The natural history of IgE-mediated food allergy: Can skin prick tests and serum-specific IgE predict the resolution of food allergy?

International Journal of Environmental Research and Public Health

Volumn 10, Issue 10, 2013, Pages 5039-5061

  Peters, Rachel L ^a,b   Gurrin, Lyle C ^a,b   Dharmage, Shyamali C ^a,b   Koplin, Jennifer J ^a,b   Allen, Katrina J ^a,b,c  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Cow's milk; Food allergy; Hen's egg; Natural history; Peanut; Serum specific immunoglobulin E; Skin prick test; Tolerance

Indexed keywords

IMMUNOGLOBULIN E;

ALLERGY; CHILD; FOOD; LEGUME; MILK; TOLERANCE;

DISEASE COURSE; EGG ALLERGY; FOLLOW UP; GOLD STANDARD; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MILK ALLERGY; ORAL FOOD CHALLENGE; PEANUT ALLERGY; PREDICTIVE VALUE; PRICK TEST; REVIEW; SENSITIVITY AND SPECIFICITY;

ARACHIS HYPOGAEA; SIGE;

FOOD HYPERSENSITIVITY; HUMANS; IMMUNOGLOBULIN E; PREDICTIVE VALUE OF TESTS; SKIN TESTS;

EID: 84885912265     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph10105039     Document Type: Review

References (69)

1. Burr, M.L.; Merrett, T.G.; Dunstan, F.D.; Maguire, M.J. The development of allergy in high-risk children. Clin. Exp. Allergy 1997, 27, 1247-1253.
2. Liu, A.H.; Jaramillo, R.; Sicherer, S.H.; Wood, R.A.; Bock, S.A.; Burks, A.W.; Massing, M.; Cohn, R.D.; Zeldin, D.C. National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006. J. Allergy Clin. Immunol. 2010, 126, 798-806.
3. Rhodes, H.L.; Sporik, R.; Thomas, P.; Holgate, S.T.; Cogswell, J.J. Early life risk factors for adult asthma: A birth cohort study of subjects at risk. J. Allergy Clin. Immunol. 2001, 108, 720-725.
4. Tariq, S.M.; Matthews, S.M.; Hakim, E.A.; Arshad, S.H. Egg allergy in infancy predicts respiratory allergic disease by 4 years of age. Pediatr. Allergy Immunol. 2000, 11, 162-167.
5. Du Toit, G.; Santos, A.; Roberts, G.; Fox, A.T.; Smith, P.; Lack, G. The diagnosis of IgE-mediated food allergy in childhood. Pediatr. Allergy Immunol. 2009, 20, 309-319.
6. Sicherer, S.H. Epidemiology of food allergy. J. Allergy Clin. Immunol. 2011, 127, 594-602.
7. Chafen, J.J.; Newberry, S.J.; Riedl, M.A.; Bravata, D.M.; Maglione, M.; Suttorp, M.J.; Sundaram, V.; Paige, N.M.; Towfigh, A.; Hulley, B.J.; et al. Diagnosing and managing common food allergies: A systematic review. J. Am. Med. Assoc. 2010, 303, 1848-1856.
8. Osborne, N.J.; Koplin, J.J.; Martin, P.E.; Gurrin, L.C.; Lowe, A.J.; Matheson, M.C.; Ponsonby, A.L.; Wake, M.; Tang, M.L.; Dharmage, S.C.; et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J. Allergy Clin. Immunol. 2011, 127, 668-676.
9. Skolnick, H.S.; Conover-Walker, M.K.; Koerner, C.B.; Sampson, H.A.; Burks, W.; Wood, R.A. The natural history of peanut allergy. J. Allergy Clin. Immunol. 2001, 107, 367-374.
10. Ho, M.H.; Wong, W.H.; Heine, R.G.; Hosking, C.S.; Hill, D.J.; Allen, K.J. Early clinical predictors of remission of peanut allergy in children. J. Allergy Clin. Immunol. 2008, 121, 731-736.
11. Vander Leek, T.K.; Liu, A.H.; Stefanski, K.; Blacker, B.; Bock, S.A. The natural history of peanut allergy in young children and its association with serum peanut-specific IgE. J. Pediatr. 2000, 137, 749-755.
12. Sampson, H.A.; Scanlon, S.M. Natural history of food hypersensitivity in children with atopic dermatitis. J. Pediatr. 1989, 115, 23-27.
13. Fleischer, D.M.; Conover-Walker, M.K.; Christie, L.; Burks, A.W.; Wood, R.A. The natural progression of peanut allergy: Resolution and the possibility of recurrence. J. Allergy Clin. Immunol. 2003, 112, 183-189.
14. Perry, T.T.; Matsui, E.C.; Kay Conover-Walker, M.; Wood, R.A. The relationship of allergen-specific IgE levels and oral food challenge outcome. J. Allergy Clin. Immunol. 2004, 114, 144-149.
15. Nolan, R.C.; Richmond, P.; Prescott, S.L.; Mallon, D.F.; Gong, G.; Franzmann, A.M.; Naidoo, R.; Loh, R.K. Skin prick testing predicts peanut challenge outcome in previously allergic or sensitized children with low serum peanut-specific IgE antibody concentration. Pediatr. Allergy Immunol. 2007, 18, 224-230.
16. Martorell, A.; Garcia Ara, M.C.; Plaza, A.M.; Bone, J.; Nevot, S.; Echeverria, L.; Alonso, E.; Garde, J. The predictive value of specific immunoglobulin E levels in serum for the outcome of the development of tolerance in cow's milk allergy. Allergol. Immunopathol. (Madr.) 2008, 36, 325-330.
17. Saarinen, K.M.; Pelkonen, A.S.; Makela, M.J.; Savilahti, E. Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. J. Allergy Clin. Immunol. 2005, 116, 869-875.
18. Host, A.; Halken, S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990, 45, 587-596.
19. Boyano, M.T.; Martin Esteban, M.; Pascual, C.; Ojeda, J.A. Food allergy in children. II. Prognostic factors and long-term development. An. Esp. Pediatr. 1987, 26, 241-245.
20. Dieguez, M.C.; Cerecedo, I.; Muriel, A.; Zamora, J.; Abraira, V.; Camacho, E.; Antón, M.; de la Hoz, B. Utility of diagnostic tests in the follow-up of egg-allergic children. Clin. Exp. Allergy 2009, 39, 1575-1584.
21. Venter, C.; Pereira, B.; Voigt, K.; Grundy, J.; Clayton, C.B.; Higgins, B.; Arshad, S.H.; Dean, T. Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life. Allergy 2008, 63, 354-359.
22. Savage, J.H.; Matsui, E.C.; Skripak, J.M.; Wood, R.A. The natural history of egg allergy. J. Allergy Clin. Immunol. 2007, 120, 1413-1417.
23. Skripak, J.M.; Matsui, E.C.; Mudd, K.; Wood, R.A. The natural history of IgE-mediated cow's milk allergy. J. Allergy Clin. Immunol. 2007, 120, 1172-1177.
24. Boyano Martinez, T.; Garcia-Ara, C.; Diaz-Pena, J.M.; Munoz, F.M.; Garcia Sanchez, G.; Esteban, M.M. Validity of specific IgE antibodies in children with egg allergy. Clin. Exp. Allergy 2001, 31, 1464-1469.
25. Celik-Bilgil, S.; Mehl, A.; Verstege, A.; Staden, U.; Nocon, M.; Beyer, K.; Niggemann, B. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin. Exp. Allergy 2005, 35, 268-273.
26. Monti, G.; Muratore, M.C.; Peltran, A.; Bonfante, G.; Silvestro, L.; Oggero, R.; Mussa, G.C. High incidence of adverse reactions to egg challenge on first known exposure in young atopic dermatitis children: Predictive value of skin prick test and radioallergosorbent test to egg proteins. Clin. Exp. Allergy 2002, 32, 1515-1519.
27. Roberts, G.; Lack, G. Diagnosing peanut allergy with skin prick and specific IgE testing. J. Allergy Clin. Immunol. 2005, 115, 1291-1296.
28. Sampson, H.A.; Ho, D.G. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J. Allergy Clin. Immunol. 1997, 100, 444-451.
29. Sporik, R.; Hill, D.J.; Hosking, C.S. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin. Exp. Allergy 2000, 30, 1540-1546.
30. Verstege, A.; Mehl, A.; Rolinck-Werninghaus, C.; Staden, U.; Nocon, M.; Beyer, K.; Niggemann, B. The predictive value of the skin prick test weal size for the outcome of oral food challenges. Clin. Exp. Allergy 2005, 35, 1220-1226.
31. Peters, R.L.; Gurrin, L.C.; Allen, K.J. The predictive value of skin prick testing for challengeproven food allergy: A systematic review. Pediatr. Allergy Immunol. 2012, 23, 347-352.
32. Clark, A.; Islam, S.; King, Y.; Deighton, J.; Szun, S.; Anagnostou, K.; Ewan, P. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin. Exp. Allergy 2011, 41, 706-712.
33. Shek, L.P.; Soderstrom, L.; Ahlstedt, S.; Beyer, K.; Sampson, H.A. Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. J. Allergy Clin. Immunol. 2004, 114, 387-391.
34. Komata, T.; Soderstrom, L.; Borres, M.P.; Tachimoto, H.; Ebisawa, M. The predictive relationship of food-specific serum IgE concentrations to challenge outcomes for egg and milk varies by patient age. J. Allergy Clin. Immunol. 2007, 119, 1272-1274.
35. Roberts, G.; Lack, G. Food allergy-Getting more out of your skin prick tests. Clin. Exp. Allergy 2000, 30, 1495-1498.
36. Suh, J.; Lee, H.; Lee, J.H.; Cho, J.; Yu, J.S.; Kim, J.; Han, Y.; Ahn, K.; Lee, S.I. Natural course of cow's milk allergy in children with atopic dermatitis. J. Korean Med. Sci. 2011, 26, 1152-1158.
37. Wood, R.A.; Sicherer, S.H.; Vickery, B.P.; Jones, S.M.; Liu, A.H.; Fleischer, D.M.; Henning, A.K.; Mayer, L.; Burks, A.W.; Grishin, A.; et al. The natural history of milk allergy in an observational cohort. J. Allergy Clin. Immunol. 2013, 131, 805-812.
38. Spergel, J.M. Natural history of cow's milk allergy. J. Allergy Clin. Immunol. 2013, 131, 813-814.
39. Mudd, K.; Paterakis, M.; Curtin-Brosnan, J.; Matsui, E.; Wood, R. Predicting outcome of repeat milk, egg, or peanut oral food challenges. J. Allergy Clin. Immunol. 2009, 124, 1115-1116.
40. Hourihane. J.O.; Roberts, S.A.; Warner, J.O. Resolution of peanut allergy: Case-control study. BMJ 1998, 316, 1271-1275.
41. Kim, J.; Chung, Y.; Han, Y.; Ahn, K.; Lee, S.-I. The natural history and prognostic factors of egg allergy in Korean infants with atopic dermatitis. Asian Pac. J. Allergy Immunol. 2009, 27, 107-114.
42. James, J.M.; Sampson, H.A. Immunologic changes associated with the development of tolerance in children with cow milk allergy. J. Pediatr. 1992, 121, 371-377.
43. Crespo, J.F.; Pascual, C.; Ferrer, A.; Burks, A.W.; Diaz Pena, J.M.; Martin Esteban, M. Egg white-specific IgE level as a tolerance marker in the follow up of egg allergy. Allergy Proc. 1994, 15, 73-76.
44. Garcia-Ara, M.C.; Boyano-Martinez, M.T.; Diaz-Pena, J.M.; Martin-Munoz, M.F.; Martin-Esteban, M. Cow's milk-specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow's milk allergy infants. Clin. Exp. Allergy 2004, 34, 866-870.
45. Hill, D.J.; Firer, M.A.; Ball, G.; Hosking, C.S. Natural history of cows' milk allergy in children: Immunological outcome over 2 years. Clin Exp Allergy 1993, 23, 124-131.
46. Savilahti, E.M.; Saarinen, K, M.; Savilahti, E. Duration of clinical reactivity in cow's milk allergy is associated with levels of specific immunoglobulin G4 and immunoglobulin A antibodies to beta-lactoglobulin. Clin. Exp. Allergy 2010, 40, 251-256.
47. Ford, R.P.; Taylor, B. Natural history of egg hypersensitivity. Arch. Dis. Child. 1982, 57, 649-652.
48. Montesinos, E.; Martorell, A.; Felix, R.; Cerda, J.C. Egg white specific IgE levels in serum as clinical reactivity predictors in the course of egg allergy follow-up. Pediatr. Allergy Immunol. 2010, 21, 634-639.
49. Boyano-Martinez, T.; Garcia-Ara, C.; Diaz-Pena, J.M.; Martin-Esteban, M. Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. J. Allergy Clin. Immunol. 2002, 110, 304-309.
50. Konstantinou, G.N.; Giavi, S.; Kalobatsou, A.; Vassilopoulou, E.; Douladiris, N.; Saxoni-Papageorgiou, P.; Papadopoulos, N.G. Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: Hypothesis-generating observations. J. Allergy Clin. Immunol. 2008, 122, 414-415.
51. Lemon-Mule, H.; Sampson, H.A.; Sicherer, S.H.; Shreffler, W.G.; Noone, S.; Nowak-Wegrzyn, A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J. Allergy Clin. Immunol. 2008, 122, 977-983.
52. Leonard, S.A.; Sampson, H.A.; Sicherer, S.H.; Noone, S.; Moshier, E. L; Godbold, J.; Nowak-We{ogonek}grzyn, A. Dietary baked egg accelerates resolution of egg allergy in children. J. Allergy Clin. Immunol. 2012, 130, 473-480.
53. Yavuz, S.T.; Buyuktiryaki, B.; Sahiner, U.M.; Birben, E.; Tuncer, A.; Yakarisik, S.; Karabulut, E.; Kalayci, O.; Sackesen, C. Factors that predict the clinical reactivity and tolerance in children with cow's milk allergy. Ann. Allergy Asthma Immunol. 2013, 110, 284-289.
54. Santos, A.; Dias, A.; Pinheiro, J.A. Predictive factors for the persistence of cow's milk allergy. Pediatr. Allergy Immunol. 2010, 21, 1127-1134.
55. DunnGalvin, A.; Daly, D.; Cullinane, C.; Stenke, E.; Keeton, D.; Erlewyn-Lajeunesse, M.; Roberts, G.C.; Lucas, J.; Hourihane, J.O. Highly accurate prediction of food challenge outcome using routinely available clinical data. J. Allergy Clin. Immunol. 2011, 127, 633-639.
56. Varshney, P.; Jones, S.M.; Scurlock, A.M.; Perry, T.T.; Kemper, A.; Steele, P.; Hiegel, A.; Kamilaris, J.; Carlisle, S.; Yue, X.; et al. A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response. J. Allergy Clin. Immunol. 2011, 127, 654-660.
57. Kim, E.H.; Bird, J.A.; Kulis, M.; Laubach, S.; Pons, L.; Shreffler, W.; Steele, P.; Kamilaris, J.; Vickery, B.; Burks, A.W. Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization. J. Allergy Clin. Immunol. 2011, 127, 640-646.
58. Osborne, N.J.; Koplin, J.J.; Martin, P.E.; Gurrin, L.C.; Thiele, L.; Tang, M.L.; Ponsonby, A.L.; Dharmage, S.C.; Allen, K.J.; HealthNuts Study Investigators. The HealthNuts population-based study of paediatric food allergy: Validity, safety and acceptability. Clin. Exp. Allergy 2010, 40, 1516-1522.
59. Kaczmarski, M.; Wasilewska, J.; Cudowska, B.; Semeniuk, J.; Klukowski, M.; Matuszewska, E. The natural history of cow's milk allergy in north-eastern Poland. Adv. Med. Sci. 2013, 58, 22-30.
60. Elizur, A.; Rajuan, N.; Goldberg, M.R.; Leshno, M.; Cohen, A.; Katz, Y. Natural course and risk factors for persistence of IgE-mediated cow's milk allergy. J. Pediatr. 2012, 161, 482-487. e1.
61. Dang, T.D. Characterization of plasma cytokines in an infant population cohort of challengeproven food allergy. Exp. Allergy Immunol. 2013, doi:10.1111/all.12215.
62. Dang, T.D.; Tang, M.; Choo, S.; Licciardi, P.V.; Koplin, J.J.; Martin, P.E.; Tan, T.; Gurrin, L.C.; Ponsonby, A.L.; Tey, D.; et al. Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. J. Allergy Clin. Immunol. 2012, 129, 1056-1063.
63. Ahrens, B.; Lopes de Oliveira, L.C.; Grabenhenrich, L.; Schulz, G.; Niggemann, B.; Wahn, U.; Beyer, K. Individual cow's milk allergens as prognostic markers for tolerance development? Clin. Exp. Allergy 2012, 42, 1630-1637.
64. Marriage, D.E.; Erlewyn-Lajeunesse, M.; Unsworth, D.J.; Henderson, A.J. Unscrambling egg allergy: The daignostic value of specific IgE concentrations and skin prick tests for ovomucoid and egg white in the management of chidlren with hen's egg allergy. Int. Sch. Res. Netw. 2012, doi:10.5402/2012/627545.
65. Jarvinen, K.M.; Beyer, K.; Vila, L.; Bardina, L.; Mishoe, M.; Sampson, H.A. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007, 62, 758-765.
66. Rubio, A.; Vivinus-Nebot, M.; Bourrier, T.; Saggio, B.; Albertini, M.; Bernard, A. Benefit of the basophil activiation test in deciding when to reintroduce cow's milk in allergic children. Allergy 2011, 66, 92-100.
67. Ford, L.S.; Bloom, K.A.; Nowak-Wegrzyn, A.H.; Shreffler, W.G.; Masilamani, M.; Sampson, H.A. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance. J. Allergy Clin. Immunol. 2013, 131, 180-186.
68. Ocmant, A.; Mulier, S.; Hanssens, L.; Goldman, M.; Casimer, G.; Mascart, F.; Schandené, L. Basophil activiation tests for the diagnosis of food allergy in children. Clin. Exp. Allergy 2009, 39, 1234-1245.
69. Tan, T.H.; Ellis, J.A.; Saffery, R.; Allen, K.J. The role of genetics and environment in the rise of childhood food allergy. Clin. Exp. Allergy 2012, 42, 20-29.