Monoclonal Antibodies as Novel Neurotherapeutic Agents in CNS Injury and Repair

International Review of Neurobiology

Volumn 102, Issue , 2012, Pages 23-45

  Sharma, Aruna ^a   Sharma, Hari Shanker ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; DYNORPHIN A; DYNORPHIN A ANTIBODY; MONOCLONAL ANTIBODY; NEURONAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE ANTIBODY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE ANTIBODY; SEROTONIN; SEROTONIN ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BRAIN INJURY; CENTRAL NERVOUS SYSTEM INJURY; CLOSED HEAD INJURY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; HEAD INJURY; HUMAN; IN VIVO STUDY; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD INJURY; TISSUE REPAIR;

EID: 84862851323     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386986-9.00002-8     Document Type: Chapter

References (48)

1. Bentley G.A., Boulot G., Riottot M.M., Poljak R.J. Three-dimensional structure of an idiotope-anti-idiotope complex. Nature 1990, 348(6298):254-257.
2. Chung-a-on K.O., Soyombo O., Spur B.W., Lee T.H. Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1, 4, 5-trisphosphate generation in human neutrophils by lipoxin A4. Br. J. Pharmacol. 1996, 117(6):1334-1340.
3. Couraud P.O. Structural analysis of the epitopes recognized by monoclonal antibodies to angiotensin II. J. Immunol. 1986, 136(9):3365-3370.
4. Couraud P.O. Anti-angiotensin II anti-idiotypic antibodies bind to angiotensin II receptor. J. Immunol. 1987, 138(4):1164-1168.
5. Frelinger A.L., Cohen I., Plow E.F., Smith M.A., Roberts J., Lam S.C., Ginsberg M.H. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J. Biol. Chem. 1990, 265(11):6346-6352.
6. Frelinger A.L., Du X.P., Plow E.F., Ginsberg M.H. Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J. Biol. Chem. 1991, 266(26):17106-17111.
7. Garcia K.C., Desiderio S.V., Ronco P.M., Verroust P.J., Amzel L.M. Recognition of angiotensin II: antibodies at different levels of an idiotypic network are superimposable. Science 1992, 257(5069):528-531.
8. Garcia K.C., Ronco P.M., Verroust P.J., Brünger A.T., Amzel L.M. Three-dimensional structure of an angiotensin II-Fab complex at 3 A: hormone recognition by an anti-idiotypic antibody. Science 1992, 257(5069):502-507.
9. Gifford L.A., Chernov-Rogan T., Harvey J.P., Koo C.H., Goldman D.W., Goetzl E.J. Recognition of human polymorphonuclear leukocyte receptors for leukotriene B4 by rabbit anti-idiotypic antibodies to a mouse monoclonal antileukotriene B4. J. Immunol. 1987, 138(4):1184-1189.
10. Hökfelt T., Fahrenkrug J., Ju G., Ceccatelli S., Tsuruo Y., Meister B., Mutt V., Rundgren M., Brodin E., Terenius L., et al. Analysis of peptide histidine-isoleucine/vasoactive intestinal polypeptide-immunoreactive neurons in the central nervous system with special reference to their relation to corticotropin releasing factor- and enkephalin-like immunoreactivities in the paraventricular hypothalamic nucleus. Neuroscience 1987, 23(3):827-857.
11. Jerne N.K. Recent advances in immunology. Schweiz. Rundsch. Med. Prax. 1974, 63(50):1493-1494.
12. Kasirer-Friede A., Kahn M.L., Shattil S.J. Platelet integrins and immunoreceptors. Immunol. Rev. 2007, 218(1):247-264. Review.
13. Kuroda Y., Shimamoto Y. Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats. J. Neuroimmunol. 1991, 34(2-3):159-164.
14. Leskovar A., Moriarty L.J., Turek J.J., Schoenlein I.A., Borgens R.B. The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems. J. Exp. Biol. 2000, 203(Pt 12):1783-1795.
15. Nguyen D.H., Taub D. Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood 2002, 99(12):4298-4306.
16. Pan W., Zadina J.E., Harlan R.E., Weber J.T., Banks W.A., Kastin A.J. Tumor necrosis factor-alpha: a neuromodulator in the CNS. Neurosci. Biobehav. Rev. 1997, 21(5):603-613. Review.
17. Pan W., Kastin A.J., Bell R.L., Olson R.D. Upregulation of tumor necrosis factor alpha transport across the blood-brain barrier after acute compressive spinal cord injury. J. Neurosci. 1999, 19(9):3649-3655.
18. Pan W., Zhang L., Liao J., Csernus B., Kastin A.J. Selective increase in TNF alpha permeation across the blood-spinal cord barrier after SCI. J. Neuroimmunol. 2003, 134(1-2):111-117.
19. Pettersson A., Boketoft A., Sabirsh A., Nilsson N.E., Kotarsky K., Olde B., Owman C. First-generation monoclonal antibodies identifying the human leukotriene B (4) receptor-1. Biochem. Biophys. Res. Commun. 2000, 279(2):520-525.
20. Picard C., Ronco P., Moullier P., Yao J., Baudouin B., Geniteau L.M., Verroust P. Epitope diversity of angiotensin II analysed with monoclonal antibodies. Immunology 1986, 57(1):19-24.
21. Prammer K.V., Boyer J., Ugen K., Shattil S.J., Kieber-Emmons T. Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies. Receptor 1994, 4(2):93-108.
22. Puzon-McLaughlin W., Kamata T., Takada Y. Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha (IIb) beta (3). J. Biol. Chem. 2000, 275(11):7795-7802.
23. Reichmann E., Ball R., Groner B., Friis R.R. New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally. J. Cell Biol. 1989, 108(3):1127-1138.
24. Sabirsh A., Pettersson A., Boketoft A., Kotarsky K., Owman C. Differential inhibition of receptor activation by two mouse monoclonal antibodies specific for the human leukotriene B4 receptor, BLT1. Int. Immunopharmacol. 2003, 3(13-14):1829-1839.
25. Schwartz M., Solomon A., Lavie V., Ben-Bassat S., Belkin M., Cohen A. Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Res. 1991, 545(1-2):334-338.
26. Sharma H.S. Influence of serotonin on the blood-brain and blood-spinal cord barriers. The Blood-Spinal Cord and Brain Barriers in Health and Disease 2004, 117-158. Elsevier Academic Press, San Diego Section IV. H.S. Sharma, J. Westman (Eds.).
27. Sharma H.S. Pathophysiology of the blood-spinal cord barrier in traumatic injury. The Blood-Spinal Cord and Brain Barriers in Health and Disease 2004, 437-518. Elsevier Academic Press, San Diego Section VI. H.S. Sharma, J. Westman (Eds.).
28. Sharma H.S. Blood-Central Nervous System Barriers: The Gateway to Neurodegeneration, Neuroprotection and Neuroregeneration. Handbook of Neurochemistry and Molecular Neurobiology: Brain and Spinal Cord Trauma 2009, 363-457. Springer-Verlag, Berlin, 11, chapter 17. A. Lajtha, N. Banik, S.K. Ray (Eds.).
29. Sharma H.S. A combination of tumor necrosis factor-alpha and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat. Ann. N. Y. Acad. Sci. 2010, 1199:175-185.
30. Sharma H.S. Early microvascular reactions and blood-spinal cord barrier disruptions are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection. J. Neural Transm. 2010, 118:155-176. (in press).
31. Sharma H.S., Alm P. Role of nitric oxide on the blood-brain and the spinal cord barriers. The Blood-Spinal Cord and Brain Barriers in Health and Disease 2004, 191-230. Elsevier Academic Press, San Diego Section IV. H.S. Sharma, J. Westman (Eds.).
32. Sharma H.S., Sharma A. Antibodies as promising novel neuroprotective agents in the central nervous system injuries. CNS. Med. Chem. 2008, 8(3):143-169.
33. Sharma H.S., Westman J. The Blood-Spinal Cord and Brain Barriers in Health and Disease 2004, Academic Press, San Diego, pp. 1-617.
34. Sharma H.S., Olsson Y., Dey P.K. Changes in blood-brain barrier and cerebral blood flow following elevation of circulating serotonin level in anesthetized rats. Brain Res. 1990, 517(1-2):215-223.
35. Sharma H.S., Olsson Y., Nyberg F. Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma. Prog. Brain Res. 1995, 104(1):401-416.
36. Sharma H.S., Olsson Y., Persson S., Nyberg F. Trauma-induced opening of the the bloodspinalcord barrier is reduced by indomethacin, an inhibitor of prostaglandin biosynthesis. Experimentalobservations in the rat using [131I]-sodium, Evans blue and lanthanum as tracers. Restor.Neurol.Neurosci 1995, 7(4):207-215.
37. Sharma H.S., Westman J., Olsson Y., Alm P. Involvement of nitric oxide in acute spinal cord injury: an immunocytochemical study using light and electron microscopy in the rat. Neurosci. Res. 1996 Mar, 24(4):373-384.
38. Sharma H.S., Westman J., Nyberg F. Topical application of 5-HT antibodies reduces edema and cell changes following trauma of the rat spinal cord. Acta Neurochir. Suppl. 1997, 70(1):155-158.
39. Sharma H.S., Nyberg F., Gordh T., Alm P., Westman J. Topical application of insulin like growth factor-1 reduces edema and upregulation of neuronal nitric oxide synthase following trauma to the rat spinal cord. Acta. Neurochir. Suppl. 1997, 70:130-133.
40. Sharma H.S., Nyberg F., Westman J., Alm P., Gordh T., Lindholm D. Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat. Amino Acids. 1998, 14(1-3):121-129.
41. Sharma H.S., Westman J., Nyberg F. Pathophysiology of brain edema and cell changesfollowing hyperthermic brain injury. Prog. Brain Res 1998, 115:351-412. Review. 13.
42. Sharma H.S., Alm P., Westman J. Nitric oxide and carbon monoxide in the brain pathology of heat stress. Prog. Brain Res. 1998, 115:297-333. Review.
43. Sharma H.S., Winkler T., Stålberg E., Gordh T., Alm P., Westman J. Topical application of TNF-alpha antiserum attenuates spinal cord trauma induced edema formation, microvascular permeability disturbances and cell injury in the rat. Acta Neurochir. Suppl. 2003, 86:407-413.
44. Sharma H.S., Nyberg F., Gordh T., Alm P. Topical application of dynorphin A (1-17) antibodies attenuates neuronal nitric oxide synthase up-regulation, edema formation, and cell injury following focal trauma to the rat spinal cord. Acta Neurochir. Suppl. 2006, 96:309-315.
45. Sharma H.S., Patnaik R., Patnaik S., Mohanty S., Sharma A., Vannemreddy P. Antibodies to serotonin attenuate closed head injury induced blood brain barrier disruption and brain pathology. Ann. N. Y. Acad. Sci. 2007, 1122:295-312.
46. Taub R., Gould R.J., Garsky V.M., Ciccarone T.M., Hoxie J., Friedman P.A., Shattil S.J. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J. Biol. Chem. 1989, 264(1):259-265.
47. Winkler T., Sharma H.S., Gordh T., Badgaiyan R.D., Stålberg E., Westman J. Topical application of dynorphin A (1-17) antiserum attenuates trauma induced alterations in spinal cord evoked potentials, microvascular permeability disturbances, edema formation and cell injury: an experimental study in the rat using electrophysiological and morphological approaches. Amino Acids. 2002, 23(1-3):273-281.
48. Waldmann T.A. Immunotherapy: past, present and future. Nat. Med. 2003, 9(3):269-277.