메뉴 건너뛰기




Volumn 250, Issue , 2013, Pages 228-238

Combination therapy in a transgenic model of Alzheimer's disease

Author keywords

Alzheimer's disease; Magnetic resonance spectroscopy; R flurbiprofen; Scyllo inositol

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; FLURBIPROFEN; INOSITOL DERIVATIVE; SCYLLOINOSITOL; UNCLASSIFIED DRUG;

EID: 84886296169     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.10.001     Document Type: Article
Times cited : (28)

References (32)
  • 1
    • 77956259428 scopus 로고    scopus 로고
    • Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models
    • (pii:S0028-3908(10)00087-0)
    • Choi J.K., Carreras I., Dedeoglu A., Jenkins B.G. Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. Neuropharmacology 2010, 59(4-5):353-357. (pii:S0028-3908(10)00087-0). 10.1016/j.neuropharm.2010.03.011.
    • (2010) Neuropharmacology , vol.59 , Issue.4-5 , pp. 353-357
    • Choi, J.K.1    Carreras, I.2    Dedeoglu, A.3    Jenkins, B.G.4
  • 3
    • 34548317423 scopus 로고    scopus 로고
    • Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations
    • Czirr E., Leuchtenberger S., Dorner-Ciossek C., Schneider A., Jucker M., Koo E.H., Pietrzik C.U., Baumann K., Weggen S. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J. Biol. Chem. 2007, 282(34):24504-24513. 10.1074/jbc.M700618200.
    • (2007) J. Biol. Chem. , vol.282 , Issue.34 , pp. 24504-24513
    • Czirr, E.1    Leuchtenberger, S.2    Dorner-Ciossek, C.3    Schneider, A.4    Jucker, M.5    Koo, E.H.6    Pietrzik, C.U.7    Baumann, K.8    Weggen, S.9
  • 4
    • 2442582930 scopus 로고    scopus 로고
    • MRS analysis of AD mouse brain that express mutant human APP shows altered neurochemical profile
    • Dedeoglu A., Choi J.K., Cormier K., Kowall N.W., Jenkins B.G. MRS analysis of AD mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004, 1012(1-2):60-65. 10.1016/j.brainres.2004.02.079.
    • (2004) Brain Res. , vol.1012 , Issue.1-2 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 6
    • 34249867410 scopus 로고    scopus 로고
    • Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology
    • Fenili D., Brown M., Rappaport R., McLaurin J. Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology. J. Mol. Med. (Berl.) 2007, 85(6):603-611. 10.1007/s00109-007-0156-7.
    • (2007) J. Mol. Med. (Berl.) , vol.85 , Issue.6 , pp. 603-611
    • Fenili, D.1    Brown, M.2    Rappaport, R.3    McLaurin, J.4
  • 7
    • 17844374592 scopus 로고    scopus 로고
    • Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease
    • Gasparini L., Ongini E., Wilcock D., Morgan D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Res. Brain Res. Rev. 2005, 48(2):400-408. 10.1016/j.brainresrev.2004.12.029.
    • (2005) Brain Res. Brain Res. Rev. , vol.48 , Issue.2 , pp. 400-408
    • Gasparini, L.1    Ongini, E.2    Wilcock, D.3    Morgan, D.4
  • 8
    • 0028242015 scopus 로고
    • Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers
    • Geisslinger G., Lotsch J., Menzel S., Kobal G., Brune K. Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers. Br. J. Clin. Pharmacol. 1994, 37(4):392-394.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , Issue.4 , pp. 392-394
    • Geisslinger, G.1    Lotsch, J.2    Menzel, S.3    Kobal, G.4    Brune, K.5
  • 9
    • 72549105935 scopus 로고    scopus 로고
    • Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
    • Green R.C., Schneider L.S., Amato D.A., Beelen A.P., Wilcock G., Swabb E.A., Zavitz K.H. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009, 302(23):2557-2564. 10.1001/jama.2009.1866.
    • (2009) JAMA , vol.302 , Issue.23 , pp. 2557-2564
    • Green, R.C.1    Schneider, L.S.2    Amato, D.A.3    Beelen, A.P.4    Wilcock, G.5    Swabb, E.A.6    Zavitz, K.H.7
  • 13
    • 0037088914 scopus 로고    scopus 로고
    • Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    • (doi:22/6/2246 [pii])
    • Jantzen P.T., Connor K.E., DiCarlo G., Wenk G.L., Wallace J.L., Rojiani A.M., Coppola D., Morgan D., Gordon M.N. Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J. Neurosci. 2002, 22(6):2246-2254. (doi:22/6/2246 [pii]).
    • (2002) J. Neurosci. , vol.22 , Issue.6 , pp. 2246-2254
    • Jantzen, P.T.1    Connor, K.E.2    DiCarlo, G.3    Wenk, G.L.4    Wallace, J.L.5    Rojiani, A.M.6    Coppola, D.7    Morgan, D.8    Gordon, M.N.9
  • 16
    • 34547884277 scopus 로고    scopus 로고
    • Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice
    • Kukar T., Prescott S., Eriksen J.L., Holloway V., Murphy M.P., Koo E.H., Golde T.E., Nicolle M.M. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 2007, 8:54. 10.1186/1471-2202-8-54.
    • (2007) BMC Neurosci. , vol.8 , pp. 54
    • Kukar, T.1    Prescott, S.2    Eriksen, J.L.3    Holloway, V.4    Murphy, M.P.5    Koo, E.H.6    Golde, T.E.7    Nicolle, M.M.8
  • 18
    • 0034674785 scopus 로고    scopus 로고
    • Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta-induced toxicity
    • McLaurin J., Golomb R., Jurewicz A., Antel J.P., Fraser P.E. Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta-induced toxicity. J. Biol. Chem. 2000, 275(24):18495-18502. 10.1074/jbc.M906994199.
    • (2000) J. Biol. Chem. , vol.275 , Issue.24 , pp. 18495-18502
    • McLaurin, J.1    Golomb, R.2    Jurewicz, A.3    Antel, J.P.4    Fraser, P.E.5
  • 21
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    • Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006, 26(40):10129-10140.
    • (2006) J Neurosci. , vol.26 , Issue.40 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 22
    • 38149013121 scopus 로고    scopus 로고
    • Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation
    • Page R.M., Baumann K., Tomioka M., Perez-Revuelta B.I., Fukumori A., Jacobsen H., Flohr A., Luebbers T., Ozmen L., Steiner H., Haass C. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J. Biol. Chem. 2008, 283(2):677-683. 10.1074/jbc.M708754200.
    • (2008) J. Biol. Chem. , vol.283 , Issue.2 , pp. 677-683
    • Page, R.M.1    Baumann, K.2    Tomioka, M.3    Perez-Revuelta, B.I.4    Fukumori, A.5    Jacobsen, H.6    Flohr, A.7    Luebbers, T.8    Ozmen, L.9    Steiner, H.10    Haass, C.11
  • 25
    • 5644239087 scopus 로고    scopus 로고
    • Alzheimer disease: mechanistic understanding predicts novel therapies
    • (doi:140/8/627 [pii])
    • Selkoe D.J. Alzheimer disease: mechanistic understanding predicts novel therapies. Ann. Intern. Med. 2004, 140(8):627-638. (doi:140/8/627 [pii]).
    • (2004) Ann. Intern. Med. , vol.140 , Issue.8 , pp. 627-638
    • Selkoe, D.J.1
  • 26
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
    • Selkoe D.J. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav. Brain Res. 2008, 192(1):106-113. 10.1016/j.bbr.2008.02.016.
    • (2008) Behav. Brain Res. , vol.192 , Issue.1 , pp. 106-113
    • Selkoe, D.J.1
  • 28
    • 33846003098 scopus 로고    scopus 로고
    • Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers
    • Townsend M., Cleary J.P., Mehta T., Hofmeister J., Lesne S., O'Hare E., Walsh D.M., Selkoe D.J. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Ann. Neurol. 2006, 60(6):668-676. 10.1002/ana.21051.
    • (2006) Ann. Neurol. , vol.60 , Issue.6 , pp. 668-676
    • Townsend, M.1    Cleary, J.P.2    Mehta, T.3    Hofmeister, J.4    Lesne, S.5    O'Hare, E.6    Walsh, D.M.7    Selkoe, D.J.8
  • 29
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • (pii:S0896627304006038)
    • Walsh D.M., Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004, 44(1):181-193. (pii:S0896627304006038). 10.1016/j.neuron.2004.09.010.
    • (2004) Neuron , vol.44 , Issue.1 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 30
    • 0027993545 scopus 로고
    • Chiral pharmacokinetics of Rac-flurbiprofen and pharmacodynamics of anabolic bone response in the normal rat
    • Wechter W.J., Bigornia A.E., Murray E.D., Jee W.S. Chiral pharmacokinetics of Rac-flurbiprofen and pharmacodynamics of anabolic bone response in the normal rat. Chirality 1994, 6(6):457-459. 10.1002/chir.530060602.
    • (1994) Chirality , vol.6 , Issue.6 , pp. 457-459
    • Wechter, W.J.1    Bigornia, A.E.2    Murray, E.D.3    Jee, W.S.4
  • 32
    • 0041876229 scopus 로고    scopus 로고
    • Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity
    • Weggen S., Eriksen J.L., Sagi S.A., Pietrzik C.U., Ozols V., Fauq A., Golde T.E., Koo E.H. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J. Biol. Chem. 2003, 278(34):31831-31837. 10.1074/jbc.M303592200.
    • (2003) J. Biol. Chem. , vol.278 , Issue.34 , pp. 31831-31837
    • Weggen, S.1    Eriksen, J.L.2    Sagi, S.A.3    Pietrzik, C.U.4    Ozols, V.5    Fauq, A.6    Golde, T.E.7    Koo, E.H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.