Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 74, Issue 3, 2010, Pages 483-494

  Heikkilä, Teemu ^a,c   Santos, Hélder A ^b   Kumar, Narendra ^c   Murzin, Dmitry Yu ^c   Salonen, Jarno ^a   Laaksonen, Timo ^b   Peltonen, Leena ^b   Hirvonen, Jouni ^b   Lehto, Vesa Pekka ^a,d  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Biocompatibility; Caco 2; Cell viability; Cytotoxicity; Mesoporous silica; Microparticle; Oral drug delivery

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; HYDROGEN PEROXIDE; MCM 41; PROTEINASE; REACTIVE OXYGEN METABOLITE; SBA 15; SILICON DIOXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL METABOLISM; CELL STRAIN CACO 2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INCUBATION TIME; METABOLIC ACTIVATION; X RAY DIFFRACTION;

CACO-2 CELLS; CASPASE 3; CASPASE 7; CELL SURVIVAL; DRUG CARRIERS; FLOW CYTOMETRY; HUMANS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POROSITY; REACTIVE OXYGEN SPECIES; SILICON DIOXIDE; SURFACE PROPERTIES;

EID: 77649191565     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.12.006     Document Type: Article

References (50)

1. Beck J.S., Vartuli J.C., Roth W.J., Leonowicz M.E., Kresge C.T., Schmitt K.D., Chu C.T.W., Olson D.H., Sheppard E.W., McCullen S.B., Higgins J.B., and Schlenker J.L. A new family of mesoporous molecular-sieves prepared with liquid-crystal templates. J. Am. Chem. Soc. 114 (1992) 10834-10843
2. Kresge C.T., Leonowicz M.E., Roth W.J., Vartuli J.C., and Beck J.S. Ordered mesoporous molecular-sieves synthesized by a liquid-crystal template mechanism. Nature 359 (1992) 710-712
3. Zhao D.Y., Huo Q.S., Feng J.L., Chmelka B.F., and Stucky G.D. Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures. J. Am. Chem. Soc. 120 (1998) 6024-6036
4. Zhao D.Y., Feng J.L., Huo Q.S., Melosh N., Fredrickson G.H., Chmelka B.F., and Stucky G.D. Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores. Science 279 (1998) 548-552
5. Horcajada P., Ramila A., Perez-Pariente J., and Vallet-Regi M. Influence of pore size of MCM-41 matrices on drug delivery rate. Micropor. Mesopor. Mater. 68 (2004) 105-109
6. Nunes C.D., Vaz P.D., Fernandes A.C., Ferreira P., Romao C.C., and Calhorda M.J. Loading and delivery of sertraline using inorganic micro and mesoporous materials. Eur. J. Pharm. Biopharm. 66 (2007) 357-365
7. Vallet-Regi M., Ramila A., del Real R.P., and Perez-Pariente J. A new property of MCM-41: drug delivery system. Chem. Mater. 13 (2001) 308-311
8. Han Y.J., Stucky G.D., and Butler A. Mesoporous silicate sequestration and release of proteins. J. Am. Chem. Soc. 121 (1999) 9897-9898
9. Song S.W., Hidajat K., and Kawi S. Functionalized SBA-15 materials as carriers for controlled drug delivery: influence of surface properties on matrix-drug interactions. Langmuir 21 (2005) 9568-9575
10. Vallet-Regi M. Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering. Chem. Eur. J. 12 (2006) 5934-5943
11. Fubini B., and Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic. Bio. Med. 34 (2003) 1507-1516
12. Warshawsky D., Reilman R., Cheu J., Radike M., and Rice C. Influence of particle dose on the cytotoxicity of hamster and rat pulmonary alveolar macrophage in-vitro. J. Toxicol. Environ. Health A 42 (1994) 407-421
13. Zhong B.Z., Whong W.Z., and Ong T.M. Detection of mineral-dust-induced DNA damage in two mammalian cell lines using the alkaline single cell gel/comet assay. Mutat. Res-Genet. Toxicol. Environ. 393 (1997) 181-187
14. Brown S.C., Kamal M., Nasreen N., Baumuratov A., Sharma P., Antony V.B., and Moudgil B.M. Influence of shape, adhesion and simulated lung mechanics on amorphous silica nanoparticle toxicity. Adv. Powder Technol. 18 (2007) 69-79
15. Mollo L., Levresse V., Ottaviani M.F., ElloukAchard S., Jaurand M.C., and Fubini B. Study of the stability of a paramagnetic label linked to mesoporous silica surface in contact with rat mesothelial cells in culture. Environ. Health Persp. 105 (1997) 1031-1036
16. Waters K.M., Masiello L.M., Zangar R.C., Karin N.J., Quesenberry R.D., Bandyopadhyay S., Teeguarden J.G., Pounds J.G., and Thrall B.D. Macrophage responses to silica nanoparticles are highly conserved across particle sizes. Toxicol. Sci. 107 (2009) 553-569
17. Nel A., Xia T., Madler L., and Li N. Toxic potential of materials at the nanolevel. Science 311 (2006) 622-627
18. Hamilton R.F., Thakur S.A., and Holian A. Silica binding and toxicity in alveolar macrophages. Free Radic. Bio. Med. 44 (2008) 1246-1258
19. Elias Z., Poirot O., Daniere M.C., Terzetti F., Marande A.M., Dzwigaj S., Pezerat H., Fenoglio I., and Fubini B. Fg, Cytotoxic and transforming effects of silica particles with different surface properties in Syrian hamster embryo (SHE) cells. Toxicol. in Vitro 14 (2000) 409-422
20. Elias Z., Poirot O., Fenoglio I., Ghiazza M., Daniere M.C., Terzetti F., Darne C., Coulais C., Matekovits I., and Fubini B. Surface reactivity, cytotoxic, and morphological transforming effects of diatomaceous earth products in Syrian hamster embryo cells. Toxicol. Sci. 91 (2006) 510-520
21. Huang D.M., Hung Y., Ko B.S., Hsu S.C., Chen W.H., Chien C.L., Tsai C.P., Kuo C.T., Kang J.C., Yang C.S., Mou C.Y., and Chen Y.C. Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking. FASEB 19 (2005) 2014-2016
22. Chung T.H., Wu S.H., Yao M., Lu C.W., Lin Y.S., Hung Y., Mou C.Y., Chen Y.C., and Huang D.M. The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3-L1 cells and human mesenchymal stem cells. Biomaterials 28 (2007) 2959-2966
23. Lai C.Y., Trewyn B.G., Jeftinija D.M., Jeftinija K., Xu S., Jeftinija S., and Lin V.S.Y. A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J. Am. Chem. Soc. 125 (2003) 4451-4459
24. Lu J., Liong M., Zink J.I., and Tamanoi F. Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 3 (2007) 1341-1346
25. Slowing I., Trewyn B.G., and Lin V.S.Y. Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells. J. Am. Chem. Soc. 128 (2006) 14792-14793
26. Lin Y.S., Tsai C.P., Huang H.Y., Kuo C.T., Hung Y., Huang D.M., Chen Y.C., and Mou C.Y. Well-ordered mesoporous silica nanoparticles as cell markers. Chem. Mater. 17 (2005) 4570-4573
27. Hudson S.P., Padera R.F., Langer R., and Kohane D.S. The biocompatibility of mesoporous silicates. Biomaterials 29 (2008) 4045-4055
28. Heikkila T., Salonen J., Tuura J., Kumar N., Salmi T., Murzin D.Y., Hamdy M.S., Mul G., Laitinen L., Kaukonen A.M., Hirvonen J., and Lehto V.P. Evaluation of mesoporous TCPSi, MCM-41, SBA-15 and TUD-1 materials as API carriers for oral drug delivery. Drug Deliv. 14 (2007) 337-347
29. Heikkila T., Salonen J., Tuura J., Hamdy M.S., Mul G., Kumar N., Salmi T., Murzin D.Y., Laitinen L., Kaukonen A.M., Hirvonen J., and Lehto V.P. Mesoporous silica material TUD-1 as a drug delivery system. Int. J. Pharm. 331 (2007) 133-138
30. Mellaerts R., Aerts C.A., Van Humbeeck J., Augustijns P., Van den Mooter G., and Martens J.A. Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials. Chem. Commun. 13 (2007) 1375-1377
31. Charnay C., Begu S., Tourne-Peteilh C., Nicole L., Lerner D.A., and Devoisselle J.M. Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property. Eur. J. Pharm. Biopharm. 57 (2004) 533-540
32. Ambrogi V., Perioli L., Marmottini F., Giovagnoli S., Esposito M., and Rossi C. Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate. Eur. J. Pharm. Sci. 32 (2007) 216-222
33. Mellaerts R., Mols R., Jammaer J.A.G., Aerts C.A., Annaert P., Van Humbeeck J., Van den Mooter G., Augustijns P., and Martens J.A. Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica. Eur. J. Pharm. Biopharm. 69 (2008) 223-230
34. Pasqua A.J., Sharma K.K., Shi Y.-L., Bonnie B.T., Oullette W., Dabrowiak J.C., and Asefa T. Cytotoxicity of mesoporous silica nanoparticles. J. Inorg. Biochem. 102 (2008) 1416-1423
35. Bernas A., Laukkanen P., Kumar N., Maki-Arvela P., Vayrynen J., Laine E., Holmbom B., Salmi T., and Murzin D.Y. A new heterogeneously catalytic pathway for isomerization of linoleic acid over Ru/C and Ni/H-MCM-41 catalysts. J. Catal. 210 (2002) 354-366
36. 2. J. Mol. Catal. A-Chem. 170 (2001) 195-202
37. Tinke A.P., Carnicer A., Govoreanu R., Scheltjens G., Lauwerysen L., Mertens N., Vanhoutte K., and Brewster M.E. Particle shape and orientation in laser diffraction and static image analysis size distribution analysis of micrometer sized rectangular particles. Powder Technol. 186 (2008) 154-167
38. Puerto M., Pichardo S., Jos A., and Camean A.M. Comparison of the toxicity induced by microcystin-RR and microcystin-YR in differentiated and undifferentiated Caco-2 cells. Toxicon 54 (2009) 161-169
39. Wahl B., Daum N., Ohrem H.-L., and Lehr C.-M. Novel luminescence assay offers new possibilities for the risk assessment of silica nanoparticles. Nanotoxicology 4 (2008) 243-251
40. Noda T., Iwakiri R., Fujimoto K., and Aw T.Y. Induction of mild intracellular redox imbalance inhibits proliferation of Caco-2 cells. FASEB J. 15 (2001) 2131-2139
41. Zegura B., Volcic M., Lah T.T., and Filipic M. Different sensitivities of human colon adenocarcinoma (Caco-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage. Toxicon 52 (2008) 518-525
42. Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 417 (2009) 1-13
43. Turrens J.F. Mitochondrial formation of reactive oxygen species. J. Physiol.-London 552 (2003) 335-344
44. Gebhardt B.R., Ries J., Caspary W.F., Boehles H., and Stein J. Superoxide: a major factor for stress protein induction in reoxygenation injury in the intestinal cell line Caco-2. Digestion 60 (1999) 238-245
45. Elisia I., and Kitts D.D. Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells. Mol. Cell. Biochem. 312 (2008) 139-145
46. Vallhov H., Gabrielsson S., Stromme M., Scheynius A., and Garcia-Bennett A.E. Mesoporous silica particles induce size dependent effects on human dendritic cells. Nano Lett. 7 (2007) 3576-3582
47. Desai M.P., Labhasetwar V., Walter E., Levy R.J., and Amidon G.L. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res. 14 (1997) 1568-1573
48. Fenoglio I., Croce A., Di Renzo F., Tiozzo R., and Fubini B. Pure-silica zeolites (porosils) as model solids for the evaluation of the physicochemical features determining silica toxicity to macrophages. Chem. Res. Toxicol. 13 (2000) 489-500
49. Yu L.X., Crison J.R., and Amidon G.L. Compartmental transit and dispersion model analysis of small intestinal transit flow in humans. Int. J. Pharm. 140 (1996) 111-118
50. Schiller C., Frohlich C.P., Giessmann T., Siegmund W., Monnikes H., Hosten N., and Weitschies W. Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging. Aliment. Pharmcol. Ther. 22 (2005) 971-979