G Protein-Coupled Receptor Transactivation. From Molecules to Mice

Methods in Cell Biology

Volumn 117, Issue , 2013, Pages 433-450

  Jonas, Kim C ^a   Rivero Müller, Adolfo ^b   Huhtaniemi, Ilpo T ^a,b   Hanyaloglu, Aylin C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

BAC; Dimer; Gonadotropin; GPCR; Luteinizing hormone; Mouse model; Reproduction; Signaling; Transactivation

Indexed keywords

BAC; DIMER; G PROTEIN COUPLED RECEPTOR; GONADOTROPIN; ISOPROTEIN; LUCIFERASE; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR;

ANIMAL; ANIMAL EMBRYO; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CHEMISTRY; CYTOLOGY; FEMALE; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; MALE; METABOLISM; MOUSE; MOUSE MODEL; MUTATION; PRENATAL DEVELOPMENT; PROTEIN BINDING; PROTEIN MULTIMERIZATION; REPORTER GENE; REPRODUCTION; SIGNAL TRANSDUCTION; SIGNALING; TESTIS; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

BAC; DIMER; GONADOTROPIN; GPCR; LUTEINIZING HORMONE; MOUSE MODEL; REPRODUCTION; SIGNALING; TRANSACTIVATION;

ANIMALS; CHROMOSOMES, ARTIFICIAL, BACTERIAL; EMBRYO, MAMMALIAN; FEMALE; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE; GENES, REPORTER; HEK293 CELLS; HUMANS; LUCIFERASES; MALE; MICE; MICE, TRANSGENIC; MUTATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; RECEPTORS, LH; SIGNAL TRANSDUCTION; TESTIS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 84885922450     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-408143-7.00023-2     Document Type: Chapter

References (30)

1. Chabre M., le Maire M. Monomeric G-protein-coupled receptor as a functional unit. Biochemistry 2005, 44:9395-9403.
2. Fotiadis D., Jastrzebska B., Philippsen A., Müller D.J., Palczewski K., Engel A. Structure of the rhodopsin dimer: A working model for G-protein-coupled receptors. Current Opinion in Structural Biology 2006, 16:252-259.
3. Guan R., Wu X., Feng X., Zhang M., Hébert T.E., Segaloff D.L. Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors. Cellular Signalling 2010, 22(2):247-256.
4. Han Y., Moreira I.S., Urizar E., Weinstein H., Javitch J.A. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nature Chemical Biology 2009, 5(9):688-695.
5. Huhtaniemi I., Alevizaki M. Mutations along the hypothalamic-pituitary-gonadal axis affecting male reproduction. Reproductive Biomedicine Online 2007, 15(6):622-632.
6. Huhtaniemi I.T., Themmen A.P.N. Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocrine Reviews 2000, 21:551-583.
7. Ji I., Lee C., Jeoung M., Koo Y., Sievert G.A., Ji T.H. Trans-activation of mutant follicle-stimulating hormone receptors selectively generates only one of two hormone signals. Molecular Endocrinology 2004, 18(4):968-978.
8. Ji I., Lee C., Song Y., Conn P.M., Ji T.H. Cis- and trans-activation of hormone receptors: The LH receptor. Molecular Endocrinology 2002, 16(6):1299-1308.
9. Kaupmann K., Malitschek B., Schuler V., Heid J., Froestl W., Beck P. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 1998, 396:683-687.
10. Lee C., Ji I.J., Ji T.H. Use of defined-function mutants to access receptor-receptor interactions. Methods 2002, 27(4):318-323.
11. Lee C., Ji I., Ryu K., Song Y., Conn P.M., Ji T.H. Two defective heterozygous luteinizing hormone receptors can rescue hormone action. Journal of Biological Chemistry 2002, 277(18):15795-15800.
12. Limonta P., Montagnani Marelli M., Mai S., Motta M., Martini L., Moretti R.M. GnRH receptors in cancer: From cell biology to novel targeted therapeutic strategies. Endocrine Reviews 2012, 33(5):784-811.
13. Lohse M.J. Dimerization in GPCR mobility and signaling. Current Opinion in Pharmacology 2010, 10(1):53-58.
14. Menon K.M., Menon B. Structure, function and regulation of gonadotropin receptors - A perspective. Molecular and Cellular Endocrinology 2012, 356(1-2):88-97.
15. Milligan G. The prevalence, maintenance and relevance of GPCR oligomerization. Molecular Pharmacology 2013, 84(1):158-169.
16. Monnier C., Tu H., Bourrier E., Vol C., Lamarque L., Trinquet E., et al. Trans-activation between 7TM domains: Implication in heterodimeric GABAB receptor activation. EMBO Journal 2011, 30(1):32-42.
17. Narayanan K., Chen Q. Bacterial artificial chromosome mutagenesis using recombineering. Journal of Biomedicine and Biotechnology 2011, 2011:971296.
18. Osuga Y., Hayashi M., Kudo M., Conti M., Kobilka B., Hsueh A.J. Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. Journal of Biological Chemistry 1997, 272(40):25006-25012.
19. Osuga Y., Kudo M., Kaipia A., Kobilka B., Hsueh A.J. Derivation of functional antagonists using N-terminal extracellular domain of gonadotropin and thyrotropin receptors. Molecular Endocrinology 1997, 11:1659-1668.
20. Pascal G., Milligan G. Functional complementation and the analysis of opioid receptor homodimerization. Molecular Pharmacology 2005, 68(3):905-915.
21. Pin J.P., Kniazeff J., Goudet C., Bessis A.S., Liu J., Galvez T., et al. The activation mechanism of class-C G-protein coupled receptors. Biology of the Cell 2004, 96:335-342.
22. Rivero-Müller A., Chou Y.Y., Ji I., Lajic S., Hanyaloglu A.C., Jonas K., et al. Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(5):2319-2324.
23. Rivero-Müller A., Lajic S., Huhtaniemi I. Assisted large fragment insertion by Red/ET-recombination (ALFIRE)-An alternative and enhanced method for large fragment recombineering. Nucleic Acids Research 2007, 35(10):e78.
24. Sangkuhl K., Schulz A., Schultz G., Schöneberg T. Structural requirements for mutational lutropin/choriogonadotropin receptor activation. Journal of Biological Chemistry 2002, 277:47748-47755.
25. Shizuya H., Birren B., Kim U.J., Mancino V., Slepak T., Tachiiri Y., et al. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proceedings of the National Academy of Sciences of the United States of America 1992, 89(18):8794-8797.
26. Smith N.J., Bennett K.A., Milligan G. When simple agonism is not enough: Emerging modalities of GPCR ligands. Molecular and Cellular Endocrinology 2011, 331(2):241-247.
27. Song G.J., Jones B.W., Hinkle P.M. Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(46):18303-18308.
28. Urizar E., Montanelli L., Loy T., Bonomi M., Swillens S., Gales C., et al. Glycoprotein hormone receptors: Link between receptor homodimerization and negative cooperativity. EMBO Journal 2005, 24(11):1954-1964.
29. Zhang M., Guan R., Segaloff D.L. Revisiting and questioning functional rescue between dimerized LH receptor mutants. Molecular Endocrinology 2012, 26(4):655-668.
30. Zhang F.P., Poutanen M., Wilbertz J., Huhtaniemi I. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Molecular Endocrinology 2001, 15:172-183.