Nanoporous Membrane-Based Microfluidic Biosensors

Microfluidic Devices in Nanotechnology: Applications

Volumn , Issue , 2010, Pages 47-90

  Prasad, Shalini ^a   Yadav, Yamini ^b   Bothara, Manish ^b   Kunduru, Vindhya ^a   Muthukumar, Sriram ^c  

^a Arizona State University   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c INTEL CORPORATION   (United States)

Author keywords

Membrane functionality in biosensors; Nanoporous membrane based microfluidic biosensors and nanoporous membranes in sensor development; Real time biomolecule binding measurement in biosensors nanoporous membranes into "lab on a chip" biosensing devices

Indexed keywords

EID: 84886140514     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470622551.ch2     Document Type: Chapter

References (96)

1. Adiga, S.; Curtiss, L.; Elam, J.; Pellin, M.; Shih, C.-C.; Shih, C.-M.; Lin, S.-J.; Su, Y.-Y.; Gittard, S.; Zhang, J.; Narayan, R. Nanoporous materials for biomedical devices. JOM J. Miner. Met. and Mater. Soc. 2008, 60, 26-32.
2. Whitesides, G.M. The origins and the future of microfluidics. Nature 2006, 442, 368-373.
3. Mohanty, S.P.; Kougianos, E. Biosensors: a tutorial review. IEEE 2006, 6, 35-40.
4. Sheehan, P.E.; Whitman, L.J. Detection limits for nanoscale biosensors. Nano Lett. 2005, 5, 803-807.
5. Cheng, K.-L.; Sheng, Y.-J.; Jiang, S.; Tsao, H.-K. Electrophoretic size separation of particles in a periodically constricted microchannel. J. Chem. Phys. 2008, 128, 101101.
6. Kuo, C.-W.; Shiu, J.-Y.; Wei, K.H.; Chen, P. Monolithic integration of well-ordered nanoporous structures in the microfluidic channels for bioseparation. J. Chromatogr. A 2007, 1162, 175-179.
7. Ulbricht, M. Advanced functional polymer membranes. Polymer 2006, 47, 2217-2262.
8. Yang, S.Y.; Jinhwan, J.P.; Moonhor, Y.; Key, R.S.; Kim, J.J.K. Virus filtration membranes prepared from nanoporous block copolymers with good dimensional stability under high pressures and excellent solvent resistance. Adv. Funct. Mater. 2008, 18, 1371-1377.
9. Lee, W.; Ji, R.; Gosele, U.; Nielsch, K. Fast fabrication of long-range ordered porous alumina membranes by hard anodization. Nat. Mater. 2006, 5, 741-747.
10. Reddy, R.K.; Bothara, M.G.; Barrett, T.W.; Carruthers, J.; Prasad, S. Nanomonitors: protein biosensors for rapid analyte analysis. IEEE Sens. J. 2008, 8, 720-723.
11. Apel, P. Track etching technique in membrane technology. Radiat. Meas. 2001, 34, 559-566.
12. Awasthi, K.; Kulshrestha, V.; Acharya, N.K.; Singh, M.; Vijay, Y.K. Ion transport through track etched polypropylene membrane. Eur. Polym. J. 2006, 42, 883-887.
13. Dobrev, D.; Neumann, R.; Angert, N.; Vetter, J. Formation of metal membranes by direct duplication of etched ion-track templates. Appl. Phys. A: Mater. Sci. Process. 2003, 76, 787-790.
14. Enculescu, I. Nanowires and nanotubes prepared using ion track membranes as templates. Digest J. Nanomater. Biostruct. 2006, 1, 15-20.
15. Siwy, Z.; Apel, P.; Dobrev, D.; Neumann, R.; Spohr, R.; Trautmann, C.; Voss, K. Ion transport through asymmetric nanopores prepared by ion track etching. Nucl. Instrum. Methods Phys. Res. B: Beam Interact. Mater. Atoms 2003, 208, 143-148.
16. Vogrin, N.; Stropnik, C.; Musil,V.; Brumen, M. The wet phase separation: the effect of cast solution thickness on the appearance of macrovoids in the membrane forming ternary cellulose acetate/acetone/water system. J. Membr. Sci. 2002, 207, 139-141.
17. Lee, H.J.; Jung, B.; Kang, Y.S.; Lee, H. Phase separation of polymer casting solution by nonsolvent vapor. J. Membr. Sci. 2004, 245, 103-112.
18. Stropnik, C.; Kaiser, V. Polymeric membranes preparation by wet phase separation: mechanisms and elementary processes. Desalination 2002, 145, 1-10.
19. Taketani, Y.; Nagaoka, S.; Kawakami, H. Fabrication of three-dimensionally ordered microporous membrane by wet phase separation. J. Appl. Polym. Sci. 2004, 92, 3016-3021.
20. Li, D.; Krantz, W.B.; Greenberg, A.R.; Sani, R.L. Membrane formation via thermally induced phase separation (TIPS): model development and validation. J. Membr. Sci. 2006, 279, 50-60.
21. Kuo, C.-Y.; Lin, H.-N.; Tsai, H.-A.; Wang, D.-M.; Lai, J.-Y. Fabrication of a high hydrophobic PVDF membrane via nonsolvent induced phase separation. Desalination 2008, 233, 40-47.
22. Fu, X.Y.; Sotani, T.; Matsuyama, H. Effect of membrane preparation method on the outer surface roughness of cellulose acetate butyrate hollowfiber membrane. Desalination 2008, 233, 10-18.
23. Kurt, R.; Simon, L.; Penterman, R.; Peeters, E.; de Koning, H.; Broer, D.J. Control over the morphology of porous polymeric membranes for flow through biosensors. J. Membr. Sci. 2008, 321, 51-60.
24. Leoni, L.; Boiarski, A.; Desai, T.A. Characterization of nanoporous membranes for immunoisolation: diffusion properties and tissue effects. Biomed. Microdevices 2002, 4, 131-139.
25. Lopez, C.A.; Fleischman, A.J.; Roy, S.; Desai, T.A. Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells. Biomaterials 2006, 27, 3075-3083.
26. Yan, X.; Liu, G.; Dickey, M.; Willson, C.G. Preparation of porous polymer membranes using nano- or micro-pillar arrays as templates. Polymer 2004, 45, 8469-8474.
27. Lo, C.J.; Aref, T.; Bezryadin, A. Fabrication of symmetric sub-5 nm nanopores using focused ion and electron beams. Nanotechnology 2006, 17, 3264-3267.
28. Patterson, N.; Adams, D.P.; Hodges, V.C.; Vasile, M.J.; Michael, J.R.; Kotula, P.G. Controlled fabrication of nanopores using a direct focused ion beam approach with back face particle detection. Nanotechnology 2008, 19, 1-10.
29. Lillo, M.; Losic, D. Ion-beam pore opening of porous anodic alumina: the formation of single nanopore and nanopore arrays. Mater. Lett. 2009, 63, 457-460.
30. Kim, M.J.; McNally, B.; Murata, K.; Meller, A. Characteristics of solid-state nanometre pores fabricated using a transmission electron microscope. Nanotechnology 2007, 18, 1-5.
31. Kim, M.J.; Wanunu, M.; Bell, D.C.; Meller, A. Rapid fabrication of uniformly sized nanopores and nanopore arrays for parallel DNA analysis. Adv. Mater. 2006, 18, 3149-3153.
32. Bell, D.C. Fabrication and application of nanopores using TEM, STEM and ion beams. Microsc. Microanal. 2008, 14, 244-245.
33. Striemer, C.C.; Gaborski, T.R.; McGrath, J.L.; Fauchet, P.M. Charge- and size-based separation of macromolecules using ultrathin silicon membranes. Nature 2007, 445, 749-753.
34. Balamurugan, A.; Kannan, S.; Rajeswari, S. Structural and electrochemical behaviour of sol-gel zirconia films on 316L stainless-steel in simulated body fluid environment. Mater. Lett. 2003, 57, 4202-4205.
35. Dìaz-Garcìa, M.E.; Laìnnõ, R.B. Molecular imprinting in sol-gel materials: recent developments and applications. Microchim. Acta 2005, 149, 19-36.
36. Kumar, A.; Gupta, R. Bioactive materials for biomedical applications using sol-gel technology. Biomed. Mater. 2008, 3, 1-16.
37. Bhatia, R.B.; Brinker, C.J.; Gupta, A.K.; Singh, A.K. Aqueous sol-gel process for protein encapsulation. Chem. Mater. 2000, 12, 2434-2441.
38. Collinson, M.M. Recent trends in analytical applications of organically modified silicate materials. Trends Anal. Chem. 2002, 21, 31-39.
39. Power, M.; Hosticka, B.; Black, E.; Daitch, C.; Norris, P. Aerogels as biosensors: viral particle detection by bacteria immobilized on large pore aerogel. J. Non-Crystalline Solids 2001, 285, 303-308.
40. Tiwari, A.; Mishra, A.P.; Dhakate, S.R.; Khan, R.; Shukla, S.K. Synthesis of electrically active biopolymer-SiO2 nanocomposite aerogel. Mater. Lett. 2007, 61, 4587-4590.
41. Li, Y.K.; Chou, M.J.; Wu, T.-Y.; Jinn, T.-R.; Chen-Yang, Y.W. A novel method for preparing a protein-encapsulated bioaerogel: using a red fluorescent protein as a model. Acta Biomater. 2008, 4, 725-732.
42. Scanlon, S.; Aggeli, A.; Boden, N.; Koopmans, R.; Brydson, R.; Rayner, C.M. Peptide aerogels comprising self-assembling nanofibrils. Micro Nano Lett. 2007, 2, 24-29.
43. Yueming, Z.; Chakrabartty, S.; Muhammad-Tahir, Z.; Pal, S.; Alocilja, E.C. Spatiotemporal processing for multichannel biosensors using support vector machines. IEEE Sens. J. 2006, 6, 1644-1651.
44. Song, X.; Kaylor, R. Membrane-Based Assay Device, Kimberly-Clark Worldwide, Inc: Neenah, WI, 2002; p 24.
45. Kueng, A.; Kranz, C.; Mizaikoff, B. Imaging of ATP membrane transport with dual microdisk electrodes and scanning electrochemical microscopy. Biosens. Bioelectron. 2005, 21, 346-353.
46. Shan, D.; He,Y.;Wang, S.; Xue, H.; Zheng, H. Aporous poly(acrylonitrile-co-acrylic acid) film-based glucose biosensor constructed by electrochemical entrapment. Anal. Biochem. 2006, 356, 215-221.
47. Ekanayake, E.M.I.M.; Preethichandra, D.M.G.; Kaneto, K. Fabrication and characterization of nanostructured conducting polymer electrodes for glucose biosensor applications. In Second International Conference on Industrial and Information Systems, 2007, pp. 63-66.
48. Park, J.; Kim, H.K.; Son, Y. Glucose biosensor constructed from capped conducting microtubules of PEDOT. Sens. Actuators B: Chem. 2008, 133, 244-250.
49. Darder, M.; Aranda, P.; Herńndez-Vélez, M.; Manova, E.; Ruiz-Hitzky, E. Encapsulation of enzymes in alumina membranes of controlled pore size. Thin Solid Films 2006, 495, 321-326.
50. Shimomura, T.; Itoh, T.; Sumiya, T.; Mizukami, F.; Ono, M. Amperometric determination of choline with enzyme immobilized in a hybrid mesoporous membrane. Talanta 2009, 78, 217-220.
51. Kim, H.-J.; Yoon, S.H.; Choi, H.N.; Lyu, Y.-K.; Lee, W.-Y. Amperometric glucose biosensor based on sol-gel-derived zirconia/Nafion composite film as encapsulation matrix. Bull. Korean Chem. Soc. 2006, 27, 63-70.
52. De Stefano, L.; Rotiroti, L.; Rendina, I.; Moretti, L.; Scognamiglio,V.; Rossi, M.; D'Auria, S. Porous silicon-based optical microsensor for the detection of L-glutamine. Biosens. Bioelectron. 2006, 21, 1664-1667.
53. Bronzino, J.D. The Biomedical Engineering Handbook, Boca Raton, FL:CRCPress, 2000.
54. Liu, Y.; Zhu, Y.; Zeng, Y.; Xu, F. An effective amperometric biosensor based on gold nanoelectrode arrays. Nanoscale Res. Lett. 2009, 4, 210-215.
55. Shishkanova, T.V.; Volf, R.; Krondak, M.; Král, V. Functionalization of PVC membrane with ss oligonucleotides for a potentiometric biosensor. Biosens. Bioelectron. 2007, 22, 2712-2717.
56. Reddy, R.R.K.; Basu, I.; Bhattacharya, E.; Chadha, A. Estimation of triglycerides by a porous silicon based potentiometric biosensor. Curr. Appl. Phys. 2003, 3, 155-161.
57. Reddy, R.K.K.; Prasad, S.; Barrett, T.; Carruthers, J. Electrical immunoassays toward clinical diagnostics: identification of vulnerable cardiovascular plaque. JALA 2008, 33-39.
58. De Stefano, L.; Arcari, P.; Lamberti, A.; Sanges, C.; Rotiroti, L.; Rea, I.; Rendina, I. DNA optical detection based on porous silicon technology: from biosensors to biochips. Sensors 2007, 7, 214-221.
59. Bonanno, L.; DeLouise, L. Steric crowding effects on target detection in an affinity biosensor. Langmuir 2007, 23, 5817-5823.
60. Xue, W.; Cui, T. Carbon nanotube micropatterns and cantilever arrays fabricated with layer-by-layer nano self-assembly. Sens. Actuators A: Phys. 2007, 136, 510-517.
61. Payen, S.;Walther, D.C.; Pisano, A.P. AMEMSRF-interrogated biosensor. In Third IEEE/ EMBS Special Topic Conference on Microtechnology in Medicine and Biology, 2005, pp. 76-79.
62. Alocilja, E.C. Biosensors for detecting pathogenic bacteria in the meat industry. Meat Biotechnol. 2008, 335-359.
63. Wang, L.; Liu, Q.; Hu, Z.; Zhang, Y.;Wu, C.; Yang, M.;Wang, P. A novel electrochemical biosensor based on dynamic polymerase-extending hybridization for E. coli O157:H7 DNA detection. Talanta 2009, 78, 647-652.
64. Abdel-Hamid, I.; Ivnitski, D.; Atanasov, P.; Wilkins, E. Flow-through immunofiltration assay system for rapid detection of E. coli O157:H7. Biosens. Bioelectron. 1999, 14, 309-316.
65. Liu, Y.; Brandon, R.; Cate, M. Sensitive and rapid detection of pathogens using luminescent CdSe/ZnS dendron-nanocrystals and a porous membrane immunofilter. Anal. Chem. 2007, 79, 8796-8802.
66. Zhang, D.; Alocilja, E.C. Characterization of nanoporous silicon-basedDNAbiosensor for the detection of Salmonella enteritidis. IEEE Sens. J. 2008, 8, 775-780.
67. Riccardi, C. d.S.; Kranz, C.; Kowalik, J.; Yamanaka, H.; Mizaikoff, B.; Josowicz, M. Label-free DNA detection of hepatitis C virus based on modified conducting polypyrrole films at microelectrodes and atomic force microscopy tip-integrated electrodes. Anal. Chem. 2008, 80, 237-245.
68. Rossi, A.M.; Wang, L.; Reipa, V.; Murphy, T.E. Porous silicon biosensor for detection of viruses. Biosens. Bioelectron. 2007, 23, 741-745.
69. Gyurcsányi, R.E. Chemically-modified nanopores for sensing. Trends Anal. Chem. 2008, 27, 627-639.
70. Reichmuth, D.S.;Wang, S.K.; Barrett, L.M.; Throckmorton, D.J.; Einfeld,W.; Singh, A.K. Rapid microchip-based electrophoretic immunoassays for the detection of swine influenza virus. Lab Chip 2008, 8, 1319-1324.
71. Saha, S.; Arya, S.K.; Singh, S.P.; Sreenivas, K.; Malhotra, B.D.; Gupta, V. Nanoporous cerium oxide thin film for glucose biosensor. Biosens. Bioelectron. 2009, 24, 2040-2045.
72. Wei,W.-Z.; Zhai, X.-R.; Zeng, J.-X.; Gao, Y.-P.; Gong, S.-G. New amperometric glucose biosensor by entrapping glucose oxidase into chitosan/nanoporous ZrO2/multiwalled carbon nanotubes nanocomposite film. J. Central South Univ. Technol. 2007, 14, 73-77.
73. Wang, J.; Thomas, D.F.; Chen, A. Nonenzymatic electrochemical glucose sensor based on nanoporous PtPb networks. Anal. Chem. 2008, 80, 997-1004.
74. Vamvakaki, V.; Chaniotakis, N.A. Immobilization of enzymes into nanocavities for the improvement of biosensor stability. Biosens. Bioelectron. 2007, 22, 2650-2655.
75. Ekanayake, E.M.I.M.; Preethichandra, D.M.G.; Kaneto, K. Polypyrrole nanotube array sensor for enhanced adsorption of glucose oxidase in glucose biosensors. Biosens. Bioelectron. 2007, 23, 107-113.
76. Fink, D.; Klinkovich, I.; Bukelman, O.; Marks, R.S.; Kiv, A.; Fuks, D.; Fahrner, W.R.; Alfonta, L. Glucose determination using a re-usable enzyme-modified ion track membrane sensor. Biosens. Bioelectron. 2009, 2418, 2702-2708.
77. Li, J.; Peng, T.; Peng, Y. A cholesterol biosensor based on entrapment of cholesterol oxidase in a silicic sol-gel matrix at a Prussian Blue modified electrode. Electroanalysis 2003, 15, 1031-1037.
78. Li, J.-P.; Gu, H.-N. A selective cholesterol biosensor based on composite film modified electrode for amperometric detection. J. Chin. Chem. Soc. 2006, 53, 575-582.
79. Singh, S.P.; Sunil, K.A.; Pratibha, P.; Malhotra, B.D.; Shibu, S.; Sreenivas, K.; Vinay, G. Cholesterol biosensor based on rf sputtered zinc oxide nanoporous thin film. Appl. Phys. Lett. 2007, 91, 063901.
80. Arya, S.K.; Solanki, P.R.; Singh, S.P.; Kaneto, K.; Pandey, M.K.; Datta, M.; Malhotra, B.D. Poly-(3-hexylthiophene) self-assembled monolayer based cholesterol biosensor using surface plasmon resonance technique. Biosens. Bioelectron. 2007, 22, 2516-2524.
81. Ansari, A.A.; Kaushik, A.; Solanki, P.R.; Malhotra, B.D. Sol-gel derived nanoporous cerium oxide film for application to cholesterol biosensor. Electrochem. Commun. 2008, 10, 1246-1249.
82. Song, M.-J.; Yun, D.-H.; Min, N.-K.; Hong, S.-I. Electrochemical biosensor array for liver diagnosis using silanization technique on nanoporous silicon electrode. J. Biosci. Bioeng. 2007, 103, 32-37.
83. Song, M.-J.; Yun, D.-H.; Min, N.-K.; Hong, S.-I. Electrochemical biosensor array for liver diagnosis using a silanization technique on nano-porous silicon electrode. In Nanotechnology Materials and Devices Conference, NMDC 2006, IEEE, 2006, pp. 362-363.
84. Yang, Z.; Si, S.; Dai, H.; Zhang, C. Piezoelectric urea biosensor based on immobilization of urease onto nanoporous alumina membranes. Biosens. Bioelectron. 2007, 22, 3283-3287.
85. Yang, Z.; Si, S.; Zhang, C. Study on the activity and stability of urease immobilized onto nanoporous alumina membranes. Microporous Mesoporous Mater. 2008, 111, 359-366.
86. Zaytseva, N.V.; Goral, V.N.; Montagna, R.A.; Baeumner, A.J. Development of a microfluidic biosensor module for pathogen detection. Lab Chip 2005, 5, 805-811.
87. Joo, S.; Park, S.; Chung, T.D.; Kim, H.C. Integration of a nanoporous platinum thin film into a microfluidic system for non-enzymatic electrochemical glucose sensing. Anal. Sci. 2007, 23, 277-281.
88. Metz, S.; Trautmann, C.; Bertsch, A.; Renaud, P. Polyimide microfluidic devices with integrated nanoporous filtration areas manufactured by micromachining and ion track technology. J. Micromech. Microeng. 2004, 14, 324-331.
89. Maeng, J.-H.; Lee, B.-C.; Ko, Y.-J.; Cho,W.; Ahn, Y.; Cho, N.-G.; Lee, S.-H.; Hwang, S.Y. A novel microfluidic biosensor based on an electrical detection system for alpha-fetoprotein. Biosens. Bioelectron. 2007, 23, 1319-1325.
90. Goral, V.N.; Zaytseva, N.V.; Baeumner, A.J. Electrochemical microfluidic biosensor for the detection of nucleic acid sequences. Lab Chip 2006, 6, 414-421.
91. Kwakye, S.; Goral, V.N.; Baeumner, A.J. Electrochemical microfluidic biosensor for nucleic acid detection with integrated minipotentiostat. Biosens. Bioelectron. 2006, 21, 2217-2223.
92. Yu, J.; Liu, Z.; Liu, Q.;Yuen, K.T.; Mak, A.F.T.;Yang, M.; Leung, P. Apolyethylene glycol (PEG) microfluidic chip with nanostructures for bacteria rapid patterning and detection. Sens. Actuators A: Phys. 2009, 154(2), 288-294.
93. Vargas-Bernal, R. Topologies based on microfluidics of pesticides biosensors. In Proceedings of the Electronics, Robotics and Automotive Mechanics Conference, IEEE Computer Society, 2007.
94. Nikolelis, D.P.; Raftopoulou, G.; Nikoleli, G.-P.; Simantiraki, M. Stabilized lipid membrane based biosensors with incorporated enzyme for repetitive uses. Electroanalysis 2006, 18, 2467-2474.
95. Parkinson, J.; Gordon, R. Beyond micromachining: the potential of diatoms. Trends Biotechnol. 1999, 17, 190-196.
96. De Stefano, L.; Lamberti, A.; Rotiroti, L.; De Stefano, M. Interfacing the nanostructured biosilica microshells of the marine diatom Coscinodiscus wailesii with biological matter. Acta Biomater. 2008, 4, 126-130.