) Thyroid , vol.20 , pp. 323-326
    • Makita, N.1    Miyakawa, M.2    Fujita, T.3    Iiri, T.4
  • 57
    • 0035017876 scopus 로고    scopus 로고
    • Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary
    • (doi:10.1210/en.142.6.2468)
    • Matikainen T, Perez GI, Zheng TS, Kluzak TR, Rueda BR, Flavell RA &Tilly JL 2001 Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary. Endocrinology 142 2468-2480. (doi:10.1210/en.142.6.2468)
    • (2001) Endocrinology , vol.142 , pp. 2468-2480
    • Matikainen, T.1    Perez, G.I.2    Zheng, T.S.3    Kluzak, T.R.4    Rueda, B.R.5    Flavell, R.A.6    Tilly, J.L.7
  • 58
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB et al. 2003 In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clinical Cancer Research 9 327-337.
    • (2003) Clinical Cancer Research , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3    Louie, S.G.4    Christensen, J.G.5    Li, G.6    Schreck, R.E.7    Abrams, T.J.8    Ngai, T.J.9    Lee, L.B.10
  • 59
    • 77956290435 scopus 로고    scopus 로고
    • Abnormalities of thyroid function in Japanese patients with metastatic renal cell carcinoma treated with sorafenib: A prospective evaluation
    • (doi:10.1016/j.urolonc.2009.08.011)
    • Miyake H, Kurahashi T, Yamanaka K, Kondo Y, Muramaki M, Takenaka A, Inoue TA & Fujisawa M 2010 Abnormalities of thyroid function in Japanese patients with metastatic renal cell carcinoma treated with sorafenib: A prospective evaluation. Urologic Oncology 28 515-519. (doi:10.1016/j.urolonc.2009.08.011)
    • (2010) Urologic Oncology , vol.28 , pp. 515-519
    • Miyake, H.1    Kurahashi, T.2    Yamanaka, K.3    Kondo, Y.4    Muramaki, M.5    Takenaka, A.6    Inoue, T.A.7    Fujisawa, M.8
  • 60
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and plateletderived growth factor receptor, in patients with metastatic renal cell carcinoma
    • (doi:10.1200/JCO.2005.02.2574)
    • Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE et al. 2006 Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and plateletderived growth factor receptor, in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 24 16-24. (doi:10.1200/JCO.2005.02.2574)
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3    Hudes, G.R.4    Wilding, G.5    Figlin, R.A.6    Ginsberg, M.S.7    Kim, S.T.8    Baum, C.M.9    Deprimo, S.E.10
  • 62
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double blind, randomised, placebo-controlled phase III trial
    • (doi:10.1016/S0140-6736(08) 61039-9)
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Grünwald V, Thompson JA, Figlin RA, Hollaender N et al. 2008 Efficacy of everolimus in advanced renal cell carcinoma: a double blind, randomised, placebo-controlled phase III trial. Lancet 372 449-456. (doi:10.1016/S0140- 6736(08) 61039-9)
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6    Grünwald, V.7    Thompson, J.A.8    Figlin, R.A.9    Hollaender, N.10
  • 64
    • 84872281935 scopus 로고    scopus 로고
    • Randomised, open label. Phase III trial of pazopanib versus sunitinib in first-line treatment of patients with metastatic renal cell carcinoma (mRCC) ; results of the COMPARZ trial
    • September 28-October 2, 2012, Vienna (abstract 8LBA-PR)
    • Motzer RJ, Hutson TE, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, De Souza P, Merchan JR, Fife K, et al. 2012 Randomised, open label. Phase III trial of pazopanib versus sunitinib in first-line treatment of patients with metastatic renal cell carcinoma (mRCC) ; results of the COMPARZ trial. Congress of the ESMO, September 28-October 2, 2012, Vienna (abstract 8LBA-PR)
    • (2012) Congress of the ESMO
    • Motzer, R.J.1    Hutson, T.E.2    Reeves, J.3    Hawkins, R.4    Guo, J.5    Nathan, P.6    Staehler, M.7    De Souza, P.8    Merchan, J.R.9    Fife, K.10
  • 65
    • 33750162642 scopus 로고    scopus 로고
    • Association between development of hypothyroidism and improved survival in patients with head and neck cancer
    • (doi:10.1001/archotol.132.10.1041)
    • Nelson M, Hercbergs A, Rybicki L & Strome M 2006 Association between development of hypothyroidism and improved survival in patients with head and neck cancer. Archives of Otolaryngology, Head & Neck Surgery 132 1041-1046. (doi:10.1001/archotol.132.10.1041)
    • (2006) Archives of Otolaryngology, Head & Neck Surgery , vol.132 , pp. 1041-1046
    • Nelson, M.1    Hercbergs, A.2    Rybicki, L.3    Strome, M.4
  • 66
    • 0035929669 scopus 로고    scopus 로고
    • The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
    • (doi:10.1074/jbc.M103992200)
    • Oberg C, Li J, Pauley A, Wolf E, Gurney M & Lendahl U 2001 The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. Journal of Biological Chemistry 276 35847-35853. (doi:10.1074/jbc.M103992200)
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 35847-35853
    • Oberg, C.1    Li, J.2    Pauley, A.3    Wolf, E.4    Gurney, M.5    Lendahl, U.6
  • 68
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • (doi:10.1182/blood-2002-07-2307)
    • O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A et al. 2003 SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101 3597-3605. (doi:10.1182/blood-2002-07-2307)
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3    Ngai, T.J.4    Louie, S.G.5    Yee, K.W.6    Wong, L.M.7    Hong, W.8    Lee, L.B.9    Town, A.10
  • 69
    • 0028084421 scopus 로고
    • Patterns of failure following surgical resection of renal cell carcinoma: Implications for adjuvant local and systemic therapy
    • Rabinovitch RA, Zelefsky MJ, Gaynor JJ & Fuks Z 1994 Patterns of failure following surgical resection of renal cell carcinoma: implications for adjuvant local and systemic therapy. Journal of Clinical Oncology 12 206-212.
    • (1994) Journal of Clinical Oncology , vol.12 , pp. 206-212
    • Rabinovitch, R.A.1    Zelefsky, M.J.2    Gaynor, J.J.3    Fuks, Z.4
  • 70
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • (doi:10.1200/JCO.2005.03.6723)
    • Ratain MJ, Eisen T & Stadler WM 2006 Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 24 2505-2512. (doi:10.1200/JCO. 2005.03.6723)
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 72
    • 81855163405 scopus 로고    scopus 로고
    • Hypothyroidism correlates with a better prognosis in metastatic renal cancer patients treated with sorafenib or sunitinib
    • (doi:10.1007/s00345- 010-0627-2)
    • Riesenbeck LM, Bierer S, Hoffmeister I, Köpke T, Papavassilis P, Hertle L, Thielen B & Herrmann E 2011 Hypothyroidism correlates with a better prognosis in metastatic renal cancer patients treated with sorafenib or sunitinib. World Journal of Urology 29 807-813. (doi:10.1007/s00345- 010-0627-2)
    • (2011) World Journal of Urology , vol.29 , pp. 807-813
    • Riesenbeck, L.M.1    Bierer, S.2    Hoffmeister, I.3    Köpke, T.4    Papavassilis, P.5    Hertle, L.6    Thielen, B.7    Herrmann, E.8
  • 73
    • 65949122058 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma
    • (doi:10.1002/ cncr.24227)
    • Rini BI 2009 Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer 115 2306-2312. (doi:10.1002/ cncr.24227)
    • (2009) Cancer , vol.115 , pp. 2306-2312
    • Rini, B.I.1
  • 77
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon a versus interferon a monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • (doi:10.1200/JCO. 2009.26.5561)
    • Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J et al. 2010 Phase III trial of bevacizumab plus interferon a versus interferon a monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. Journal of Clinical Oncology 28 2137-2143. (doi:10.1200/JCO. 2009.26.5561)
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Archer, L.6    Atkins, J.N.7    Picus, J.8    Czaykowski, P.9    Dutcher, J.10
  • 78
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
    • (doi:10.1016/S0140-6736(11) 61613-9)
    • Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG et al. 2011 Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS) : a randomised phase 3 trial. Lancet 378 1931-1939. (doi:10.1016/S0140- 6736(11) 61613-9)
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3    Kaprin, A.4    Szczylik, C.5    Hutson, T.E.6    Michaelson, M.D.7    Gorbunova, V.A.8    Gore, M.E.9    Rusakov, I.G.10
  • 79
    • 1242318752 scopus 로고    scopus 로고
    • TSH-activated signaling pathways in thyroid tumorigenesis
    • (doi:10.1016/j.mce.2003.10.029)
    • Rivas M & Santisteban P 2003 TSH-activated signaling pathways in thyroid tumorigenesis. Molecular and Cellular Endocrinology 13 31-45. (doi:10.1016/j.mce.2003.10.029)
    • (2003) Molecular and Cellular Endocrinology , vol.13 , pp. 31-45
    • Rivas, M.1    Santisteban, P.2
  • 81
    • 1542285326 scopus 로고    scopus 로고
    • Hypothyroidism
    • (doi:10.1016/S0140-6736(04) 15696-1)
    • Roberts CG & Ladenson PW 2004 Hypothyroidism. Lancet 363 793-803. (doi:10.1016/S0140-6736(04) 15696-1)
    • (2004) Lancet , vol.363 , pp. 793-803
    • Roberts, C.G.1    Ladenson, P.W.2
  • 82
    • 79959286206 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with metastatic breast cancer
    • (doi:10.1200/JCO.2010.31.2975)
    • Rugo HS, Stopeck AT, Joy AA, Chan S, Verma S, Lluch A, Liau KF, Kim S, Bycott P, Rosbrook B et al. 2011 Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with metastatic breast cancer. Journal of Clinical Oncology 29 2459-2465. (doi:10.1200/JCO.2010.31.2975)
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 2459-2465
    • Rugo, H.S.1    Stopeck, A.T.2    Joy, A.A.3    Chan, S.4    Verma, S.5    Lluch, A.6    Liau, K.F.7    Kim, S.8    Bycott, P.9    Rosbrook, B.10
  • 84
    • 46349101365 scopus 로고    scopus 로고
    • Effect of sunitinib on growth and function of FRTL-5 thyroid cells
    • (doi:10.1089/thy.2007.0336)
    • Salem AK, Fenton MS, Marion KM & Hershman JM 2008 Effect of sunitinib on growth and function of FRTL-5 thyroid cells. Thyroid 18 631-635. (doi:10.1089/thy.2007.0336)
    • (2008) Thyroid , vol.18 , pp. 631-635
    • Salem, A.K.1    Fenton, M.S.2    Marion, K.M.3    Hershman, J.M.4
  • 89
    • 77953419143 scopus 로고    scopus 로고
    • Management of side effects associated with sunitinib therapy for patients with renal cell carcinoma
    • Schwandt A, Wood LS, Rini B & Dreicer R 2009 Management of side effects associated with sunitinib therapy for patients with renal cell carcinoma. OncoTargets and Therapy 2 51-61.
    • (2009) OncoTargets and Therapy , vol.2 , pp. 51-61
    • Schwandt, A.1    Wood, L.S.2    Rini, B.3    Dreicer, R.4
  • 91
    • 84863084848 scopus 로고    scopus 로고
    • Does sunitinib-induced hypothyroidism play a role in the activity of sunitinib in metastatic renal cell carcinoma?
    • (doi:10.1159/ 000337079)
    • Sella A, Hercbergs AH, Hanovich E & Kovel S 2012 Does sunitinib-induced hypothyroidism play a role in the activity of sunitinib in metastatic renal cell carcinoma? Chemotherapy 58 200-205. (doi:10.1159/ 000337079)
    • (2012) Chemotherapy , vol.58 , pp. 200-205
    • Sella, A.1    Hercbergs, A.H.2    Hanovich, E.3    Kovel, S.4
  • 95
    • 33751502244 scopus 로고    scopus 로고
    • Anti-apoptotic effects of 3,5,30- triiodothyronine in mouse hepatocytes
    • (doi:10.1677/joe.1.07061)
    • Sukocheva OA & Carpenter DO 2006 Anti-apoptotic effects of 3,5,30- triiodothyronine in mouse hepatocytes. Journal of Endocrinology 191 447-458. (doi:10.1677/joe.1.07061)
    • (2006) Journal of Endocrinology , vol.191 , pp. 447-458
    • Sukocheva, O.A.1    Carpenter, D.O.2
  • 96
    • 78449253608 scopus 로고    scopus 로고
    • Novel multitargeted anticancer oral therapies: Sunitinib and sorafenib as a paradigm
    • Sulkes A 2010 Novel multitargeted anticancer oral therapies: sunitinib and sorafenib as a paradigm. Israel Medical Association Journal 12 628-632.
    • (2010) Israel Medical Association Journal , vol.12 , pp. 628-632
    • Sulkes, A.1
  • 98
    • 80755140681 scopus 로고    scopus 로고
    • Key predictive factors of axitinib (AG-013736) -induced proteinuria and efficacy: A phase II study in Japanese patients with cytokine-refractory metastatic renal cell Carcinoma
    • (doi:10.1016/j.ejca.2011.07.014)
    • Tomita Y, Uemura H, Fujimoto H, Kanayama HO, Shinohara N, Nakazawa H, Imai K, Umeyama Y, Ozono S, Naito S et al. 2011 Key predictive factors of axitinib (AG-013736) -induced proteinuria and efficacy: a phase II study in Japanese patients with cytokine-refractory metastatic renal cell Carcinoma. European Journal of Cancer 47 2592-2602. (doi:10.1016/j.ejca.2011.07.014)
    • (2011) European Journal of Cancer , vol.47 , pp. 2592-2602
    • Tomita, Y.1    Uemura, H.2    Fujimoto, H.3    Kanayama, H.O.4    Shinohara, N.5    Nakazawa, H.6    Imai, K.7    Umeyama, Y.8    Ozono, S.9    Naito, S.10
  • 99
    • 67650173972 scopus 로고    scopus 로고
    • Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy
    • (doi:10.1038/nrclinonc.2009.4)
    • Torino F, Corsello SM, Longo R, Barnabei A & Gasparini G 2009 Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy. Nature Reviews. Clinical Oncology 6 219-228. (doi:10.1038/nrclinonc.2009.4)
    • (2009) Nature Reviews. Clinical Oncology , vol.6 , pp. 219-228
    • Torino, F.1    Corsello, S.M.2    Longo, R.3    Barnabei, A.4    Gasparini, G.5
  • 102
    • 27544452298 scopus 로고
    • Radioimmunoassay of human plasma thyrotropin
    • (doi:10.1172/JCI105234)
    • Utiger RD 1965 Radioimmunoassay of human plasma thyrotropin. Journal of Clinical Investigation 44 1277-1286. (doi:10.1172/JCI105234)
    • (1965) Journal of Clinical Investigation , vol.44 , pp. 1277-1286
    • Utiger, R.D.1
  • 108
    • 58149463969 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and the thyroid as both an unintended and an intended target
    • (doi:10.4158/EP.14.5.618)
    • VetterML, Kaul S& Iqbal N 2008 Tyrosine kinase inhibitors and the thyroid as both an unintended and an intended target. Endocrine Practice 14 618-624. (doi:10.4158/EP.14.5.618)
    • (2008) Endocrine Practice , vol.14 , pp. 618-624
    • Vetter, M.L.1    Kaul, S.2    Iqbal, N.3
  • 109
    • 0031967581 scopus 로고    scopus 로고
    • Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function
    • (doi:10.1677/joe.0.1570005)
    • Wang JF, Milosveski V, Schramek C, Fong GH, Becks GP & Hill DJ 1998 Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function. Journal of Endocrinology 157 5-12. (doi:10.1677/joe.0. 1570005)
    • (1998) Journal of Endocrinology , vol.157 , pp. 5-12
    • Wang, J.F.1    Milosveski, V.2    Schramek, C.3    Fong, G.H.4    Becks, G.P.5    Hill, D.J.6
  • 110
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • (doi:10.1158/0008- 5472.CAN-04-1443)
    • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M et al. 2004 BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Research 64 7099-7109. (doi:10.1158/0008- 5472.CAN-04-1443)
    • (2004) Cancer Research , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6    Chen, C.7    Zhang, X.8    Vincent, P.9    McHugh, M.10
  • 113
    • 34248632840 scopus 로고    scopus 로고
    • Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity
    • (doi:10.1089/thy.2006.0308)
    • Wong E, Rosen LS, Mulay M, Vanvugt A, Dinolfo M, Tomoda C, SugawaraM & Hershman JM 2007 Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity. Thyroid 17 351-355. (doi:10.1089/thy.2006.0308)
    • (2007) Thyroid , vol.17 , pp. 351-355
    • Wong, E.1    Rosen, L.S.2    Mulay, M.3    Vanvugt, A.4    Dinolfo, M.5    Tomoda, C.6    Sugawara, M.7    Hershman, J.M.8
  • 114
    • 80053611910 scopus 로고    scopus 로고
    • Interactions of thyroid hormone and FSH in the regulation of rat granulosa cell apoptosis
    • Zhang C, Xia G & Tsang BK 2011 Interactions of thyroid hormone and FSH in the regulation of rat granulosa cell apoptosis. Frontiers in Bioscience 1 1401-1413.
    • (2011) Frontiers in Bioscience , vol.1 , pp. 1401-1413
    • Zhang, C.1    Xia, G.2    Tsang, B.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.