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Volumn 29, Issue 6, 2013, Pages 608-613

Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease

Author keywords

Adhesion molecules; angiogenesis; endothelium; inflammatory bowel disease; lymphangiogenesis

Indexed keywords

CD18 ANTIGEN; ETROLIZUMAB; FIBROBLAST GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A;

EID: 84886094366     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328365d37c     Document Type: Review
Times cited : (39)

References (74)
  • 1
    • 33748293143 scopus 로고    scopus 로고
    • Etiopathogenesis of inflammatory bowel diseases
    • Danese S, Fiocchi C. Etiopathogenesis of inflammatory bowel diseases. World J Gastroenterol 2006; 12:4807-4812. (Pubitemid 44323204)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.30 , pp. 4807-4812
    • Danese, S.1    Fiocchi, C.2
  • 2
    • 0030783258 scopus 로고    scopus 로고
    • Intestinal inflammation: A complex interplay of immune and nonimmune cell interactions
    • Fiocchi C. Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions. Am J Physiol 1997; 273 (4 Pt 1):G769-G775.
    • (1997) Am J Physiol , vol.273 , Issue.4 PART 1
    • Fiocchi, C.1
  • 3
    • 0032716518 scopus 로고    scopus 로고
    • From immune activation to gut tissue injury: The pieces of the puzzle are coming together
    • DOI 10.1016/S0016-5085(99)70411-7
    • Fiocchi C. From immune activation to gut tissue injury: the pieces of the puzzle are coming together. Gastroenterology 1999; 117:1238-1241. (Pubitemid 29512685)
    • (1999) Gastroenterology , vol.117 , Issue.5 , pp. 1238-1241
    • Fiocchi, C.1
  • 7
    • 0141609935 scopus 로고    scopus 로고
    • Inflammation and thrombosis
    • Esmon CT. Inflammation and thrombosis. J Thromb Haemost 2003; 1:1343-1348.
    • (2003) J Thromb Haemost , vol.1 , pp. 1343-1348
    • Esmon, C.T.1
  • 8
    • 0031978507 scopus 로고    scopus 로고
    • Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease
    • DOI 10.1016/S0016-5085(98)70328-2
    • Panes J, Granger DN. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 1998; 114:1066-1090. (Pubitemid 28217575)
    • (1998) Gastroenterology , vol.114 , Issue.5 , pp. 1066-1090
    • Panes, J.1    Granger, D.N.2
  • 9
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • DOI 10.1016/S0140-6736(07)60750-8, PII S0140673607607508
    • Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immu-nobiology. Lancet 2007; 369:1627-1640. (Pubitemid 46722636)
    • (2007) Lancet , vol.369 , Issue.9573 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 10
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration. Two sides of the same coin
    • von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000; 343:1020-1034.
    • (2000) N Engl J Med , vol.343 , pp. 1020-1034
    • Von Andrian, U.H.1    MacKay, C.R.2
  • 11
    • 32144454172 scopus 로고    scopus 로고
    • Mechanisms of disease: The many roles of chemokines and chemokine receptors in inflammation
    • DOI 10.1056/NEJMra052723
    • Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354:610-621. (Pubitemid 43209108)
    • (2006) New England Journal of Medicine , vol.354 , Issue.6 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 12
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • DOI 10.1016/S0092-8674(02)00971-6
    • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-687. (Pubitemid 35283958)
    • (2002) Cell , vol.110 , Issue.6 , pp. 673-687
    • Hynes, R.O.1
  • 16
    • 77954406973 scopus 로고    scopus 로고
    • Leukocyte traffic control: A novel therapeutic strategy for inflammatory bowel disease
    • Fiorino G, Correale C, Fries W, et al. Leukocyte traffic control: a novel therapeutic strategy for inflammatory bowel disease. Expert Rev Clin Immunol 2010; 6:567-572.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 567-572
    • Fiorino, G.1    Correale, C.2    Fries, W.3
  • 17
    • 59849127969 scopus 로고    scopus 로고
    • Leukocyte adhesion molecules in animal models of inflammatory bowel disease
    • Rivera-Nieves J, Gorfu G, Ley K. Leukocyte adhesion molecules in animal models of inflammatory bowel disease. Inflamm Bowel Dis 2008; 14:1715-1735.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1715-1735
    • Rivera-Nieves, J.1    Gorfu, G.2    Ley, K.3
  • 18
    • 43449095992 scopus 로고    scopus 로고
    • Antiadhesion molecule therapies in inflammatory bowel disease: Touch and go
    • Stefanelli T, Malesci A, De La Rue SA, Danese S. Antiadhesion molecule therapies in inflammatory bowel disease: touch and go. Autoimmun Rev 2008; 7:364-369.
    • (2008) Autoimmun Rev , vol.7 , pp. 364-369
    • Stefanelli, T.1    Malesci, A.2    De La Rue, S.A.3    Danese, S.4
  • 27
    • 0025806992 scopus 로고
    • Granulomatous vasculitis in Crohn's disease
    • Wakefield AJ, Sankey EA, Dhillon AP, et al. Granulomatous vasculitis in Crohn's disease. Gastroenterology 1991; 100 (5 Pt 1):1279-1287.
    • (1991) Gastroenterology , vol.100 , Issue.5 PART 1 , pp. 1279-1287
    • Wakefield, A.J.1    Sankey, E.A.2    Dhillon, A.P.3
  • 28
    • 40949100047 scopus 로고    scopus 로고
    • Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases
    • Ginnan R, Guikema BJ, Halligan KE, et al. Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseases. Free Radic Biol Med 2008; 44:1232-1245.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1232-1245
    • Ginnan, R.1    Guikema, B.J.2    Halligan, K.E.3
  • 29
    • 77952701611 scopus 로고    scopus 로고
    • Angiopoietin-2 in experimental colitis
    • Ganta VC, Cromer W, Mills GL, et al. Angiopoietin-2 in experimental colitis. Inflamm Bowel Dis 2010; 16:1029-1039.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1029-1039
    • Ganta, V.C.1    Cromer, W.2    Mills, G.L.3
  • 30
    • 0029127219 scopus 로고
    • Current pathologic methods for measuring intratumoral micro-vessel density within breast carcinoma and other solid tumors
    • Review
    • Weidner N. Current pathologic methods for measuring intratumoral micro-vessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995; 36:169-180; Review.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 169-180
    • Weidner, N.1
  • 32
    • 62449300644 scopus 로고    scopus 로고
    • Neutralizing antivascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: Direct evidence for the pathogenic role of VEGF
    • Tolstanova G, Khomenko T, Deng X, et al. Neutralizing antivascular endothelial growth factor (VEGF) antibody reduces severity of experimental ulcerative colitis in rats: direct evidence for the pathogenic role of VEGF. J Pharmacol Exp Therapeut 2009; 328:749-757.
    • (2009) J Pharmacol Exp Therapeut , vol.328 , pp. 749-757
    • Tolstanova, G.1    Khomenko, T.2    Deng, X.3
  • 35
    • 58649111743 scopus 로고    scopus 로고
    • VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
    • e5
    • Scaldaferri F, Vetrano S, Sans M, et al. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology 2009; 136:585-595; e5.
    • (2009) Gastroenterology , vol.136 , pp. 585-595
    • Scaldaferri, F.1    Vetrano, S.2    Sans, M.3
  • 37
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • DOI 10.1038/74651
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nature Med 2000; 6:389-395. (Pubitemid 30208155)
    • (2000) Nature Medicine , vol.6 , Issue.4 , pp. 389-395
    • Carmeliet, P.1
  • 38
    • 0031688934 scopus 로고    scopus 로고
    • Chronic inflammation: Links with angiogenesis and wound healing
    • Majno G. Chronic inflammation: links with angiogenesis and wound healing. Am J Pathol 1998; 153:1035-1039. (Pubitemid 28465827)
    • (1998) American Journal of Pathology , vol.153 , Issue.4 , pp. 1035-1039
    • Majno, G.1
  • 39
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • DOI 10.1038/nm0603-653
    • Carmeliet P. Angiogenesis in health and disease. Nature Med 2003; 9:653-660. (Pubitemid 36749213)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 40
    • 44449094600 scopus 로고    scopus 로고
    • Up-regulation of intestinal vascular endothelial growth factor by Afa/Dr diffusely adhering Escherichia coli
    • Cane G, Moal VL, Pages G, et al. Up-regulation of intestinal vascular endothelial growth factor by Afa/Dr diffusely adhering Escherichia coli. PloS One 2007; 2:e1359.
    • (2007) PloS One , vol.2
    • Cane, G.1    Moal, V.L.2    Pages, G.3
  • 42
    • 70449485061 scopus 로고    scopus 로고
    • Targeted therapies in inflammatory bowel disease
    • Siegmund B. Targeted therapies in inflammatory bowel disease. Dig Dis 2009; 27:465-469.
    • (2009) Dig Dis , vol.27 , pp. 465-469
    • Siegmund, B.1
  • 43
    • 84869215386 scopus 로고    scopus 로고
    • Natalizumab for moderate to severe Crohn's disease in clinical practice: The Mayo Clinic Rochester experience
    • Kane SV, Horst S, Sandborn WJ, et al. Natalizumab for moderate to severe Crohn's disease in clinical practice: the Mayo Clinic Rochester experience. Inflamm Bowel Dis 2012; 18:2203-2208.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 2203-2208
    • Kane, S.V.1    Horst, S.2    Sandborn, W.J.3
  • 45
    • 84880254401 scopus 로고    scopus 로고
    • A randomised phase i study of etrolizumab (rhuMAb beta7) in moderate to severe ulcerative colitis
    • Rutgeerts PJ, Fedorak RN, Hommes DW, et al. A randomised phase I study of etrolizumab (rhuMAb beta7) in moderate to severe ulcerative colitis. Gut 2013; 62:1122-1130.
    • (2013) Gut , vol.62 , pp. 1122-1130
    • Rutgeerts, P.J.1    Fedorak, R.N.2    Hommes, D.W.3
  • 47
    • 57249089077 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al. Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 2008; 6:1370-1377.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1370-1377
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 48
    • 84884538154 scopus 로고    scopus 로고
    • Long-term clinical experience with vedolizumab in patients with inflammatory bowel disease
    • Parikh A, Fox I, Leach T, et al. Long-term clinical experience with vedolizumab in patients with inflammatory bowel disease. Inflamm Bowel Dis 2013; 19:1691-1699.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 1691-1699
    • Parikh, A.1    Fox, I.2    Leach, T.3
  • 49
    • 84884816010 scopus 로고    scopus 로고
    • Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice
    • Sugiura T, Kageyama S, Andou A, et al. Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohn Colitis 2013; S1873-9946:00138-4.
    • (2013) J Crohn Colitis
    • Sugiura, T.1    Kageyama, S.2    Andou, A.3
  • 50
    • 84863105061 scopus 로고    scopus 로고
    • Oral treatment with novel alpha4 integrin blocker, AJM300, is efficacious in a rat model of DNBS-induced colitis
    • Ito H, Kihara H, Andou A, et al. Oral treatment with novel alpha4 integrin blocker, AJM300, is efficacious in a rat model of DNBS-induced colitis. Gastroenterology 2005; 128:A200-A210.
    • (2005) Gastroenterology , vol.128
    • Ito, H.1    Kihara, H.2    Andou, A.3
  • 51
    • 79955562875 scopus 로고    scopus 로고
    • Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Takazoe M, Watanabe M, Kawaguchi T, et al. Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2009; 136:A181-A190.
    • (2009) Gastroenterology , vol.136
    • Takazoe, M.1    Watanabe, M.2    Kawaguchi, T.3
  • 52
    • 0033596831 scopus 로고    scopus 로고
    • A safety and pharmacokinetic study of intravenous natalizumab in patients with MS
    • Sheremata WA, Vollmer TL, Stone LA, et al. A safety and pharmacokinetic study of intravenous natalizumab in patients with MS. Neurology 1999; 52:1072-1074. (Pubitemid 29161624)
    • (1999) Neurology , vol.52 , Issue.5 , pp. 1072-1074
    • Sheremata, W.A.1    Vollmer, T.L.2    Stone, L.A.3    Willmer-Hulme, A.J.4    Koller, M.5
  • 53
    • 70149111495 scopus 로고    scopus 로고
    • Progressive multifocal leukoence-phalopathy after natalizumab monotherapy
    • Linda H, von Heijne A, Major EO, et al. Progressive multifocal leukoence-phalopathy after natalizumab monotherapy. N Engl J Med 2009; 361:1081-1087.
    • (2009) N Engl J Med , vol.361 , pp. 1081-1087
    • Linda, H.1    Von Heijne, A.2    Major, E.O.3
  • 54
    • 79953797881 scopus 로고    scopus 로고
    • Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease
    • Rutella S, Fiorino G, Vetrano S, et al. Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease. Am J Gastroenterol 2011; 106:762-770.
    • (2011) Am J Gastroenterol , vol.106 , pp. 762-770
    • Rutella, S.1    Fiorino, G.2    Vetrano, S.3
  • 55
    • 84879348192 scopus 로고    scopus 로고
    • Therapeutic DNA vaccination and RNA interference in inflammatory bowel disease
    • Gardlik R, Bartonova A, Celec P. Therapeutic DNA vaccination and RNA interference in inflammatory bowel disease. Int J Mol Med 2013; 32:492-496.
    • (2013) Int J Mol Med , vol.32 , pp. 492-496
    • Gardlik, R.1    Bartonova, A.2    Celec, P.3
  • 56
    • 84884670183 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis
    • Knod L, Donovan EC, Chernoguz A, et al. Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis. J Surg Res 2013; 184:101-107.
    • (2013) J Surg Res , vol.184 , pp. 101-107
    • Knod, L.1    Donovan, E.C.2    Chernoguz, A.3
  • 57
    • 34247513403 scopus 로고    scopus 로고
    • Bevacizumab and postponed suture leakages after surgery for ulcerative colitis and rectal cancer [5]
    • DOI 10.1136/gut.2006.112524
    • Adenis A, Vanseymortier L, Foissey D, Colombel JF. Bevacizumab and postponed suture leakages after surgery for ulcerative colitis and rectal cancer. Gut 2007; 56:734. (Pubitemid 46662946)
    • (2007) Gut , vol.56 , Issue.5 , pp. 734
    • Adenis, A.1    Vanseymortier, L.2    Foissey, D.3    Colombel, J.-F.4
  • 58
    • 77950364116 scopus 로고    scopus 로고
    • Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury
    • Hindryckx P, Waeytens A, Laukens D, et al. Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury. Lab Invest 2010; 90:566-576.
    • (2010) Lab Invest , vol.90 , pp. 566-576
    • Hindryckx, P.1    Waeytens, A.2    Laukens, D.3
  • 59
    • 54949104422 scopus 로고    scopus 로고
    • Acute exacerbation of hemorrhagic rectocolitis during antiangiogenic therapy with sunitinib and sorafenib
    • Loriot Y, Boudou-Rouquette P, Billemont B, et al. Acute exacerbation of hemorrhagic rectocolitis during antiangiogenic therapy with sunitinib and sorafenib. Ann Oncol 2008; 19:1975.
    • (2008) Ann Oncol , vol.19 , pp. 1975
    • Loriot, Y.1    Boudou-Rouquette, P.2    Billemont, B.3
  • 60
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • DOI 10.1038/nature04480, PII NATURE04480
    • Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature 2005; 438:946-953. (Pubitemid 43093960)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 61
    • 2942668041 scopus 로고    scopus 로고
    • Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation
    • DOI 10.1016/j.it.2004.05.003, PII S1471490604001565
    • Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 2004; 25:387-395. (Pubitemid 38780956)
    • (2004) Trends in Immunology , vol.25 , Issue.7 , pp. 387-395
    • Saharinen, P.1    Tammela, T.2    Karkkainen, M.J.3    Alitalo, K.4
  • 62
    • 38349133365 scopus 로고    scopus 로고
    • The forgotten role of lymphangitis in Crohn's disease
    • Van Kruiningen HJ, Colombel JF. The forgotten role of lymphangitis in Crohn's disease. Gut 2008; 57:1-4.
    • (2008) Gut , vol.57 , pp. 1-4
    • Van Kruiningen, H.J.1    Colombel, J.F.2
  • 63
    • 0014896219 scopus 로고
    • Experimental lymphatic obstruction in the ileum
    • Kalima TV. Experimental lymphatic obstruction in the ileum. Ann Chir Gynae-col Fenn 1970; 59:187-201.
    • (1970) Ann Chir Gynae-col Fenn , vol.59 , pp. 187-201
    • Kalima, T.V.1
  • 64
    • 0014729691 scopus 로고
    • Intestinal villus in experimental lymphatic obstruction. Correlation of light and electron microscopic findings with clinical diseases
    • Kalima TV, Collan Y. Intestinal villus in experimental lymphatic obstruction. Correlation of light and electron microscopic findings with clinical diseases. Scand J Gastroenterol 1970; 5:497-510.
    • (1970) Scand J Gastroenterol , vol.5 , pp. 497-510
    • Kalima, T.V.1    Collan, Y.2
  • 65
    • 0344407018 scopus 로고    scopus 로고
    • Increase in podoplanin-expressing intestinal lymphatic vessels in inflammatory bowel disease
    • Geleff S, Schoppmann SF, Oberhuber G. Increase in podoplanin-expressing intestinal lymphatic vessels in inflammatory bowel disease. Virchows Arch 2003; 442:231-237. (Pubitemid 36399216)
    • (2003) Virchows Archiv , vol.442 , Issue.3 , pp. 231-237
    • Geleff, S.1    Schoppmann, S.F.2    Oberhuber, G.3
  • 66
    • 37549014137 scopus 로고    scopus 로고
    • Lymphangiogenesis in Crohn's disease: An immunohistochemical study using monoclonal antibody D2-40
    • Pedica F, Ligorio C, Tonelli P, et al. Lymphangiogenesis in Crohn's disease: an immunohistochemical study using monoclonal antibody D2-40. Virchows Arch 2008; 452:57-63.
    • (2008) Virchows Arch , vol.452 , pp. 57-63
    • Pedica, F.1    Ligorio, C.2    Tonelli, P.3
  • 67
    • 79961206954 scopus 로고    scopus 로고
    • Increased lymphatic vessel density and lymphangiogenesis in inflammatory bowel disease
    • Rahier JF, De Beauce S, Dubuquoy L, et al. Increased lymphatic vessel density and lymphangiogenesis in inflammatory bowel disease. Aliment Pharmacol Ther 2011; 34:533-543.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 533-543
    • Rahier, J.F.1    De Beauce, S.2    Dubuquoy, L.3
  • 68
    • 1442305271 scopus 로고    scopus 로고
    • Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease
    • Fogt F, Pascha TL, Zhang PJ, et al. Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease. Int J Mol Med 2004; 13:211-214.
    • (2004) Int J Mol Med , vol.13 , pp. 211-214
    • Fogt, F.1    Pascha, T.L.2    Zhang, P.J.3
  • 70
    • 84886099875 scopus 로고    scopus 로고
    • Is lymphatic status related to regression of inflammation in Crohn's disease?
    • Tonelli F, Giudici F, Liscia G. Is lymphatic status related to regression of inflammation in Crohn's disease? World J Gastrointest Surg 2012; 4:228-233.
    • (2012) World J Gastrointest Surg , vol.4 , pp. 228-233
    • Tonelli, F.1    Giudici, F.2    Liscia, G.3
  • 71
    • 0036306121 scopus 로고    scopus 로고
    • Vascular growth factors and lymphangiogenesis
    • Jussila L, Alitalo K. Vascular growth factors and lymphangiogenesis. Physiol Rev 2002; 82:673-700. (Pubitemid 34743335)
    • (2002) Physiological Reviews , vol.82 , Issue.3 , pp. 673-700
    • Jussila, L.1    Alitalo, K.2
  • 72
    • 12444343144 scopus 로고    scopus 로고
    • Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody
    • Pytowski B, Goldman J, Persaud K, et al. Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst 2005; 97:14-21.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 14-21
    • Pytowski, B.1    Goldman, J.2    Persaud, K.3
  • 73
    • 84885390076 scopus 로고    scopus 로고
    • Stimulation of lymphatic function via VEGFR-3 as a novel therapy for chronic experimental intestinal inflammation
    • D'Alessio S, Correale C, Arena V, et al. Stimulation of lymphatic function via VEGFR-3 as a novel therapy for chronic experimental intestinal inflammation. Gastroenterology 2012; 142:S84-S85.
    • (2012) Gastroenterology , vol.142
    • D'Alessio, S.1    Correale, C.2    Arena, V.3
  • 74
    • 84884609221 scopus 로고    scopus 로고
    • Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement
    • Jurisic G, Sundberg JP, Detmar M. Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflamm Bowel Dis 2013; 19:1983-1989.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 1983-1989
    • Jurisic, G.1    Sundberg, J.P.2    Detmar, M.3


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