Preliminary study of the expression of genes connected with the orexigenic and anorexigenic system using microarray technique in anorexia nervosa

Neuropsychobiology

Volumn 57, Issue 3, 2008, Pages 116-120

  Janas Kozik, Malgorzata ^a,b   Stachowicz, Malgorzata ^a   Mazurek, Urszula ^a   Zajdel, Alicja ^a   Wilczok, Adam ^a   Krupka Matuszczyk, Irena ^a   Rybakowski, Janusz K ^c  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b John Paul II Pediatric Center   (Poland)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Anorexia nervosa; Anorexia nervosa, binge eating purging type; Anorexia nervosa, restricting type; Anorexigenic peptides; Leptin; Orexigenic peptides

Indexed keywords

GROWTH HORMONE SECRETAGOGUE RECEPTOR; LEPTIN; LEPTIN RECEPTOR; OREXIN;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; APPETITE; ARTICLE; BINGE EATING DISORDER; CASE REPORT; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; CASE-CONTROL STUDIES; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GHRELIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; LINKAGE (GENETICS); MATCHED-PAIR ANALYSIS; MENTAL DISORDERS; NEUROPEPTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LEPTIN; RECEPTORS, NEUROPEPTIDE; STATISTICS, NONPARAMETRIC;

EID: 47949130485     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000138913     Document Type: Article

References (14)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, American Psychiatric Association, 1994.
2. Rybakowski F, Slopien A, Dmitrzak-Weglarz M, Czerski P, Rajewski A, Hauser J: The 5-HT2A-1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study. Neuropsychobiology 2006;53:33-39.
3. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Lui WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M: Orexins and orexin receptors: family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998;92:573-583.
4. deLecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG: The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 1998;95:322-327.
5. Willie JT, Chemelli RM, Sinton ChM, Yanagisawa M: To eat or to sleep? Orexins in the regulation of feeding and wakefulness. Annu Rev Neurosci 2001;24:429-457.
6. Szekely M, Petervari E, Balasko M, Hernadi I, Uzsoki B: Effects of orexins on energy balance and thermoregulation. Regul Pept 2002;25:102-104.
7. Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y, Meguid MM, Kasuga M: Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005;54:18-24.
8. Pico C, Oliver P, Sanchez J, Palou A: Gastric leptin: a putative role in the short-term regulation of food intake. Br J Nutrition 2003;90:735-741.
9. Bunney WE, Bunney BG, Vawter MP, Tomita H, Li J, Evans SJ, Choudary PV, Myers RM, Jones EG, Watson SJ, Akil H: Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am J Psychiatry 2003;160:657-666.
10. Janas-Kozik M, Mazurek U, Krupka-Matuszczyk I, Stachowicz M, Głogowska-Ligus J, Wilczok T: The transcript expression profile of the leptin receptor-coding gene assayed with the oligonucleotide microarray technique - could this be an anorexia nervosa marker? Cell Mol Biol Lett 2006;11:67-74.
11. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
12. http://rmaexpress.bmbolstad.com/RMAExpress_UsersGuide.pdf.
13. Hibbs MA, Dirksen NC, Li K, Troyanskaya OG: Visualization methods for statistical analysis of microarray clusters. BMC Bioinformatics 2005;6:115.
14. Quinton ND, Meechan DW, Brown K, Easwood H, Blakemore AI: Single nucleotide polymorphisms in the leptin receptor gene: studies in anorexia nervosa. Psychiatr Genet 2004;14:191-194.