New perspectives of nanoneuroprotection, nanoneuropharmacology and nanoneurotoxicity: Modulatory role of amino acid neurotransmitters, stress, trauma, and co-morbidity factors in nanomedicine

Amino Acids

Volumn 45, Issue 5, 2013, Pages 1055-1071

  Sharma, Hari S ^a,b   Sharma, Aruna ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Blood brain barrier disruption; Co morbidity factors; Diabetes; Hypertension neuroprotection; Nanomedicine; Nanoparticles; Neural injury; Neuropathology; Neurotoxicity; Stress

Indexed keywords

4 AMINOBUTYRIC ACID; ANTIOXIDANT; ASPARTIC ACID; CARBON NANOTUBE; CEREBROLYSIN; GLUTAMIC ACID; GLYCINE; H 290 51; METAL; NANOMATERIAL; NANOPARTICLE; NANOWIRE; TITANIUM; UNCLASSIFIED DRUG;

BIOCHEMICAL OXYGEN DEMAND; BLOOD BRAIN BARRIER; BRAIN REGION; COMORBIDITY; DIABETES MELLITUS; DISEASE EXACERBATION; DRUG DELIVERY SYSTEM; EXCITOTOXICITY; HEAT STRESS; HUMAN; HYPERTENSION; HYPERTHERMIA; INJURY; NANOMEDICINE; NERVE REGENERATION; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; SCIATIC NERVE INJURY; STRESS;

ANIMALIA;

AMINO ACIDS; ANIMALS; CENTRAL NERVOUS SYSTEM; DRUG DELIVERY SYSTEMS; DRUG THERAPY; HUMANS; NANOMEDICINE; NANOPARTICLES; NEUROPROTECTIVE AGENTS; NEUROTRANSMITTER AGENTS;

EID: 84886255013     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-013-1584-z     Document Type: Review

References (59)

1. Feng L, Sharma A, Sharma HS (2010) Engineered nanoparticles from metals induce upregulation of nitric oxide and exacerbate pathophysiology of spinal cord injury in the rat. Session 428 neurotoxicity and neurodegeneration IV. Program Number: 428.2. 41st Annual Society for Neuroscience Meeting San Diego, Society for Neuroscience
2. Feng L, Sharma A, Sharma HS (2011) Engineered nanoparticles from metals aggravates neuropathic pain syndrome and exacerbate blood-spinal cord barrier breakdown, astrocytic activation and neural injury. Nanosymposium 323.06 nanoparticles as therapeutic tools for diseases of the nervous system. 41st Annual Society for Neuroscience Meeting, Washington, USA
3. Fisher E, Boenink M, van der Burg S, Woodbury N (2012) Responsible healthcare innovation: anticipatory governance of nanodiagnostics for theranostics medicine. Expert Rev Mol Diagn 12(8):857-870. doi: 10.1586/erm.12.125
4. Lafuente JV, Patnaik R, Sharma A, Sharma HS (2011) Engineered nanoparticles from metals influence glutamate, aspartate, GABA and glycine neurotransmission in the normal and injured spinal cord. Amino Acids 41(1):S25-S25
5. Lafuente JV, Sharma A, Patnaik R, Muresanu DF, Sharma HS (2012) Diabetes exacerbates nanoparticles induced brain pathology. CNS Neurol Disord Drug Targets 11(1):26-39
6. Menon PK, Muresanu DF, Sharma A, Mössler H, Sharma HS (2012) Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 11(1):40-9
7. Muresanu DF, Sharma HS (2007) Chronic hypertension aggravates heat stress induced cognitive dysfunction and brain pathology: an experimental study in the rat, using growth hormone therapy for possible neuroprotection. Ann N Y Acad Sci 1122:1-22 (Pubitemid 350249538)
8. Muresanu DF, Sharma A, Sharma HS (2010) Diabetes aggravates heat stress-induced blood-brain barrier breakdown, reduction in cerebral blood flow, edema formation, and brain pathology: possible neuroprotection with growth hormone. Ann N Y Acad Sci 1199:15-26. doi: 10.1111/j.1749-6632.2009.05328.x
9. Muresanu DF, Patnaik R, Sharma A, Sharma HS (2011a) Nanowired cerebrolysin restores imbalance of excitatory and inhibitory amino acid neurotransmitters in the CNS following hyperthermia induced brain pathology. Amino Acids 41(1):S29-S29
10. Muresanu DF, Patnaik R, Sharma A, Sharma HS (2011b) Engineered nanoparticles from metals Ag, Cu, and Al (50-60 nm) induce oxidative stress, blood-brain barrier disruption, neuronal nitric oxide synthase upregulation, and cell injury in the rat brain. Neuroprotective effects of insulin like growth factor-1. Cell Transplant 20(4):576-576
11. Muresanu DF, Sharma A, Tian ZR, Smith MA, Sharma HS (2012) Nanowired drug delivery of antioxidant compound H-290/51 enhances neuroprotection in hyperthermia-induced neurotoxicity. CNS Neurol Disord Drug Targets 11(1):50-64
12. Rapoport SI (1976) Blood brain barrier in physiology and medicine. Raven Press, New York
13. Sharma HS (1982) Blood-Brain Barrier in stress, Ph D Thesis, Banaras Hindu University, Varanasi, India, pp 1-85
14. Sharma HS (1998) Neurobiology of the nitric oxide in the nervous system. Basic and clinical perspectives. Amino Acids 14(1-3):83-85 (Pubitemid 28051156)
15. Sharma HS (1999) Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia: new role of heat shock protein, nitric oxide and carbon monoxide. an experimental study in the rat using light and electron microscopy. Acta Universitatis Upsaliensis 830:1-94
16. Sharma HS (2000) Neurodegeneration and regeneration in the CNS. New roles of heat shock proteins, nitric oxide and carbon monoxide. Amino Acids 19(1):335-337
17. Sharma HS (2002) Neurobiology of the CNS injury and repair: new roles of amino acids, growth factors and neuropeptides - introduction. Amino Acids 23(1-3):217-219
18. Sharma HS (2004a) Blood-brain and spinal cord barriers in stress. In: Sharma HS, Westman J (eds) The blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 231-298
19. Sharma HS (2004b) Pathophysiology of the blood-spinal cord barrier in traumatic injury. In: Sharma HS, Westman J (eds) The blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 437-518
20. Sharma HS (2006) Hyperthermia influences excitatory and inhibitory amino acid neurotransmitters in the central nervous system. An experimental study in the rat using behavioural, biochemical, pharmacological, and morphological approaches. J Neural Transm 113(4):497-519
21. Sharma HS (2007a) Nanoneuroscience: emerging concepts on nanoneurotoxicity and nanoneuroprotection. Nanomedicine (Lond) 2(6):753-758
22. Sharma HS (2007b) Interaction between amino acid neurotransmitters and opioid receptors in hyperthermia-induced brain pathology. Prog Brain Res 162:295-317 (Pubitemid 47080952)
23. Sharma HS (2009a) Nanoneuroscience and Nanoneuropharmacology. Book series: progress in brain research, vol 180. Elsevier, The Netherlands, pp 1-350
24. Sharma HS (2009b) Blood-central nervous system barriers: the gateway to neurodegeneration, neuroprotection and neuroregeneration. In: Lajtha A, Banik N, Ray SK (eds) Handbook of neurochemistry and molecular neurobiology: brain and spinal cord trauma. Springer, Berlin/Heidelberg/New York, pp 363-457
25. Sharma HS (2009c) A special section on nanoneuroscience: nanoneurotoxicity and nanoneuroprotection. J Nanosci Nanotechnol 9(8):4992-4995
26. Sharma HS (2011) Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection. J Neural Transm 118(1):155-176
27. Sharma HS, Sharma A (2007) Nanoparticles aggravate heat stress induced cognitive deficits, blood-brain barrier disruption, edema formation and brain pathology. Prog Brain Res 162:245-273 (Pubitemid 47086304)
28. Sharma HS, Sharma A (2010a) Nanoneuroprotection and nanoneurotoxicity: recent progress and future perspectives. Nanomedicine (Lond) 5(4):533-7. doi: 10.2217/nnm.10.25
29. Sharma HS, Sharma A (2010b) Breakdown of the blood-brain barrier in stress alters cognitive dysfunction and induces brain pathology. New perspective for neuroprotective strategies. In: Ritsner M (ed) Brain protection in schizophrenia, mood and cognitive disorders. Springer, Berlin/New York, pp 243-304
30. Sharma HS (2012) New perspectives of central nervous system injury and neuroprotection, vol 102. Academic Press, Elsevier, San Diego, pp 2-395
31. Sharma A, Sharma HS (2012a) Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair. Int Rev Neurobiol 102:23-45. doi: 10.1016/B978-0-12-386986-9.00002-8
32. Sharma HS, Sharma A (2012b) Neurotoxicity of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 11(1):65-80
33. Sharma HS, Sharma A (2012c) Recent perspectives on nanoneuroprotection & nanoneurotoxicity. CNS & Neurological Disorders - Drug Targets 11(1)
34. Sharma HS, Sharma A (2012d) Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors. Wiley Interdiscip Rev Nanomed Nanobiotechnol 4(2):184-203. doi: 10.1002/wnan.172
35. Sharma HS, Sharma A (2012e) Rodent spinal cord injury model and application of neurotrophic factors for neuroprotection. Methods Mol Biol 846:393-415. doi: 10.1007/978-1-61779-536-7-33
36. Sharma HS, Sjöquist PO (2002) A new antioxidant compound H-290/51 modulates glutamate and GABA immunoreactivity in the rat spinal cord following trauma. Amino Acids 23(1-3):261-272
37. Sharma HS, Westman J (2004) Blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 1-650
38. Sharma HS, Nyberg F, Westman J, Alm P, Gordh T, Lindholm D (1998) Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat. Amino Acids 14(1-3):121-129 (Pubitemid 28051161)
39. Sharma HS, Nyberg F, Gordh T, Alm P, Westman J (2000) Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat. Amino Acids 19(1):351-361
40. Sharma HS, Ali SF, Dong W, Tian ZR, Patnaik R, Patnaik S, Sharma A, Boman A, Lek P, Seifert E, Lundstedt T (2007) Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord. Ann N Y Acad Sci 1122:197-218 (Pubitemid 350249549)
41. Sharma HS, Ali SF, Hussain SM, Schlager JJ, Sharma A (2009a) Influence of engineered nanoparticles from metals on the blood-brain barrier permeability, cerebral blood flow, brain edema and neurotoxicity. An experimental study in the rat and mice using biochemical and morphological approaches. J Nanosci Nanotechnol 9(8):5055-5072
42. Sharma HS, Ali SF, Tian ZR, Hussain SM, Schlager JJ, Sjöquist PO, Sharma A, Muresanu DF (2009b) Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51. J Nanosci Nanotechnol 9(8):5073-5090
43. Sharma HS, Ali S, Tian ZR, Patnaik R, Patnaik S, Lek P, Sharma A, Lundstedt T (2009c) Nano-drug delivery and neuroprotection in spinal cord injury. J Nanosci Nanotechnol 9(8):5014-5037
44. Sharma HS, Muresanu DF, Sharma A, Patnaik R, Lafuente JV (2009d) Chapter 9 - Nanoparticles influence pathophysiology of spinal cord injury and repair. Prog Brain Res 180:154-180
45. Sharma HS, Patnaik R, Sharma A, Sjöquist PO, Lafuente JV (2009e) Silicon dioxide nanoparticles (SiO2, 40-50 nm) exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches. J Nanosci Nanotechnol 9(8):4970-4980
46. Sharma HS, Patnaik R, Sharma A (2010a) Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. J Nanosci Nanotechnol 10(12):7931-7945
47. Sharma HS, Patnaik R, Sharma A (2010b) Exposure of manganese nanoparticle induce blood-brain barrier disruption, brain pathology and cognitive and motor dysfunctions in rats. Eur J Neuol 17(Suppl 3):409 (Special Issue: Abstracts of the 14th Congress of the EFNS, Geneva, Switzerland)
48. Sharma HS, Sharma A, Hussain S, Schlager J, Sjöquist PO, Muresanu D (2010c) A new antioxidant compound H-290/51 attenuates nanoparticle induced neurotoxicity and enhances neurorepair in hyperthermia. Acta Neurochir Suppl 106:351-357
49. Sharma HS, Muresanu DF, Patnaik R, Stan AD, Vacaras V, Perju-Dumbrav L, Alexandru B, Buzoianu A, Opincariu I, Menon PK, Sharma A (2011a) Superior neuroprotective effects of cerebrolysin in heat stroke following chronic intoxication of Cu or Ag engineered nanoparticles. A comparative study with other neuroprotective agents using biochemical and morphological approaches in the rat. J Nanosci Nanotechnol 11(9):7549-7569
50. Sharma HS, Ali SF, Patnaik R, Zimmermann-Meinzingen S, Sharma A, Muresanu DF (2011b)Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) expression in the rat spinal cord following morphine dependence and withdrawal: possible new therapy for pain management. Curr Neuropharmacol 9(1):223-235. doi: 10.2174/157015911795017100
51. Sharma HS, Sharma A, Mössler H, Muresanu DF (2012a) Neuroprotective effects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: modulatory roles of co-morbidity factors and nanoparticle intoxication. Int Rev Neurobiol 102:249-276. doi: 10.1016/B978-0-12-386986-9. 00010-7
52. Sharma A, Muresanu DF, Mössler H, Sharma HS (2012b) Superior neuroprotective effects of cerebrolysin in nanoparticle-induced exacerbation of hyperthermia-induced brain pathology. CNS Neurol Disord Drug Targets 11(1):7-25
53. Sharma HS, Castellani RJ, Smith MA, Sharma A (2012c) The blood-brain barrier in Alzheimer's disease: novel therapeutic targets and nanodrug delivery. Int Rev Neurobiol 102:47-90. doi: 10.1016/B978-0-12-386986-9.00003-X
54. Singh S (2010) Nanomedicine: nanoscale drugs and delivery systems. J Nanosci Nanotechnol 10:7906-7918
55. Singh S, Nalwa HS (2007) Nanotechnology and health safety - toxicity and risk assessments of nanostructured materials on human health. J Nanosci Nanotechnol 7:3048
56. Tian ZR, Sharma A, Nozari A, Subramaniam R, Lundstedt T, Sharma HS (2012) Nanowired drug delivery to enhance neuroprotection in spinal cord injury. CNS Neurol Disord Drug Targets 11(1):86-95
57. Tosi G, Bondioli L, Ruozi B, Badiali L, Severini GM, Biffi S, De Vita A, Bortot B, Dolcetta D, Forni F, Vandelli MA (2011) NIR-labeled nanoparticles engineered for brain targeting: in vivo optical imaging application and fluorescent microscopy evidences. J Neural Transm 118(1):145-153
58. Uchegbu IF, Siew A (2012) Nanomedicines and nanodiagnostics come of age. J Pharm Sci. doi: 10.1002/jps.23377
59. Zhao YL, Nalwa HS (eds) (2007) Nanotoxicology - interactions of nanomaterials with biological systems. American Scientific Publishers, Los Angeles