Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in Vitro and in Vivo

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 11, 2013, Pages 5307-5314

  Da Silva, Cristiane França ^a   Da Gama Jaen Batista, Denise ^a   De Araújo, Julianna Siciliano ^a   Batista, Marcos Meuser ^a   Lionel, Jessica ^a   De Souza, Elen Mello ^a   Hammer, Erica Ripoll ^a   Da Silva, Patricia Bernardino ^a   De Mieri, Maria ^b   Adams, Michael ^b   Zimmermann, Stefanie ^b,c   Hamburger, Matthias ^b   Brun, Reto ^c   Schühly, Wolfgang ^d   De Nazaré Correia Soeiro, Maria ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b UNIVERSITY OF BASEL   (Switzerland)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; BENZNIDAZOLE; CYNAROPICRIN; PSILOSTACHYIN A; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL MEMBRANE; CELL VACUOLE; CHAGAS DISEASE; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; FEMALE; FUNGAL STRAIN; HISTOPATHOLOGY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM TOLERATED DOSE; MICROAUTOPHAGY; MORTALITY; MOUSE; MULTIVESICULAR BODY; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; AUTOPHAGY; CELL MEMBRANE; CHAGAS DISEASE; LACTONES; LIVER; MALE; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; NITROIMIDAZOLES; PARASITIC SENSITIVITY TESTS; SESQUITERPENES; SURVIVAL ANALYSIS; TREATMENT FAILURE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; VACUOLES;

EID: 84885937797     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00595-13     Document Type: Article

References (38)

1. Salomon CJ. 2011. First century of Chagas' disease: an overview on novel approaches to nifurtimox and benzonidazole delivery systems. J. Pharm. Sci. 101:888-894.
2. Díaz-Chiguer DL, Márquez-Navarro A, Nogueda-Torres B, de la Luz León-Ávila G, Pérez-Villanueva J, Hernández- Campos A, Castillo R, Ambrosio JR, Nieto-Meneses R, Yépez-Mulia L, Hernández-Luis F. 2012. In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi. Acta Trop. 122:108-112.
3. Rassi A, Jr, Rassi A, Marcondes de Rezende J. 2012. American trypanosomiasis (Chagas disease). Infect. Dis. Clin. N. Am. 26:275-291.
4. Soeiro MN, de Castro SL. 2009. Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opin. Ther. Targets 13:105-121.
5. Le Loup G, Pialoux G, Lescure FX. 2011. Update in treatment of Chagas disease. Curr. Opin. Infect. Dis. 24:428-434.
6. Newman DJ, Cragg GM. 2012. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 75:311-335.
7. Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, de Soeiro NCM, Steindel M, Tempone AG. 2012. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases. Part I. Curr. Med. Chem. 19:2128-2175.
8. Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, de Soeiro NCM, Steindel M, Tempone AG. 2012. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases. Part II. Curr. Med. Chem. 19:2176-2228.
9. Cho JY, Kim AR, Jung JH, Chun T, Rhee MH, Yoo ES. 2004. Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. Eur. J. Pharmacol. 492:85-94.
10. Otoguro K, Iwatsuki M, Ishiyama A, Namatame M, Nishihara-Tukashima A, Kiyohara H, Hashimoto T, Asakawa Y, Omura S, Yamada H. 2011. In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei. Phytochemistry 72:2024-2030.
11. Julianti T, Hata Y, Zimmermann S, Kaiser M, Hamburger M, Adams M. 2011. Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia 82:955-959.
12. Zimmermann S, Kaiser M, Brun R, Hamburger M, Adams M. 2012. Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei. Planta Med. 78:553-556.
13. Berger I, Passreiter CM, Cáceres A, Kubelka W. 2001. Antiprotozoal activity of Neurolaena lobata. Phytother. Res. 15:327-330.
14. Barrera PA, Jimenez-Ortiz V, Tonn C, Giordano O, Galanti N, Sosa MA. 2008. Natural sesquiterpene lactones are active against Leishmania mexicana. J. Parasitol. 94:1143-1149.
15. Tiuman TS, Ueda-Nakamura T, Garcia Cortez DA, Dias Filho BP, Morgado-Díaz JA, de Souza W, Nakamura CV. 2005. Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium. Antimicrob. Agents Chemother. 49:176-182.
16. Nour AM, Khalid SA, Kaiser M, Brun R, Abdallah WE, Schmidt TJ. 2009. The antiprotozoal activity of sixteen Asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum. Planta Med. 75:1363-1368.
17. Ganfon H, Bero J, Tchinda AT, Gbaguidi F, Gbenou J, Moudachirou M, Frédérich M, Quetin-Leclercq J. 2012. Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C. J. Ethnopharmacol. 141:411-417.
18. Karioti A, Skaltsa H, Kaiser M, Tasdemir D. 2009. Trypanocidal, leishmanicidal and cytotoxic effects of anthecotulide-type linear sesquiterpene lactones from Anthemis auriculata. Phytomedicine 16:783-787.
19. Brengio SD, Belmonte SA, Guerreiro E, Giordano OS, Pietrobon EO, Sosa MA. 2000. The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi. J. Parasitol. 86:407-412.
20. Jimenez-Ortiz V, Brengio SD, Giordano O, Tonn C, Sánchez M, Burgos MH, Sosa MA. 2005. The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes. J. Parasitol. 91:170-174.
21. Sülsen VP, Frank FM, Cazorla SI, Anesini CA, Malchiodi EL, Freixa B, Vila R, Muschietti LV, Martino VS. 2008. Trypanocidal and leishmanicidal activities of sesquiterpene lactones from Ambrosia tenuifolia Sprengel (Asteraceae). Antimicrob. Agents Chemother. 52:2415-2419.
22. Batista DG, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro MN. 2010. Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment. Antimicrob. Agents Chemother. 54:2940-2952.
23. Zimmermann S, Thomi S, Kaiser M, Hamburger M, Adams M. 2012. Antiprotozoal screening and HPLC based activity profiling for leads from European plants. Sci. Pharm. 80:205-213.
24. Ha TJ, Jang DS, Lee JK, Lee KD, Lee J, Hwang SW. 2003. Cytotoxic effects of sesquiterpene lactones from flowers of Hemisteptia lyrata B. Arch. Pharm. Res. 26:925-928.
25. Werner H, Raulais D, Anderson GD. 1973. Sesquiterpene lactones from Ambrosia cordifolia. Phytochemistry 12:1415-1420.
26. Borges-del-Castillo J, Manresa-Ferrero MT, Rodríguez-Luis F, Vázquez-Bueno P, Joseph-Nathan P. 1981. 13C NMR study of psilostachyinolides from some Ambrosia species. Org. Magn. Res. 17:232-234.
27. Meirelles MN, Araujo-Jorge TC, Miranda CF, De Souza W, Barbosa HS. 1986. Interaction of Trypanosoma cruzi with heart muscle cells: ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro. Eur. J. Cell Biol. 41:198-206.
28. Da Silva CF, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Som P, Boykin DW, Soeiro MN. 2011. In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi. J. Antimicrob. Chemother. 66:1295-1297.
29. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
30. Silva CF, Batista MM, Mota RA, de Souza EM, Stephens CE, Som P, Boykin DW, Soeiro MN. 2007. Activity of "reversed" diamidines against Trypanosoma cruzi in vitro. Biochem. Pharmacol. 73:1939-1946.
31. da Silva CF, Batista MM, Batista Dda de Souza GEM, da Silva PB, de Oliveira GM, Meuser AS, Shareef AR, Boykin DW, Soeiro MN. 2008. In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi. Antimicrob. Agents Chemother. 52:3307-3314.
32. da Silva CF, Batista DG, Oliveira GM, de Souza EM, Hammer ER, da Silva PB, Daliry A, Araujo JS, Britto C, Rodrigues AC, Liu Z, Farahat AA, Kumar A, Boykin DW, Soeiro MN. 2012. In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form -DB1965 -against Trypanosoma cruzi infection. PLoS One 7:e30356. doi:10.1371/journal.pone.0030356.
33. de Souza EM, Oliveira GM, Boykin DW, Kumar A, Hu Q, De Nazaré Soeiro CM. 2006. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. J. Antimicrob. Chemother. 58:610-614.
34. Romanha AJ, Castro SL, Soeiro MN, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade ZA. 2010. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem. Inst. Oswaldo Cruz 105:233-238.
35. Veiga-Santos P, Desoti VC, Miranda N, Ueda-Nakamura T, Dias-Filho BP, Silva SO, Cortez DA, de Mello JC, Nakamura CV. 2013. The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi. Acta Trop. 125:349-356.
36. Fernandes MC, Da Silva EN, Pinto AV, De Castro SL, Menna-Barreto RF. 2012. A novel triazolic naphthofuranquinone induces autophagy in reservosomes and impairment of mitosis in Trypanosoma cruzi. Parasitology 139:26-36.
37. Soeiro MNC, Daliry A, Silva CF, de Souza M, Oliveira E, GG, Salomão K, Menna Barreto R, Castro SL. 2010. Electron microscopy approaches for the investigation of the cellular targets of trypanocidal agents in Trypanosoma cruzi, p 191-203. In Méndez-Vilas A, Díaz J (ed), Microscopy: science, technology, applications and education, vol 1. Formatex Research Center, Badajoz, Spain.
38. Nibret E, Youns M, Krauth-Siegel RL, Wink M. 2011. Biological activities of xanthatin from Xanthium strumarium leaves. Phytother. Res. 25: 1883-1890.