Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation

Journal of Radiation Research

Volumn 51, Issue 2, 2010, Pages 145-156

  Yamamoto, Tetsuo ^a,b   Kinoshita, Manabu ^a   Shinomiya, Nariyoshi ^a   Hiroi, Sadayuki ^a   Sugasawa, Hidekazu ^a   Matsushita, Yoshitaro ^b   Majima, Takashi ^a   Saitoh, Daizoh ^a   Seki, Shuhji ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b Military Medicine Research Unit   (Japan)

Author keywords

Apoptosis; Bone marrow transplantation; DNA microarray

Indexed keywords

ASCORBIC ACID; BONE; DNA; GENE EXPRESSION; IRRADIATION; MAMMALS; RADIATION EFFECTS; STEM CELLS;

BONE MARROW; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; DNA MICROARRAY; EXPOSED TO; GASTROINTESTINAL; PRE-TREATMENTS; RADIATION-INDUCED; STEM CELL TRANSPLANTATION; WHOLE BODY IRRADIATION;

CELL DEATH;

MUS;

EID: 77950344554     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.09078     Document Type: Article

References (38)

1. Hirama, T. and Akashi, M. (2005) Multi-organ involvement in the patient who survived the Tokai-mura criticality accident. B.J.R. Suppl 27: 17-20.
2. Flomenberg, N. and Keever, C. A. (1992) Cord blood transplants: potential utility and potential limitations. Bone Marrow Transplant. 10 Suppl 1: 115-120.
3. Ishii, T., Futami, S., Nishida, M., Suzuki, T., Sakamoto, T., Suzuki, N. and Maekawa, K. (2001) Brief note and evaluation of acute-radiation syndrome and treatment of a Tokai-mura criticality accident patient. J. Radiat. Res. 42 Suppl: S167-S182.
4. Igaki, H., Nakagawa, K., Uozaki, H., Akahane, M., Hosoi, Y., Fukayama, M., Miyagawa, K., Akashi, M., Ohtomo, K. and Maekawa, K. (2008) Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident. J. Radiat. Res. 49: 55-62.
5. Bolis, G., Zanaboni, F., Vanoli, P., Russo, A., Franchi, M., Scarfone, G. and Pecorelli, S. (1990) The impact of whole-abdomen radiotherapy on survival in advanced ovarian cancer patients with minimal residual disease after chemotherapy. Gynecol. Oncol. 39: 150-154.
6. Brown, M. (2008) What causes the radiation gastrointestinal syndrome?: overview. Int. J. Radiat. Oncol. Biol. Phys. 70: 799-800.
7. Toklu, H. Z., Sehirli, O., Ozyurt, H., Mayadagli, A. A., Eksioglu-Demiralp, E., Cetinel, S., Sahin, H., Yegen, B. C., Ulusoylu Dumlu, M., Gokmen, V. and Sener, G. (2009) Punica granatum peel extract protects against ionizing radiation-induced enteritis and leukocyte apoptosis in rats. J. Radiat. Res. 50: 345-353.
8. Weiss, J. F. and Landauer, M. R. (2003) Protection against ionizing radiation by antioxidant nutrients and phytochemicals.Toxicology 189: 1-20.
9. Mathew, D., Nair, C. K., Jacob, J. A., Biswas, N., Mukherjee, T., Kapoor, S. and Kagiya, T. V. (2007) Ascorbic acid monoglucoside as antioxidant and radioprotector. J. Radiat. Res. 48: 369-376.
10. Adaramoye, O., Ogungbenro, B., Anyaegbu, O. and Fafunso, M. (2008) Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. J. Radiat. Res. 49: 123-131.
11. Ueno, A., Vannais, D., Lenarczyk, M. and Waldren, C. A. (2002) Ascorbate, added after irradiation, reduces the mutant yield and alters the spectrum of CD59- mutations in A(L) cells irradiated with high LET carbon ions. J. Radiat. Res. 43 Suppl: S245-S249.
12. Waldren, C. A., Vannais, D. B. and Ueno, A. M. (2004) A role for long-lived radicals (LLR) in radiation-induced mutation and persistent chromosomal instability: counteraction by ascorbate and RibCys but not DMSO. Mutat. Res. 551: 255-265.
13. Harapanhalli, R. S., Yaghmai, V., Giuliani, D., Howell, R. W. and Rao, D. V. (1996) Antioxidant effects of vitamin C in mice following X-irradiation. Res. Commun. Mol. Pathol. Pharmacol. 94: 271-287.
14. Kinoshita, M., Shinomiya, N., Ono, S., Tsujimoto, H., Kawabata, T., Matsumoto, A., Hiraide, H. and Seki, S. (2006) Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa. J. Immunol. 177: 4627-4635.
15. Cesarone, M. R., Belcaro, G., Carratelli, M., Cornelli, U., De Sanctis, M. T., Incandela, L., Barsotti, A., Terranova, R. and Nicolaides, A. (1999) A simple test to monitor oxidative stress. Int. Angiol. 18: 127-130.
16. Buonocore, G., Perrone, S., Longini, M., Terzuoli, L. and Bracci, R. (2000) Total hydroperoxide and advanced oxidation protein products in preterm hypoxic babies. Pediatr. Res. 47: 221-224.
17. Huang, D. C. and Strasser, A. (2000) BH3-Only proteins-essential initiators of apoptotic cell death. Cell 103: 839-842.
18. Scholes, G. (1983) Radiation effects on DNA. The Silvanus Thompson Memorial Lecture, April 1982. Br. J. Radiol. 56: 221-231.
19. Umegaki, K., Aoki, S. and Esashi, T. (1995) Whole body X-ray irradiation to mice decreases ascorbic acid concentration in bone marrow: comparison between ascorbic acid and vitamin E. Free Radic. Biol. Med. 19: 493-497.
20. Prise, K. M., Davies, S. and Michael, B. D. (1992) A comparison of the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells. Int. J. Radiat. Biol. 61: 721-728.
21. Paris, F., Fuks, Z., Kang, A., Capodieci, P., Juan, G., Ehleiter, D., Haimovitz-Friedman, A., Cordon-Cardo, C. and Kolesnick, R. (2001) Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293: 293-297.
22. Matsuu-Matsuyama, M., Shichijo, K., Okaichi, K., Ishii, K., Wen, C. Y., Fukuda, E., Nakayama, T., Nakashima, M., Okumura, Y. and Sekine, I. (2006) Sucralfate protects intestinal epithelial cells from radiation-induced apoptosis in rats. J. Radiat. Res. 47: 1-8.
23. Matsuu-Matsuyama, M., Shichijo, K., Okaichi, K., Nakayama, T., Nakashima, M., Uemura, T., Niino, D. and Sekine, I. (2008) Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells. J. Radiat. Res. 49: 341-347.
24. Schuller, B. W., Rogers, A. B., Cormier, K. S., Riley, K. J., Binns, P. J., Julius, R., Hawthorne, M. F. and Coderre, J. A. (2007) No significant endothelial apoptosis in the radiation-induced gastrointestinal syndrome. Int. J. Radiat. Oncol. Biol. Phys. 68: 205-210.
25. el-Nahas, S. M., Mattar, F. E. and Mohamed, A. A. (1993) Radioprotective effect of vitamins C and E. Mutat. Res. 301: 143-147.
26. O'Connor, M. K., Malone, J. F., Moriarty, M. and Mulgrew, S. (1977) A radioprotective effect of vitamin C observed in Chinese hamster ovary cells. Br. J. Radiol. 50: 587-591.
27. Witenberg, B., Kletter, Y., Kalir, H. H., Raviv, Z., Fenig, E., Nagler, A., Halperin, D. and Fabian, I. (1999) Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiat. Res. 152: 468-478.
28. Biedermann, K. A., Sun, J. R., Giaccia, A. J., Tosto, L. M. and Brown, J. M. (1991) Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 88: 1394-1397.
29. Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J. and Cantilena, L. R. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc. Natl. Acad. Sci. USA 93: 3704-3709.
30. Nakamura, S. and Oku, T. (2009) Bioavailability of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid as ascorbic acid in healthy humans. Nutrition 25: 686-691.
31. Chandrasekharan, D. K., Kagiya, T. V. and Nair, C. K. (2009) Radiation protection by 6-palmitoyl ascorbic acid-2-glucoside:studies on DNA damage in vitro, ex vivo, in vivo and oxidative stress in vivo. J. Radiat. Res. 50: 203-212.
32. Yokoyama, T., Date, C., Kokubo, Y., Yoshiike, N., Matsumura, Y. and Tanaka, H. (2000) Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study. Stroke 31: 2287-2294.
33. Hosokawa, Y., Sakakura, Y., Tanaka, L., Okumura, K., Yajima, T. and Kaneko, M. (2005) Radiation-induced apoptosisis independent of caspase-8 but dependent on cytochrome c and the caspase-9 cascade in human leukemia HL60 cells. J. Radiat. Res. 46: 293-303.
34. Green, D. R. (1998) Apoptotic pathways: the roads to ruin. Cell 94: 695-698.
35. Strasser, A., O'Connor, L. and Dixit, V. M. (2000) Apoptosis signaling. Annu. Rev. Biochem. 69: 217-245.
36. Wang, X. (2001) The expanding role of mitochondria in apoptosis. Genes Dev. 15: 2922-2933.
37. Choi, S. A., Kim, S. J. and Chung, K. C. (2006) Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations. FEBS Lett 580: 5275-5282.
38. Chandrasekaran, Y., McKee, C. M., Ye, Y. and Richburg, J. H. (2006) Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. Biol. Reprod. 74: 560-568.