Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa

Psychiatry Research

Volumn 210, Issue 1, 2013, Pages 287-293

  Kim, Yunjung ^a   Trace, Sara E ^a   Crowley, James J ^a   Brownley, Kimberly A ^a   Hamer, Robert M ^a,b   Pisetsky, David S ^c,d   Sullivan, Patrick F ^a   Bulik, Cynthia M ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b IL   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DURHAM VA MEDICAL CENTER   (United States)

Author keywords

Biomarkers; Eating disorder; Genetic; Genome; Renourishment; Transcriptome

Indexed keywords

ADULT; ANOREXIA NERVOSA; ARTICLE; BLOOD; BODY MASS; C16ORF11 GENE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CPA3 GENE; CYP11A1 GENE; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION; HUMAN; LINC00235 GENE; OBESITY; OR51A2 GENE; OR51A4 GENE; OR51L1 GENE; OR52J3 GENE; PRIORITY JOURNAL; RECEPTOR GENE; RNA SEQUENCE; UPREGULATION; WEIGHT CHANGE; WEIGHT GAIN;

BIOMARKERS; EATING DISORDER; GENETIC; GENOME; RENOURISHMENT; TRANSCRIPTOME;

ABSORPTIOMETRY, PHOTON; ADULT; ANOREXIA NERVOSA; BODY COMPOSITION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; SEQUENCE ANALYSIS, RNA; WEIGHT GAIN; YOUNG ADULT;

EID: 84885843392     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2013.05.026     Document Type: Article

References (68)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, American Psychiatric Press, Washington, D.C, (text revision). 4th ed.
2. Aschenbrenner K., Scholze N., Joraschky P., Hummel T. Gustatory and olfactory sensitivity in patients with anorexia and bulimia in the course of treatment. Journal of Psychiatric Research 2008, 43:129-137.
3. Bailer U.F., Frank G.K., Henry S.E., Price J.C., Meltzer C.C., Weissfeld L., Mathis C.A., Drevets W.C., Wagner A., Hoge J., Ziolko S.K. Altered brain serotioni 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635. Archives of General Psychiatry 2005, 62:1032-1041.
4. Bergen A.W., Yeager M., Welch R.A., Haque K., Ganjei J.K., van den Bree M.B., Mazzanti C., Nardi I., Fichter M.M., Halmi K.A., Kaplan A.S., Strober M., Treasure J., Woodside D.B., Bulik C.M., Bacanu S.A., Devlin B., Berrettini W.H., Goldman D., Kaye W.H. Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology 2005, 30:1703-1710.
5. Birmingham C.L., Su J., Hlynsky J.A., Goldner E.M., Gao M. The mortality rate from anorexia nervosa. International Journal of Eating Disorders 2005, 38:143-146.
6. Brambilla F., Monteleone P., Bortolotti F., Dalle Grave R., Todisco P., Favaro A., Santonastaso P., Ramacciotti C., Paoli, Maj M. Persistent amenorrhoea in weight-recovered anorexics: psychological and biological aspects. Psychiatry Research 2003, 118:249-257.
7. Bronsky J., Nedvidkova J., Krasnicanova H., Vesela M., Schmidtova J., Koutek J., Kellermayer R., Chada M., Kabelka Z., Hrdlicka M., Nevoral J., Prusa R. Changes of orexin A plasma levels in girls with anorexia nervosa during eight weeks of realimentation. International Journal of Eating Disorders 2011, 44:547-552.
8. Brown R.F., Bartrop R., Beumont P., Birmingham C.L. Bacterial infections in anorexia nervosa: delayed recognition increases complications. International Journal of Eating Disorders 2005, 37:261. 261.
9. Carter J.C., Blackmore E., Sutandar-Pinnock K., Woodside D.B. Relapse in anorexia nervosa: a survival analysis. Psychological Medicine 2004, 34:671-679.
10. Chiang Y.F., Lin H.T., Hu J.W., Tai Y.C., Lin Y.C., Hu M.C. Differential regulation of the human CYP11A1 promoter in mouse brain and adrenals. Journal of Cellular Physiology 2011, 226:1998-2005.
11. Choquette A.C., Bouchard L., Drapeau V., Lemieux S., Tremblay A., Bouchard C., Vohl M.C., Pérusse L. Association between olfactory receptor genes, eating behavior and adiposity: results from the Quebec Family Study. Physiology and Behavior 2012, 105:772-776.
12. Connan F., Lightman S.L., Landau S., Wheeler M., Treasure J., Campbell I.C. An investigation of hypothalamic-pituitary-adrenal axis hyperactivity in anorexia nervosa: the role of CRH and AVP. Journal of Psychiatric Research 2007, 41:131-143.
13. Delvenne V., Goldman S., De Maertelaer V., Simon Y., Luxen A., Lotstra F. Brain hypometabolism of glucose in anorexia nervosa: normalizaiton after weight gain. Biological Psychiatry 1996, 40:761-768.
14. Dennis G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane L.C., Lempicki R.A. Database for annotation, visualization, and integrated discovery. Genome Biology 2003, 4:3.
15. Dhahbi J.M., Atamna H., Boffelli D., Martin D.I., Spindler S.R. mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction. Physiological Genomics 2012, 44:331-344.
16. Drew R.E., Rodnick K.J., Settles M., Wacyk J., Churchill E., Powell M.S., Hardy R.W., Murdoch G.K., Hill R.A., Robison B.D. Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio). Physiological Genomics 2008, 35:283-295.
17. Ehrlich S., Weiss D., Burghardt R., Infante-Duarte C., Brockhaus S., Muschler M.A., Bleich S., Lehmkuhl U., Frieling H. Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa. Journal of Psychiatric Research 2010, 44:827-833.
18. Fedoroff I.C., Stoner S.A., Andersen A.E., Doty R.L., Rolls B.J. Olfactory dysfunction in anorexia and bulimia. International Journal of Eating Disorders 1995, 18:71-77.
19. Fairburn C.G, Harrison P.J. Eating disorders. Lancet 2003, 361:407-416.
20. First M.B., Spitzer R., Gibbon M., Williams J.B. Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I), Clinican Version 2002, American Psychiatric Press, Washington, D.C.
21. Frieling H., Bleich S., Otten J., Romer K.D., Kornhuber J., de Zwaan M., Jacoby G.E., Wilhelm J., Hillemacher T. Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity. Neuropsychopharmacology 2008, 33:2605-2609.
22. Galusca B., Costes N., Zito N.G., Peyron R., Bossu C., Lang F., Le Bars D., Estour B. Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F]MPPF PET scan study. Biological Psychiatry 2008, 64:1009-1013.
23. Goldzak-Kunik G., Friedman R., Spitz M., Sandler L., Leshem M. Intact sensory function in anorexia nervosa. American Journal of Clinical Nutrition 2012, 95:272-282.
24. Gonzalez F.J., Gelboin H.V. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metabolism Reviews 1994, 26:165-183.
25. Gribnau J., Grootegoed J.A. Origin and evolution of X chromosome inactivation. Current Opinion in Cell Biology 2012, 24:397-404.
26. Gut I., Danielova V., Holubova J., Soucek P., Kluckova H. Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism. Archives of Toxicology 2000, 74:437-446.
27. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
28. Huang Z., Roy P., Waxman D.J. Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. Biochemical Pharmacology 2000, 59:61-72.
29. Janas-Kozik M., Stachowicz M., Mazurek U., Zajdel A., Wilczok A., Krupka-Matuszczyk I., Rybakowski J.K. Preliminary study of the expression of genes connected with the orexigenic and anorexigenic system using microarray technique in anorexia nervosa. Neuropsychobiology 2008, 57:116-120.
30. Kahl K.G., Kruse N., Rieckmann P., Schmidt M.H. Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa. Psychoneuroendocrinology 2004, 29:13-20.
31. Kaye W.H., Gwirtsman H., George T., Ebert M.H., Petersen R. Caloric consumption ativity levels after weight recovery in anorexia nervosa: a prolonged delay in normalization. International Journal of Eating Disorders 1986, 5:489-502.
32. Kaye W.H., Frank G.K., McConaha C. Altered dopamine activity after recovery from restricting-type anorexia nervosa. Neuropsychopharmacology 1999, 21:503-506.
33. Krauth C., Buser K., Vogel H. How high are the costs of eating disorders - anorexia nervosa and bulimia nervosa -for German society?. European Journal of Health Economics 2002, 3:244-250.
34. Leek J.T., Scharpf R.B., Bravo H.C., Simcha D., Langmead B., Johnson W.E., Geman D., Baggerly K., Irizarry R.A. Tackling the widespread and critical impact of batch effects in high-throughput data. Nature Reviews Genetics 2010, 11:733-739.
35. Lob S., Pickel J., Bidlingmaier M., Schaaf L., Backmund H., Gerlinghoff M., Stalla G.K. Serum leptin monitoring in anorectic patients during refeeding therapy. Experimental and Clinical Endocrinology and Diabetes 2003, 111:178-282.
36. Marcos A., Nova E., Montero A. Changes in the immune system are conditioned by nutrition. European Journal of Clinical Nutrition 2003, 57:S66-S69.
37. Mika C., Holtkamp K., Heer M., Günther R.W., Herpertz-Dahlmann B. A 2-year prospective study of bone metabolism and bone meneral density in adolescents with anorexia nervosa. Journal of Neural Transmission 2007, 114:1611-1618.
38. Millar H.R., Wardell F., Vyvyan J.P., Naji S.A., Prescott G.J., Eagles J.M. Anorexia nervosa mortality in Northeast Scotland, 1965-1999. American Journal of Psychiatry 2005, 162:753-757.
39. Mira M., Stewart P.M., Vizzard J., Abraham S. Biochemical abnormalities in anorexia nervosa and bulimia. Annals of Clinical Biochemistry 1987, 24:29-35.
40. Mitchell A.C., Leak R.K., Zigmond M.J., Cameron J.L., Mirnics K. Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys. Genomics 2012, 99:144-151.
41. Mont L., Castro J. Anorexia nervosa: a disease with potentially lethal repercussions on the heart. Revista Española de Cardiología 2003, 56:652-653.
42. Morgan J.F., Bolton J., Sedgwick P.M., Patel S., Lacey J.H., Conway G.S. Journal of Clinical Endocrinology and Metabolism 1999, 84:2257.
43. Nakazato M., Hashimoto K., Shimizu E., Kumakiri C., Koizumi H., Okamura N., Mitsumori M., Komatsu N., Lyo M. Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders. Biological Psychiatry 2003, 54:485-490.
44. Narnaware Y.K., Peter R.E. Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish. Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology 2001, 129:633-637.
45. Nova E., Gomez-Martinez S., Morande G., Marcos A. Cytokine production by blood mononuclear cells from in-patients with anorexia nervosa. British Journal of Nutrition 2002, 88:183-188.
46. Ortega-Hernandez O.D., Kivity S., Shoenfeld Y. Olfaction, psychiatric disorders and autoimmunity: is there a common genetic association?. Autiomminuity 2009, 42:80-88.
47. Oshlack A., Robinson M.D., Young M.D. From RNA-seq reads to differential expression results. Genome Biology 2010, 11:220.
48. Papadopoulos F.C., Ekbom A., Brandt L., Ekselius L. Excess mortality, causes of death and prognostic factors in anorexia nervosa. British Journal of Psychiatry 2009, 194:10-17.
49. Plank M., Wuttke D., van Dam S., Clarke S.A., de Magalhaes J.P. A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. Molecular Biosystems 2012, 8:1339-1349.
50. Rapps N., Giel K.E., Söhngen E., Salini A., Enck P., Bischoff S.C., Zipfel S. Olfactory deficits in patients with anorexia nervosa. European Eating Disorder Review 2010, 18:385-389.
51. Raymond N.C., Dysken M., Bettin K., Eckert E.D., Crow S.J., Markus K., Pomeroy C. Cytokine production in patients with anorexia nervosa, bulimia nervosa, and obesity. International Journal of Eating Disorders 2000, 28:293-302.
52. Scalfi L., Polito A., Bianchi L., Marra M., Caldara A., Nicolai E., Contaldo F. Body composition changes in patients with anorexia nervosa after complete weight recovery. European Journal of Clinical Nutrition 2002, 56:15-20.
53. Schecklmann M., Pfannstiel C., Fallgatter A.J., Warnke A., Gerlach M., Ramonos M. Olfaction in child and adolescent anorexia nervosa. Journal of Neural Transmission 2012, 119:721-728.
54. Silber T.J., Chan M. Immunologic cytofluorometric studies in adolescents with anorexia nervosa. International Journal of Eating Disorders 1996, 19:415-418.
55. Storch C.H., Nikendei C., Schild S., Haefeli W.E., Weiss J., Herzog W. Expression and activity of P-glycoprotein (MDR1/ABCB1) in peripheral blood mononuclear cells from patients with anorexia nervosa compared with healthy controls. International Journal of Eating Disorders 2008, 41:432-438.
56. Støving R.K., Andries A., Brixen K., Flyvbjerg A., Hørder K., Frystyk J. Leptin, ghrelin, and endocannabinoids: potential therapeutic targets in anorexia nervosa. Journal of Psychiatric Research 2009, 43:671-679.
57. Sullivan P.F. Mortality in anorexia nervosa. American Journal of Psychiatry 1995, 152:1073-1074.
58. Sullivan P.F., Fan C., Perou C.M. Evaluating the comparability of gene expression in blood and brain. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 2006, 141:261-268.
59. Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immuniology 2006, 6:772-783.
60. Trapnell C., Pachter L., Salzberg S.L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 2009, 25:1105-1111.
61. Tuckey R.C. Progesterone synthesis by the human placenta. Placenta 2005, 26:273-281.
62. Turecki G., Rouleau G.A., Mari J., Joober R., Morgan K. Lack of association between bipolar disorder and tyrosine hydroxylase: a meta-analysis. American Journal of Medical Genetics 1997, 74:348-352.
63. Ulger Z., Gürses D., Ozyurek A.R., Arikan C., Levent E., Aydoǧdu S. Follow-up of cardiac abnormalities in female adolescents with anorexia nervosa after refeeding. Acta Cardiologica 2006, 61:43-49.
64. Umeki S. Biochemical abnormalities of the serum in anorexia nervosa. Journal of Nervous and Mental Disease 1988, 176:503-506.
65. Usdan L.S., Khaodhiar L., Apovian C.M. The endocrinopathies of anorexia nervosa. Endocrine Practice 2008, 14:1055-1063.
66. Weiss D., Infante-Duarte C., Salbach-Andrae H., Burghardt R., Hamann I., Pfeiffer E., Lehmkuhl U., Ehrlich S. Preproenkephalin expression in peripheral blood mononuclear cells of acutely underweight and recovered patients with anorexia nervosa. Neuropsychobiology 2010, 62:151-157.
67. Wu H.S., Lin H.T., Wang C.K., Chiang Y.F., Chu H.P., Hu M.C. Human CYP11A1 promoter drives Cre recombinase expression in brain in addition to adrenals and gonads. Genesis 2007, 45:59-65.
68. Zipfel S., Lowe B., Reas D.L., Deter H.C., Herzog W. Long-term prognosis in anorexia nervosa: lessons from a 21-year follow-up study. Lancet 2000, 355:721-722.