Determination of ghrelin structure in the barfin flounder (Verasper moseri) and involvement of ingested fatty acids in ghrelin acylation

Frontiers in Endocrinology

Volumn 4, Issue SEP, 2013, Pages

  Kaiya, Hiroyuki ^a   Andoh, Tadashi ^b   Ichikawa, Takashi ^c   Amiya, Noriko ^d   Matsuda, Kouhei ^e   Kangawa, Kenji ^a   Miyazato, Mikiya ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b FISHERIES RESEARCH AGENCY   (Japan)

^c FISHERIES RESEARCH AGENCY   (Japan)

^d KITASATO UNIVERSITY   (Japan)

^e UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Acyl modification; Barfin flounder; CDNA cloning; Fatty acid; Feed; Ghrelin; Ingestion

Indexed keywords

EID: 84886001555     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00117     Document Type: Article

References (30)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matuso H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide. Nature (1999) 402:656-60. doi:10.1038/45230.
2. Kaiya H, Kojima M, Hosoda H, Koda A, Yamamoto K, Kitajima Y, et al. Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Biol Chem (2001) 276:40441-8. doi:10.1074/jbc. M105212200.
3. Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A (2008) 105:6320-5. doi:10.1073/pnas.0800708105.
4. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell (2008) 132:387-96. doi:10.1016/j.cell.2008.01.017.
5. Sakata I, Yang J, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, et al. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab (2009) 297:E134-41. doi:10.1152/ajpendo.90859.2008.
6. Kang K, Zmuda E, Sleeman MW. Physiological role of ghrelin as revealed by the ghrelin and GOAT knockout mice. Peptides (2011) 32:2236-41. doi:10.1016/j.peptides.2011.04.028.
7. Kojima M, Ida T, Sato T. Structure of mammalian and nonmammalian ghrelins. Vitam Horm (2008) 77:31-46. doi:10.1016/S0083-6729(06)77003-0.
8. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem (2003) 278:64-70. doi:10.1074/jbc. M205366200.
9. Nishi Y, Hiejima H, Hosoda H, Kaiya H, Mori K, Fukue Y, et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology (2005) 146:2255-64. doi:10.1210/en.2004-0695.
10. Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med (2009) 15:741-5. doi:10.1038/nm.1997.
11. Shlimun A, Unniappan S. Ghrelin O-acyl transferase:bridging ghrelin and energy homeostasis. Int J Pept (2011) 2011:217957. doi:10.1155/2011/217957.
12. Kaiya H, Miyazato M, Kangawa K, Peter RE, Unniappan S. Ghrelin:a multifunctional hormone in non-mammalian vertebrates. Comp Biochem Physiol A Mol Integr Physiol (2008) 149:109-28. doi:10.1016/j.cbpa.2007.12.004.
13. Kaiya H, Miyazato M, Kangawa K. Recent advances in the phylogenetic study of ghrelin. Peptides (2011) 32:2155-74. doi:10.1016/j.peptides.2011.04.027.
14. Kaiya H, Van der Gayten S, Kojima M, Hosoda H, Kitajima Y, Matsumoto M, et al. Chicken ghrelin:purification, cDNA cloning, and biological activity. Endocrinology (2002) 143:3445-63. doi:10.1210/en.2002-220255.
15. Kaiya H, Sakata I, Kojima M, Hosoda H, Sakai T, Kangawa K. Structural determination and histochemical localization of ghrelin in the red-eared slider turtle, Trachemys scripta elegans. Gen Comp Endocrinol (2004) 138:50-7. doi:10.1016/j.ygcen.2004.05.005.
16. Kaiya H, Kojima M, Hosoda H, Moriyama S, Takahashi A, Kawauchi H, et al. Peptide purification, cDNA and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout. Endocrinology (2003) 144:5215-26. doi:10.1210/en.2003-1085.
17. Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, et al. Amidated fish ghrelin:purification, cDNA cloning in the Japanese eel and its biological activity. J Endocrinol (2003) 176:415-23. doi:10.1677/joe.0.1760415.
18. Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, et al. Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol B Biochem Mol Biol (2003) 135:421-9. doi:10.1016/S1096-4959(03)00109-X.
19. Kaiya H, Small BC, Lelania Bilodeau A, Shepherd BS, Kojima M, Hosoda H, et al. Purification, cDNA cloning, and characterization of ghrelin in channel catfish, Ictalurus punctatus. Gen Comp Endocrinol (2005) 143:201-10. doi:10.1016/j.ygcen.2005.03.012.
20. Miura T, Maruyama K, Kaiya H, Miyazato M, Kangawa K, Uchiyama M, et al. Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus. Peptides (2009) 30:758-65. doi:10.1016/j.peptides.2008.12.016.
21. Kawakoshi A, Kaiya H, Riley LG, Hirano T, Grau EG, Miyazato M, et al. Identification of a ghrelin-like peptide in two species of shark, Sphyrna lewini and Carcharhinus melanopterus. Gen Comp Endocrinol (2007) 151:259-68. doi:10.1016/j.ygcen.2006.10.012.
22. Fox BK, Riley LG, Dorough C, Kaiya H, Hirano T, Grau EG. Effects of homologous ghrelins on the growth hormone/insulin-like growth factor-I in the tilapia, Oreochromis mossambicus. Zoolog Sci (2007) 24:391-400. doi:10.2108/zsj.24.391.
23. Schwandt SE, Peddu SC, Riley LG. Differential roles for octanoylated and decanoylated ghrelins in regulating appetite and metabolism. Int J Pept (2010) 2010:275804.
24. Yamato M, Sakata I, Wada R, Kaiya H, Sakai T. Exogenous administration of octanoic acid accelerates octanoylated ghrelin production in the proventriculus of neonatal chicks. Biochem Biophys Res Commun (2005) 333:583-9. doi:10.1016/j.bbrc.2005.05.107.
25. Nishi Y, Yoh J, Hiejima H, Kojima M. Structures and molecular forms of the ghrelin-family peptides. Peptides (2011) 32:2175-82. doi:10.1016/j.peptides.2011.07.024.
26. Yoh J, Nishi Y, Hosoda H, Tajiri Y, Yamada K, Yanase T, et al. Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics. Regul Pept (2011) 167:140-8. doi:10.1016/j.regpep.2010.12.010.
27. Ida T, Miyazato M, Naganobu K, Nakahara K, Sato M, Lin XZ, et al. Purification and characterization of feline ghrelin and its possible role. Domest Anim Endocrinol (2007) 32:93-105. doi:10.1016/j.domaniend.2006.01.002.
28. Ida T, Miyazato M, Lin XZ, Kaiya H, Sato T, Nakahara K, et al. Purification and characterization of caprine ghrelin and its effect on growth hormone release. J Mol Neurosci (2010) 42:99-105. doi:10.1007/s12031-010-9379-0.
29. Wada R, Sakata I, Kaiya H, Nakamura K, Hayashi Y, Kangawa K, et al. Existence of ghrelin-immunopositive and -expressing cells in the proventriculus of the hatching and adult chicken. Regul Pept (2003) 111:123-8. doi:10.1016/S0167-0115(02)00265-3.
30. Ohgusu H, Shirouzu K, Nakamura Y, Nakashima Y, Ida T, Sato T, et al. Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. Biochem Biophys Res Commun (2009) 386:153-8. doi:10.1016/j.bbrc.2009.06.001.