메뉴 건너뛰기




Volumn 8, Issue , 2013, Pages 4015-4031

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: A comparative study between three dimensional and two dimensional macroporous silica

Author keywords

3D ordered macroporous silica; In vitro cytotoxicity; In vitro dissolution; Mesoporous silica; Poorly soluble drugs; Stability test

Indexed keywords

INDOMETACIN; MCM 41; SBA 15; SILICON DIOXIDE; UNCLASSIFIED DRUG;

EID: 84886037623     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S52605     Document Type: Article
Times cited : (99)

References (56)
  • 1
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2001;46(1-3): 3-26.
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 2
    • 34547864243 scopus 로고    scopus 로고
    • Drug delivery strategies for poorly water-soluble drugs
    • Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv. 2007;4(4):403-416.
    • (2007) Expert Opin Drug Deliv , vol.4 , Issue.4 , pp. 403-416
    • Fahr, A.1    Liu, X.2
  • 3
    • 34548031413 scopus 로고    scopus 로고
    • Drug solubility: How to measure it, how to improve it
    • Dressman J, Christos R. Drug solubility: how to measure it, how to improve it. Adv Drug Del Rev. 2007;59(7):531-532.
    • (2007) Adv Drug Del Rev , vol.59 , Issue.7 , pp. 531-532
    • Dressman, J.1    Christos, R.2
  • 4
    • 0037312695 scopus 로고    scopus 로고
    • Nanosizing: A formulation approach for poorly-water-soluble compounds
    • Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci. 2003;18(2):113-120.
    • (2003) Eur J Pharm Sci , vol.18 , Issue.2 , pp. 113-120
    • Merisko-Liversidge, E.1    Liversidge, G.G.2    Cooper, E.R.3
  • 5
    • 0035937599 scopus 로고    scopus 로고
    • Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future
    • Müller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Adv Drug Deliv Rev. 2001;47(1):3-19.
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.1 , pp. 3-19
    • Müller, R.H.1    Jacobs, C.2    Kayser, O.3
  • 6
    • 34548049221 scopus 로고    scopus 로고
    • Oral lipid-based formulations
    • Hauss DJ. Oral lipid-based formulations. Adv Drug Deliv Rev. 2007;59(7):667-676.
    • (2007) Adv Drug Deliv Rev , vol.59 , Issue.7 , pp. 667-676
    • Hauss, D.J.1
  • 7
    • 39149116670 scopus 로고    scopus 로고
    • Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration
    • Cole ET, Cadé D, Benameur H. Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration. Adv Drug Deliv Rev. 2008;60(6):747-756.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.6 , pp. 747-756
    • Cole, E.T.1    Cadé, D.2    Benameur, H.3
  • 8
    • 0034601240 scopus 로고    scopus 로고
    • Improving drug solubility for oral delivery using solid dispersions
    • Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm. 2000;50(1):47-60.
    • (2000) Eur J Pharm Biopharm , vol.50 , Issue.1 , pp. 47-60
    • Leuner, C.1    Dressman, J.2
  • 9
    • 36549042006 scopus 로고    scopus 로고
    • Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
    • Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007;12(23-24):1068-1075.
    • (2007) Drug Discov Today , vol.12 , Issue.23-24 , pp. 1068-1075
    • Vasconcelos, T.1    Sarmento, B.2    Costa, P.3
  • 10
    • 29244438801 scopus 로고    scopus 로고
    • Adsorption of meloxicam on porous calcium silicate: Characterization and tablet formulation
    • Sharma S, Sher P, Badve S, Pawar AP. Adsorption of meloxicam on porous calcium silicate: characterization and tablet formulation. AAPS PharmSciTech. 2005;6(4):E618-E625.
    • (2005) AAPS PharmSciTech , vol.6 , Issue.4
    • Sharma, S.1    Sher, P.2    Badve, S.3    Pawar, A.P.4
  • 11
    • 31344476101 scopus 로고    scopus 로고
    • Dissolution rate improvement of poorly water-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriers
    • Friedrich H, Fussnegger B, Kolter K, Bodmeier R. Dissolution rate improvement of poorly water-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriers. Eur J Pharm Biopharm. 2006;62(2):171-177.
    • (2006) Eur J Pharm Biopharm , vol.62 , Issue.2 , pp. 171-177
    • Friedrich, H.1    Fussnegger, B.2    Kolter, K.3    Bodmeier, R.4
  • 12
    • 47049131872 scopus 로고    scopus 로고
    • Dissolution-rate enhancement of fenofibrate by adsorption onto silica using supercritical carbon dioxide
    • Sanganwar GP, Gupta RB. Dissolution-rate enhancement of fenofibrate by adsorption onto silica using supercritical carbon dioxide. Int J Pharm. 2008;360(1-2):213-218.
    • (2008) Int J Pharm , vol.360 , Issue.1-2 , pp. 213-218
    • Sanganwar, G.P.1    Gupta, R.B.2
  • 13
    • 0036173224 scopus 로고    scopus 로고
    • Improvement of solubility and oral bioavailability of a poorly water-soluble drug, TAS-301, by its melt-adsorption on a porous calcium silicate
    • Kinoshita M, Baba K, Nagayasu A, et al. Improvement of solubility and oral bioavailability of a poorly water-soluble drug, TAS-301, by its melt-adsorption on a porous calcium silicate. J Pharm Sci. 2002;91(2): 362-370.
    • (2002) J Pharm Sci , vol.91 , Issue.2 , pp. 362-370
    • Kinoshita, M.1    Baba, K.2    Nagayasu, A.3
  • 14
    • 0141939433 scopus 로고    scopus 로고
    • Adsorption of drugs on silica aerogels
    • Smirnova I, Mamic J, Arlt W. Adsorption of drugs on silica aerogels. Langmuir. 2003;19(20):8521-8525.
    • (2003) Langmuir , vol.19 , Issue.20 , pp. 8521-8525
    • Smirnova, I.1    Mamic, J.2    Arlt, W.3
  • 15
    • 59049088106 scopus 로고    scopus 로고
    • Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs
    • Tan A, Simovic S, Davey AK, Rades T, Prestidge CA. Silica-lipid hybrid (SLH) microcapsules: a novel oral delivery system for poorly soluble drugs. J Control Release. 2009;134(1):62-70.
    • (2009) J Control Release , vol.134 , Issue.1 , pp. 62-70
    • Tan, A.1    Simovic, S.2    Davey, A.K.3    Rades, T.4    Prestidge, C.A.5
  • 16
    • 33749431861 scopus 로고    scopus 로고
    • Amorphization of Indomethacin by Co-Grinding with Neusilin US2: Amorphization kinetics, physical stability and mechanism
    • Bahl D, Bogner RH. Amorphization of Indomethacin by Co-Grinding with Neusilin US2: amorphization kinetics, physical stability and mechanism. Pharm Res. 2006;23(10):2317-2325.
    • (2006) Pharm Res , vol.23 , Issue.10 , pp. 2317-2325
    • Bahl, D.1    Bogner, R.H.2
  • 17
    • 8744298235 scopus 로고    scopus 로고
    • Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels
    • Smirnova I, Suttiruengwong S, Seiler M, Arlt W. Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels. Pharm Dev Technol. 2004;9(4):443-452.
    • (2004) Pharm Dev Technol , vol.9 , Issue.4 , pp. 443-452
    • Smirnova, I.1    Suttiruengwong, S.2    Seiler, M.3    Arlt, W.4
  • 19
    • 46749123819 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    • Slowing II, Vivero-Escoto JL, Wu CW, Lin VS. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev. 2008;60(11):1278-1288.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.11 , pp. 1278-1288
    • Slowing, I.I.1    Vivero-Escoto, J.L.2    Wu, C.W.3    Lin, V.S.4
  • 20
    • 69749084951 scopus 로고    scopus 로고
    • Recent advances in ceramic implants as drug delivery systems for biomedical applications
    • Colilla M, Manzano M, Vallet-Regí M. Recent advances in ceramic implants as drug delivery systems for biomedical applications. Int J Nanomedicine. 2008;3(4):403-414.
    • (2008) Int J Nanomedicine , vol.3 , Issue.4 , pp. 403-414
    • Colilla, M.1    Manzano, M.2    Vallet-Regí, M.3
  • 21
    • 0026931265 scopus 로고
    • Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
    • Kresge C, Leonowicz M, Roth W, Vartuli J, Beck J. Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature. 1992;359(6397):710-712.
    • (1992) Nature , vol.359 , Issue.6397 , pp. 710-712
    • Kresge, C.1    Leonowicz, M.2    Roth, W.3    Vartuli, J.4    Beck, J.5
  • 22
    • 84863065869 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
    • Chen B, Wang Z, Quan G, et al. In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation. Int J Nanomedicine. 2012;7:199-209.
    • (2012) Int J Nanomedicine , vol.7 , pp. 199-209
    • Chen, B.1    Wang, Z.2    Quan, G.3
  • 24
    • 33846566855 scopus 로고    scopus 로고
    • Mesoporous silica material TUD-1 as a drug delivery system
    • Heikkilä T, Salonen J, Tuura J, et al. Mesoporous silica material TUD-1 as a drug delivery system. Int J Pharm. 2007;331(1):133-138.
    • (2007) Int J Pharm , vol.331 , Issue.1 , pp. 133-138
    • Heikkilä, T.1    Salonen, J.2    Tuura, J.3
  • 26
    • 0032563228 scopus 로고    scopus 로고
    • Synthesis of macroporous minerals with highly ordered three-dimensional arrays of spheroidal voids
    • Holland BT, Blanford CF, Stein A. Synthesis of macroporous minerals with highly ordered three-dimensional arrays of spheroidal voids. Science. 1998;281(5376):538-540.
    • (1998) Science , vol.281 , Issue.5376 , pp. 538-540
    • Holland, B.T.1    Blanford, C.F.2    Stein, A.3
  • 27
    • 2942733243 scopus 로고    scopus 로고
    • Structural and electrochemical properties of three-dimensionally ordered macroporous tin(IV) oxide films
    • Lytle JC, Yan H, Ergang NS, Smyrl WH, Stein A. Structural and electrochemical properties of three-dimensionally ordered macroporous tin(IV) oxide films. J Mater Chem. 2004;14:1616-1622.
    • (2004) J Mater Chem , vol.14 , pp. 1616-1622
    • Lytle, J.C.1    Yan, H.2    Ergang, N.S.3    Smyrl, W.H.4    Stein, A.5
  • 28
    • 17144397132 scopus 로고    scopus 로고
    • Synthesis and rate performance of monolithic macroporous carbon electrodes for lithium-ion secondary batteries
    • Lee K, Lytle J, Ergang N, Oh S, Stein A. Synthesis and rate performance of monolithic macroporous carbon electrodes for lithium-ion secondary batteries. Adv Funct Mater. 2005;15(4):547-556.
    • (2005) Adv Funct Mater , vol.15 , Issue.4 , pp. 547-556
    • Lee, K.1    Lytle, J.2    Ergang, N.3    Oh, S.4    Stein, A.5
  • 29
    • 0033824609 scopus 로고    scopus 로고
    • Colloidal crystals as templates for porous materials
    • Velev OD, Lenhoff AM. Colloidal crystals as templates for porous materials. Curr Opin Colloid In. 2000;5(1-2):56-63.
    • (2000) Curr Opin Colloid In , vol.5 , Issue.1-2 , pp. 56-63
    • Velev, O.D.1    Lenhoff, A.M.2
  • 30
    • 0035556846 scopus 로고    scopus 로고
    • Colloidal crystal templating of three-dimensionally ordered macroporous solids: Materials for photonics and beyond
    • Stein A, Schroden RC. Colloidal crystal templating of three-dimensionally ordered macroporous solids: materials for photonics and beyond. Curr Opin Solid St Mater Sci. 2001;5(6):553-564.
    • (2001) Curr Opin Solid St Mater Sci , vol.5 , Issue.6 , pp. 553-564
    • Stein, A.1    Schroden, R.C.2
  • 31
    • 0035997888 scopus 로고    scopus 로고
    • Disordered drug delivery: Destiny, dynamics and the Deborah number
    • Hancock BC. Disordered drug delivery: destiny, dynamics and the Deborah number. J Pharm Pharmacol. 2002;54(6):737-746.
    • (2002) J Pharm Pharmacol , vol.54 , Issue.6 , pp. 737-746
    • Hancock, B.C.1
  • 32
    • 0028597539 scopus 로고
    • Crystallization of indomethacin from the amorphous state below and above its glass transition temperature
    • Yoshioka M, Hancock BC, Zografi G. Crystallization of indomethacin from the amorphous state below and above its glass transition temperature. J Pharm Sci. 1994;83(12):1700-1705.
    • (1994) J Pharm Sci , vol.83 , Issue.12 , pp. 1700-1705
    • Yoshioka, M.1    Hancock, B.C.2    Zografi, G.3
  • 33
    • 24644524165 scopus 로고    scopus 로고
    • Disorder and dissolution enhancement: Deposition of ibuprofen on to insoluble polymers
    • Williams AC, Timmins P, Lu M, Forbes RT. Disorder and dissolution enhancement: deposition of ibuprofen on to insoluble polymers. Eur J Pharm Sci. 2005;26(3-4):288-294.
    • (2005) Eur J Pharm Sci , vol.26 , Issue.3-4 , pp. 288-294
    • Williams, A.C.1    Timmins, P.2    Lu, M.3    Forbes, R.T.4
  • 34
    • 84863350595 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles: Synthesis, biocompatibility and drug delivery
    • Tang F, Li L, Chen D. Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery. Adv Mater Weinheim. 2012;24(12): 1504-1534.
    • (2012) Adv Mater Weinheim , vol.24 , Issue.12 , pp. 1504-1534
    • Tang, F.1    Li, L.2    Chen, D.3
  • 35
    • 84872674627 scopus 로고    scopus 로고
    • The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes
    • Fu C, Liu T, Li L, Liu H, Chen D, Tang F. The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes. Biomaterials. 2013;34(10):2565-2575.
    • (2013) Biomaterials , vol.34 , Issue.10 , pp. 2565-2575
    • Fu, C.1    Liu, T.2    Li, L.3    Liu, H.4    Chen, D.5    Tang, F.6
  • 36
    • 84858671501 scopus 로고    scopus 로고
    • Influence of silica nanoparticles on dilational rheology of DPPC-palmitic acid Langmuir monolayers
    • Guzmán E, Liggieri L, Santini E, et al. Influence of silica nanoparticles on dilational rheology of DPPC-palmitic acid Langmuir monolayers. Soft Matter. 2012;8:3938-3948.
    • (2012) Soft Matter , vol.8 , pp. 3938-3948
    • Guzmán, E.1    Liggieri, L.2    Santini, E.3
  • 37
    • 77649191565 scopus 로고    scopus 로고
    • Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells
    • Heikkilä T, Santos HA, Kumar N, et al. Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells. Eur J Pharm Biopharm. 2010;74(3):483-494.
    • (2010) Eur J Pharm Biopharm , vol.74 , Issue.3 , pp. 483-494
    • Heikkilä, T.1    Santos, H.A.2    Kumar, N.3
  • 38
    • 44649100271 scopus 로고    scopus 로고
    • Cytotoxicity of mesoporous silica nanomaterials
    • Di Pasqua AJ, Sharma KK, Shi YL, et al. Cytotoxicity of mesoporous silica nanomaterials. J Inorg Biochem. 2008;102(7):1416-1423.
    • (2008) J Inorg Biochem , vol.102 , Issue.7 , pp. 1416-1423
    • Di Pasqua, A.J.1    Sharma, K.K.2    Shi, Y.L.3
  • 39
    • 80053578495 scopus 로고    scopus 로고
    • The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis
    • Lee S, Yun HS, Kim SH. The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis. Biomaterials. 2011;32(35):9434-9443.
    • (2011) Biomaterials , vol.32 , Issue.35 , pp. 9434-9443
    • Lee, S.1    Yun, H.S.2    Kim, S.H.3
  • 40
    • 76249133449 scopus 로고    scopus 로고
    • Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs
    • Wang F, Hui H, Barnes TJ, Barnett C, Prestidge CA. Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs. Mol Pharm. 2010;7(1):227-236.
    • (2010) Mol Pharm , vol.7 , Issue.1 , pp. 227-236
    • Wang, F.1    Hui, H.2    Barnes, T.J.3    Barnett, C.4    Prestidge, C.A.5
  • 41
    • 80052103864 scopus 로고    scopus 로고
    • Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug
    • Hu Y, Wang J, Zhi Z, Jiang T, Wang S. Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug. J Colloid Interface Sci. 2011;363(1):410-417.
    • (2011) J Colloid Interface Sci , vol.363 , Issue.1 , pp. 410-417
    • Hu, Y.1    Wang, J.2    Zhi, Z.3    Jiang, T.4    Wang, S.5
  • 42
    • 0033225286 scopus 로고    scopus 로고
    • The preparation of highly ordered MCM-41 with extremely low surfactant concentration
    • Cai Q, Lin WY, Xiao FS, Pang WQ, Chen XH, Zou BS. The preparation of highly ordered MCM-41 with extremely low surfactant concentration. Micropor Mesopor Mater. 1999;32(1-2):1-15.
    • (1999) Micropor Mesopor Mater , vol.32 , Issue.1-2 , pp. 1-15
    • Cai, Q.1    Lin, W.Y.2    Xiao, F.S.3    Pang, W.Q.4    Chen, X.H.5    Zou, B.S.6
  • 43
    • 0032559316 scopus 로고    scopus 로고
    • Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores
    • Zhao D, Feng J, Huo Q, et al. Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores. Science. 1998;279(5350):548-552.
    • (1998) Science , vol.279 , Issue.5350 , pp. 548-552
    • Zhao, D.1    Feng, J.2    Huo, Q.3
  • 44
    • 67651159268 scopus 로고    scopus 로고
    • Creation of three-dimensionally ordered macroporous Au/CeO2 catalysts with controlled pore sizes and their enhanced catalytic performance for formaldehyde oxidation
    • Zhang J, Jin Y, Li C, et al. Creation of three-dimensionally ordered macroporous Au/CeO2 catalysts with controlled pore sizes and their enhanced catalytic performance for formaldehyde oxidation. Appl Catal B: Environmental. 2009;91(1-2):11-20.
    • (2009) Appl Catal B: Environmental , vol.91 , Issue.1-2 , pp. 11-20
    • Zhang, J.1    Jin, Y.2    Li, C.3
  • 45
    • 80054001572 scopus 로고    scopus 로고
    • Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy
    • Hu Y, Zhi Z, Wang T, Jiang T, Wang S. Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy. Eur J Pharm Biopharm. 2011;79(3): 544-551.
    • (2011) Eur J Pharm Biopharm , vol.79 , Issue.3 , pp. 544-551
    • Hu, Y.1    Zhi, Z.2    Wang, T.3    Jiang, T.4    Wang, S.5
  • 46
    • 0035990530 scopus 로고    scopus 로고
    • Enhancement of dissolution rate and anti-inflammatory effects of piroxicam using solvent deposition technique
    • Barzegar-Jalali M, Maleki N, Garjani A, et al. Enhancement of dissolution rate and anti-inflammatory effects of piroxicam using solvent deposition technique. Drug Dev Ind Pharm. 2002;28(6):681-686.
    • (2002) Drug Dev Ind Pharm , vol.28 , Issue.6 , pp. 681-686
    • Barzegar-Jalali, M.1    Maleki, N.2    Garjani, A.3
  • 47
    • 80052923691 scopus 로고    scopus 로고
    • 3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol
    • Hu Y, Zhi Z, Zhao Q, et al. 3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol. Micropor Mesopor Mater. 2012;147(1):94-101.
    • (2012) Micropor Mesopor Mater , vol.147 , Issue.1 , pp. 94-101
    • Hu, Y.1    Zhi, Z.2    Zhao, Q.3
  • 48
    • 84939775172 scopus 로고
    • Reporting physisorption data for gas/solid systems - with special reference to the determination of surface area and porosity
    • Sing K, Everett D, Haul R, et al. Reporting physisorption data for gas/solid systems - with special reference to the determination of surface area and porosity. Pure Appl Chem. 1985;57(4):603-619.
    • (1985) Pure Appl Chem , vol.57 , Issue.4 , pp. 603-619
    • Sing, K.1    Everett, D.2    Haul, R.3
  • 49
    • 41549142680 scopus 로고    scopus 로고
    • Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica
    • Mellaerts R, Mols R, Jammaer JA, et al. Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica. Eur J Pharm Biopharm. 2008;69(1): 223-230.
    • (2008) Eur J Pharm Biopharm , vol.69 , Issue.1 , pp. 223-230
    • Mellaerts, R.1    Mols, R.2    Jammaer, J.A.3
  • 50
    • 77952884208 scopus 로고    scopus 로고
    • The development of a dense gas solvent exchange process for the impregnation of pharmaceuticals into porous chitosan
    • Ji C, Barrett A, Poole-Warren LA, Foster NR, Dehghani F. The development of a dense gas solvent exchange process for the impregnation of pharmaceuticals into porous chitosan. Int J Pharm. 2010;391(1-2): 187-196.
    • (2010) Int J Pharm , vol.391 , Issue.1-2 , pp. 187-196
    • Ji, C.1    Barrett, A.2    Poole-Warren, L.A.3    Foster, N.R.4    Dehghani, F.5
  • 51
    • 34247529516 scopus 로고    scopus 로고
    • Investigation of drug-porous adsorbent interactions in drug mixtures with selected porous adsorbents
    • Madieh S, Simone M, Wilson W, Mehra D, Augsburger L. Investigation of drug-porous adsorbent interactions in drug mixtures with selected porous adsorbents. J Pharm Sci. 2007;96(4):851-863.
    • (2007) J Pharm Sci , vol.96 , Issue.4 , pp. 851-863
    • Madieh, S.1    Simone, M.2    Wilson, W.3    Mehra, D.4    Augsburger, L.5
  • 52
    • 34548023425 scopus 로고    scopus 로고
    • Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
    • Blagden N, de Matas M, Gavan PT, York P. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev. 2007;59(7):617-630.
    • (2007) Adv Drug Deliv Rev , vol.59 , Issue.7 , pp. 617-630
    • Blagden, N.1    de Matas, M.2    Gavan, P.T.3    York, P.4
  • 53
    • 1142303337 scopus 로고    scopus 로고
    • What is the true solubility advantage for amorphous pharmaceuticals?
    • Hancock BC, Parks M. What is the true solubility advantage for amorphous pharmaceuticals? Pharm Res. 2000;17(4):397-404.
    • (2000) Pharm Res , vol.17 , Issue.4 , pp. 397-404
    • Hancock, B.C.1    Parks, M.2
  • 54
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1-2):55-63.
    • (1983) J Immunol Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 55
    • 84860388978 scopus 로고    scopus 로고
    • Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells
    • Li Y, Sun L, Jin M, et al. Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells. Toxicol In Vitro. 2011;25(7):1343-1352.
    • (2011) Toxicol In Vitro , vol.25 , Issue.7 , pp. 1343-1352
    • Li, Y.1    Sun, L.2    Jin, M.3
  • 56
    • 44649100271 scopus 로고    scopus 로고
    • Cytotoxicity of mesoporous silica nanomaterials
    • Di Pasqua AJ, Sharma KK, Shi YL, et al. Cytotoxicity of mesoporous silica nanomaterials. J Inorg Biochem. 2008;102(7):1416-1423.
    • (2008) J Inorg Biochem , vol.102 , Issue.7 , pp. 1416-1423
    • Di Pasqua, A.J.1    Sharma, K.K.2    Shi, Y.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.