Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness

Circulation Research

Volumn 107, Issue 1, 2010, Pages 117-125

  Santhanam, Lakshmi ^a   Tuday, Eric C ^a   Webb, Alanah K ^a   Dowzicky, Phillip ^a   Kim, Jae Hyung ^a   Oh, Young Jun ^a,b   Sikka, Gautam ^a   Kuo, Maggie ^a   Halushka, Marc K ^a   MacGregor, Anne M ^a   Dunn, Jessilyn ^a   Gutbrod, Sarah ^a   Yin, David ^a   Shoukas, Artin ^a   Nyhan, Daniel ^a   Flavahan, Nicholas A ^a   Belkin, Alexey M ^c   Berkowitz, Dan E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yonsei University College of Medicine   (South Korea)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; S nitrosation; S nitrosylation; Tissue transglutaminase; Vascular stiffness

Indexed keywords

CYSTAMINE; MATRIX PROTEIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

AGING; ANIMAL EXPERIMENT; AORTA; ARTERIAL STIFFNESS; ARTICLE; BIOAVAILABILITY; BLOOD VESSEL; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MEDIATOR; MOUSE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; VASCULAR ENDOTHELIUM;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GTP-BINDING PROTEINS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; NIH 3T3 CELLS; NITRIC OXIDE; RATS; RATS, INBRED F344; TRANSGLUTAMINASES;

EID: 77954761224     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.215228     Document Type: Article

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