Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in rats

Brain Research

Volumn 1157, Issue 1, 2007, Pages 112-120

  Park, So Youn ^a   Lee, Jeong Hyun ^a   Kim, Chi Dae ^a,b   Rhim, Byung Yong ^a   Hong, Ki Whan ^a,b   Lee, Won Suk ^a,b  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

Cilostazol; Combination therapy; MCA occlusion; Myeloperoxidase; Probucol; Synergism

Indexed keywords

3 NITROTYROSINE; CASPASE 3; CILOSTAZOL; MYELOPEROXIDASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROBUCOL; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVITY; MALE; MEDICAL ASSESSMENT; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL MARKERS; BRAIN ISCHEMIA; CASPASE 3; CEREBRAL INFARCTION; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PEROXIDASE; POLY(ADP-RIBOSE) POLYMERASES; PROBUCOL; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES; TELENCEPHALON; TETRAZOLES; TREATMENT OUTCOME; TYROSINE;

RATTUS;

EID: 34250676140     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.04.051     Document Type: Article

References (30)

1. Cao G., Clark R.S., Pei W., Yin W., Zhang F., Sun F.Y., Graham S.H., and Chen J. Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. J. Cereb. Blood Flow Metab. 23 (2003) 1137-1150
2. Chapman T.M., and Goa K.L. Cilostazol: a review of its use in intermittent claudication. Am. J. Cardiovasc. Drugs 3 (2003) 117-138
3. Chiarugi A., and Moskowitz M.A. Poly(ADP-ribose) polymerase-1 activity promotes NF-κB-driven transcription and microglial activation: implication for neurodegenerative disorders. J. Neurochem. 85 (2003) 306-317
4. Choi J.M., Shin H.K., Kim K.Y., Lee J.H., and Hong K.W. Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats. J. Pharmacol. Exp. Ther. 300 (2002) 787-793
5. Endres M., Wang Z.Q., Namura S., Waeber C., and Moskowitz M.A. Ischemic brain injury is mediated by the activation of poly(ADPribose) polymerase. J. Cereb. Blood Flow Metab. 17 (1997) 1143-1151
6. Ferns G.A.A., Forster L., Stewart-Lee A., Nourooz-Zadeh J., and Anggard E.E. Probucol inhibits mononuclear cell adhesion to vascular endothelium in the cholesterol-fed rabbit. Atherosclerosis 100 (1993) 171-181
7. Fruebis J., Gonzales V., Silvestre M., and Palinski W. Effect of probucol treatment on gene expression of VCAM-1, MCP-1 and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 1289-1302
8. Ha H.C., and Snyder S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 13978-13982
9. Hong K.W., Kim K.Y., Shin H.K., Lee J.H., Choi J.M., Kwak Y.G., Kim C.D., Lee W.S., and Rhim B.Y. Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation. J. Pharmacol. Exp. Ther. 306 (2003) 1182-1190
10. Johansson J., Olsson A.G., Bergstrand L., Elinder L.S., Nilsson S., Erikson U., Molgaard J., Holme I., and Walldius G. Lowering of HDL2b by probucol partly explains the failure of the drug to affect femoral atherosclerosis in subjects with hypercholesterolemia. A Probucol Quantitative Regression Swedish Trial (PQRST) Report. Arterioscler. Thromb. Vasc. Biol. 15 (1995) 1049-1056
11. Joly L.M., Benjelloun N., Plotkine M., and Charriaut-Marlangue C. Distribution of poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat. Pediatr. Res. 53 (2003) 776-782
12. Kimura Y., Tani T., Kanbe T., and Watanabe K. Effect of cilostazol on platelet aggregation and experimental thrombosis. Arzneimittel-Forschung 35 (1985) 1144-1149
13. Knowles J.W., and Maeda N. Genetic modifiers of atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 2336-2345
14. Komjati K., Mabley J.G., Virag L., Southan G.J., Salzman A.L., and Szabo C. Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. Int. J. Mol. Med. 13 (2004) 373-382
15. Kuzuya M., and Kuzuya F. Probucol as an antioxidant and antiatherogenic drug. Free Radic. Biol. Med. 14 (1993) 67-77
16. Lee J.H., Lee Y.K., Ishikawa M., Koga K., Fukunaga M., Miyakoda G., Mori T., Hosokawa T., and Hong K.W. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats-an MRI study. Brain Res. 994 (2003) 91-98
17. Lee J.H., Kim K.Y., Lee Y.K., Park S.Y., Kim C.D., Lee W.S., Rhim B.Y., and Hong K.W. Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats. J. Pharmacol. Exp. Ther. 308 (2004) 896-903
18. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
19. Mallikaarjun S., Forbes W.P., and Bramer S.L. Interaction potential and tolerability of the coadministration of cilostazol and aspirin. Clin. Pharmacokinet. 37 (1999) 87-93
20. Narasimhan P., Fujimura M., Noshita N., and Chan P.H. Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia. Mol. Brain Res. 113 (2003) 28-36
21. Nelson C.W., Wei E.P., Povlishock J.T., Kontos H.A., and Moskowitz M.A. Oxygen radicals in cerebral ischemia. Am. J. Physiol. 263 (1992) H1356-H1362
22. Nicholson D.W., and Thornberry N.A. Caspases: killer proteases. Trends Biochem. Sci. 22 (1997) 299-306
23. Park S.Y., Lee J.H., Kim Y.K., Kim C.D., Rhim B.Y., Lee W.S., and Hong K.W. Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and MCP-1 expression via LOX-1 receptor activation. J. Pharmacol. Exp. Ther. 312 (2005) 1241-1248
24. Park S.Y., Lee J.H., Kim C.D., Lee W.S., Park W.S., Han J., Kwak Y.G., Kim K.Y., and Hong K.W. Cilostazol suppresses superoxide production and expression of adhesion molecules in human endothelial cells via mediation of cAMP-dependent protein kinase-mediated maxi-K channel activation. J. Pharmacol. Exp. Ther. 317 (2006) 1238-1245
25. Peters O., Back T., Lindauer U., Busch C., Megow D., Dreier J., and Dirnagl U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 18 (1998) 196-205
26. Plesnila N., Zhu C., Culmsee C., Groger M., Moskowitz M.A., and Blomgren K. Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 24 (2004) 458-466
27. Reinoehl J., Frankovich D., Machado C., Kawasaki R., Baga J.J., Pires L.A., Steinman R.T., Fromm B.S., and Lehmann M.H. Probucol-associated tachyarrhythmic events and QT prolongation: importance of gender. Am. Heart J. 131 (1996) 1184-1191
28. Takahashi K., Greenberg J.H., Jackson P., Maclin K., and Zhang J. Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 17 (1997) 1137-1142
29. Tardif J.C., Gote G., Lesperance J., Bourassa M., Lambert J., Doucet S., Bilodeau L., Nattel S., and De Guise P. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. N. Engl. J. Med. 337 (1997) 365-372
30. Zapolska-Downar D., Zapolski-Downar A., Markiewski M., Ciechanowicz A., Kaczmarczyk M., and Naruszewicz M. Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells. Atherosclerosis 155 (2001) 123-130