Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax

Oral Diseases

Volumn 19, Issue 8, 2013, Pages 767-774

  Yu, H J ^a   Shin, J A ^a   Nam, J S ^b   Kang, B S ^c   Cho, S D ^a  

^a Chonbuk National University   (South Korea)

^b Gachon University College of Medicine   (South Korea)

^c Kyungpook National University Hospital   (South Korea)

Author keywords

Apoptosis; Bax; Dibenzylideneacetone; Oral cancer; Specificity protein 1

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ANTINEOPLASTIC AGENT; DIBENZYLIDENEACETONE; MITHRAMYCIN; MITHRAMYCIN A; PROTEIN BAX; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; ALKANONE; DIBENZYLIDENE ACETONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL VIABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE TARGETING; HUMAN; HUMAN CELL; MOUTH CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING; DRUG EFFECTS; MOUTH TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DOWN-REGULATION; HUMANS; MOUTH NEOPLASMS; PENTANONES; SP1 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED;

EID: 84885902275     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/odi.12062     Document Type: Article

References (46)

1. Anand P, Sung B, Kunnumakkara AB, Rajasekharan KN, Aggarwal BB (2011). Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors. Biochem Pharmacol 82: 1901-1909.
2. Bai X, Deng H (2010). [Research progress on relationship between transcription factor Sp1 and tumor]. Zhejiang Da Xue Xue Bao Yi Xue Ban 39: 215-220.
3. Bhandarkar SS, Bromberg J, Carrillo C et al (2008). Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clin Cancer Res 14: 5743-5748.
4. Burlacu A (2003). Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 7: 249-257.
5. Chadalapaka G, Jutooru I, Chintharlapalli S et al (2008). Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 68: 5345-5354.
6. Chintharlapalli S, Papineni S, Ramaiah SK, Safe S (2007). Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res 67: 2816-2823.
7. Choi ES, Shim JH, Jung JY et al (2011). Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1. Cancer Sci 102: 742-748.
8. Chun JY, Hu Y, Pinder E et al (2007). Selenium inhibition of survivin expression by preventing Sp1 binding to its promoter. Mol Cancer Ther 6: 2572-2580.
9. Colon J, Basha MR, Madero-Visbal R et al (2011). Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs 29: 41-51.
10. Danial NN (2007). BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin Cancer Res 13: 7254-7263.
11. Dong L, Wang W, Wang F et al (1999). Mechanisms of transcriptional activation of bcl-2 gene expression by 17 beta-estradiol in breast cancer cells. J Biol Chem 274: 32099-32107.
12. Duan H, Heckman CA, Boxer LM (2005). Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol 25: 1608-1619.
13. Eslin D, Sankpal UT, Lee C et al (2011). Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: a novel therapeutic agent for neuroblastoma. Mol Carcinog.
14. Gross A, McDonnell JM, Korsmeyer SJ (1999). BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911.
15. Ho PS, Ko YC, Yang YH, Shieh TY, Tsai CC (2002). The incidence of oropharyngeal cancer in Taiwan: an endemic betel quid chewing area. J Oral Pathol Med 31: 213-219.
16. Igata E, Inoue T, Ohtani-Fujita N et al (1999). Molecular cloning and functional analysis of the murine bax gene promoter. Gene 238: 407-415.
17. Jemal A, Bray F, Center MM et al (2011). Global cancer statistics. CA Cancer J Clin 61: 69-90.
18. Jiang NY, Woda BA, Banner BF et al (2008). Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 17: 1648-1652.
19. Kavurma MM, Khachigian LM (2003). Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. J Biol Chem 278: 32537-32543.
20. Lee WT, Tubbs RR, Teker AM et al (2008). Use of in situ hybridization to detect human papillomavirus in head and neck squamous cell carcinoma patients without a history of alcohol or tobacco use. Arch Pathol Lab Med 132: 1653-1656.
21. Li L, Davie JR (2010). The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat 192: 275-283.
22. Maruccia M, Onesti MG, Parisi P et al (2012). Lip cancer: a 10-year retrospective epidemiological study. Anticancer Res 32: 1543-1546.
23. Mikhailov V, Mikhailova M, Pulkrabek DJ et al (2001). Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem 276: 18361-18374.
24. Pages G, Pouyssegur J (2005). Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors. Cardiovasc Res 65: 564-573.
25. Patel SG, DiMario JX (2001). Two distal Sp1-binding cis-elements regulate fibroblast growth factor receptor 1 (FGFR1) gene expression in myoblasts. Gene 270: 171-180.
26. Pietrzak M, Puzianowska-Kuznicka M (2008). p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter. Biol Chem 389: 383-393.
27. Prakobwong S, Gupta SC, Kim JH et al (2011a). Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Carcinogenesis 32: 1372-1380.
28. Prakobwong S, Khoontawad J, Yongvanit P et al (2011b). Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer 129: 88-100.
29. Prasad S, Yadav VR, Ravindran J, Aggarwal BB (2011). ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. Cancer Res 71: 538-549.
30. Safe S, Abdelrahim M (2005). Sp transcription factor family and its role in cancer. Eur J Cancer 41: 2438-2448.
31. Sankpal UT, Goodison S, Abdelrahim M, Basha R (2011). Targeting Sp1 transcription factors in prostate cancer therapy. Med Chem 7: 518-525.
32. Shi M, Cai Q, Yao L et al (2006). Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol Int 30: 221-226.
33. Shim JH, Shin JA, Jung JY et al (2011). Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1. Eur J Cancer Prev 20: 102-111.
34. Shin JA, Shim JH, Jeon JG et al (2011). Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1. Oral Dis 17: 162-170.
35. Shin JA, Kim JJ, Choi ES et al (2012). In vitro apoptotic effects of methanol extracts of Dianthus chinensis and Acalypha australis L. targeting specificity protein 1 in human oral cancer cells. Head Neck.
36. Suske G (1999). The Sp-family of transcription factors. Gene 238: 291-300.
37. Tan NY, Khachigian LM (2009). Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol 29: 2483-2488.
38. Ulrich E, Kauffmann-Zeh A, Hueber AO et al (1997). Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member. Genomics 44: 195-200.
39. Wang XB, Peng WQ, Yi ZJ, Zhu SL, Gan QH (2007). [Expression and prognostic value of transcriptional factor sp1 in breast cancer]. Ai Zheng 26: 996-1000.
40. Wang Y, Xiao J, Zhou H et al (2011). A novel monocarbonyl analogue of curcumin, (1E, 4E)-1, 5-bis(2, 3-dimethoxyphenyl)penta-1, 4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway. J Med Chem 54: 3768-3778.
41. Wei D, Wang L, He Y et al (2004). Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res 64: 2030-2038.
42. Wen CP, Tsai MK, Chung WS et al (2010). Cancer risks from betel quid chewing beyond oral cancer: a multiple-site carcinogen when acting with smoking. Cancer Causes Control 21: 1427-1435.
43. Xu R, Zhang P, Huang J et al (2007). Sp1 and Sp3 regulate basal transcription of the survivin gene. Biochem Biophys Res Commun 356: 286-292.
44. Yao JC, Wang L, Wei D et al (2004). Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. Clin Cancer Res 10: 4109-4117.
45. Zhang J, Zhu ZG, Ji J et al (2005). Transcription factor Sp1 expression in gastric cancer and its relationship to long-term prognosis. World J Gastroenterol 11: 2213-2217.
46. Zheng TZ, Boyle P, Hu HF et al (1990). Tobacco smoking, alcohol consumption, and risk of oral cancer: a case-control study in Beijing, People's Republic of China. Cancer Causes Control 1: 173-179.