-
1
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT i randomised trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, et al: Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-1549.
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
Mayer, L.F.4
Schreiber, S.5
Colombel, J.F.6
-
2
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
DOI 10.1056/NEJMoa050516
-
Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, et al: Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462-2476. (Pubitemid 41770166)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.23
, pp. 2462-2476
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.G.3
Reinisch, W.4
Olson, A.5
Johanns, J.6
Travers, S.7
Rachmilewitz, D.8
Hanauer, S.B.9
Lichtenstein, G.R.10
De Villiers, W.J.S.11
Present, D.12
Sands, B.E.13
Colombel, J.F.14
-
3
-
-
0034754480
-
Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway
-
Lugering A, Schmidt M, Lugering N, Pauels HG, Domschke W, Kucharzik T: Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 2001; 121: 1145-1157.
-
(2001)
Gastroenterology
, vol.121
, pp. 1145-1157
-
-
Lugering, A.1
Schmidt, M.2
Lugering, N.3
Pauels, H.G.4
Domschke, W.5
Kucharzik, T.6
-
4
-
-
34147211616
-
Te Velde AA, ten Cate FJ, et al: Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease
-
Van den Brande JM, Koehler TC, Zelinkova Z, Bennink RJ, te Velde AA, ten Cate FJ, et al: Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease. Gut 2007; 56: 509-517.
-
(2007)
Gut
, vol.56
, pp. 509-517
-
-
Van Den Brande, J.M.1
Koehler, T.C.2
Zelinkova, Z.3
Bennink, R.J.4
-
5
-
-
34447515607
-
Maintenance therapy with certolizumab pegol for Crohn's disease
-
DOI 10.1056/NEJMoa062897
-
Schreiber S, Khaliq-Kareemi M, Lawrance IC, Thomsen OO, Hanauer SB, McColm J, et al: Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med 2007; 357: 239-250. (Pubitemid 47080388)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.3
, pp. 239-250
-
-
Schreiber, S.1
Khaliq-Kareemi, M.2
Lawrance, I.C.3
Thomsen, O.O.4
Hanauer, S.B.5
McColm, J.6
Bloomfield, R.7
Sandborn, W.J.8
-
6
-
-
34447523749
-
Certolizumab pegol for the treatment of Crohn's disease
-
Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, et al: Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 2007; 357: 228-238.
-
(2007)
N Engl J Med
, vol.357
, pp. 228-238
-
-
Sandborn, W.J.1
Feagan, B.G.2
Stoinov, S.3
Honiball, P.J.4
Rutgeerts, P.5
Mason, D.6
-
7
-
-
4344700784
-
Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor-- antibody treatment
-
Zeissig S, Bojarski C, Buergel N, Mankertz J, Zeitz M, Fromm M, et al: Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor-- antibody treatment. Gut 2004; 53: 1295-1302.
-
(2004)
Gut
, vol.53
, pp. 1295-1302
-
-
Zeissig, S.1
Bojarski, C.2
Buergel, N.3
Mankertz, J.4
Zeitz, M.5
Fromm, M.6
-
8
-
-
0028861975
-
Antibodies to interleukin-12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W: Antibodies to interleukin-12 abrogate established experimental colitis in mice. J Exp Med 1995; 182: 1281-1290.
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
Stuber, E.4
Strober, W.5
-
9
-
-
70449478775
-
-
Mannon PJ, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D, et al: Anti-interleukin-
-
Anti-interleukin
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
-
10
-
-
8344284998
-
Antibody for active Crohn's disease
-
antibody for active Crohn's disease. N Engl J Med 2004; 351: 2069-2079.
-
(2004)
N Engl J Med
, vol.351
, pp. 2069-2079
-
-
-
11
-
-
33845340501
-
A genomewide association study identifies IL-23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al: A genomewide association study identifies IL-23R as an inflammatory bowel disease gene. Science 2006; 314: 1461-1463.
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
Rioux, J.D.4
Silverberg, M.S.5
Daly, M.J.6
-
12
-
-
34247560627
-
IL- 23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
-
Tremelling M, Cummings F, Fisher SA, Mansfield J, Gwilliam R, Keniry A, et al: IL- 23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology 2007; 132: 1657-1664.
-
(2007)
Gastroenterology
, vol.132
, pp. 1657-1664
-
-
Tremelling, M.1
Cummings, F.2
Fisher, S.A.3
Mansfield, J.4
Gwilliam, R.5
Keniry, A.6
-
13
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13: 715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
-
14
-
-
0141835046
-
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
-
Becker C, Wirtz S, Blessing M, Pirhonen J, Strand D, Bechthold O, et al: Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003; 112: 693-706.
-
(2003)
J Clin Invest
, vol.112
, pp. 693-706
-
-
Becker, C.1
Wirtz, S.2
Blessing, M.3
Pirhonen, J.4
Strand, D.5
Bechthold, O.6
-
15
-
-
33748588423
-
The orphan nuclear receptor ROR- t directs the differentiation program of proinflammatory IL-17+ T-helper cells
-
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al: The orphan nuclear receptor ROR- t directs the differentiation program of proinflammatory IL-17+ T-helper cells. Cell 2006; 126: 1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
-
16
-
-
33747089041
-
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
-
Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, et al: Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006; 25: 309-318.
-
(2006)
Immunity
, vol.25
, pp. 309-318
-
-
Uhlig, H.H.1
McKenzie, B.S.2
Hue, S.3
Thompson, C.4
Joyce-Shaikh, B.5
Stepankova, R.6
-
17
-
-
33750530394
-
IL-23 plays a key role in Helicobacter hepaticus -induced T-cell-dependent colitis
-
Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, et al: IL-23 plays a key role in Helicobacter hepaticus -induced T-cell-dependent colitis. J Exp Med 2006; 203: 2485-2494.
-
(2006)
J Exp Med
, vol.203
, pp. 2485-2494
-
-
Kullberg, M.C.1
Jankovic, D.2
Feng, C.G.3
Hue, S.4
Gorelick, P.L.5
McKenzie, B.S.6
-
18
-
-
33750505009
-
Interleukin-23 drives innate and T-cell-mediated intestinal inflammation
-
Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, et al: Interleukin-23 drives innate and T-cell-mediated intestinal inflammation. J Exp Med 2006; 203: 2473-2483.
-
(2006)
J Exp Med
, vol.203
, pp. 2473-2483
-
-
Hue, S.1
Ahern, P.2
Buonocore, S.3
Kullberg, M.C.4
Cua, D.J.5
McKenzie, B.S.6
-
19
-
-
33846036986
-
IL-23: A master regulator in Crohn disease
-
Neurath MF: IL-23: A master regulator in Crohn disease. Nat Med 2007; 13: 26-28.
-
(2007)
Nat Med
, vol.13
, pp. 26-28
-
-
Neurath, M.F.1
-
20
-
-
0035199921
-
MAdCAM mediates lymphocyte- endothelial cell adhesion in a murine model of chronic colitis
-
Shigematsu T, Specian RD, Wolf RE, Grisham MB, Granger DN: MAdCAM mediates lymphocyte- endothelial cell adhesion in a murine model of chronic colitis. Am J Physiol 2001; 281:G1309-G1315.
-
(2001)
Am J Physiol
, vol.281
-
-
Shigematsu, T.1
Specian, R.D.2
Wolf, R.E.3
Grisham, M.B.4
Granger, D.N.5
-
21
-
-
0033815802
-
Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1
-
Kato S, Hokari R, Matsuzaki K, Iwai A, Kawaguchi A, Nagao S, et al: Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1. J Pharmacol Exp Ther 2000; 295: 183-189.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 183-189
-
-
Kato, S.1
Hokari, R.2
Matsuzaki, K.3
Iwai, A.4
Kawaguchi, A.5
Nagao, S.6
-
22
-
-
0037413468
-
Natalizumab for active Crohn's disease
-
Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, et al: Natalizumab for active Crohn's disease. N Engl J Med 2003; 348: 24-32.
-
(2003)
N Engl J Med
, vol.348
, pp. 24-32
-
-
Ghosh, S.1
Goldin, E.2
Gordon, F.H.3
Malchow, H.A.4
Rask-Madsen, J.5
Rutgeerts, P.6
-
23
-
-
34247884424
-
Natalizumab for the Treatment of Active Crohn's Disease: Results of the ENCORE Trial
-
DOI 10.1053/j.gastro.2007.03.024, PII S0016508507005380
-
Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, et al: Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE Trial. Gastroenterology 2007; 132: 1672-1683. (Pubitemid 46695722)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1672-1683
-
-
Targan, S.R.1
Feagan, B.G.2
Fedorak, R.N.3
Lashner, B.A.4
Panaccione, R.5
Present, D.H.6
Spehlmann, M.E.7
Rutgeerts, P.J.8
Tulassay, Z.9
Volfova, M.10
Wolf, D.C.11
Hernandez, C.12
Bornstein, J.13
Sandborn, W.J.14
-
24
-
-
0033546663
-
The effect of anti-- 4 integrin antibody on brain lesion activity in MS. the UK Antegren Study Group
-
Tubridy N, Behan PO, Capildeo R, Chaudhuri A, Forbes R, Hawkins CP, et al: The effect of anti-- 4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group. Neurology 1999; 53: 466-472.
-
(1999)
Neurology
, vol.53
, pp. 466-472
-
-
Tubridy, N.1
Behan, P.O.2
Capildeo, R.3
Chaudhuri, A.4
Forbes, R.5
Hawkins, C.P.6
-
25
-
-
22844439662
-
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon-- 1 a for multiple sclerosis
-
Kleinschmidt-DeMasters BK, Tyler KL: Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon-- 1 a for multiple sclerosis. N Engl J Med 2005; 353: 369-374.
-
(2005)
N Engl J Med
, vol.353
, pp. 369-374
-
-
Kleinschmidt-Demasters, B.K.1
Tyler, K.L.2
-
26
-
-
22844445230
-
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
-
Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D: Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005; 353: 375-381.
-
(2005)
N Engl J Med
, vol.353
, pp. 375-381
-
-
Langer-Gould, A.1
Atlas, S.W.2
Green, A.J.3
Bollen, A.W.4
Pelletier, D.5
-
27
-
-
22844445587
-
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
-
Van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M, et al: Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 2005; 353: 362-368.
-
(2005)
N Engl J Med
, vol.353
, pp. 362-368
-
-
Van Assche, G.1
Van Ranst, M.2
Sciot, R.3
Dubois, B.4
Vermeire, S.5
Noman, M.6
-
28
-
-
22844438117
-
Progressive multifocal leukoencephalopathy and natalizumab - Unforeseen consequences
-
Berger JR, Koralnik IJ: Progressive multifocal leukoencephalopathy and natalizumab - unforeseen consequences. N Engl J Med 2005; 353: 414-416.
-
(2005)
N Engl J Med
, vol.353
, pp. 414-416
-
-
Berger, J.R.1
Koralnik, I.J.2
-
29
-
-
4344600302
-
A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy
-
Du Pasquier RA, Kuroda MJ, Zheng Y, Jean- Jacques J, Letvin NL, Koralnik IJ: A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. Brain 2004; 127: 1970-1978.
-
(2004)
Brain
, vol.127
, pp. 1970-1978
-
-
Du Pasquier, R.A.1
Kuroda, M.J.2
Zheng, Y.3
Jean- Jacques, J.4
Letvin, N.L.5
Koralnik, I.J.6
-
30
-
-
4444348496
-
Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals
-
Du Pasquier RA, Schmitz JE, Jean-Jacques J, Zheng Y, Gordon J, Khalili K, et al: Detection of JC virus-specific cytotoxic T lymphocytes in healthy individuals. J Virol 2004; 78: 10206-10210.
-
(2004)
J Virol
, vol.78
, pp. 10206-10210
-
-
Du Pasquier, R.A.1
Schmitz, J.E.2
Jean-Jacques, J.3
Zheng, Y.4
Gordon, J.5
Khalili, K.6
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