In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi

Acta Tropica

Volumn 122, Issue 1, 2012, Pages 108-112

  Díaz Chiguer, Dylan L ^a   Márquez Navarro, Adrián ^a   Nogueda Torres, Benjamín ^a   de la Luz León ávila, Gloria ^a   Pérez Villanueva, Jaime ^b   Hernández Campos, Alicia ^b   Castillo, Rafael ^b   Ambrosio, Javier R ^c   Nieto Meneses, Rocío ^a   Yépez Mulia, Lilián ^d   Hernández Luis, Francisco ^b  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Benzimidazole derivative; Chagas's disease; Trypanosoma cruzi

Indexed keywords

5 CHLORO 1 METHYL 1H BENZIMIDAZOLE 2 THIOL; 5 CHLORO 1H BENZIMIDAZOLE 2 THIOL; 6 CHLORO 1 METHYL 1H BENZIMIDAZOLE 2 THIOL; ANTHELMINTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BENZNIDAZOLE; NIFURTIMOX; UNCLASSIFIED DRUG;

BIOASSAY; BLOOD; CHAGAS DISEASE; CONCENTRATION (COMPOSITION); DRUG; ENZYME ACTIVITY; PARASITE; TOXICITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; ASSAY; CHAGAS DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LC 50; LYSIS; MOUSE; NONHUMAN; PARASITEMIA; SINGLE DRUG DOSE; STRAIN DIFFERENCE; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; VERO CELL;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; PARASITEMIA; PARASITIC SENSITIVITY TESTS; TREATMENT OUTCOME; TRYPANOSOMA CRUZI; VERO CELLS;

MURINAE; TRYPANOSOMA CRUZI;

EID: 84857115113     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2011.12.009     Document Type: Article

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