In vitro and in vivo protective effects of granulocyte colony-stimulating factor against radiation-induced intestinal injury

Archives of Pharmacal Research

Volumn 36, Issue 10, 2013, Pages 1252-1261

  Kim, Joong Sun ^a   Yang, Miyoung ^c   Lee, Chang Geun ^a   Kim, Sung Dae ^a   Kim, Jung Ki ^a   Yang, Kwangmo ^a,b  

^a Dongnam Institute of Radiological and Medical Science   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

G CSF; Intestine; Mice; Radiation

Indexed keywords

ANTIINFLAMMATORY AGENT; CASPASE 3; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 17; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PROTEIN P53; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL DEATH; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; IRRADIATION; JEJUNUM MUCOSA; MALE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INDUCED INTESTINAL INJURY; RADIATION INJURY; RADIATION PROTECTION;

ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; GRANULOCYTE COLONY-STIMULATING FACTOR; INTERLEUKIN-6; JEJUNUM; MALE; MICE; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84885956353     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0164-9     Document Type: Article

References (33)

1. Augustine, A.D., T. Gondre-Lewis, W. Mcbride, L. Miller, T.C. Pellmar, and S. Rockwell. 2005. Animal models for radiation injury, protection and therapy. Radiation Research 164: 100-109.
2. Azoulay, E., H. Attalah, A. Harf, B. Schlemmer, and C. Delclaux. 2001. Granulocyte colony-stimulating factor or neutrophil-induced pulmonary toxicity: myth or reality? Systematic review of clinical case reports and experimental data. Chest 120: 1695-1701.
3. Bolis, G., F. Zanaboni, P. Vanoli, A. Russo, M. Franchi, G. Scarfone, and S. Pecorelli. 1990. The impact of whole-abdomen radiotherapy on survival in advanced ovarian cancer patients with minimal residual disease after chemotherapy. Gynecologic Oncology 39: 150-154.
4. Cheah, K.Y., G.S. Howarth, R. Yazbeck, T.H. Wright, E.J. Whitford, C. Payne, R.N. Butler, and S.E. Bastian. 2009. Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. Cancer Biology & Therapy 8: 382-390.
5. Dale, D.C. 2002. Colony-stimulating factors for the management of neutropenia in cancer patients. Drugs 62(Suppl 1): 1-15.
6. Fei, P., and W.S. El-Deiry. 2003. P53 and radiation responses. Oncogene 22: 5774-5783.
7. Harada, M., Y. Qin, H. Takano, T. Minamino, Y. Zou, H. Toko, M. Ohtsuka, K. Matsuura, M. Sano, J. Nishi, K. Iwanaga, H. Akazawa, T. Kunieda, W. Zhu, H. Hasegawa, K. Kunisada, T. Nagai, H. Nakaya, K. Yamauchi-Takihara, and I. Komuro. 2005. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nature Medicine 11: 305-311.
8. Herodin, F., and M. Drouet. 2005. Cytokine-based treatment of accidentally irradiated victims and new approaches. Experimental Hematology 33: 1071-1080.
9. Hirama, T., S. Tanosaki, S. Kandatsu, N. Kuroiwa, T. Kamada, H. Tsuji, S. Yamada, H. Katoh, N. Yamamoto, H. Tsujii, G. Suzuki, and M. Akashi. 2003. Initial medical management of patients severely irradiated in the Tokai-mura criticality accident. The British Journal of Radiology 76: 246-253.
10. Hou, X.W., Y. Jiang, L.F. Wang, H.Y. Xu, H.M. Lin, X.Y. He, J.J. He, and S. Zhang. 2009. Protective role of granulocyte colony-stimulating factor against adriamycin induced cardiac, renal and hepatic toxicities. Toxicology Letters 187: 40-44.
11. Igaki, H., K. Nakagawa, H. Uozaki, M. Akahane, Y. Hosoi, M. Fukayama, K. Miyagawa, M. Akashi, K. Ohtomo, and K. Maekawa. 2008. Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident. Journal of Radiation Research 49: 55-62.
12. Kim, J., S. Lee, B. Jeon, W. Jang, C. Moon, and S. Kim. 2011. Protection of spermatogenesis against gamma ray-induced damage by granulocyte colony-stimulating factor in mice. Andrologia 43: 87-93.
13. Kim, J.S., S.B. Ryoo, K. Heo, J.G. Kim, T.G. Son, C. Moon, and K. Yang. 2012. Attenuating effects of granulocyte-colony stimulating factor (G-CSF) in radiation induced intestinal injury in mice. Food and Chemical Toxicology 50: 3174-3180.
14. Kim, S.H., H.J. Lee, J.S. Kim, C. Moon, J.C. Kim, H.R. Park, U. Jung, J.S. Jang, and S.K. Jo. 2009. Protective effect of an herbal preparation (HemoHIM) on radiation-induced intestinal injury in mice. Journal of Medicinal Food 12: 1353-1358.
15. Kudo, T., T. Matsumoto, I. Nakamichi, S. Yada, M. Esaki, Y. Jo, Y. Ohji, T. Yao, and M. Iida. 2008. Recombinant human granulocyte colony-stimulating factor reduces colonic epithelial cell apoptosis and ameliorates murine dextran sulfate sodium-induced colitis. Scandinavian Journal of Gastroenterology 43: 689-697.
16. Lan, X., H. Qu, W. Yao, and C. Zhang. 2008. Granulocyte-colony stimulating factor inhibits neuronal apoptosis in a rat model of diabetic cerebral ischemia. The Tohoku Journal of Experimental Medicine 216: 117-126.
17. Lee, H.J., J.S. Kim, C. Moon, J.C. Kim, S.K. Jo, and S.H. Kim. 2008. Relative biological effectiveness of fast neutrons in a multiorgan assay for apoptosis in mouse. Environmental Toxicology 23: 233-239.
18. Linard, C., A. Ropenga, M.C. Vozenin-Brotons, A. Chapel, and D. Mathe. 2003. Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layer. American journal of physiology. Gastrointestinal and Liver Physiology 285: G556-G565.
19. Macvittie, T.J., and A.M. Farese. 2002. Cytokine-based treatment of radiation injury: potential benefits after low-level radiation exposure. Military Medicine 167: 68-70.
20. Martins, A., J. Han, and S.O. Kim. 2010. The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis. IUBMB Life 62: 611-617.
21. Monti, P., J. Wysocki, A. Van Der Meeren, and N.M. Griffiths. 2005. The contribution of radiation-induced injury to the gastrointestinal tract in the development of multi-organ dysfunction syndrome or failure. BJR Supplement/BIR 27: 89-94.
22. Nenci, A., C. Becker, A. Wullaert, R. Gareus, G. Van Loo, S. Danese, M. Huth, A. Nikolaev, C. Neufert, B. Madison, D. Gumucio, M.F. Neurath, and M. Pasparakis. 2007. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446: 557-561.
23. Panja, A., S. Goldberg, L. Eckmann, P. Krishen, and L. Mayer. 1998. The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells. Journal of Immunology 161: 3675-3684.
24. Park, E., N.H. Lee, H.G. Joo, and Y. Jee. 2008. Modulation of apoptosis of eckol against ionizing radiation in mice. Biochemical and Biophysical Research Communications 372: 792-797.
25. Tamura, T., X. Cui, N. Sakaguchi, and M. Akashi. 2008. Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis. Food and Chemical Toxicology 46: 3080-3089.
26. Uckun, F.M., L. Souza, K.G. Waddick, M. Wick, and C.W. Song. 1990. In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice. Blood 75: 638-645.
27. Wang, Z.W., J.M. Zhou, Z.S. Huang, A.P. Yang, Z.C. Liu, Y.F. Xia, Y.X. Zeng, and X.F. Zhu. 2004. Aloe polysaccharides mediated radioprotective effect through the inhibition of apoptosis. Journal of Radiation Research 45: 447-454.
28. Weiss, J.F., and M.R. Landauer. 2009. History and development of radiation-protective agents. International Journal of Radiation Biology 85: 539-573.
29. Wroblewski, R., M. Jalnas, G. Van Decker, J. Bjork, J. Wroblewski, and G.M. Roomans. 2002. Effects of irradiation on intestinal cells in vivo and in vitro. Histology and Histopathology 17: 165-177.
30. Yamada, S., Y. Naito, T. Takagi, K. Mizushima, Y. Hirai, R. Horie, K. Fukumoto, K. Inoue, A. Harusato, N. Yoshida, K. Uchiyama, O. Handa, T. Ishikawa, H. Konishi, N. Wakabayashi, N. Yagi, S. Kokura, M. Kita, and T. Yoshikawa. 2011. Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice. Journal of Gastroenterology and Hepatology 26: 398-404.
31. Yamamoto, T., M. Kinoshita, N. Shinomiya, S. Hiroi, H. Sugasawa, Y. Matsushita, T. Majima, D. Saitoh, and S. Seki. 2010. Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation. Journal of Radiation Research 51: 145-156.
32. Yoon, Y.D., J.H. Kim, K.H. Lee, and J.K. Kim. 2005. Amifostine has an inhibitory effect on the radiation-induced p53-branched cascade in the immature mouse ovary. In Vivo 19: 509-514.
33. Zhang, L., W. Sun, J. Wang, M. Zhang, S. Yang, Y. Tian, S. Vidyasagar, L.A. Pena, K. Zhang, Y. Cao, L. Yin, W. Wang, L. Zhang, K.L. Schaefer, L.J. Saubermann, S.G. Swarts, B.M. Fenton, P.C. Keng, and P. Okunieff. 2010. Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. International Journal of Radiation Oncology Biology Physics 77: 261-268.