Metabolite profiling and a transcriptional activation assay provide direct evidence of androgen receptor antagonism by bisphenol A in fish

Environmental Science and Technology

Volumn 46, Issue 17, 2012, Pages 9673-9680

  Ekman, D R ^a   Hartig, P C ^a   Cardon, M ^a   Skelton, D M ^a   Teng, Q ^a   Durhan, E J ^a   Jensen, K M ^a   Kahl, M D ^a   Villeneuve, D L ^a   Gray, L E ^a   Collette, T W ^a   Ankley, G T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTORS; ANTAGONISTIC ACTIVITY; ANTI-ANDROGENIC; BISPHENOL A; ECOLOGICAL RISKS; ENVIRONMENTAL CONTAMINATION; ESTROGEN RECEPTOR; FATHEAD MINNOW; H NMR SPECTROSCOPY; HIGH RESOLUTION; HUMAN HEALTH; IN-VITRO; IN-VITRO ANALYSIS; IN-VIVO; KNOWLEDGE GAPS; METABOLITE PROFILES; METABOLITE PROFILING; METABOLOMICS; PIMEPHALES PROMELAS; TRANSCRIPTIONAL ACTIVATIONS; TRENBOLONE; UNIVARIATE;

BINARY MIXTURES; HEALTH RISKS;

METABOLITES;

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; TRENBOLONE;

ANDROGEN; ANTAGONISM; BIOACCUMULATION; BIOASSAY; CYPRINID; ECOTOXICOLOGY; ESTROGENIC COMPOUND; GENE EXPRESSION; METABOLITE; PHENOL; POLLUTION EXPOSURE; PUBLIC HEALTH; RISK ASSESSMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUATIC ENVIRONMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FISH; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LIVER METABOLISM; MALE; METABOLITE; MULTIVARIATE ANALYSIS; NONHUMAN; PIMEPHALES PROMELAS; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSCRIPTION INITIATION; UNIVARIATE ANALYSIS; WATER CONTAMINATION;

ANDROGEN RECEPTOR ANTAGONISTS; ANDROGENS; ANIMALS; BENZHYDRYL COMPOUNDS; CYPRINIDAE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; LIVER; MALE; METABOLOME; PHENOLS; RECEPTORS, ANDROGEN; TRANSCRIPTIONAL ACTIVATION; TRENBOLONE ACETATE;

PIMEPHALES PROMELAS; VERTEBRATA;

EID: 84865713234     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es3014634     Document Type: Article

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