Predicting the behavioral impact of transcranial direct current stimulation: Issues and limitations

Frontiers in Human Neuroscience

Volumn , Issue OCT, 2013, Pages

  de Berker, Archy O ^a   Bikson, Marom ^b   Bestmann, Sven ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b City University of New York   (United States)

Author keywords

Computational neurostimulation; Modeling; Neuroenhancement; Neuromodulation; Validation

Indexed keywords

ARTICLE; BEHAVIOR CHANGE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CELL MEMBRANE DEPOLARIZATION; COMPUTATIONAL NEUROSTIMULATION; HUMAN; NERVE CELL PLASTICITY; NERVE CONDUCTION; NERVE EXCITABILITY; NEUROMODULATION; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION; TRANSCRANIAL DIRECT CURRENT STIMULATION; VALIDATION STUDY;

EID: 84886376687     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00613     Document Type: Article

References (43)

1. Bestmann, S., and Feredoes, E. (2013). Combined neurostimulation and neuroimaging in cognitive neuroscience: past, present, and future. Ann. N. Y.Acad. Sci. 1296,11-30. doi: 10.1111/nyas.12110
2. Bikson, M., Inoue, M., Akiyama, H., Deans, J. K., Fox, J. E., Miyakawa, H., et al. (2004). Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro. J. Physiol. (Lond.) 557, 175-190. doi: 10.1113/jphys- iol.2003.055772
3. Bikson, M., Rahman, A., and Datta, A. (2012). Computational models of transcranial direct current stimulation. Clin. EEG Neurosci. 43, 176-183. doi: 10.1177/1550059412445138
4. Brasil-Neto, J. P. (2012). Learning, memory, and transcranial direct current stimulation. Front. Psychiatry 3:80. doi: 10.3389/fpsyt.2012.00080
5. Brunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Fregni, F., et al. (2012). Clinical research with transcranial direct current stimulation (tDCS): challenges and future directions. Brain Stimul. 5, 175-195. doi: 10.1016/j.brs.2011.03.002
6. Chan, C. Y., Hounsgaard, J., and Nicholson, C. (1988). Effects of electric fields on transmembrane potential and excitability of turtle cerebellar Purkinje cells in vitro. J. Physiol. (Lond.) 402,751-771.
7. Datta, A., Bansal, V., Diaz, J., Patel, J., Reato, D., and Bikson, M. (2009). Gyri-precise head model of transcranial direct current stimulation: improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimul. 2, 201-207.e1. doi: 10.1016/j.brs.2009.03.005
8. Datta, A., Truong, D., Minhas, P., Parra, L. C., and Bikson, M. (2012). InterIndividual variation during tran- scranial direct current stimulation and normalization of dose using MRI-derived computational models. Front. Psychiatry 3:91. doi: 10.3389/fpsyt.2012.00091
9. Datta, A., Zhou, X., Su, Y., Parra, L. C., and Bikson, M. (2013). Validation of finite element model of transcranial electrical stimulation using scalp potentials: implications for clinical dose. J. Neural Eng. 10, 036018. doi: 10.1088/1741-2560/10/3/036018
10. Di Lazzaro, V., Ziemann, U., and Lemon, R. N. (2008). State of the art: physiology of transcranial motor cortex stimulation. Brain Stimul. 1, 345- 362. doi: 10.1016/j.brs.2008.07.004
11. Dmochowski, J. P., Bikson, M., Datta, A., Richardson, J., Fridriksson, J., and Parra, L. C. (2012). On the role of electric field orientation in optimal design of transcranial current stimulation. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 6426-6429. doi: 10.1109/EMBC.2012.6347465
12. Dmochowski, J. P., Datta, A., Bikson, M., Su, Y., and Parra, L. C. (2011). Optimized multi-electrode stimulation increases focalityand intensityat target. J. Neural Eng. 8, 046011. doi: 10.1088/1741-2560/8/4/046011
13. Edwards, D., Cortes, M., Datta, A., Minhas, P., Wassermann, E. M., and Bikson, M. (2013). Physiological and modeling evidence for focal transcra- nial electrical brain stimulation in humans: a basis for high-definition tDCS. Neuroimage 74, 266-275. doi: 10.1016/j.neuroimage.2013.01. 042
14. Esser, S. K., Hill, S. L., and Tononi, G. (2005). Modeling the effects of transcranial magnetic stimulation on cortical circuits. J. Neurophysiol. 94, 622-639. doi: 10.1152/jn.01230.2004
15. Friston, K. J., Harrison, L., and Penny, W. (2003). Dynamic causal modelling. Neuroimage 19, 1273-1302. doi: 10.1016/S1053-8119(03) 00202-7
16. Fritsch, G., and Hitzig, E. (1870). Ueber die elektrische Erregbarkeit des Grosshirns. Archiv. fur Anatomie, Physiologie und wissenschaftliche Medicin. Leipzig: Veit, 300-332.
17. Goldman-Rakic, P. S. (1996). Regional and cellular fractionation of working memory. Proc. Natl. Acad. Sci. U.S.A. 93, 13473. doi: 10.1073/pnas.93.24.13473
18. Hebb, D. O. (1949). The Organisation of Behaviour: A Neuropsychological Theory. New York: Wiley
19. Hess, C. W., Mills, K. R., and Murray, N. M. (1987). Responses in small hand muscles from magnetic stimulation of the human brain. J. Physiol. (Lond.) 388, 397-419.
20. Huang, Y., Su, Y., Rorden, C., Dmochowski, J., Datta, A., and Parra, L. C. (2012). An automated method for high-definition transcra- nial direct current stimulation modeling. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 5376-5379. doi: 10.1109/EMBC.2012.6347209
21. Iuculano, T. T., and Kadosh, R. R. C. (2013). The mental cost of cognitive enhancement. J. Neurosci. 33, 4482-4486. doi: 10.1523/JNEUROSCI.4927-12.2013
22. Kujirai, T., Caramia, M. D., Rothwell, J. C., Day, B. L., Thompson, P. D., Ferbert, A., et al. (1993). Corticocortical inhibition in human motor cortex. J. Physiol. 471,501-519.
23. Kuo, H.-I., Bikson, M., Datta, A., Minhas, P., Paulus, W., Kuo, M. -F., et al. (2013). Comparing cortical plasticity induced by conventional and high-definition 4x1 ring tDCS: a neurophysiological study. Brain Stimul. 6, 644-648. doi: 10.1016/j.brs.2012.09.010
24. Lang, N., Siebner, H. R., Ward, N. S., Lee, L., Nitsche, M. A., Paulus, W., et al. (2005). How does transcranial DCstimulation of the primarymotor cortex alter regional neuronal activity in the human brain? Eur. J. Neurosci. 22, 495-504. doi: 10.1111/j.1460- 9568.2005.04233.x
25. Lisman, J., Lichtman, J. W., and Sanes, J. R. (2003). Opinion: LTP: perils and progress. Nat. Rev. Neurosci. 4, 926-929. doi: 10.1038/nrn1259
26. Marquez-Ruiz, J., Leal-Campanario, R., Sanchez-Campusano, R., Molaee- Ardekani, B., Wendling, F., Miranda, P. C., et al. (2012). Transcra- nial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits. Proc. Natl. Acad. Sci. U.S.A. 109, 6710-6715. doi: 10.1073/pnas.1121147109
27. McDonnell, M. D., and Ward, L. M. (2011). The benefits of noise in neural systems: bridging theory and experiment. Nat. Rev. Neurosci. 12, 415-426. doi: 10.1038/nrn3061
28. Miranda, P. C., Mekonnen, A., Salvador, R., and Ruffini, G. (2013). The electric field in the cortex during transcranial current stimulation. Neuroimage 70, 48-58. doi: 10.1016/j.neuroimage.2012.12.034
29. Moran, R. J., Symmonds, M., Stephan, K. E., Friston, K. J., and Dolan, R. J. (2011). An in vivo assay of synaptic function mediating human cognition. Curr. Biol. 21, 1320-1325. doi: 10.1016/j.cub.2011.06.053
30. Nitsche, M.A. (2011). Beyondthe target area: remote effects of non-invasive brain stimulation in humans. J. Physiol. (Lond.) 589, 3053-3054. doi: 10.1113/jphysiol.2011.211599
31. Nitsche, M. A., Doemkes, S., Karakose, T., Antal, A., Liebetanz, D., Lang, N., et al. (2007). Shaping the effects of transcranial direct current stimulation of the human motor cortex. J. Neurophysiol. 97, 3109-3117. doi: 10.1152/jn.01312.2006
32. Nitsche, M. A., and Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak tran- scranial direct current stimulation. J. Physiol. (Lond.) 527, 633-639. doi: 10.1111/j.1469-7793.2000.t01-1- 00633.x
33. Radman, T., Ramos, R. L., Brumberg, J. C., and Bikson, M. (2009). Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro. Brain Stimul. 2, 215-228. doi: 10.1016/j.brs.2009.03.007
34. Rahman, A., Reato, D., Arlotti, M., Gasca, F., Datta, A., Parra, L. C., et al. (2013). Cellular effects of acute direct current stimulation: somatic and synaptic terminal effects. J. Physiol. (Lond.) 591, 2563-2578. doi: 10.1113/jphysiol.2012.247171
35. Ranieri, F. F., Podda, M. V. M., Riccardi, E. E., Frisullo, G. G., Dileone, M. M., Profice, P. P., et al. (2012). Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation. J. Neurophysiol. 107, 1868-1880. doi: 10.1152/jn.00319.2011
36. Redondo, R. L., and Morris, R. G. M. (2011). Making memories last: the synaptic tagging and capture hypothesis. Nat. Rev. Neurosci. 12, 17-30. doi: 10.1038/nrn2963
37. Roche, N., Lackmy, A., Achache, V., Bussel, B., and Katz, R. (2009). Impact of transcranial direct current stimulation on spinal network excitability in humans. J. Physiol. (Lond.) 587, 5653-5664. doi: 10.1113/jphysiol.2009.177550
38. Ruffini, G., Wendling, F., Merlet, I., Molaee-Ardekani, B., Mekkonen, A., Salvador, R., et al. (2012). Tran- scranial current brain stimulation (tCS): models and technologies. IEEE Trans. Neural Syst. Reha- bil. Eng. 21, 333-345. doi: 10.1109/TNSRE.2012.2200046
39. Schwarzkopf, D. S., Silvanto, J., and Rees, G. (2011). Stochastic resonance effects reveal the neural mechanisms of transcranial magnetic stimulation. J. Neurosci. 31, 3143-3147. doi: 10.1523/JNEUR0SCI.4863-10.2011
40. Siebner, H. R., Bergmann, T. O., Best- mann, S., Massimini, M., Johansen- Berg, H., Mochizuki, H., et al. (2009). Consensus paper: combining transcranial stimulation with neuroimaging. Brain Stimul. 2, 58-80. doi: 10.1016/j.brs.2008.11.002
41. Truong, D. Q., Magerowski, G., Blackburn, G. L., Bikson, M., and Alonso-Alonso, M. (2013). Computational modeling of tran- scranial direct current stimulation (tDCS) in obesity: impact of head fat and dose guidelines. Neuroimage (Amst.) 2, 759-766. doi: 10.1016/j.nicl.2013.05.011
42. Windhoff, M., Opitz, A., and Thielscher, A. (2013). Electric field calculations in brain stimulation based on finite elements: an optimized processing pipeline for the generation and usage of accurate individual head models. Hum. Brain Mapp. 34, 923-935. doi: 10.1002/hbm. 21479
43. Zheng, X., Alsop, D. C., and Schlaug, G. (2011). Effects of tran- scranial direct current stimulation (tDCS) on human regional cerebral blood flow. Neuroimage 58, 26-33. doi: 10.1016/j.neuroimage.2011. 06.018