Probucol and cilostazol exert a combinatorial anti-atherogenic effect in cholesterol-fed rabbits

Thrombosis Research

Volumn 132, Issue 5, 2013, Pages 565-571

  Chen, Yulong ^a   Zhao, Sihai ^a   Huang, Bingqiao ^a   Wang, Yanli ^a   Li, Yafeng ^a   Waqar, Ahmed Bilal ^b   Liu, Ruihan ^a   Bai, Liang ^a   Fan, Jianglin ^b   Liu, Enqi ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Atherosclerosis; Cilostazol; Probucol; Rabbits; S nitrosylation

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; CILOSTAZOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; NITRIC OXIDE; PROBUCOL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; MACROPHAGE; MALE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

ATHEROSCLEROSIS; C-REACTIVE PROTEIN; CILOSTAZOL; CRP; CZ; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENOS; HCD; HDL; HDL-C; HIGH CHOLESTEROL DIET; HIGH-DENSITY LIPOPROTEIN CHOLESTEROL; HIGH-DENSITY LIPOPROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUVECS; LDL-C; LOW-DENSITY LIPOPROTEIN CHOLESTEROL; MACROPHAGES; MALONDIALDEHYDE; MDA; MF; NITRIC OXIDE; NO; PB; PROBUCOL; RABBITS; REACTIVE OXYGEN SPECIES; ROS; S-NITROSYLATION; SMC; SMOOTH MUSCLE CELL; SOD; SUPEROXIDE DISMUTASE; TC; TOTAL CHOLESTEROL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AORTA; ATHEROSCLEROSIS; CHOLESTEROL, DIETARY; DRUG THERAPY, COMBINATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPIDS; MALE; PLATELET AGGREGATION INHIBITORS; PROBUCOL; RABBITS; TETRAZOLES;

EID: 84886088368     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.09.007     Document Type: Article

References (43)

1. C.D. Mathers, and D. Loncar Projections of global mortality and burden of disease from 2002 to 2030 PLoS Med 3 2006 e442
2. D.J. Maron, S. Fazio, and M.F. Linton Current perspectives on statins Circulation 101 2000 207 213
3. S. Yamashita, and Y. Matsuzawa Where are we with probucol: a new life for an old drug? Atherosclerosis 207 2009 16 23
4. M. Ishigami, S. Yamashita, N. Sakai, K. Hirano, T. Arai, and T. Maruyama High-density lipoproteins from probucol-treated patients have increased capacity to promote cholesterol efflux from mouse peritoneal macrophages loaded with acetylated low-density lipoproteins Eur J Clin Invest 27 1997 285 292
5. A.K. Lau, S.B. Leichtweis, P. Hume, R. Mashima, J.Y. Hou, and X. Chaufour Probucol promotes functional reendothelialization in balloon-injured rabbit aortas Circulation 107 2003 2031 2036
6. K. Hirano, C. Ikegami, K. Tsujii, Z. Zhang, F. Matsuura, and Y. Nakagawa-Toyama Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism Arterioscler Thromb Vasc Biol 25 2005 2422 2427
7. T. Miida, U. Seino, O. Miyazaki, O. Hanyu, S. Hirayama, and T. Saito Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling Atherosclerosis 200 2008 329 335
8. C. Lugnier Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents Pharmacol Ther 109 2006 366 398
9. D.B. Wilhite, A.J. Comerota, F.A. Schmieder, R.C. Throm, J.P. Gaughan, and A.K. Rao Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time J Vasc Surg 38 2003 710 713
10. J.H. Lee, G.T. Oh, S.Y. Park, J.H. Choi, J.G. Park, and C.D. Kim Cilostazol reduces atherosclerosis by inhibition of superoxide and tumor necrosis factor-alpha formation in low-density lipoprotein receptor-null mice fed high cholesterol J Pharmacol Exp Ther 313 2005 502 509
11. K.Y. Kim, H.K. Shin, J.M. Choi, and K.W. Hong Inhibition of lipopolysaccharide-induced apoptosis by cilostazol in human umbilical vein endothelial cells J Pharmacol Exp Ther 300 2002 709 715
12. H. Ota, M. Eto, M.R. Kano, S. Ogawa, K. Iijima, and M. Akishita Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells Arterioscler Thromb Vasc Biol 28 2008 1634 1639
13. M.J. Kim, K.G. Park, K.M. Lee, H.S. Kim, S.Y. Kim, and C.S. Kim Cilostazol inhibits vascular smooth muscle cell growth by downregulation of the transcription factor E2F Hypertension 45 2005 552 556
14. S.Y. Park, J.H. Lee, C.D. Kim, W.S. Lee, W.S. Park, and J. Han Cilostazol suppresses superoxide production and expression of adhesion molecules in human endothelial cells via mediation of cAMP-dependent protein kinase-mediated maxi-K channel activation J Pharmacol Exp Ther 317 2006 1238 1245
15. Y. Hattori, K. Suzuki, A. Tomizawa, N. Hirama, T. Okayasu, and S. Hattori Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells Cardiovasc Res 81 2009 133 139
16. K. Nakaya, M. Ayaori, H. Uto-Kondo, T. Hisada, M. Ogura, and E. Yakushiji Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo Atherosclerosis 213 2010 135 141
17. M. Shiomi, S. Yamada, and T. Ito Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary plaque-prone WHHL rabbits Atherosclerosis 178 2005 287 294
18. S. Zhao, C. Zhang, Y. Lin, P. Yang, Q. Yu, and Y. Chu The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits Thromb Res 123 2008 281 287
19. A.B. Waqar, T. Koike, Y. Yu, T. Inoue, T. Aoki, and E. Liu High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits Atherosclerosis 213 2010 148 155
20. Q. Yu, Y. Li, Y. Wang, S. Zhao, P. Yang, and Y. Chen C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits Histol Histopathol 27 2012 529 535
21. S. Chakrabarti, O. Lekontseva, A. Peters, and S.T. Davidge 17β-Estradiol induces protein S-nitrosylation in the endothelium Cardiovasc Res 85 2010 796 805
22. M.T. Forrester, M.W. Foster, M. Benhar, and J.S. Stamler Detection of protein S-nitrosylation with the biotin-switch technique Free Radic Biol Med 46 2009 119 126
23. T. Kita, Y. Nagano, M. Yokode, K. Ishii, N. Kume, and A. Ooshima probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia Proc Natl Acad Sci U S A 84 1987 5928 5931
24. J. Fruebis, V. Gonzalez, M. Silvestre, and W. Palinski Effect of probucol treatment on gene expression of VCAM-1, MCP-1, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis Arterioscler Thromb Vasc Biol 17 1997 1289 1302
25. B.J. Wu, K. Kathir, P.K. Witting, K. Beck, K. Choy, and C. Li Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging J Exp Med 203 2006 1117 1127
26. S. Yamamoto, H. Tanigawa, X. Li, Y. Komaru, J.T. Billheimer, and D.J. Rader Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport Circulation 124 2011 1382 1390
27. F. Bonomini, S. Tengattini, A. Fabiano, R. Bianchi, and R. Rezzani Atherosclerosis and oxidative stress Histol Histopathol 23 2008 381 390
28. B. Niemann, S. Rohrbach, R.A. Catar, G. Muller, M. Barton, and H. Morawietz Native and oxidized low-density lipoproteins stimulate endothelin-converting enzyme-1 expression in human endothelial cells Biochem Biophys Res Commun 334 2005 747 753
29. H.K. Shin, Y.K. Kim, K.Y. Kim, J.H. Lee, and K.W. Hong Remnant lipoprotein particles induce apoptosis in endothelial cells by NAD(P)H oxidase-mediated production of superoxide and cytokines via lectin-like oxidized low-density lipoprotein receptor-1 activation: prevention by cilostazol Circulation 109 2004 1022 1028
30. W.C. Chang, Y.M. Yu, C.H. Wu, Y.H. Tseng, and K.Y. Wu Reduction of oxidative stress and atherosclerosis in hyperlipidemic rabbits by dioscorea rhizome Can J Physiol Pharmacol 83 2005 423 430
31. S.Y. Park, J.H. Lee, C.D. Kim, B.Y. Rhim, K.W. Hong, and W.S. Lee Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in rats Brain Res 1157 2007 112 120
32. S.Y. Park, J.H. Lee, H.K. Shin, C.D. Kim, W.S. Lee, and B.Y. Rhim Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive oxygen species and inflammatory markers in cultured human coronary artery endothelial cells Korean J Physiol Pharmacol 12 2008 165 170
33. P.O. Bonetti, L.O. Lerman, and A. Lerman Endothelial dysfunction: a marker of atherosclerotic risk Arterioscler Thromb Vasc Biol 23 2003 168 175
34. K. Matsushita, C.N. Morrell, B. Cambien, S.X. Yang, M. Yamakuchi, and C. Bao Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide- sensitive factor Cell 115 2003 139 150
35. S.J. Lee, K.M. Kim, S. Namkoong, C.K. Kim, Y.C. Kang, and H. Lee Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine J Biol Chem 280 2005 5781 5788
36. S. Thibeault, Y. Rautureau, M. Oubaha, D. Faubert, B.C. Wilkes, and C. Delisle S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability Mol Cell 39 2010 468 476
37. X. Pi, Y. Wu, J.E. Ferguson, A.L. Portbury, and C. Patterson SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration Proc Natl Acad Sci U S A 106 2009 5675 5680
38. C.J. Oliveira, M.F. Curcio, M.S. Moraes, M. Tsujita, L.R. Travassos, and A. Stern The low molecular weight S-nitrosothiol, S-nitroso-N -acetylpenicillamine, promotes cell cycle progression in rabbit aortic endothelial cells Nitric Oxide 18 2008 241 255
39. L. Santhanam, E.C. Tuday, A.K. Webb, P. Dowzicky, J.H. Kim, and Y.J. Oh Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases invascular stiffness Circ Res 107 2010 117 125
40. J. Haendeler, J. Hoffmann, A.M. Zeiher, and S. Dimmeler Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins Circulation 110 2004 856 861
41. A. Hashimoto, G. Miyakoda, Y. Hirose, and T. Mori Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A- and phosphatidylinositol 3-kinase/Akt-dependent mechanism Atherosclerosis 189 2006 350 357
42. J.L. Jiang, N.S. Li Ns, Y.J. Li, and H.W. Deng Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level Br J Pharmacol 135 2002 1175 1182
43. J.H. Kim, S.H. Park, S.S. Bae, K.W. Hong, Y.D. Kim, and K.P. Park Combinatorial effect of probucol and cilostazol in focal ischemic mice with hypercholesterolemia J Pharmacol Exp Ther 338 2011 451 457