Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 79, Issue 3, 2011, Pages 544-551

  Hu, Yanchen ^a   Zhi, Zhuangzhi ^a   Wang, Tianyi ^a   Jiang, Tongying ^a   Wang, Siling ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

3 D ordered macroporous silica; Drug nanoparticles; Gastric damage; In vitro dissolution

Indexed keywords

INDOMETACIN; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG CAPSULE; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; HYDROPHILICITY; NONHUMAN; PARTICLE SIZE; RAT; STOMACH INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; GASTRIC MUCOSA; INDOMETHACIN; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; PEPTIC ULCER HEMORRHAGE; POROSITY; RATS; SILICON DIOXIDE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STOMACH ULCER; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 80054001572     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.07.001     Document Type: Article

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