Antioxidant and in vitro anticancer effect of 2-pyrrolidinone rich fraction of Brassica oleracea var. capitata through induction of apoptosis in human cancer cells

Phytotherapy Research

Volumn 27, Issue 11, 2013, Pages 1664-1670

  Thangam, Ramar ^a,b   Suresh, Veeraperumal ^c   Rajkumar, Mayan ^b   Vincent, Jally Damien ^b   Gunasekaran, Palani ^b   Anbazhagan, Chinnathambi ^c   Kaveri, Krishnasamy ^b   Kannan, Soundarapandian ^a  

^a BHARATHIAR UNIVERSITY   (India)

^b Institute of Preventive Medicine   (India)

^c ANNAMALAI UNIVERSITY   (India)

Author keywords

apoptosis; Brassica oleracea var. capitata; cytotoxicity; DPPH scavenging; G0 G1 cell cycle arrest

Indexed keywords

2 PYRROLIDINONE; ASCORBIC ACID;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BRASSICA OLERACEA; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PHYTOCHEMISTRY; PLANT LEAF;

BRASSICA OLERACEA VAR. CAPITATA;

APOPTOSIS; BRASSICA OLERACEA VAR. CAPITATA; CYTOTOXICITY; DPPH SCAVENGING; G0/G1 CELL CYCLE ARREST;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; BRASSICA; CELL CYCLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; PLANT LEAVES; PYRROLIDINONES;

EID: 84886298568     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4908     Document Type: Article

References (23)

1. Ayaz FA, Ayaz HS, Karaoglu AS, et al,. 2008. Phenolic acid contents of kale (Brassica oleraceae L. var. acephala DC.) extracts and their antioxidant and antibacterial activities. Food Chem 107: 19-25.
2. Barry BW,. 1987. Mode of action of penetration enhancer in human skin. J Cont Rel 6: 85-87.
3. Bazzano LA, Serdula MK, Liu S,. 2002. Dietary intakes of F&V and risk of cardiovascular disease. Curr Atheroscler Rep 5: 492-499.
4. Beecher CW,. 1994. Cancer preventive properties of varieties of Brassica oleracea. Am J Clin Nutr 59: 1166-1170.
5. Cartea ME, Velasco P, Obregon S, Padilla G, Haro HB,. 2008. Seasonal variation in glucosinolate content in Brassica oleracea crops grown in northwestern Spain. Phytochem 69: 403-410.
6. Conaway CC, Yang YM, Chung FL,. 2002. Iso-thiocyanate as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 3: 233-255.
7. Dai O, Borenstein AR, Wu Y, Jackson J, Larson EB,. 2006. Fruit and vegetable juices and Alyheimers disease: the Kame project. Am J Med 119: 751-759.
8. Fejes S, Kéry A, Blázovics A, et al,. 1998. Investigation of the in vitro antioxidant effect of Petroselinum crispum (Mill.) Nym. ex A. W. Hill. Acta Pharm Hung 68 (3): 150-6.
9. Ferreres F, Pereira DM, Valentão P, et al,. 2009. Simple and reproducible HPLC-DAD-ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots. J Pharm Biomed Anal 51: 65-69.
10. Fowke JH, Chung FL, Jin F, et al,. 2003. Urinary iso-thiocyanate levels, Brassica, and human breast cancer. Cancer Res 63: 3980-3986.
11. Gould PD, Locke JCW, Larue C, et al,. 2006. The molecular basis of temperature compensation in the Arabidopsis circadian clock. Plant Cell 18: 1177-1187.
12. Jadzyn J, Malecki J, Jadzyn C,. 1978. Dielectric polarization of 2-pyrrolidinone-benzene solutions. J Phys Chem 82: 2128-2130.
13. Kassie F, Parzefall W, Musk S, et al,. 1996. Genotoxic effects of crude juice from Brassica vegetables and juices extracts from phytopharmaceutical reparations and spices of cruciferous plants origin in bacterial and mammalian cells. Chem Biol Interact 10: 1-16.
14. Kusznierewicz B, Bartoszek A, Wolska L, Drzewiecki J, Gorinstein S, Namiesnik J,. 2008. Partial characterization of white cabbages (Brassica oleracea var. capitata f. alba) from different regions by glucosinolates, bioactive compounds, total antioxidant activities and proteins. LWT- Food Sci Technol 41: 1-9.
15. Lee J, Koo N, Min DB,. 2004. Comprehensive review in food science and food safety. Inst Food Technol 3: 21-33.
16. Leong LP, Shui G,. 2002. An investigation of antioxidant capacity of fruits in Singapore markets. Food Chem 76: 69-75.
17. Maritess C, Small S, Hill WM,. 2005. Alternative nutrition therapies in cancer patients. Sem Oncol Nurs 21: 173-176.
18. Mosmann T,. 1983. Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-60
19. Nilsson J, Olsson K, Engqvist G, et al,. 2006. Variation in the content of glucosinolates, hydroxycinnamic acids, carotenoids, total antioxidant capacity and low-molecular-weight carbohydrates in Brassica vegetables. J Sci Food Agr 86: 528-538.
20. Sanchez-Moreno C,. 2002. Review: methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Sci Technol Int 8 (3): 121-37.
21. Sundarraj S, Thangam R, Sreevani V, Kaveri K, Gunasekaran P, Kannan S,. 2012. Gamma Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J Ethnopharmacol 141: 80-809.
22. Thangam R, Gunasekaran P, Kaveri K, et al,. 2012. A novel disintegrin protein from Naja naja venom induces cytotoxicity and apoptosis in human cancer cell lines in vitro. Process Biochem 47: 1243-1249
23. Wu XJ, Hansen C,. 2008. Antioxidant capacity, Phenolic content, Polysaccharide content of Lentinus edodes grown in Whey permeate-based submerged culture. J Food Sci 73: 1-8.