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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 22, 2013, Pages 6087-6092

The application of Heck reaction in the synthesis of guaianolide sesquiterpene lactones derivatives selectively inhibiting resistant acute leukemic cells

(5) Ding, Ya Hui a Fan, Hong Xia a Long, Jing a Zhang, Quan a Chen, Yue a

a NANKAI UNIVERSITY (China)

Author keywords

Acute myelogenous leukemia; Dehydrocostus lactone; Guaianolide type sesquiterpene lactones; Micheliolide; Synthesis

Indexed keywords

ANTILEUKEMIC AGENT; DEHYDROCOSTUS LACTONE; DOXORUBICIN; GUAIANOLIDE DERIVATIVE; SESQUITERPENE LACTONE DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HECK REACTION; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ACUTE MYELOGENOUS LEUKEMIA; DEHYDROCOSTUS LACTONE; GUAIANOLIDE-TYPE SESQUITERPENE LACTONES; MICHELIOLIDE; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HL-60 CELLS; HUMANS; LACTONES; LEUKEMIA, MYELOID, ACUTE; SESQUITERPENES, GUAIANE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885953497 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.09.028 Document Type: Article

Times cited : (34)

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