High-density lipoproteins from probucol-treated patients have increased capacity to promote cholesterol efflux from mouse peritoneal macrophages loaded with acetylated low-density lipoproteins

European Journal of Clinical Investigation

Volumn 27, Issue 4, 1997, Pages 285-292

  Ishigami, M ^a   Yamashita, S ^a   Sakai, N ^a   Hirano, K I ^a   Arai, T ^a   Maruyama, T ^a   Takami, S ^a   Koyama, M ^a   Kameda Takemura, K ^a   Matsuzawa, Y ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Atherosclerosis; Cholesteryl ester transfer protein; High density lipoprotein; Macrophage; Probucol; Reverse cholesterol transport

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PROBUCOL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; HYPERLIPIDEMIA; IN VITRO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 8244252283     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1997.1040657.x     Document Type: Article

References (39)

1. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. Am J Med 1977;62:707-14.
2. Glomset JA. The plasma lecithin: cholesterol acyltransferase reaction. J Lipid Res 1968;9:155-67.
3. Badimon JJ, Badimon L, Galves A, Dische R, Fuster V. High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits. Lab Invest 1989;60:455-61.
4. Badimon JJ, Badimon L, Fuster V. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest 1990;85:1234-41.
5. Ho YK, Brown MS, Goldstein JL. Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages. J Lipid Res 1980;21:391-8.
6. Stein O, Stein Y, Halperin G. Interaction between macrophages and mesenchymal cells. Effect of LDL- or HDL-containing media, added to cholesteryl ester-loaded macrophages, on cholesterol esterification in mesenchymal cells. Biochim Biophys Acta 1982;712:597-604.
7. Miller NE, La Ville A, Crook D. Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit. Nature 1985;314:109-11.
8. Baker SG, Joffe BI, Mendelsohn D, Seftel HC. Treatment of homozygous familial hypercholesterolemia with probucol. S Afr Med J 1982;62:7-11.
9. Yamamoto A, Matsuzawa Y, Kishino B, Hayashi R, Hirobe K, Kikkawa T. Effect of probucol on homozygous cases of familial hypercholesterolemia. Atherosclerosis 1983;48:157-66.
10. Harris RSJ, Gilmore HRI, Bricker LA, Kiem IM, Rubin E. Long-term oral administration of probucol [4, 4′- (isopropylidenedithio) bis (2, 6-di-t-butylphenol)] (DH-581) in the management of hypercholesterolemia. J Am Geriatr Soc 1974;22:167-75.
11. Carew TE, Schwenke GC, Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemia rabbit. Proc Natl Acad Sci USA 1987;84:7725-9.
12. 2 cholesterolemia with abnormal cholesteryl ester transfer. Am J Cardiol 1988;62:66B-72B.
13. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-53.
14. Basu SK, Goldstein JL, Anderson RGW, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA 1976;73:3178-82.
15. Nichols AV, Krauss RM, Musliner TA. Non-denaturing polyacrylamide gradient gel electrophoresis. Methods Enzymol 1986;128:417-31.
16. Goldstein JL, Ho YK, Brown MS, Innerarity TL, Mahley RW. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine β-very low density lipoproteins. J Biol Chem 1980;255:1839-48.
17. Hara A, Radin NS. Lipid extraction of tissue with a low-toxicity solvent. Anal Biochem 1978;90:420-6.
18. Heider JG, Boyett RL. The picomole determination of free and total cholesterol in cells in culture. J Lipid Res 1978;19:514-18.
19. Miyazaki A, Rahim ATMA, Ohta T, Morino Y, Horiuchi S. High density lipoprotein mediates selective reduction in cholesteryl esters from macrophage foam cells. Biochim Biophys Acta 1992;1126:73-80.
20. Lowry OH, Rosebrough JL, Farr AL, Randall RJ. Protein measurement with the folin-phenol reagent. J Biol Chem 1951;193:265-75.
21. Goldstein JL, Basu SK, Brown MS. Assays of LDL receptor activity. Methods Enzymol 1983;98:241-60.
22. Kato H, Nakanishi T, Arai H, Nishida HI, Nishida T. Purification, microheterogeneity, and stability of human lipid transfer protein. J Biol Chem 1989;264:4082-7.
23. Burstein M, Scholnick HR. Lipoprotein-polyanion-metal interactions. Adv Lipid Res 1973;11:67-108.
24. Goto Y, Akanuma Y, Harano Y et al. Determination by the SRID method of normal values of serum apolipoproteins (A-I, A-II, B, C-II, C-III, and E) in normolipidemic healthy Japanese subjects. J Clin Biochem Nutr 1986;1:73-88.
25. Franceschini G, Sirtori M, Vaccarino V, Gianfranceschini G, Rezzonico L, Chiesa G, Sirtori C. Mechanisms of HDL reduction after probucol: changes in HDL subfractions and increased cholesteryl ester transfer. Arteriosclerosis 1989;9:462-9.
26. Chiesa G, Michelagnoli S, Cassinotti M et al. Mechanism of high-density lipoprotein reduction after probucol treatment: changes in plasma cholesterol esterification/transfer and lipase activities. Metabolism 1993;42:229-35.
27. Suckling KE, Stange EF. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 1985;26:647-71.
28. Sirtori CR, Sirtori M, Calabresi L, Franceschini G. Changes in high density lipoprotein subfraction distribution and increased cholesteryl ester transfer after probucol. Am J Cardiol 1988;62:73B-76B.
29. McPherson R, Hogue M, Milne RW, Tall AR, Marcel YL. Increase in plasma cholesteryl ester transfer protein during probucol treatment. Arterioscler Thromb 1991;11:476-81.
30. Kita T, Nagano Y, Yokode M et al. Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci USA 1987;84:5928-31.
31. Ku G, Doherty NS, Schmidt LF, Jackson RL. Inhibition by probucol of interleukin-1 secretion and its implication in atherosclerosis. Am J Cardiol 1988;62:77B-81B.
32. Akeson AL, Woods CW, Mosher LB, Thomas CE, Jackson RL. Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol. Atherosclerosis 1991;86:261-70.
33. Brown MS, Goldstein JL. A receptor mediated pathway for cholesterol homeostasis. Science 1986;232:34-47.
34. Yamamoto A, Takaichi S, Hara H, Nishikawa O, Yokoyama S, Yamamura T, Yamaguchi T. Probucol prevents lipid storage in macrophages. Atherosclerosis 1988;62:209-17.
35. Zambon S, Brazg R, Aviram M, Oram JF, Bierman EL. The effect of probucol on HDL-mediated sterol translocation and efflux from cells. Atherosclerosis 1992;94:51-60.
36. Ishigami M, Yamashita S, Sakai N et al. Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins. J Biochem 1994;116:257-62.
37. Castro GR, Fielding CJ. Early incorporation of cell-derived cholesterol into pre-β-migrating high-density lipoprotein. Biochemistry 1988;27:25-9.
38. Yamashita S, Ishigami M, Arai T et al. Very high density lipoproteins induced by plasma cholesteryl ester transfer protein (CETP) have a potent antiatherogenic function. Ann NY Acad Sci 1995;748:606-8.
39. Leblond L, Marcel YL. The amphipathic α-helical repeats of apolipoprotein A-I are responsible for binding of high density lipoproteins to HepG2 cells. J Biol Chem 1990;266:6058-67.