-
1
-
-
84876149257
-
Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence
-
10.1002/hep.26141 Feb 4 [Epub 2013]
-
K. Mohd Hanafiah, J. Groeger, A.D. Flaxman, and S.T. Wiersma Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence Hepatology 57 2013 1333 1342 10.1002/hep.26141 Feb 4 [Epub 2013]
-
(2013)
Hepatology
, vol.57
, pp. 1333-1342
-
-
Mohd Hanafiah, K.1
Groeger, J.2
Flaxman, A.D.3
Wiersma, S.T.4
-
3
-
-
84885954793
-
-
Press release issued by Vertex 23 May. Available at (accessed 14.06.11)
-
FDA Approves INCIVEK((telaprevir) for People with Hepatitis C 2011 Press release issued by Vertex 23 May. Available at http://investors.vrtx.com/ releasedetail.cfm?ReleaseID=580154 (accessed 14.06.11)
-
(2011)
FDA Approves INCIVEK((telaprevir) for People with Hepatitis C
-
-
-
4
-
-
65449152185
-
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
-
J.G. McHutchison, G.T. Everson, and S.C. Gordon Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection N Engl J Med 360 2009 1827 1838
-
(2009)
N Engl J Med
, vol.360
, pp. 1827-1838
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
5
-
-
77950817619
-
Telaprevir for previously treated chronic HCV infection
-
J.G. McHutchison, M.P. Manns, and A.J. Muir Telaprevir for previously treated chronic HCV infection N Engl J Med 362 2010 1292 1303
-
(2010)
N Engl J Med
, vol.362
, pp. 1292-1303
-
-
McHutchison, J.G.1
Manns, M.P.2
Muir, A.J.3
-
6
-
-
79953176289
-
Boceprevir for previously treated chronic HCV genotype 1 infection
-
B.R. Bacon, S.C. Gordon, and E. Lawitz Boceprevir for previously treated chronic HCV genotype 1 infection N Engl J Med 364 2011 1207 1217
-
(2011)
N Engl J Med
, vol.364
, pp. 1207-1217
-
-
Bacon, B.R.1
Gordon, S.C.2
Lawitz, E.3
-
7
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
F. Poordad, J. McCone Jr., and B.R. Bacon Boceprevir for untreated chronic HCV genotype 1 infection N Engl J Med 364 2011 1195 1206
-
(2011)
N Engl J Med
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone, Jr.J.2
Bacon, B.R.3
-
8
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
I.M. Jacobson, J.G. McHutchison, and G. Dusheiko Telaprevir for previously untreated chronic hepatitis C virus infection N Engl J Med 364 2011 2405 2416
-
(2011)
N Engl J Med
, vol.364
, pp. 2405-2416
-
-
Jacobson, I.M.1
McHutchison, J.G.2
Dusheiko, G.3
-
9
-
-
79959381354
-
Telaprevir for retreatment of HCV infection
-
S. Zeuzem, P. Andreone, and S. Pol Telaprevir for retreatment of HCV infection N Engl J Med 364 2011 2417 2428
-
(2011)
N Engl J Med
, vol.364
, pp. 2417-2428
-
-
Zeuzem, S.1
Andreone, P.2
Pol, S.3
-
11
-
-
77953013128
-
Rapid emergence of protease inhibitor resistance in hepatitis C virus
-
L. Rong, H. Dahari, R.M. Ribeiro, and A.S. Perelson Rapid emergence of protease inhibitor resistance in hepatitis C virus Sci Transl Med 2 2010 30 32
-
(2010)
Sci Transl Med
, vol.2
, pp. 30-32
-
-
Rong, L.1
Dahari, H.2
Ribeiro, R.M.3
Perelson, A.S.4
-
12
-
-
44449142885
-
Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients
-
DOI 10.1093/jac/dkn085
-
S. Le Pogam, A. Seshaadri, A. Kosaka, S. Chiu, H. Kang, S. Hu, S. Rajyaguru, J. Symons, N. Cammack, and I. Nájera Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients J Antimicrob Chemother 61 2008 1205 1216 (Pubitemid 351753583)
-
(2008)
Journal of Antimicrobial Chemotherapy
, vol.61
, Issue.6
, pp. 1205-1216
-
-
Le Pogam, S.1
Seshaadri, A.2
Kosaka, A.3
Chiu, S.4
Kang, H.5
Hu, S.6
Rajyaguru, S.7
Symons, J.8
Cammack, N.9
Najera, I.10
-
13
-
-
58149388300
-
Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
-
T. Kuntzen, J. Timm, and A. Berical Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients Hepatology 48 2008 1769 1778
-
(2008)
Hepatology
, vol.48
, pp. 1769-1778
-
-
Kuntzen, T.1
Timm, J.2
Berical, A.3
-
14
-
-
84868029979
-
Characterization of hepatitis C virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir
-
S. Le Pogam, J.M. Yan, M. Chhabra, M. Ilnicka, H. Kang, A. Kosaka, S. Ali, D.J. Chin, N.S. Shulman, and P. Smith Characterization of hepatitis C virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir Antimicrob Agents Chemother 56 2012 5494 5502
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 5494-5502
-
-
Le Pogam, S.1
Yan, J.M.2
Chhabra, M.3
Ilnicka, M.4
Kang, H.5
Kosaka, A.6
Ali, S.7
Chin, D.J.8
Shulman, N.S.9
Smith, P.10
-
15
-
-
79959401302
-
Natural polymorphisms associated with resistance to new antivirals against HCV in newly diagnosed HIV-HCV-coinfected patients
-
A. Trevino, C. de Mendoza, and P. Parra Natural polymorphisms associated with resistance to new antivirals against HCV in newly diagnosed HIV-HCV-coinfected patients Antivir Ther 16 2011 413 416
-
(2011)
Antivir Ther
, vol.16
, pp. 413-416
-
-
Trevino, A.1
De Mendoza, C.2
Parra, P.3
-
16
-
-
84877580079
-
The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank
-
R. Alves, A.T. Queiroz, M.G. Pessoa, E.F. da Silva, D.F. Mazo, F.J. Carrilho, R.J. Carvalho-Filho, and I.M. de Carvalho The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank J Viral Hepat 20 2013 414 421
-
(2013)
J Viral Hepat
, vol.20
, pp. 414-421
-
-
Alves, R.1
Queiroz, A.T.2
Pessoa, M.G.3
Da Silva, E.F.4
Mazo, D.F.5
Carrilho, F.J.6
Carvalho-Filho, R.J.7
De Carvalho, I.M.8
-
17
-
-
0031009603
-
Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa
-
N.P. Lam, A.U. Neumann, D.R. Gretch, T.E. Wiley, A.S. Perelson, and T.J. Layden Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa Hepatology 26 1997 226 231 (Pubitemid 27280329)
-
(1997)
Hepatology
, vol.26
, Issue.1
, pp. 226-231
-
-
Lam, N.P.1
Neumann, A.U.2
Gretch, D.R.3
Wiley, T.E.4
Perelson, A.S.5
Layden, T.J.6
-
18
-
-
84876572287
-
The origin of hepatitis C virus
-
P. Simmonds The origin of hepatitis C virus Curr Top Microbiol Immunol 369 2013 1 15
-
(2013)
Curr Top Microbiol Immunol
, vol.369
, pp. 1-15
-
-
Simmonds, P.1
-
19
-
-
42949167169
-
The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors
-
DOI 10.1128/AAC.01317-07
-
M.F. McCown, S. Rajyaguru, S. Le Pogam, S. Ali, W.R. Jiang, H. Kang, J. Symons, N. Cammack, and I. Najera The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors Antimicrob Agents Chemother 52 2008 1604 1612 (Pubitemid 351614649)
-
(2008)
Antimicrobial Agents and Chemotherapy
, vol.52
, Issue.5
, pp. 1604-1612
-
-
McCown, M.F.1
Rajyaguru, S.2
Le Pogam, S.3
Ali, S.4
Jiang, W.-R.5
Kang, H.6
Symons, J.7
Cammack, N.8
Najera, I.9
-
20
-
-
80052123459
-
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
-
J.M. Gottwein, T.K. Scheel, T.B. Jensen, L. Ghanem, and Bukh Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses J. Gastroenterol 141 2011 1067 1079
-
(2011)
J. Gastroenterol
, vol.141
, pp. 1067-1079
-
-
Gottwein, J.M.1
Scheel, T.K.2
Jensen, T.B.3
Ghanem, L.4
Bukh5
-
21
-
-
79952296871
-
Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α
-
T.K. Scheel, J.M. Gottwein, L.S. Mikkelsen, T.B. Jensen, and J. Bukh Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α Gastroenterology 140 2011 1032 1042
-
(2011)
Gastroenterology
, vol.140
, pp. 1032-1042
-
-
Scheel, T.K.1
Gottwein, J.M.2
Mikkelsen, L.S.3
Jensen, T.B.4
Bukh, J.5
-
22
-
-
84877580533
-
Analysis of genotype 2 and 3 hepatitis C virus variants in patients treated with telaprevir demonstrates a consistent resistance profile across genotypes
-
S. De Meyer, A. Ghys, G.R. Foster, M. Beumont, B. Van Baelen, T.I. Lin, I. Dierynck, H. Ceulemans, and G. Picchio Analysis of genotype 2 and 3 hepatitis C virus variants in patients treated with telaprevir demonstrates a consistent resistance profile across genotypes J Viral Hepat 20 2013 395 403
-
(2013)
J Viral Hepat
, vol.20
, pp. 395-403
-
-
De Meyer, S.1
Ghys, A.2
Foster, G.R.3
Beumont, M.4
Van Baelen, B.5
Lin, T.I.6
Dierynck, I.7
Ceulemans, H.8
Picchio, G.9
-
23
-
-
84875804486
-
Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors
-
D. Hernandez, N. Zhou, J. Ueland, A. Monikowski, and F. McPhee Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors J Clin Virol 57 2013 13 18
-
(2013)
J Clin Virol
, vol.57
, pp. 13-18
-
-
Hernandez, D.1
Zhou, N.2
Ueland, J.3
Monikowski, A.4
McPhee, F.5
-
24
-
-
84855509792
-
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
-
M.H. Powdrill, E.P. Tchesnokov, R.A. Kozak, R.S. Russell, R. Martin, E.S. Svarovskaia, H. Mo, R.D. Kouyos, and M. Götte Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance Proc Natl Acad Sci U S A 108 2011 20509 20513
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 20509-20513
-
-
Powdrill, M.H.1
Tchesnokov, E.P.2
Kozak, R.A.3
Russell, R.S.4
Martin, R.5
Svarovskaia, E.S.6
Mo, H.7
Kouyos, R.D.8
Götte, M.9
-
25
-
-
66149128046
-
GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796
-
M.F. McCown, S. Rajyaguru, S. Kular, N. Cammack, and I. Najera GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796 Antimicrob Agents Chemother 53 2009 2129 2132
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 2129-2132
-
-
McCown, M.F.1
Rajyaguru, S.2
Kular, S.3
Cammack, N.4
Najera, I.5
-
26
-
-
79958830099
-
Hepatitis C virus resistance to protease inhibitors
-
P. Halfon, and S. Locarnini Hepatitis C virus resistance to protease inhibitors J Hepatol 55 2011 192 206
-
(2011)
J Hepatol
, vol.55
, pp. 192-206
-
-
Halfon, P.1
Locarnini, S.2
-
27
-
-
80051810561
-
Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication
-
D. Leen, V. Inge, F. Mathy, and N. Johan Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication Antimicrob Agents Chemother 55 2011 4103 4113
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 4103-4113
-
-
Leen, D.1
Inge, V.2
Mathy, F.3
Johan, N.4
-
28
-
-
34247594930
-
Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir
-
DOI 10.1053/j.gastro.2007.02.037, PII S0016508507003940
-
C. Sarrazin, T.L. Kieffer, and D. Bartels Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir Gastroenterology 132 2007 1767 1777 (Pubitemid 46677938)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
Hanzelka, B.4
Muh, U.5
Welker, M.6
Wincheringer, D.7
Zhou, Y.8
Chu, H.9
Lin, C.10
Weegink, C.11
Reesink, H.12
Zeuzem, S.13
Kwong, A.D.14
-
29
-
-
33749360242
-
Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX-950: A Phase Ib, Placebo-Controlled, Randomized Study
-
DOI 10.1053/j.gastro.2006.07.013, PII S0016508506015393
-
H.W. Reesink, S. Zeuzem, and C.J. Weegink Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study Gastroenterology 131 2006 997 1002 (Pubitemid 44498690)
-
(2006)
Gastroenterology
, vol.131
, Issue.4
, pp. 997-1002
-
-
Reesink, H.W.1
Zeuzem, S.2
Weegink, C.J.3
Forestier, N.4
Van Vliet, A.5
Van De Wetering De Rooij, J.6
McNair, L.7
Purdy, S.8
Kauffman, R.9
Alam, J.10
Jansen, P.L.M.11
-
30
-
-
83455160674
-
-
Vertex Pharmaceuticals, Inc. Cambridge, MA, USA
-
Incivek Prescribing Information 2011 Vertex Pharmaceuticals, Inc. Cambridge, MA, USA
-
(2011)
Incivek Prescribing Information
-
-
-
31
-
-
83455166816
-
-
Schering Corporation, a subsidiary of Merck and Co. Whitehouse Station, NJ, USA
-
Victrelis Prescribing Information 2011 Schering Corporation, a subsidiary of Merck and Co. Whitehouse Station, NJ, USA
-
(2011)
Victrelis Prescribing Information
-
-
-
32
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
DOI 10.1038/13305
-
C.A. Lesburg, M.B. Cable, E. Ferrari, Z. Hong, A.F. Mannarino, and P.C. Weber Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site Nat Struct Biol 6 1999 937 943 (Pubitemid 29463307)
-
(1999)
Nature Structural Biology
, vol.6
, Issue.10
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
33
-
-
33744930847
-
Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus
-
DOI 10.1128/JVI.02628-05
-
S. Le Pogam, H. Kang, S.F. Harris, V. Leveque, A.M. Giannetti, S. Ali, W.R. Jiang, S. Rajyaguru, G. Tavares, and C. Oshiro Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus J Virol 80 2006 6146 6154 (Pubitemid 43849192)
-
(2006)
Journal of Virology
, vol.80
, Issue.12
, pp. 6146-6154
-
-
Le Pogam, S.1
Kang, H.2
Harris, S.F.3
Leveque, V.4
Giannetti, A.M.5
Ali, S.6
Jiang, W.-R.7
Rajyaguru, S.8
Tavares, G.9
Oshiro, C.10
Hendricks, T.11
Klumpp, K.12
Symons, J.13
Browner, M.F.14
Cammack, N.15
Najera, I.16
-
34
-
-
77957913871
-
Discovery of a β-d-2′-deoxy-2′-α-fluoro-2′- β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
-
M.J. Sofia, D. Bao, W. Chang, J. Du, D. Nagarathnam, S. Rachakonda, P.G. Reddy, B.S. Ross, P. Wang, and H.R. Zhang Discovery of a β-d-2′- deoxy-2′-α-fluoro-2′-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus J Med Chem 53 2010 7202 7218
-
(2010)
J Med Chem
, vol.53
, pp. 7202-7218
-
-
Sofia, M.J.1
Bao, D.2
Chang, W.3
Du, J.4
Nagarathnam, D.5
Rachakonda, S.6
Reddy, P.G.7
Ross, B.S.8
Wang, P.9
Zhang, H.R.10
-
35
-
-
84877730954
-
Sofosbuvir for previously untreated chronic hepatitis C infection
-
E. Lawitz, A. Mangia, D. Wyles, M. Rodriguez-Torres, T. Hassanein, S.C. Gordon, M. Schultz, M.N. Davis, Z. Kayali, and K.R. Reddy Sofosbuvir for previously untreated chronic hepatitis C infection N Engl J Med 368 2013 1878 1887
-
(2013)
N Engl J Med
, vol.368
, pp. 1878-1887
-
-
Lawitz, E.1
Mangia, A.2
Wyles, D.3
Rodriguez-Torres, M.4
Hassanein, T.5
Gordon, S.C.6
Schultz, M.7
Davis, M.N.8
Kayali, Z.9
Reddy, K.R.10
-
36
-
-
33646457538
-
Inhibition of hepatitis C replicon RNA synthesis by beta-d-2′- deoxy-2′-fluoro-2′-C-methylcytidine: A specific inhibitor of hepatitis C virus replication
-
L.J. Stuyver, T.R. McBrayer, P.M. Tharnish, J. Clark, L. Hollecker, S. Lostia, T. Nachman, J. Grier, M.A. Bennett, and M.Y. Xie Inhibition of hepatitis C replicon RNA synthesis by beta-d-2′-deoxy-2′-fluoro-2′-C- methylcytidine: a specific inhibitor of hepatitis C virus replication Antivir Chem Chemother 17 2006 79 87
-
(2006)
Antivir Chem Chemother
, vol.17
, pp. 79-87
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Tharnish, P.M.3
Clark, J.4
Hollecker, L.5
Lostia, S.6
Nachman, T.7
Grier, J.8
Bennett, M.A.9
Xie, M.Y.10
-
37
-
-
35648968189
-
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor β-D-2′-deoxy-2′-fluoro-2′-C- methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species
-
DOI 10.1074/jbc.M705274200
-
H. Ma, W.R. Jiang, and N. Robledo Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-d-2′-deoxy- 2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species J Biol Chem 282 2007 29812 29820 (Pubitemid 350035263)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.41
, pp. 29812-29820
-
-
Ma, H.1
Jiang, W.-R.2
Robledo, N.3
Leveque, V.4
Ali, S.5
Lara-Jaime, T.6
Masjedizadeh, M.7
Smith, D.B.8
Cammack, N.9
Klumpp, K.10
Symons, J.11
-
38
-
-
84881025292
-
A randomized trial of mericitabine plus peginterferon alfa-2a/ribavirin for 24 weeks in treatment-naive HCV genotype 1/4 patients
-
[Epub ahead of print]
-
P.J. Pockros, D. Jensen, N. Tsai, R. Taylor, A. Ramji, C. Cooper, R. Dickson, A. Tice, R. Kulkarni, and J.M. Vierling A randomized trial of mericitabine plus peginterferon alfa-2a/ribavirin for 24 weeks in treatment-naive HCV genotype 1/4 patients Hepatology 2013 [Epub ahead of print]
-
(2013)
Hepatology
-
-
Pockros, P.J.1
Jensen, D.2
Tsai, N.3
Taylor, R.4
Ramji, A.5
Cooper, C.6
Dickson, R.7
Tice, A.8
Kulkarni, R.9
Vierling, J.M.10
-
39
-
-
84885956041
-
-
Alios BioPharma Incorporated/Vertex Pharmaceuticals Incorporated South San Francisco, CA, USA/Cambridge, MA, USA
-
C.H. Tan, J. Deval, H. Kang, C. Moy, Z. Jin, A. Jekle, R. Rijnbrand, T. Kieffer, L.M. Blatt, and S.M. Chanda ALS-2200 (VX-135) Viral Kinetic Study Shows Significant Reduction in HCV RNA in People with Genotype 1 Hepatitis C Virus Infection and Cirrhosis, and in People with Genotypes 2, 3 or 4 HCV Infection 2013 Alios BioPharma Incorporated/Vertex Pharmaceuticals Incorporated South San Francisco, CA, USA/Cambridge, MA, USA
-
(2013)
ALS-2200 (VX-135) Viral Kinetic Study Shows Significant Reduction in HCV RNA in People with Genotype 1 Hepatitis C Virus Infection and Cirrhosis, and in People with Genotypes 2, 3 or 4 HCV Infection
-
-
Tan, C.H.1
Deval, J.2
Kang, H.3
Moy, C.4
Jin, Z.5
Jekle, A.6
Rijnbrand, R.7
Kieffer, T.8
Blatt, L.M.9
Chanda, S.M.10
-
40
-
-
79955529751
-
INX-08189, a phosphoramidate prodrug of 6-O-methyl-2′-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties
-
J.H. Vernachio, B. Bleiman, K.D. Bryant, S. Chamberlain, D. Hunley, J. Hutchins, B. Ames, E. Gorovits, B. Ganguly, and A. Hall INX-08189, a phosphoramidate prodrug of 6-O-methyl-2′-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties Antimicrob Agents Chemother 55 2011 1843 1851
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 1843-1851
-
-
Vernachio, J.H.1
Bleiman, B.2
Bryant, K.D.3
Chamberlain, S.4
Hunley, D.5
Hutchins, J.6
Ames, B.7
Gorovits, E.8
Ganguly, B.9
Hall, A.10
-
41
-
-
81255184396
-
Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA
-
A.M. Lam, C. Espiritu, S. Bansal, H.M. Micolochick Steuer, V. Zennou, M.J. Otto, and P.A. Furman Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA J Virol 85 2011 12334 12342
-
(2011)
J Virol
, vol.85
, pp. 12334-12342
-
-
Lam, A.M.1
Espiritu, C.2
Bansal, S.3
Micolochick Steuer, H.M.4
Zennou, V.5
Otto, M.J.6
Furman, P.A.7
-
42
-
-
33744910421
-
In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance
-
DOI 10.1016/j.virol.2006.03.045, PII S0042682206002297
-
S. Le Pogam, W.R. Jiang, and V. Leveque In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance Virology 351 2006 349 359 (Pubitemid 44108072)
-
(2006)
Virology
, vol.351
, Issue.2
, pp. 349-359
-
-
Le Pogam, S.1
Jiang, W.-R.2
Leveque, V.3
Rajyaguru, S.4
Ma, H.5
Kang, H.6
Jiang, S.7
Singer, M.8
Ali, S.9
Klumpp, K.10
Smith, D.11
Symons, J.12
Cammack, N.13
Najera, I.14
-
43
-
-
84861109960
-
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus
-
A.M. Lam, C. Espiritu, S. Bansal, H.M. Micolochick Steuer, C. Niu, V. Zennou, M. Keilman, Y. Zhu, S. Lan, M.J. Otto, and P.A. Furman Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus Antimicrob Agents Chemother 56 2012 3359 3368
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 3359-3368
-
-
Lam, A.M.1
Espiritu, C.2
Bansal, S.3
Micolochick Steuer, H.M.4
Niu, C.5
Zennou, V.6
Keilman, M.7
Zhu, Y.8
Lan, S.9
Otto, M.J.10
Furman, P.A.11
-
44
-
-
57049112290
-
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
-
S. Ali, V. Leveque, and S. Le Pogam Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479 Antimicrob Agents Chemother 52 2008 4356 4369
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 4356-4369
-
-
Ali, S.1
Leveque, V.2
Le Pogam, S.3
-
45
-
-
1542677267
-
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro
-
G. Migliaccio, J.E. Tomassini, and S.S. Carroll Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro J Biol Chem 278 2003 49164 49170
-
(2003)
J Biol Chem
, vol.278
, pp. 49164-49170
-
-
Migliaccio, G.1
Tomassini, J.E.2
Carroll, S.S.3
-
46
-
-
84879211393
-
A randomized trial of mericitabine plus peginterferon alfa-2a/ribavirin therapy in treatment-naive HCV Genotype 1/4 patients
-
10.1002/hep.26274 Jan 24 [Epub ahead of print]
-
H. Wedemeyer, D. Jensen, R. Herring Jr., P. Ferenci, M.M. Ma, S. Zeuzem, M. Rodriguez-Torres, N. Bzowej, P. Pockros, and J. Vierling A randomized trial of mericitabine plus peginterferon alfa-2a/ribavirin therapy in treatment-naive HCV Genotype 1/4 patients Hepatology 2013 10.1002/hep.26274 Jan 24 [Epub ahead of print]
-
(2013)
Hepatology
-
-
Wedemeyer, H.1
Jensen, D.2
Herring, Jr.R.3
Ferenci, P.4
Ma, M.M.5
Zeuzem, S.6
Rodriguez-Torres, M.7
Bzowej, N.8
Pockros, P.9
Vierling, J.10
-
47
-
-
78349268362
-
RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients
-
S. Le Pogam, A. Seshaadri, A. Ewing, H. Kang, A. Kosaka, J.M. Yan, M. Berrey, B. Symonds, A. De La Rosa, N. Cammack, and I. Nájera RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients J Infect Dis 202 2010 1510 1519
-
(2010)
J Infect Dis
, vol.202
, pp. 1510-1519
-
-
Le Pogam, S.1
Seshaadri, A.2
Ewing, A.3
Kang, H.4
Kosaka, A.5
Yan, J.M.6
Berrey, M.7
Symonds, B.8
De La Rosa, A.9
Cammack, N.10
Nájera, I.11
-
48
-
-
84877739274
-
Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options
-
I.M. Jacobson, S.C. Gordon, K.V. Kowdley, E.M. Yoshida, M. Rodriguez-Torres, M.S. Sulkowski, M.L. Shiffman, E. Lawitz, G. Everson, and M. Bennett Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options N Engl J Med 368 2013 1867 1877
-
(2013)
N Engl J Med
, vol.368
, pp. 1867-1877
-
-
Jacobson, I.M.1
Gordon, S.C.2
Kowdley, K.V.3
Yoshida, E.M.4
Rodriguez-Torres, M.5
Sulkowski, M.S.6
Shiffman, M.L.7
Lawitz, E.8
Everson, G.9
Bennett, M.10
-
49
-
-
79952290371
-
Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: Recommendations from the HCV DRAG
-
A.D. Kwong, I. Najera, J. Bechtel, S. Bowden, J. Fitzgibbon, P. Harrington, D. Kempf, T.L. Kieffer, D. Koletzki, and G. Kukolj Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: recommendations from the HCV DRAG Gastroenterology 140 2011 755 760
-
(2011)
Gastroenterology
, vol.140
, pp. 755-760
-
-
Kwong, A.D.1
Najera, I.2
Bechtel, J.3
Bowden, S.4
Fitzgibbon, J.5
Harrington, P.6
Kempf, D.7
Kieffer, T.L.8
Koletzki, D.9
Kukolj, G.10
|