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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 22, 2013, Pages 6083-6086

Novel highly potent serotonin 5-HT7 receptor ligands: Structural modifications to improve pharmacokinetic properties

(11) Lacivita, Enza a Di Pilato, Pantaleo a Letizia Stama, Madia a Colabufo, Nicola Antonio a Berardi, Francesco a Perrone, Roberto a De Filippis, Bianca b Laviola, Giovanni b Adriani, Walter b Niso, Mauro a Leopoldo, Marcello a

a UNIVERSITY OF BARI (Italy)

b ISTITUTO SUPERIORE DI SANITÀ (Italy)

Author keywords

5 HT7 receptors; Arylpiperazines; Microsomial S9 fraction; Serotonin

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN; N PYRIDIN 3 YLMETHYL 3 [4 [2 (4 METHOXYPHENYL)PHENYL]PIPERAZIN 1 YL]ETHOXY]PROPANAMIDE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; SINGLE DRUG DOSE;

MUS;

5-HT(7) RECEPTORS; ARYLPIPERAZINES; MICROSOMIAL S9 FRACTION; SEROTONIN;

AMIDES; ANIMALS; BLOOD-BRAIN BARRIER; CACO-2 CELLS; HUMANS; LIGANDS; MALE; MICE; P-GLYCOPROTEINS; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885950390 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.09.025 Document Type: Article

Times cited : (6)

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