Design, synthesis, and biological evaluation studies of novel quinazolinone derivatives as anticonvulsant agents

Medicinal Chemistry Research

Volumn 22, Issue 12, 2013, Pages 5823-5831

  Zayed, Mohamed F ^a,d   Ahmed, Hany E A ^a,d   Omar, Abdel Sattar M ^b,d   Abdelrahim, Adel S ^c,d   El Adl, Khaled ^d  

^a TAIBAH UNIVERSITY   (Saudi Arabia)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c JAZAN UNIVERSITY   (Saudi Arabia)

^d Cairo University   (Egypt)

Author keywords

Anticonvulsant; Epilepsy; Neurotoxicity; Quinazolin 4(3H) one; Synthesis

Indexed keywords

3 (3 CHLOROBENZYL) 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (3,4 DICHLOROBENZYL) 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (4 BROMOBENZYL) 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (4 BROMOBENZYL) 6 IODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (4 BROMOBENZYL) 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (4 BROMOPHENYL) 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (4 CHLOROBENZYL) 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 (4 FLOROBENZYL) 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 3 BENZYL 6,8 DIIODO 2 METHYLQUINAZOLIN 4(3H) ONE; 6,8 DIIODO 2 METHYL 3 (4 METHYLBENZYL)QUINAZOLIN 4(3H) ONE; 6,8 DIIODO 2 METHYL 4H BENZO[D][1,3]OXAZIN 4 ONE; 6,8 DIIODO 3 (4 METHOXYBENZYL) 2 METHYLQUINAZOLIN 4(3H) ONE; 6,8 DIIODO3 (3 NITROBENZYL) 2 METHYLQUINAZOLIN 4(3H) ONE; 6,8 DIIODO3 (4 IODOBENZYL) 2 METHYLQUINAZOLIN 4(3H) ONE; AFLOQUALONE; ANTICONVULSIVE AGENT; ETHOSUXIMIDE; MECLOQUALONE; METHAQUALONE; PENTETRAZOLE; PHENYTOIN; QUINAZOLINONE DERIVATIVE; TRIMETHADIONE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ATAXIA; COMPARATIVE STUDY; CONTROLLED STUDY; CONVULSION; DEATH; DRUG DESIGN; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; ELECTRIC SHOCK; EPILEPSY; LD 50; LIPID SOLUBILITY; LIPOPHILICITY; MALE; MOTOR COORDINATION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; SEDATION; SPIKE WAVE; STRUCTURE ACTIVITY RELATION; THERAPY EFFECT;

EID: 84886093010     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0569-5     Document Type: Article

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