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Volumn 19, Issue 1, 2013, Pages 324-331

Activated protein C inhibits proliferation and tumor necrosis factor α-stimulated activation of p38, c-Jun NH2-terminal kinase (JNK) and Akt in rheumatoid synovial fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATED PROTEIN C; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; PROTEIN C; TUMOR NECROSIS FACTOR;

EID: 84886378624     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2013.00034     Document Type: Article
Times cited : (10)

References (69)
  • 2
    • 33750341495 scopus 로고    scopus 로고
    • Mitogen activated protein kinase inhibitors: Where are we now and where are we going?
    • Sweeney SE, Firestein GS. (2006) Mitogen activated protein kinase inhibitors: where are we now and where are we going? Ann. Rheum. Dis. 65 (Suppl. 3):383-8.
    • (2006) Ann. Rheum. Dis. , vol.65 , Issue.SUPPL. 3 , pp. 383-388
    • Sweeney, S.E.1    Firestein, G.S.2
  • 3
    • 84871778727 scopus 로고    scopus 로고
    • Duality of fibroblast-like synoviocytes in RA: Passive responders and imprinted aggressors
    • Bottini N, Firestein GS. (2013) Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat. Rev. Rheumatol. 9:24-33.
    • (2013) Nat. Rev. Rheumatol. , vol.9 , pp. 24-33
    • Bottini, N.1    Firestein, G.S.2
  • 5
    • 0026033431 scopus 로고
    • Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts
    • Bucala R, Ritchlin C, Winchester R, Cerami A. (1991) Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J. Exp. Med. 173:569-74.
    • (1991) J. Exp. Med. , vol.173 , pp. 569-574
    • Bucala, R.1    Ritchlin, C.2    Winchester, R.3    Cerami, A.4
  • 6
    • 67349111091 scopus 로고    scopus 로고
    • Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice
    • Jung YO, et al. (2009) Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice. Immunol. Lett. 123:138-43.
    • (2009) Immunol. Lett. , vol.123 , pp. 138-143
    • Jung, Y.O.1
  • 8
    • 0025348745 scopus 로고
    • How important are T cells in chronic rheumatoid synovitis?
    • Firestein GS, Zvaifler NJ. (1990) How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 33:768-73.
    • (1990) Arthritis Rheum. , vol.33 , pp. 768-773
    • Firestein, G.S.1    Zvaifler, N.J.2
  • 9
    • 69949140663 scopus 로고    scopus 로고
    • Type I interferons might form the link between toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)
    • Roelofs MF, et al. (2009) Type I interferons might form the link between toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA). Ann. Rheum. Dis. 68:1486-93.
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1486-1493
    • Roelofs, M.F.1
  • 10
    • 0034944752 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt
    • Zhang HG, et al. (2001) Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis Rheum. 44:1555-67.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1555-1567
    • Zhang, H.G.1
  • 11
    • 0034671571 scopus 로고    scopus 로고
    • Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice
    • Nasu K, et al. (2000) Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice. J. Immunol. 165:7246-52.
    • (2000) J. Immunol. , vol.165 , pp. 7246-7252
    • Nasu, K.1
  • 12
    • 66149154257 scopus 로고    scopus 로고
    • Hypoxia-induced abrogation of contact-dependent inhibition of rheumatoid arthritis synovial fibroblast proliferation
    • Nonomura Y, et al. (2009) Hypoxia-induced abrogation of contact-dependent inhibition of rheumatoid arthritis synovial fibroblast proliferation. J. Rheumatol. 36:698-705.
    • (2009) J. Rheumatol. , vol.36 , pp. 698-705
    • Nonomura, Y.1
  • 13
    • 84861665800 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in adults with septic shock
    • Ranieri VM, et al. (2012) Drotrecogin alfa (activated) in adults with septic shock. N. Engl. J. Med. 366:2055-64.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2055-2064
    • Ranieri, V.M.1
  • 14
    • 51449117497 scopus 로고    scopus 로고
    • Activated protein C: An anticoagulant that does more than stop clots
    • Jackson CJ, Xue M. (2008) Activated protein C: an anticoagulant that does more than stop clots. Int. J. Biochem. Cell. Biol. 40:2692-7.
    • (2008) Int. J. Biochem. Cell. Biol. , vol.40 , pp. 2692-2697
    • Jackson, C.J.1    Xue, M.2
  • 15
    • 0036719236 scopus 로고    scopus 로고
    • New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins
    • Esmon CT. (2002) New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins. J. Exp. Med. 196:561-4.
    • (2002) J. Exp. Med. , vol.196 , pp. 561-564
    • Esmon, C.T.1
  • 16
    • 2942744463 scopus 로고    scopus 로고
    • Protease-activated receptor signaling in the regulation of inflammation
    • Ruf W. (2004) Protease-activated receptor signaling in the regulation of inflammation. Crit. Care Med. 32 (Suppl. 5):S287-92.
    • (2004) Crit. Care Med. , vol.32 , Issue.SUPPL. 5
    • Ruf, W.1
  • 17
    • 80054987132 scopus 로고    scopus 로고
    • Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38
    • Julovi SM, et al. (2011) Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38. Am. J. Pathol. 179:2233-42.
    • (2011) Am. J. Pathol. , vol.179 , pp. 2233-2242
    • Julovi, S.M.1
  • 18
    • 3142680906 scopus 로고    scopus 로고
    • Activated protein C induces endothelial cell proliferation by mitogenactivated protein kinase activation in vitro and angiogenesis in vivo
    • Uchiba M, et al. (2004) Activated protein C induces endothelial cell proliferation by mitogenactivated protein kinase activation in vitro and angiogenesis in vivo. Circ. Res. 95:34-41.
    • (2004) Circ. Res. , vol.95 , pp. 34-41
    • Uchiba, M.1
  • 19
    • 65249136659 scopus 로고    scopus 로고
    • Activated protein C mediates a healing phenotype in cultured tenocytes
    • Xue M, et al. (2009) Activated protein C mediates a healing phenotype in cultured tenocytes. J. Cell Mol. Med. 13:749-57.
    • (2009) J. Cell Mol. Med. , vol.13 , pp. 749-757
    • Xue, M.1
  • 20
    • 3142690433 scopus 로고    scopus 로고
    • Elevation of activated protein C in synovial joints in rheumatoid arthritis and its correlation with matrix metalloproteinase 2
    • Buisson-Legendre N, Smith S, March L, Jackson C. (2004) Elevation of activated protein C in synovial joints in rheumatoid arthritis and its correlation with matrix metalloproteinase 2. Arthritis Rheum. 50:2151-6.
    • (2004) Arthritis Rheum. , vol.50 , pp. 2151-2156
    • Buisson-Legendre, N.1    Smith, S.2    March, L.3    Jackson, C.4
  • 21
    • 0028141352 scopus 로고
    • Studies of thrombin-induced proteoglycan release in the degradation of human and bovine cartilage
    • Furmaniak-Kazmierczak E, et al. (1994) Studies of thrombin-induced proteoglycan release in the degradation of human and bovine cartilage. J. Clin. Invest. 94:472-80.
    • (1994) J. Clin. Invest. , vol.94 , pp. 472-480
    • Furmaniak-Kazmierczak, E.1
  • 22
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-24.
    • (1988) Arthritis Rheum. , vol.31 , pp. 315-324
    • Arnett, F.C.1
  • 23
    • 84855358855 scopus 로고    scopus 로고
    • Transcriptome analysis reveals specific changes in osteoarthritis synovial fibroblasts
    • Del Rey MJ, et al. (2012) Transcriptome analysis reveals specific changes in osteoarthritis synovial fibroblasts. Ann. Rheum. Dis. 71:275-80.
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 275-280
    • Del Rey, M.J.1
  • 24
    • 0032903908 scopus 로고    scopus 로고
    • The transcriptional program in the response of human fibroblasts to serum
    • Iyer VR, et al. (1999) The transcriptional program in the response of human fibroblasts to serum. Science. 283:83-7.
    • (1999) Science , vol.283 , pp. 83-87
    • Iyer, V.R.1
  • 25
    • 33745612740 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38
    • Hiramitsu T, et al. (2006) Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38. Rheumatology (Oxford). 45:824-32.
    • (2006) Rheumatology (Oxford). , vol.45 , pp. 824-832
    • Hiramitsu, T.1
  • 26
    • 77951997255 scopus 로고    scopus 로고
    • Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts
    • Neumann E, et al. (2010) Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts. Arthritis Res. Ther. 12:R83.
    • (2010) Arthritis Res. Ther. , vol.12
    • Neumann, E.1
  • 27
    • 38449112810 scopus 로고    scopus 로고
    • Acquisition, culture, and phenotyping of synovial fibroblasts
    • Rosengren S, Boyle DL, Firestein GS. (2007) Acquisition, culture, and phenotyping of synovial fibroblasts. Methods Mol. Med. 135:365-75.
    • (2007) Methods Mol. Med. , vol.135 , pp. 365-375
    • Rosengren, S.1    Boyle, D.L.2    Firestein, G.S.3
  • 28
    • 84862810833 scopus 로고    scopus 로고
    • A novel procedure for absolute real-time quantification of gene expression patterns
    • Lu Y, Xie L, Chen J. (2012) A novel procedure for absolute real-time quantification of gene expression patterns. Plant Methods. 8:9.
    • (2012) Plant Methods , vol.8 , pp. 9
    • Lu, Y.1    Xie, L.2    Chen, J.3
  • 29
    • 84862524456 scopus 로고    scopus 로고
    • Fractalkine stimulates cell growth and increases its expression via NFkappaB pathway in RA-FLS
    • Guo X, et al. (2012) Fractalkine stimulates cell growth and increases its expression via NFkappaB pathway in RA-FLS. Int. J. Rheum. Dis. 15:322-9.
    • (2012) Int. J. Rheum. Dis. , vol.15 , pp. 322-329
    • Guo, X.1
  • 30
    • 84873318484 scopus 로고    scopus 로고
    • Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10
    • Laragione T, Gulko PS. (2012) Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10. Mol. Med. 18:1009-17.
    • (2012) Mol. Med. , vol.18 , pp. 1009-1017
    • Laragione, T.1    Gulko, P.S.2
  • 31
    • 46549088304 scopus 로고    scopus 로고
    • Hyaluronan inhibits IL-1betastimulated collagenase production via downregulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells
    • Julovi SM, Ito H, Hiramitsu T, Yasuda T, Nakamura T. (2008) Hyaluronan inhibits IL-1betastimulated collagenase production via downregulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells. Mod. Rheumatol. 18:263-70.
    • (2008) Mod. Rheumatol. , vol.18 , pp. 263-270
    • Julovi, S.M.1    Ito, H.2    Hiramitsu, T.3    Yasuda, T.4    Nakamura, T.5
  • 32
    • 71549117557 scopus 로고    scopus 로고
    • Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
    • Lefevre S, et al. (2009) Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat. Med. 15:1414-20.
    • (2009) Nat. Med. , vol.15 , pp. 1414-1420
    • Lefevre, S.1
  • 34
    • 0031733349 scopus 로고    scopus 로고
    • Monoclonal expansion of synoviocytes in rheumatoid arthritis
    • Imamura F, et al. (1998) Monoclonal expansion of synoviocytes in rheumatoid arthritis. Arthritis Rheum. 41:1979-86.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1979-1986
    • Imamura, F.1
  • 35
    • 34247583326 scopus 로고    scopus 로고
    • Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts
    • Meinecke I, et al. (2007) Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 104:5073-8.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 5073-5078
    • Meinecke, I.1
  • 36
    • 0029855587 scopus 로고    scopus 로고
    • Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
    • Muller-Ladner U, et al. (1996) Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am. J. Pathol. 149:1607-15.
    • (1996) Am. J. Pathol. , vol.149 , pp. 1607-1615
    • Muller-Ladner, U.1
  • 37
    • 45349100915 scopus 로고    scopus 로고
    • Denatured collagen modulates the phenotype of normal and wounded human skin equivalents
    • Egles C, et al. (2008) Denatured collagen modulates the phenotype of normal and wounded human skin equivalents. J. Invest. Dermatol. 128:1830-7.
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 1830-1837
    • Egles, C.1
  • 38
    • 0142148287 scopus 로고    scopus 로고
    • Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis
    • Nonomura Y, Kohsaka H, Nagasaka K, Miyasaka N. (2003) Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis. J. Immunol. 171:4913-9.
    • (2003) J. Immunol. , vol.171 , pp. 4913-4919
    • Nonomura, Y.1    Kohsaka, H.2    Nagasaka, K.3    Miyasaka, N.4
  • 39
    • 34547869352 scopus 로고    scopus 로고
    • A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis
    • Woods JM, et al. (2006) A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis. Arthritis Res. Ther. 8:R113.
    • (2006) Arthritis Res. Ther. , vol.8
    • Woods, J.M.1
  • 40
    • 84855275513 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis
    • Mavers M, et al. (2012) Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis. Arthritis Rheum. 64:141-52.
    • (2012) Arthritis Rheum. , vol.64 , pp. 141-152
    • Mavers, M.1
  • 41
    • 33846175113 scopus 로고    scopus 로고
    • FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice
    • Ohori M, Takeuchi M, Maruki R, Nakajima H, Miyake H. (2007) FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch. Pharmacol. 374:311-6.
    • (2007) Naunyn Schmiedebergs Arch. Pharmacol. , vol.374 , pp. 311-316
    • Ohori, M.1    Takeuchi, M.2    Maruki, R.3    Nakajima, H.4    Miyake, H.5
  • 42
    • 35348923750 scopus 로고    scopus 로고
    • Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms
    • Thiel MJ, et al. (2007) Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms. Arthritis Rheum. 56:3347-57.
    • (2007) Arthritis Rheum. , vol.56 , pp. 3347-3357
    • Thiel, M.J.1
  • 43
    • 77951523628 scopus 로고    scopus 로고
    • Kinetic analysis of synovial signalling and gene expression in animal models of arthritis
    • Fukushima A, Boyle DL, Corr M, Firestein GS. (2010) Kinetic analysis of synovial signalling and gene expression in animal models of arthritis. Ann. Rheum. Dis. 69:918-23.
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 918-923
    • Fukushima, A.1    Boyle, D.L.2    Corr, M.3    Firestein, G.S.4
  • 44
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351:95-105.
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 46
    • 84874310577 scopus 로고    scopus 로고
    • Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells
    • Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J, Rozengurt E. (2013) Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. PLoS One. 8:e57289.
    • (2013) PLoS One. , vol.8
    • Soares, H.P.1    Ni, Y.2    Kisfalvi, K.3    Sinnett-Smith, J.4    Rozengurt, E.5
  • 47
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, et al. (2008) Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J. Clin. Invest. 118:3065-74.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3065-3074
    • Carracedo, A.1
  • 48
    • 34248563290 scopus 로고    scopus 로고
    • The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition
    • Meloche S, Pouyssegur J. (2007) The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition. Oncogene. 26:3227-39.
    • (2007) Oncogene. , vol.26 , pp. 3227-3239
    • Meloche, S.1    Pouyssegur, J.2
  • 49
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
    • Woods D, et al. (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell. Biol. 17:5598-611.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5598-5611
    • Woods, D.1
  • 50
    • 34547197372 scopus 로고    scopus 로고
    • Predominant activation of MAP kinases and pro-destructive/proinflammatory features by TNF alpha in earlypassage synovial fibroblasts via TNF receptor-1: Failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis
    • Kunisch E, et al. (2007) Predominant activation of MAP kinases and pro-destructive/proinflammatory features by TNF alpha in earlypassage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis. Ann. Rheum. Dis. 66:1043-51.
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 1043-1051
    • Kunisch, E.1
  • 51
    • 0344153852 scopus 로고    scopus 로고
    • Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation
    • Pillinger MH, et al. (2003) Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation. J. Immunol. 171:6080-9.
    • (2003) J. Immunol. , vol.171 , pp. 6080-6089
    • Pillinger, M.H.1
  • 52
    • 0033623180 scopus 로고    scopus 로고
    • Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: Divergence of IL-1 and TNFdependent signal transduction in rabbit primary synovial fibroblasts
    • Barchowsky A, Frleta D, Vincenti MP. (2000) Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNFdependent signal transduction in rabbit primary synovial fibroblasts. Cytokine. 2000:79.
    • (2000) Cytokine , pp. 79
    • Barchowsky, A.1    Frleta, D.2    Vincenti, M.P.3
  • 53
    • 84874422827 scopus 로고    scopus 로고
    • Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis
    • Binder NB, et al. (2013) Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis. Arthritis Rheum. 65:608-17.
    • (2013) Arthritis Rheum. , vol.65 , pp. 608-617
    • Binder, N.B.1
  • 54
    • 74849138395 scopus 로고    scopus 로고
    • Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts
    • Luo SF, et al. (2010) Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 62:105-16.
    • (2010) Arthritis Rheum. , vol.62 , pp. 105-116
    • Luo, S.F.1
  • 55
    • 33645867986 scopus 로고    scopus 로고
    • A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes
    • Cha HS, et al. (2006) A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J. Pharmacol. Exp. Ther. 317:571-8.
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 571-578
    • Cha, H.S.1
  • 56
    • 17244364098 scopus 로고    scopus 로고
    • Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: A detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study
    • Smolen JS, et al. (2005) Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. Arthritis Rheum. 52:1020-30.
    • (2005) Arthritis Rheum. , vol.52 , pp. 1020-1030
    • Smolen, J.S.1
  • 57
    • 33750324355 scopus 로고    scopus 로고
    • Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: Results from the trial of etanercept and methotrexate with radiographic and patient outcomes
    • Landewe R, van der Heijde D, Klareskog L, van Vollenhoven R, Fatenejad S. (2006) Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes. Arthritis Rheum. 54:3119-25.
    • (2006) Arthritis Rheum. , vol.54 , pp. 3119-3125
    • Landewe, R.1    van der Heijde, D.2    Klareskog, L.3    van Vollenhoven, R.4    Fatenejad, S.5
  • 58
    • 67650472833 scopus 로고    scopus 로고
    • Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis
    • Emery P, et al. (2009) Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis. J. Rheumatol. 36:1429-41.
    • (2009) J. Rheumatol. , vol.36 , pp. 1429-1441
    • Emery, P.1
  • 59
    • 78650934811 scopus 로고    scopus 로고
    • Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38
    • Julovi SM, Ito H, Nishitani K, Jackson CJ, Nakamura T. (2011) Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38. J. Orthop. Res. 29:258-64.
    • (2011) J. Orthop. Res. , vol.29 , pp. 258-264
    • Julovi, S.M.1    Ito, H.2    Nishitani, K.3    Jackson, C.J.4    Nakamura, T.5
  • 61
    • 0033758633 scopus 로고    scopus 로고
    • Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogenactivated protein kinase, in synovial tissue and cells in rheumatoid arthritis
    • Schett G, et al. (2000) Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogenactivated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum. 43:2501-12.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2501-2512
    • Schett, G.1
  • 62
    • 0034942860 scopus 로고    scopus 로고
    • NF-kappa B in rheumatoid arthritis: A pivotal regulator of inflammation, hyperplasia, and tissue destruction
    • Makarov SS. (2001) NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res. 3:200-6.
    • (2001) Arthritis Res. , vol.3 , pp. 200-206
    • Makarov, S.S.1
  • 63
    • 36749017585 scopus 로고    scopus 로고
    • Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes
    • Xue M, March L, Sambrook PN, Fukudome K, Jackson CJ. (2007) Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Ann. Rheum. Dis. 66:1574-80.
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 1574-1580
    • Xue, M.1    March, L.2    Sambrook, P.N.3    Fukudome, K.4    Jackson, C.J.5
  • 64
    • 77956566269 scopus 로고    scopus 로고
    • A proof-of-concept and drugdrug interaction study of pamapimod, a novel p38 MAP kinase inhibitor, with methotrexate in patients with rheumatoid arthritis
    • Zhang X, Huang Y, Navarro MT, Hisoire G, Caulfield JP. (2010) A proof-of-concept and drugdrug interaction study of pamapimod, a novel p38 MAP kinase inhibitor, with methotrexate in patients with rheumatoid arthritis. J. Clin. Pharmacol. 50:1031-8.
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 1031-1038
    • Zhang, X.1    Huang, Y.2    Navarro, M.T.3    Hisoire, G.4    Caulfield, J.P.5
  • 65
    • 79955563297 scopus 로고    scopus 로고
    • A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis
    • Genovese MC, et al. (2011) A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J. Rheumatol. 38:846-54.
    • (2011) J. Rheumatol. , vol.38 , pp. 846-854
    • Genovese, M.C.1
  • 66
    • 78650645825 scopus 로고    scopus 로고
    • Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients
    • Coulthard LR, et al. (2011) Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. Ann. Rheum. Dis. 70:98-103.
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 98-103
    • Coulthard, L.R.1
  • 67
    • 84857238808 scopus 로고    scopus 로고
    • Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets
    • de Launay D, et al. (2012) Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. Ann. Rheum. Dis. 71:415-23.
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 415-423
    • de Launay, D.1
  • 68
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. (2002) The phosphoinositide 3-kinase pathway. Science. 296:1655-7.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 69
    • 84855283952 scopus 로고    scopus 로고
    • Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis
    • Xue M, et al. (2012) Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum. 64:88-98.
    • (2012) Arthritis Rheum. , vol.64 , pp. 88-98
    • Xue, M.1


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