PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4751-4759

  Ingallinella, Paolo ^a,c   Peier, Andrea M ^b   Pocai, Alessandro ^b   Marco, Annalise Di ^a   Desai, Kunal ^b   Zytko, Karolina ^a   Qian, Ying ^b   Du, Xiaobing ^b   Cellucci, Antonella ^a   Monteagudo, Edith ^a   Laufer, Ralph ^a   Bianchi, Elisabetta ^a   Marsh, Donald J ^b,c   Pessi, Antonello ^a,c,d  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Diasorin SpA   (Italy)

^d PeptiPharma   (Italy)

Author keywords

Diabetes; Neuromedin U; Obesity; PEG

Indexed keywords

MACROGOL; NEUROMEDIN U; NEUROMEDIN U DERIVATIVE; PEGYLATED NEUROMEDIN U; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG PURIFICATION; DRUG SAFETY; GEL PERMEATION CHROMATOGRAPHY; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ION EXCHANGE CHROMATOGRAPHY; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OBESITY; PEGYLATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE TOLERANCE TEST; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPEPTIDES; OBESITY; POLYETHYLENE GLYCOLS; RECEPTORS, NEUROTRANSMITTER; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 84863990336     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.003     Document Type: Article

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