γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells

Journal of Ethnopharmacology

Volumn 141, Issue 3, 2012, Pages 803-809

  Sundarraj, Shenbagamoorthy ^a   Thangam, Ramar ^a,b   Sreevani, Vellingiri ^a   Kaveri, Krishnasamy ^b   Gunasekaran, Palani ^b   Achiraman, Shanmugam ^c   Kannan, Soundarapandian ^a  

^a BHARATHIAR UNIVERSITY   (India)

^b Institute of Preventive Medicine   (India)

^c BHARATHIDASAN UNIVERSITY   (India)

Author keywords

Acacia nilotica; Apoptosis; G2 M arrest; Human cancer cells; MTT assay; Traditional medicine Africa and Asia

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACACIA NILOTICA EXTRACT; BROXURIDINE; CLIONASTEROL; CYCLIN B; CYCLIN E; DOXORUBICIN; MYC PROTEIN; SITOSTEROL DERIVATIVE; UNCLASSIFIED DRUG;

ACACIA NILOTICA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; TRADITIONAL MEDICINE;

ACACIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B; CYCLIN E; HUMANS; PLANT EXTRACTS; PLANT LEAVES; PROTO-ONCOGENE PROTEINS C-MYC; SITOSTEROLS;

ACACIA NILOTICA;

EID: 84861336661     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.03.014     Document Type: Article

References (18)

1. A.B. Awad, and C.S. Fink Phytosterols as anticancer dietary components: evidence and mechanism of action The Journal of Nutrition 130 2000 2127 2130
2. A.B. Awad, R. Roy, and C.S. Fink Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells Oncology Reports 10 2003 497 500
3. A.B. Awada, M. Chinnama, C.S. Finka, and P.G. Bradford β-Sitosterol activates Fas signaling in human breast cancer cells Phytomedicine 14 2007 747 754
4. R. Balamurugan, V. Duraipandiyan, and S. Ignacimuthu Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats European Journal of Pharmacology 667 2011 410 418
5. J.M. Choi, E.O. Lee, H.J. Lee, K.H. Kim, K.S. Ahn, B.S. Shim, N.I. Kim, M.C. Song, N.I. Baek, and S.H. Kim Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities Phytotherapy Research 21 2007 954 959
6. A. El-Tahir, G.M.H. Satti, and S.A. Khalid Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Acacia nilotica Phytotherapy Research 13 1999 474 478
7. J. Gao, A. Sanchez-Medina, B.A. Pendry, M.J. Hughes, G.P. Webb, and O. Corcoran Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures Journal of Pharmacy & Pharmaceutical Sciences 11 2008 77 87
8. T. Ghosh, T.K. Maity, and J. Singh Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice Oriental Pharmacy and Experimental Medicine 11 2011 41 49
9. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA: A Cancer Journal for Clinicians 61 2011 69 90
10. T. Kalaivani, and L. Mathew Free radical scavenging activity from leaves of Acacia nilotica (L.) Wild. ex Delile, an Indian medicinal tree Food and Chemical Toxicology 48 2010 298 305
11. K. Kaur, H. Michael, S. Arora, P. Harkonen, and S. Kumar In vitro bioactivity-guided fractionation and characterization of polyphenolic inhibitory fractions from Acacia nilotica (L.) Willd. ex Del. Journal of Ethnopharmacology 99 2005 353 360
12. C.S. Lai, R.H.M.H. Mas, N.K. Nair, S.M. Mansor, and V. Navaratnam Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae) Journal of Ethnopharmacology 127 2010 486 494
13. S.N.A. Malek, S.K. Shin, N.A. Wahab, and H. Yaacob Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves Molecules 14 2009 1713 1724
14. P.D. Meena, P. Kaushik, S. Shukla, A.K. Soni, M. Kumar, and A. Kumar Anticancer and antimutagenic properties of Acacia nilotica (Linn.) on 7,12-dimethylbenz(a) anthracene-induced skin papillomagenesis in Swiss albino mice Asian Pacific Journal of Cancer Prevention 7 2006 627 632
15. D.O. Moon, M.O. Kim, Y.H. Choi, and G.Y. Kim Beta-sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways Cancer Letters 264 2008 181 191
16. B.N. Singh, B.R. Singh, R.L. Singh, D. Prakash, B.K. Sarma, and H.B. Singh Antioxidant and anti-quorum sensing activities of green pod of Acacia nilotica L. Food and Chemical Toxicology 47 2009 778 786
17. B. Sultana, F. Anwar, and R. Przybylski Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. trees Food Chemistry 104 2007 1106 1114
18. R.L. von Holtz, C.S. Fink, and A.B. Awad Beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells Nutrition and Cancer 32 1998 8 12