Protective effect of an herbal preparation (HemoHIM) on radiation-induced intestinal injury in mice

Journal of Medicinal Food

Volumn 12, Issue 6, 2009, Pages 1353-1358

  Kim, Sung Ho ^a   Lee, Hae June ^b   Kim, Joong Sun ^a   Moon, Changjong ^a   Kim, Jong Choon ^a   Park, Hae Ran ^c   Jung, Uhee ^c   Jang, Jong Sik ^d   Jo, Sung Kee ^c  

^a Chonnam National University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

^d Kyungpook National University   (South Korea)

Author keywords

Apoptosis; Crypt; HemoHIM; Intestine; Radiation

Indexed keywords

ANGELICA ROOT; HEMOHIM; HERBACEOUS AGENT; PAEONIA RADIX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL LAMINA LENGTH; CELL PROTECTION; CNIDIUM; COBALT THERAPY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; GAMMA IRRADIATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE CRYPT; INTESTINE CRYPT DEPTH; INTESTINE INJURY; MOUSE; MUCOSAL LENGTH; NONHUMAN; PARAMETER; PRIORITY JOURNAL; RADIATION DOSE; RADIATION ENTEROPATHY; TISSUE STRUCTURE; VILLUS HEIGHT; WHOLE BODY RADIATION;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GAMMA RAYS; HUMANS; INTESTINES; MICE; MICE, INBRED ICR; PLANT PREPARATIONS; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS;

MUS;

EID: 74349118143     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2008.1322     Document Type: Article

References (23)

1. Potten CS, Wilson JW, Booth C: Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. Stem Cells 1997;15:82-93.
2. Jagetia GC: Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr 2007;40: 74-81.
3. Jo SK, Park HR, Jung U, Oh H, Kim SH, Yee ST: Protective effect of a herbal preparation (HemoHIM) on the selfrenewal tissues and immune system against g-irradiation. J Korean Soc Food Sci Nutr 2005;34:805-813.
4. Jo SK, Lee HJ, Kim SR, Kim JC, Bae CS, Jung U, Park HR, Jang JS, Kim SH: Antiinflammatory activity of an herbal preparation (HemoHIM) in rats. Phytother Res 2007;21:625-628.
5. Park HR, Jo SK, Jung U, Yee ST: Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM. Phytother Res 2008;22:36-42.
6. Jo SK, Kim SH, Yee ST, Park HR, Oh H, Byun MW: Herbal composition for improving anticancer activity, immune response and hematopoiesis of the body, and protecting the body from oxidative damage, and the method of preparing the same. U.S. Patent 6,964,785. November 15, 2005.
7. Withers HR, Elkind MM: Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med 1970;17:261-267.
8. Potten CS, Grant HK: The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine. Br J Cancer 1998;78:993-1003.
9. Weil MM, Stephens LC, Amos CI, Ruifrok AC, Mason KA: Strain difference in jejunal crypt cell susceptibility to radiationinduced apoptosis. Int J Radiat Biol 1996;70:579-585.
10. Sigdestad CP, Connor AM, Scott RM: Effect of chemical protectors on the response of the intestine to roentgen or fission neutron irradiation. Acta Radiol Ther Phys Biol 1976;15:401-409.
11. Potten CS, Booth D, Haley JD: Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo. Br J Cancer 1997;75:1454-1459.
12. Wu SG, Miyamoto T: Radioprotection of the intestinal crypts of mice by recombinant human interleukin-1 alpha. Radiat Res 1990;123:112-115.
13. Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H: Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei Murill against X-irradiation in B6C3F1 mice: increased small intestinal crypt survival and prolongation of average time to animal death. Int J Mol Med 2005;15:401-406.
14. Lee HJ, Kim SR, Kim JC, Kang CM, Lee YS, Jo SK, Kim TH, Jang JS, Nah SY, Kim SH: In vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides. Phytother Res 2006;20:392-395.
15. Booth C, Booth D, Williamson S, Demchyshyn LL, Potten CS: Teduglutide ([Gly2]GLP-2) protects small intestinal stem cells from radiation damage. Cell Prolif 2004;37:385-400.
16. Ijiri K, Potten CS: Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. Br J Cancer 1983;47:175-185.
17. Driák D, Osterreicher J, Vávrová J, Reháková Z, Vilasová Z: Morphological changes of rat jejunum after whole body gammairradiation and their impact in biodosimetry. Physiol Res 2008;57:475-479.
18. Lee TK, Johnke RM, Allison RR, O'Brien KF, Dobbs LJ Jr: Radioprotective potential of ginseng. Mutagenesis 2005;20:237-243.
19. Hosseinimehr SJ: Trends in the development of radioprotective agents. Drug Discov Today 2007;12:794-805.
20. Choi YE, Ahn H, Ryu JH: Polyacetylenes from Angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages. Biol Pharm Bull 2000;23:884-886.
21. Dai Y, But PP, Chan YP, Matsuda H, Kubo M: Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Tang. Biol Pharm Bull 2002;25:1175-1178.
22. Lu ZM, Yu YR, Tang H, Zhang XX: [The protective effects of radix astragali and rhizoma ligustici chuanxiong on endothelial dysfunction in type 2 diabetic patients with microalbuminuria]. Sichuan Da Xue Xue Bao Yi Xue Ban 2005;36:529-532.
23. Cho CH, Mei QB, Shang P: Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats. Planta Med 2000;66:348-351.