Working Memory and Default Mode Network abnormalities in unaffected siblings of schizophrenia patients

Schizophrenia Research

Volumn 150, Issue 2-3, 2013, Pages 555-562

  de Leeuw, Max ^a   Kahn, René S ^a   Zandbelt, Bram B ^b   Widschwendter, Christian G ^c   Vink, Matthijs ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b VANDERBILT UNIVERSITY   (United States)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Default Mode Network; DLPFC; Schizophrenia; Siblings; Working memory

Indexed keywords

ADULT; ANTERIOR CINGULATE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DEFAULT MODE NETWORK; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; MENTAL TASK; NEUROIMAGING; PARIETAL CORTEX; POSTERIOR CINGULATE; PREFRONTAL CORTEX; PREMOTOR CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SIBLING; TASK PERFORMANCE; UNAFFECTED SIBLING; WORKING MEMORY;

DEFAULT MODE NETWORK; DLPFC; SCHIZOPHRENIA; SIBLINGS; WORKING MEMORY;

ADULT; BRAIN MAPPING; CORPUS STRIATUM; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MENTAL RECALL; MODELS, NEUROLOGICAL; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SIBLINGS; YOUNG ADULT;

EID: 84886289708     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.08.016     Document Type: Article

References (58)

1. Altamura M., Elvevåg B., Blasi G., Bertolino A., Callicott J.H., Weinberger Daniel R., Mattay V.S., Goldberg T.E. Dissociating the effects of Sternberg working memory demands in prefrontal cortex. Psychiatry Res. 2007, 154:103-114.
2. Angrilli A., Spironelli C., Elbert T., Crow T.J., Marano G., Stegagno L. Schizophrenia as failure of left hemispheric dominance for the phonological component of language. PLoS One 2009, 4:e4507.
3. Anticevic A., Repovs G., Shulman Gordon L., Barch D.M. When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage 2010, 49:2638-2648.
4. Anticevic A., Repovs G., Barch D.M. Working memory encoding and maintenance deficits in schizophrenia: neural evidence for activation and deactivation abnormalities. Schizophr. Bull. 2013, 39:168-178.
5. Bäckman L., Nyberg L., Soveri A., Johansson J., Andersson M., Dahlin E., Neely Anna S., Virta J., Laine M., Rinne J.O. Effects of working-memory training on striatal dopamine release. Science (New York, N.Y.) 2011, 333:718.
6. Baddeley A. Working memory. Science (New York, N.Y.) 1992, 255:556-559.
7. Barrantes-Vidal N., Aguilera M., Campanera S., Fatjó-Vilas M., Guitart M., Miret S., Valero S., Fañanás L. Working memory in siblings of schizophrenia patients. Schizophr. Res. 2007, 95:70-75.
8. Brahmbhatt S.B., Haut K., Csernansky J.G., Barch D.M. Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings. Schizophr. Res. 2006, 87:191-204.
9. Braskie M.N., Landau S.M., Wilcox C.E., Taylor S.D., O'Neil J.P., Baker S.L., Madison C.M., Jagust W.J. Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Hum. Brain Mapp. 2011, 32:947-961.
10. Brunelin J., d'Amato T., Van Os J., Costes N., Suaud Chagny M.-F., Saoud M. Increased left striatal dopamine transmission in unaffected siblings of schizophrenia patients in response to acute metabolic stress. Psychiatry Res. 2010, 181:130-135.
11. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., Verchinksi B., Weinberger Daniel R. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am. J. Psychiatry 2003, 160:709-719.
12. Chen L.-S., Rice T.K., Thompson P.A., Barch D.M., Csernansky J.G. Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia. Schizophr. Res. 2009, 111:159-166.
13. Dahlin E., Neely Anna Stigsdotter, Larsson A., Bäckman L., Nyberg L. Transfer of learning after updating training mediated by the striatum. Science (New York, N.Y.) 2008, 320:1510-1512.
14. Davis K.L., Kahn R.S., Ko G., Davidson M. Dopamine in schizophrenia: a review and reconceptualization. Am. J. Psychiatry 1991, 148:1474-1486.
15. Davis C.E., Jeste D.V., Eyler L.T. Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia. Schizophr. Res. 2005, 78:45-60.
16. Delawalla Z., Csernansky J.G., Barch D.M. Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia. Biol. Psychiatry 2008, 63:490-497.
17. Ettinger U., Williams S.C.R., Fannon D., Premkumar P., Kuipers E., Möller H.-J., Kumari V. Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment. Psychopharmacology 2011, 216:17-27.
18. Fusar-Poli P., Meyer-Lindenberg A. Striatal presynaptic dopamine in schizophrenia, Part I: Meta-analysis of dopamine active transporter (DAT) density. Schizophr. Bull. 2013, 39:22-32.
19. Fusar-Poli P., Meyer-Lindenberg A. Striatal presynaptic dopamine in schizophrenia, Part II: Meta-analysis of [18F/11C]-DOPA PET studies. Schizophr. Bull. 2013, 39:33-42.
20. Gottesman I.I. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160:636-645.
21. Häfner H., Maurer K., Löffler W., Riecher-Rössler A. The influence of age and sex on the onset and early course of schizophrenia. Br. J. Psychiatry J. Ment. Sci. 1993, 162:80-86.
22. Hahn B., Hollingworth A., Robinson B.M., Kaiser S.T., Leonard C.J., Beck V.M., Kappenman E.S., Luck S.J., Gold J.M. Control of working memory content in schizophrenia. Schizophr. Res. 2012, 134:70-75.
23. Jang J.H., Jung W.H., Choi J.-S., Choi C.-H., Kang D.-H., Shin N.Y., Hong K.S., Kwon J.S. Reduced prefrontal functional connectivity in the default mode network is related to greater psychopathology in subjects with high genetic loading for schizophrenia. Schizophr. Res. 2011, 127:58-65.
24. Karch S., Leicht G., Giegling I., Lutz J., Kunz J., Buselmeier M., Hey P., Spörl A., Jäger L., Meindl T., Pogarell O., Möller H.-J., Hegerl U., Rujescu D., Mulert C. Inefficient neural activity in patients with schizophrenia and nonpsychotic relatives of schizophrenic patients: evidence from a working memory task. J. Psychiatr. Res. 2009, 43:1185-1194.
25. Karlsgodt K.H., Glahn D.C., Van Erp T.G.M., Therman S., Huttunen M., Manninen M., Kaprio J., Cohen M.S., Lönnqvist J., Cannon T.D. The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr. Res. 2007, 89:191-197.
26. Knutson B., Gibbs S.E.B. Linking nucleus accumbens dopamine and blood oxygenation. Psychopharmacology 2007, 191:813-822.
27. Kriegeskorte N., Simmons W.K., Bellgowan P.S.F., Baker C.I. Circular analysis in systems neuroscience: the dangers of double dipping. Nat. Neurosci. 2009, 12:535-540.
28. Li X., Branch C.A., Bertisch H.C., Brown K., Szulc K.U., Ardekani B.A., DeLisi L.E. An fMRI study of language processing in people at high genetic risk for schizophrenia. Schizophr. Res. 2007, 91:62-72.
29. Lovinger D.M., Tyler E. Synaptic transmission and modulation in the neostriatum. Int. Rev. Neurobiol. 1996, 39:77-111.
30. Mayer J.S., Roebroeck A., Maurer Konrad, Linden D.E.J. Specialization in the default mode: task-induced brain deactivations dissociate between visual working memory and attention. Hum. Brain Mapp. 2010, 31:126-139.
31. Meda S.A., Bhattarai M., Morris N.A., Astur R.S., Calhoun V.D., Mathalon D.H., Kiehl K.A., Pearlson G.D. An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients. Schizophr. Res. 2008, 104:85-95.
32. Meda S.A., Gill A., Stevens M.C., Lorenzoni R.P., Glahn D.C., Calhoun V.D., Sweeney J.A., Tamminga C.A., Keshavan M.S., Thaker G., Pearlson G.D. Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives. Biol. Psychiatry 2012, 71:881-889.
33. Meyer-Lindenberg A., Weinberger Daniel R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 2006, 7:818-827.
34. Murty V.P., Sambataro F., Radulescu E., Altamura M., Iudicello J., Zoltick B., Weinberger Daniel R., Goldberg T.E., Mattay V.S. Selective updating of working memory content modulates meso-cortico-striatal activity. Neuroimage 2011, 57:1264-1272.
35. Raemaekers M., Ramsey N.F., Vink M., Van den Heuvel M.P., Kahn R.S. Brain activation during antisaccades in unaffected relatives of schizophrenic patients. Biol. Psychiatry 2006, 59:530-535.
36. Raichle M.E., MacLeod A.M., Snyder A.Z., Powers W.J., Gusnard D.A., Shulman G.L. A default mode of brain function. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:676-682.
37. Rasetti R., Weinberger Daniel R. Intermediate phenotypes in psychiatric disorders. Curr. Opin. Genet. Dev. 2011, 21:340-348.
38. Repovš G., Barch D.M. Working memory related brain network connectivity in individuals with schizophrenia and their siblings. Front. Hum. Neurosci. 2012, 6:137.
39. Repovs G., Csernansky J.G., Barch D.M. Brain network connectivity in individuals with schizophrenia and their siblings. Biol. Psychiatry 2011, 69:967-973.
40. Schedules for Clinical Assessment in Neuropsychiatry(SCAN), 1992. World Health Organization, Geneva, Switzerland.
41. Schott B.H., Minuzzi L., Krebs R.M., Elmenhorst D., Lang M., Winz O.H., Seidenbecher C.I., Coenen H.H., Heinze H.-J., Zilles K., Düzel E., Bauer A. Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release. J. Neurosci. Off. J. Soc. Neurosci. 2008, 28:14311-14319.
42. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 1998, 59(Suppl. 2):22-33. quiz 34-57.
43. Snitz B.E., Macdonald A.W., Carter C.S. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr. Bull. 2006, 32:179-194.
44. Sternberg S. High-speed scanning in human memory. Science (New York, N.Y.) 1966, 153:652-654.
45. Tan H.-Y., Chen Q., Goldberg T.E., Mattay V.S., Meyer-Lindenberg A., Weinberger Daniel R., Callicott J.H. Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. J. Neurosci. Off. J. Soc. Neurosci. 2007, 27:13393-13401.
46. Thermenos H.W., Seidman L.J., Breiter H., Goldstein J.M., Goodman J.M., Poldrack R., Faraone S.V., Tsuang Ming T. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study. Biol. Psychiatry 2004, 55:490-500.
47. Tomasi D., Volkow N.D., Wang R., Telang F., Wang G.-J., Chang L., Ernst T., Fowler J.S. Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention. PLoS One 2009, 4:e6102.
48. Tsuang M.T. Genotypes, phenotypes, and the brain. A search for connections in schizophrenia. Br. J. Psychiatry J. Ment. Sci. 1993, 163:299-307.
49. Van Buuren M., Vink M., Rapcencu A.E., Kahn R.S. Exaggerated brain activation during emotion processing in unaffected siblings of patients with schizophrenia. Biol. Psychiatry 2011, 70:81-87.
50. Van Dijk K.R.A., Sabuncu M.R., Buckner R.L. The influence of head motion on intrinsic functional connectivity MRI. Neuroimage 2012, 59:431-438.
51. Van Veelen N.M.J., Vink M., Ramsey N.F., Kahn R.S. Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia. Schizophr. Res. 2010, 123:22-29.
52. Van Veelen N.M.J., Vink M., Ramsey N.F., Sommer I.E.C., Van Buuren M., Hoogendam J.M., Kahn R.S. Reduced language lateralization in first-episode medication-naive schizophrenia. Schizophr. Res. 2011, 127:195-201.
53. Van Veelen N.M.J., Vink M., Ramsey N.F., Van Buuren M., Hoogendam J.M., Kahn R.S. Prefrontal lobe dysfunction predicts treatment response in medication-naive first-episode schizophrenia. Schizophr. Res. 2011, 129:156-162.
54. Vink M., Ramsey N.F., Raemaekers M., Kahn R.S. Striatal dysfunction in schizophrenia and unaffected relatives. Biol. Psychiatry 2006, 60:32-39.
55. Weinberger D.R., Gallhofer B. Cognitive function in schizophrenia. Int. Clin. Psychopharmacol. 1997, 12(Suppl. 4):S29-S36.
56. Whitfield-Gabrieli S., Thermenos H.W., Milanovic S., Tsuang Ming T., Faraone S.V., McCarley R.W., Shenton M.E., Green A.I., Nieto-Castanon A., LaViolette P., Wojcik J., Gabrieli J.D.E., Seidman L.J. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:1279-1284.
57. Wing J.K., Babor T., Brugha T., Burke J., Cooper J.E., Giel R., Jablenski A., Regier D., Sartorius N. SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Arch. Gen. Psychiatry 1990, 47:589-593.
58. Zandbelt B.B., Van Buuren M., Kahn R.S., Vink M. Reduced proactive inhibition in schizophrenia is related to corticostriatal dysfunction and poor working memory. Biol. Psychiatry 2011, 70:1151-1158.