Renal carcinoma cell-derived exosomes induce human immortalized line of Jurkat t lymphocyte apoptosis in vitro

Urologia Internationalis

Volumn 91, Issue 3, 2013, Pages 363-369

  Yang, Lin ^a   Wu, Xiaohou ^a   Wang, Dan ^a   Luo, Chunli ^a   Chen, Lixue ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cytology; Enzyme linked immunosorbent assay; Exosomes; Fas ligand; Immune evasion; Jurkat T cells; Renal cell carcinoma

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOKINE; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER CELL; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CANCER CELL CULTURE; CENTRIFUGATION; GIEMSA STAIN; IMMUNE EVASION; JURKAT CELL LINE; ULTRAFILTRATION;

ADENOCARCINOMA; APOPTOSIS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXOSOMES; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-6; JURKAT CELLS; KIDNEY NEOPLASMS; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 84886419938     PISSN: 00421138     EISSN: 14230399     Source Type: Journal    
DOI: 10.1159/000348747     Document Type: Article

References (21)

1. Jemal A, Siegel R, Xu J, Ward E: Cancer statistics. CA Cancer J Clin 2010; 60: 277-300.
2. Jemal A, Clegg LX, Ward E, Ries LA, Wu X, Jamison PM, Wingo PA, Howe HL, Anderson RN, Edwards BK: Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer 2004; 101: 3-27.
3. Milella M, Felici A: Biology of metastatic renal cell carcinoma. J Cancer 2011; 2: 369-373.
4. Thery C, Ostrowski M, Segura E: Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009; 9: 581-593.
5. Thery C, Zitvogel L, Amigorena S: Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002; 2: 569-579.
6. Yang C, Robbins PD: The roles of tumor-derived exosomes in cancer pathogenesis. Clin Dev Immunol 2011; 2011: 842849.
7. Clayton A, Mason MD: Exosomes in tumour immunity. Curr Oncol 2009; 16: 46-49.
8. Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, Squarcina P, Accornero P, Lozupone F, Lugini L, Stringaro A, Molinari A, Arancia G, Gentile M, Parmiani G, Fais S: Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med 2002; 195: 1303-1316.
9. Huber V, Fais S, Iero M, Lugini L, Canese P, Squarcina P, Zaccheddu A, Colone M, Arancia G, Gentile M, Seregni E, Valenti R, Ballabio G, Belli F, Leo E, Parmiani G, Rivoltini L: Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology 2005; 128: 1796-1804.
10. Abusamra AJ, Zhong Z, Zheng X, Li M, Ichim TE, Chin JL, Min WP: Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis. Blood Cells Mol Dis 2005; 35: 169-173.
11. Lotvall J, Valadi H: Cell to cell signalling via exosomes through esRNA. Cell Adh Migr 2007; 1: 156-158.
12. Couzin J: Cell biology: the ins and outs of exosomes. Science 2005; 308: 1862-1863.
13. Zhang Y, Luo CL, He BC, Zhang JM, Cheng G, Wu XH: Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma. Int J Oncol 2010; 36: 133-140.
14. Zhang Y, Wu XH, Luo CL, Zhang JM, He BC, Chen G: Interleukin-12-anchored exosomes increase cytotoxicity of T lymphocytes by reversing the JAK/STAT pathway impaired by tumor-derived exosomes. Int J Mol Med 2010; 25: 695-700.
15. Clayton A, Mitchell JP, Court J, Mason MD, Tabi Z: Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin- 2. Cancer Res 2007; 67: 7458-7466.
16. Kharaziha P, Ceder S, Li Q, Panaretakis T: Tumor cell-derived exosomes: a message in a bottle. Biochim Biophys Acta 2012; 1826: 103-111.
17. Kim JW, Wieckowski E, Taylor DD, Reichert TE, Watkins S, Whiteside TL: Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res 2005; 11: 1010-1020.
18. OReilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang JG, Belz GT, Smyth MJ, Bouillet P, Robb L, Strasser A: Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 2009; 461: 659-663.
19. Siegel RM, Chan FK, Chun HJ, Lenardo MJ: The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol 2000; 1: 469-474.
20. Iero M, Valenti R, Huber V, Filipazzi P, Parmiani G, Fais S, Rivoltini L: Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ 2008; 15: 80-88.
21. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.