Hypoxia-induced abrogation of contact-dependent inhibition of rheumatoid arthritis synovial fibroblast proliferation

Journal of Rheumatology

Volumn 36, Issue 4, 2009, Pages 698-705

  Nonomura, Yoshinori ^a   Mizoguchi, Fumitaka ^a   Suzuki, Akiko ^a   Nanki, Toshihiro ^a   Kato, Hiroyuki ^b   Miyasaka, Nobuyuki ^a   Kohsaka, Hitoshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cadherin; Cyclin dependent kinase inhibitor; Hypoxia; Rheumatoid arthritis; Synovial fibroblasts

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN DEPENDENT KINASE INHIBITOR 1B; NERVE CELL ADHESION MOLECULE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RNA; THYMIDINE; TRITIUM; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; ANTIBODY; CADHERIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL GROWTH; CELL HYPOXIA; CELL LYSATE; CELL PROLIFERATION; CONTACT INHIBITION; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANOXIA; CYTOLOGY; IMMUNOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANOXIA; ANTIBODIES; ARTHRITIS, RHEUMATOID; CADHERINS; CELL PROLIFERATION; CELLS, CULTURED; CONTACT INHIBITION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FIBROBLASTS; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 66149154257     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.080188     Document Type: Article

References (35)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.
2. Gaber T, Dziurla R, Tripmacher, R, Burmester GR, Buttgereit F. Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis 2005;64:971-80.
3. Lund-Olesen K. Oxygen tension in synovial fluids. Arthritis Rheum 1970;13:767-76.
4. Treuhaft PS, McCarty DJ. Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum 1971;14:475-84.
5. Cha HS, Ahn KS, Jeon CH, Kim J, Song YW, Koh EM. Influence of hypoxia on the expression of matrix metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 in rheumatoid synovial fibroblasts. Clin Exp Rheumatol 2003;21:593-8.
6. Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 2005;175:6257-63.
7. Ten VS, Pinsky DJ. Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care 2002;8:242-50.
8. Peacock AJ, Scott P, Plevin R, Wadsworth R, Welsh D. Hypoxia enhances proliferation and generation of IP3 in pulmonary artery fibroblasts but not in those from the mesenteric circulation. Chest 1998;114:24S.
9. Roy S, Khanna S, Bickerstaff AA, et al. Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1). Circ Res 2003;92:264-71.
10. Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 2001;21:3336-42.
11. Zygmunt A, Tedesco VC, Udho E, Krucher NA. Hypoxia stimulates p16 expression and association with cdk4. Exp Cell Res 2002;278:53-60.
12. Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 2001;276:7919-26.
13. Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004;23:1949-56.
14. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12.
15. INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nature Med 1999;5:760-7.
16. Nasu K, Kohsaka H, Nonomura Y, et al. Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice. J Immunol 2000;165:7246-52.
17. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
18. Mialhe A, Levacher G, Champelovier P, et al. Expression of E-, P-, N-cadherins and catenins in human bladder carcinoma cell lines. J Urol 2000;164:826-35.
19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and 2(-Delta Delta C(T)) method. Methods 2001;25:402-8.
20. Nishimoto N, Ito A, Ono M, et al. IL-6 inhibits the proliferation of fibroblastic synovial cells from rheumatoid arthritis patients in the presence of soluble IL-6 receptor. Int Immunol 2000;12:187-93.
21. INK4 mediates contact-inhibition of growth. Oncogene 1999;18:277-81.
22. Ritt MG, Mayor J, Wojcieszyn J, Smith R, Barton CL, Modiano JF. Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition. Cancer Lett 2000;158:73-84.
23. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev 1994;8:9-22.
24. Cip1/WAF1, and Bax proteins. J Biol Chem 2004;279:13496-505.
25. kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 1999;154:313-23.
26. Levenberg S, Yarden A, Kam Z, Geiger B. p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry. Oncogene 1999;18:869-76.
27. St. Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM, Kerbel RS. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 1998;142:557-71.
28. Valencia X, Higgins JM, Kiener HP, et al. Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. J Exp Med 2004;200:1673-9.
29. Kiener HP, Lee DM, Agarwal SK, Brenner MB. Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro. Am J Pathol 2006;168:1486-99.
30. Blake DR, Merry P, Unsworth J, et al. Hypoxic-reperfusion injury in the inflamed human joint. Lancet 1989;8633:289-93.
31. Poellinger L, Johnson RS. HIF-1 and hypoxic response: the plot thickens. Curr Opin Genet Dev 2004;14:81-5.
32. Kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas. Carcinogenesis 2005;26:1021-34.
33. Imai T, Horiuchi A, Wang C, et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 2003;163:1437-47.
34. de Laplanche E, Gouget K, Cleris G, et al. Physiological oxygenation status is required for fully differentiated phenotype in kidney cortex proximal tubules. Am J Physiol Renal Physiol 2006;291:750-60.
35. Lee DM, Kiener HP, Agarwal SK, et al. Cadherin-11 in synovial lining formation and pathology in arthritis. Science 2007; 315:1006-10.