Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues

Medicinal Chemistry Research

Volumn 20, Issue 8, 2011, Pages 1280-1286

  Gawad, Nagwa M Abdel ^a   Georgey, Hanan Hanna ^a   Youssef, Riham M ^a   Sayed, Nehad A El ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Anticonvulsant activity; Benzylidene; Pyrazole; Quinazolinones; Thiadiazole; Triazole

Indexed keywords

1 (3,4 DIMETHOXYPHENYL) 4 PHENYL [1,2,4]TRIAZOLO[4,3]QUINAZOLIN 5(4H) ONE; 1 (4 CHLOROPHENYL) 4 PHENYL [1,2,4]TRIAZOLO[4,3A]QUINAZOLIN 5(4H) ONE; 2 (3 OXO 5,6 DIPHENYL 2,3,4,5 TETRAHYDROPYRIDAZIN 4 YLTHIO) 3 PHENYL QUINAZOLIN 4(3H) ONE; 2 (4 OXO 3 PHENYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETOHYDRAZIDE; 2 (BROMOMETHYL)QUINAZOLIN 4(3H) ONE; 2 [2 (4 BROMOPHENYL) 2 OXOETHYLTHIO] 3 ETHYLQUINAZOLIN 4(3H) ONE; 2 [2 (4 BROMOPHENYL) 2 OXOETHYLTHIO] 3 PHENYLQUINAZOLIN 4(3H) ONE; 2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL] 3 PHENYLQUINAZOLIN 4(3H) ONE; 2 [2 (4 CHLOROPHENYL) 2 OXOETHYLTHIO] 3 PHENYLQUINAZOLIN 4(3H) ONE; 2 [2 (4 METHOXYPHENYL) 2 OXOETHYLTHIO] 3 PHENYLQUINAZOLIN 4(3H) ONE; 2 [[5 (4 CHLOROPHENYL) [1,3,4]THIADIAZOL 2 YLAMINO]METHYL] 3H QUINAZOLIN 4 ONE; 2 [[5 (4 DIMETHYLAMINOPHENYL) [1,3,4]THIADIAZOL 2 YLAMINO]METHYL] 3H QUINAZOLIN 4 ONE; 2 [[5 (4 METHOXYPHENYL) [1,3,4]THIADIAZOL 2 YLAMINO]METHYL] 3H QUINAZOLIN 4 ONE; 2 PROPYLPENTANOIC ACID 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YLMETHYL ESTER; 3 (4 OXO 3,4 DIHYDRO QUINAZOLIN 2 YLMETHYL) 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 3 2 THIOXO 2,3 DIHYDROQUINAZOLIN 4(1H) ONE; 4 (4 OXO 3 PHENYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)PYRIDAZIN 3,6 DIONE; 5 AMINO 1 (4 OXO 3 PHENYL 3,4 DIHYDROQUINAZOLIN 2 YL) 1H PYRAZOLE 4 CARBONITRILE; ANTICONVULSIVE AGENT; DIAZEPAM; PHENOBARBITAL; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; SEIZURE; TREATMENT RESPONSE;

EID: 80054766187     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9465-4     Document Type: Article

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