-
1
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 2008;111:2516-20.
-
(2008)
Blood
, vol.111
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
-
2
-
-
0026774146
-
Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species
-
Tajima H, Matsumoto K, Nakamura T. Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species. Exp Cell Res 1992;202:423-31.
-
(1992)
Exp Cell Res
, vol.202
, pp. 423-431
-
-
Tajima, H.1
Matsumoto, K.2
Nakamura, T.3
-
3
-
-
0025805633
-
Identification of the hepatocyte growth factor receptor as the c-MET proto-oncogene product
-
Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA. Identification of the hepatocyte growth factor receptor as the c-MET proto-oncogene product. Science 1991;251:802-4.
-
(1991)
Science
, vol.251
, pp. 802-804
-
-
Bottaro, D.P.1
Rubin, J.S.2
Faletto, D.L.3
Chan, A.M.4
Kmiecik, T.E.5
Vande Woude, G.F.6
Aaronson, S.A.7
-
4
-
-
0028181118
-
Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)
-
Longati P, Bardelli A, Ponzetto C, Naldini L, Comoglio PM. Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene 1994;9:49-57.
-
(1994)
Oncogene
, vol.9
, pp. 49-57
-
-
Longati, P.1
Bardelli, A.2
Ponzetto, C.3
Naldini, L.4
Comoglio, P.M.5
-
5
-
-
0028351702
-
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
-
Ponzetto C, Bardelli A, Zhen Z, Maina F, dalla Zonca P, Giordano S, Graziani A, Panayotou G, Comoglio PM. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994;77:261-71.
-
(1994)
Cell
, vol.77
, pp. 261-271
-
-
Ponzetto, C.1
Bardelli, A.2
Zhen, Z.3
Maina, F.4
dalla Zonca, P.5
Giordano, S.6
Graziani, A.7
Panayotou, G.8
Comoglio, P.M.9
-
6
-
-
0035930341
-
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
-
Peschard P, Fournier TM, Lamorte L, Naujokas MA, Band H, Langdon WY, Park M. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell 2001;8:995-1004.
-
(2001)
Mol Cell
, vol.8
, pp. 995-1004
-
-
Peschard, P.1
Fournier, T.M.2
Lamorte, L.3
Naujokas, M.A.4
Band, H.5
Langdon, W.Y.6
Park, M.7
-
7
-
-
0345601083
-
Met, metastasis, motility and more
-
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003;4:915-25.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande Woude, G.F.4
-
8
-
-
0029825852
-
Hepatocyte growth factor and its receptor c-MET in multiple myeloma
-
Borset M, Hjorth-Hansen H, Seidel C, Sundan A, Waage A. Hepatocyte growth factor and its receptor c-MET in multiple myeloma. Blood 1996;88:3998-4004.
-
(1996)
Blood
, vol.88
, pp. 3998-4004
-
-
Borset, M.1
Hjorth-Hansen, H.2
Seidel, C.3
Sundan, A.4
Waage, A.5
-
9
-
-
0036493522
-
Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells
-
Zhan F, Hardin J, Kordsmeier B, et al. Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. Blood 2002;99:1745-57.
-
(2002)
Blood
, vol.99
, pp. 1745-1757
-
-
Zhan, F.1
Hardin, J.2
Kordsmeier, B.3
-
10
-
-
0032006829
-
Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group
-
Seidel C, Borset M, Turesson I, Abildgaard N, Sundan A, Waage A. Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group. Blood 1998;91:806-12.
-
(1998)
Blood
, vol.91
, pp. 806-812
-
-
Seidel, C.1
Borset, M.2
Turesson, I.3
Abildgaard, N.4
Sundan, A.5
Waage, A.6
-
11
-
-
33947605189
-
HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma
-
Standal T, Abildgaard N, Fagerli UM, Stordal B, Hjertner O, Borset M, Sundan A. HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. Blood 2007;109:3024-30.
-
(2007)
Blood
, vol.109
, pp. 3024-3030
-
-
Standal, T.1
Abildgaard, N.2
Fagerli, U.M.3
Stordal, B.4
Hjertner, O.5
Borset, M.6
Sundan, A.7
-
12
-
-
72149116701
-
The effect of timing in the administration of hepatocyte growth factor to modulate BMP-2-induced osteoblast differentiation
-
Kawasaki T, Niki Y, Miyamoto T, Horiuchi K, Matsumoto M, Aizawa M, Toyama Y. The effect of timing in the administration of hepatocyte growth factor to modulate BMP-2-induced osteoblast differentiation. Biomaterials 2010;31:1191-8.
-
(2010)
Biomaterials
, vol.31
, pp. 1191-1198
-
-
Kawasaki, T.1
Niki, Y.2
Miyamoto, T.3
Horiuchi, K.4
Matsumoto, M.5
Aizawa, M.6
Toyama, Y.7
-
15
-
-
84861733799
-
MET: a promising anticancer therapeutic target
-
Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol 2012;9:314-26.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 314-326
-
-
Peters, S.1
Adjei, A.A.2
-
16
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
Hamers-Casterman C, Atarhouch T, Muyldermans S, Robinson G, Hamers C, Songa EB, Bendahman N, Hamers R. Naturally occurring antibodies devoid of light chains. Nature 1993;363:446-8.
-
(1993)
Nature
, vol.363
, pp. 446-448
-
-
Hamers-Casterman, C.1
Atarhouch, T.2
Muyldermans, S.3
Robinson, G.4
Hamers, C.5
Songa, E.B.6
Bendahman, N.7
Hamers, R.8
-
17
-
-
0035312546
-
Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains
-
Muyldermans S, Cambillau C, Wyns L. Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains. Trends Biochem Sci 2001;26:230-5.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 230-235
-
-
Muyldermans, S.1
Cambillau, C.2
Wyns, L.3
-
19
-
-
84862742132
-
Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapy
-
Vosjan MJ, Vercammen J, Kolkman JA, Stigter-van Walsum M, Revets H, van Dongen GA. Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapy. Mol Cancer Ther 2012;11:1017-25.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1017-1025
-
-
Vosjan, M.J.1
Vercammen, J.2
Kolkman, J.A.3
Stigter-van Walsum, M.4
Revets, H.5
van Dongen, G.A.6
-
20
-
-
84855850311
-
Impact of albumin on drug delivery-new applications on the horizon
-
Elsadek B, Kratz F. Impact of albumin on drug delivery-new applications on the horizon. J Control Release 2012;157:4-28.
-
(2012)
J Control Release
, vol.157
, pp. 4-28
-
-
Elsadek, B.1
Kratz, F.2
-
21
-
-
84885915829
-
-
inventors; Biological materials related to c-MET. WO patent WO 2012/042026 A1.
-
Beste G, Denayer T, Hermans G, Szyroki A, Steffensen S, Ververken CJ, inventors; Biological materials related to c-MET. WO patent WO 2012/042026 A1. 2012.
-
(2012)
-
-
Beste, G.1
Denayer, T.2
Hermans, G.3
Szyroki, A.4
Steffensen, S.5
Ververken, C.J.6
-
22
-
-
84885913330
-
-
inventor; Novel antibodies inhibiting c-MET dimerization, and uses thereof. WO patent WO 2009/007427 A2.
-
Goetsch L, inventor; Novel antibodies inhibiting c-MET dimerization, and uses thereof. WO patent WO 2009/007427 A2. 2009.
-
(2009)
-
-
Goetsch, L.1
-
23
-
-
84885899938
-
-
inventors; Humanized Anti-CMET Antagonists. US patent US 2007/0092520 A1.
-
Dennis MS, Billeci K, Young J, Zheng Z, inventors; Humanized Anti-CMET Antagonists. US patent US 2007/0092520 A1. 2007.
-
(2007)
-
-
Dennis, M.S.1
Billeci, K.2
Young, J.3
Zheng, Z.4
-
24
-
-
10744228765
-
A selective small molecule inhibitor of c-MET kinase inhibits c-MET-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo
-
Christensen JG, Schreck R, Burrows J, et al. A selective small molecule inhibitor of c-MET kinase inhibits c-MET-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res 2003;63:7345-55.
-
(2003)
Cancer Res
, vol.63
, pp. 7345-7355
-
-
Christensen, J.G.1
Schreck, R.2
Burrows, J.3
-
25
-
-
84885898969
-
-
inventors; Biological materials related to c-MET. US patent US 2012/0244164 A1.
-
Beste G, Hermans G, Steffensen S, Szyroki A, Ververken CJ, Denayer T, inventors; Biological materials related to c-MET. US patent US 2012/0244164 A1. 2012.
-
(2012)
-
-
Beste, G.1
Hermans, G.2
Steffensen, S.3
Szyroki, A.4
Ververken, C.J.5
Denayer, T.6
-
26
-
-
5144226615
-
A selective c-MET inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
-
Hov H, Holt RU, Ro TB, Fagerli UM, Hjorth-Hansen H, Baykov V, Christensen JG, Waage A, Sundan A, Borset M. A selective c-MET inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells. Clin Cancer Res 2004;10:6686-94.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6686-6694
-
-
Hov, H.1
Holt, R.U.2
Ro, T.B.3
Fagerli, U.M.4
Hjorth-Hansen, H.5
Baykov, V.6
Christensen, J.G.7
Waage, A.8
Sundan, A.9
Borset, M.10
-
27
-
-
42149157176
-
Hepatocyte growth factor promotes migration of human myeloma cells
-
Holt RU, Fagerli UM, Baykov V, Ro TB, Hov H, Waage A, Sundan A, Borset M. Hepatocyte growth factor promotes migration of human myeloma cells. Haematologica 2008;93:619-22.
-
(2008)
Haematologica
, vol.93
, pp. 619-622
-
-
Holt, R.U.1
Fagerli, U.M.2
Baykov, V.3
Ro, T.B.4
Hov, H.5
Waage, A.6
Sundan, A.7
Borset, M.8
-
28
-
-
17844396927
-
Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor
-
Holt RU, Baykov V, Ro TB, Brabrand S, Waage A, Sundan A, Borset M. Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor. Haematologica 2005;90:479-88.
-
(2005)
Haematologica
, vol.90
, pp. 479-488
-
-
Holt, R.U.1
Baykov, V.2
Ro, T.B.3
Brabrand, S.4
Waage, A.5
Sundan, A.6
Borset, M.7
-
29
-
-
0030767656
-
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies
-
Arbabi Ghahroudi M, Desmyter A, Wyns L, Hamers R, Muyldermans S. Selection and identification of single domain antibody fragments from camel heavy-chain antibodies. FEBS Lett 1997;414:521-6.
-
(1997)
FEBS Lett
, vol.414
, pp. 521-526
-
-
Arbabi Ghahroudi, M.1
Desmyter, A.2
Wyns, L.3
Hamers, R.4
Muyldermans, S.5
-
30
-
-
33645241975
-
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
-
De Genst E, Silence K, Decanniere K, Conrath K, Loris R, Kinne J, Muyldermans S, Wyns L. Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc Natl Acad Sci U S A 2006;103:4586-91.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4586-4591
-
-
De Genst, E.1
Silence, K.2
Decanniere, K.3
Conrath, K.4
Loris, R.5
Kinne, J.6
Muyldermans, S.7
Wyns, L.8
-
31
-
-
0036182644
-
Single-domain antibody fragments with high conformational stability
-
Dumoulin M, Conrath K, Van Meirhaeghe A, Meersman F, Heremans K, Frenken LG, Muyldermans S, Wyns L, Matagne A. Single-domain antibody fragments with high conformational stability. Protein Sci 2002;11:500-15.
-
(2002)
Protein Sci
, vol.11
, pp. 500-515
-
-
Dumoulin, M.1
Conrath, K.2
Van Meirhaeghe, A.3
Meersman, F.4
Heremans, K.5
Frenken, L.G.6
Muyldermans, S.7
Wyns, L.8
Matagne, A.9
-
32
-
-
0142232284
-
The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
-
Joosten V, Lokman C, Van Den Hondel CA, Punt PJ. The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. Microb Cell Fact 2003;2:1.
-
(2003)
Microb Cell Fact
, vol.2
, pp. 1
-
-
Joosten, V.1
Lokman, C.2
Van Den Hondel, C.A.3
Punt, P.J.4
-
34
-
-
33845922737
-
Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies
-
Roovers RC, Laeremans T, Huang L, De Taeye S, Verkleij AJ, Revets H, de Haard HJ, van Bergen en Henegouwen PM. Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies. Cancer Immunol Immunother 2007;56:303-17.
-
(2007)
Cancer Immunol Immunother
, vol.56
, pp. 303-317
-
-
Roovers, R.C.1
Laeremans, T.2
Huang, L.3
De Taeye, S.4
Verkleij, A.J.5
Revets, H.6
de Haard, H.J.7
van Bergen en Henegouwen, P.M.8
-
35
-
-
9144220168
-
Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm
-
Stijlemans B, Conrath K, Cortez-Retamozo V, Van Xong H, Wyns L, Senter P, Revets H, De Baetselier P, Muyldermans S, Magez S. Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. J Biol Chem 2004;279:1256-61.
-
(2004)
J Biol Chem
, vol.279
, pp. 1256-1261
-
-
Stijlemans, B.1
Conrath, K.2
Cortez-Retamozo, V.3
Van Xong, H.4
Wyns, L.5
Senter, P.6
Revets, H.7
De Baetselier, P.8
Muyldermans, S.9
Magez, S.10
-
36
-
-
0032955291
-
Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies
-
van der Linden RH, Frenken LG, de Geus B, Harmsen MM, Ruuls RC, Stok W, de Ron L, Wilson S, Davis P, Verrips CT. Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies. Biochim Biophys Acta 1999;1431:37-46.
-
(1999)
Biochim Biophys Acta
, vol.1431
, pp. 37-46
-
-
van der Linden, R.H.1
Frenken, L.G.2
de Geus, B.3
Harmsen, M.M.4
Ruuls, R.C.5
Stok, W.6
de Ron, L.7
Wilson, S.8
Davis, P.9
Verrips, C.T.10
-
37
-
-
0037399323
-
The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
-
Derksen PW, de Gorter DJ, Meijer HP, Bende RJ, van Dijk M, Lokhorst HM, Bloem AC, Spaargaren M, Pals ST. The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma. Leukemia 2003;17:764-74.
-
(2003)
Leukemia
, vol.17
, pp. 764-774
-
-
Derksen, P.W.1
de Gorter, D.J.2
Meijer, H.P.3
Bende, R.J.4
van Dijk, M.5
Lokhorst, H.M.6
Bloem, A.C.7
Spaargaren, M.8
Pals, S.T.9
-
38
-
-
0028860240
-
Signal transduction by cell adhesion receptors in leukocytes
-
Rosales C, Juliano RL. Signal transduction by cell adhesion receptors in leukocytes. J Leukoc Biol 1995;57:189-98.
-
(1995)
J Leukoc Biol
, vol.57
, pp. 189-198
-
-
Rosales, C.1
Juliano, R.L.2
-
39
-
-
34547106018
-
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
-
Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007;7:585-98.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 585-598
-
-
Hideshima, T.1
Mitsiades, C.2
Tonon, G.3
Richardson, P.G.4
Anderson, K.C.5
-
40
-
-
0038528630
-
The tumor microenvironment: focus on myeloma
-
Dalton WS. The tumor microenvironment: focus on myeloma. Cancer Treat Rev 2003;29(Suppl 1):11-9.
-
(2003)
Cancer Treat Rev
, vol.29
, Issue.SUPPL. 1
, pp. 11-19
-
-
Dalton, W.S.1
-
42
-
-
0037381271
-
Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity
-
Alexandrakis MG, Passam FH, Sfiridaki A, Kandidaki E, Roussou P, Kyriakou DS. Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity. Am J Hematol 2003;72:229-33.
-
(2003)
Am J Hematol
, vol.72
, pp. 229-233
-
-
Alexandrakis, M.G.1
Passam, F.H.2
Sfiridaki, A.3
Kandidaki, E.4
Roussou, P.5
Kyriakou, D.S.6
-
43
-
-
0036122019
-
Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma
-
Iwasaki T, Hamano T, Ogata A, Hashimoto N, Kitano M, Kakishita E. Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma. Br J Haematol 2002;116:796-802.
-
(2002)
Br J Haematol
, vol.116
, pp. 796-802
-
-
Iwasaki, T.1
Hamano, T.2
Ogata, A.3
Hashimoto, N.4
Kitano, M.5
Kakishita, E.6
-
44
-
-
49249100382
-
MetMAb, the one-armed 5D5 anti-c-MET antibody, inhibits orthotopic pancreatic tumor growth and improves survival
-
Jin H, Yang R, Zheng Z, et al. MetMAb, the one-armed 5D5 anti-c-MET antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 2008;68:4360-8.
-
(2008)
Cancer Res
, vol.68
, pp. 4360-4368
-
-
Jin, H.1
Yang, R.2
Zheng, Z.3
-
45
-
-
3142619403
-
The Sema domain of Met is necessary for receptor dimerization and activation
-
Kong-Beltran M, Stamos J, Wickramasinghe D. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 2004;6:75-84.
-
(2004)
Cancer Cell
, vol.6
, pp. 75-84
-
-
Kong-Beltran, M.1
Stamos, J.2
Wickramasinghe, D.3
-
46
-
-
80052511675
-
Final efficacy results from OAM4558 g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
-
Spigel DR. Final efficacy results from OAM4558 g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J Clin Oncol 2011;29(Suppl):abstr 7505.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
, pp. 7505
-
-
Spigel, D.R.1
-
47
-
-
33645518840
-
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
-
Petrelli A, Circosta P, Granziero L, Mazzone M, Pisacane A, Fenoglio S, Comoglio PM, Giordano S. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc Natl Acad Sci U S A 2006;103:5090-5.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5090-5095
-
-
Petrelli, A.1
Circosta, P.2
Granziero, L.3
Mazzone, M.4
Pisacane, A.5
Fenoglio, S.6
Comoglio, P.M.7
Giordano, S.8
-
48
-
-
53349171633
-
Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology
-
Tijink BM, Laeremans T, Budde M, Stigter-van Walsum M, Dreier T, de Haard HJ, Leemans CR, van Dongen GA. Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology. Mol Cancer Ther 2008;7:2288-97.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2288-2297
-
-
Tijink, B.M.1
Laeremans, T.2
Budde, M.3
Stigter-van Walsum, M.4
Dreier, T.5
de Haard, H.J.6
Leemans, C.R.7
van Dongen, G.A.8
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