Diminution of the NMDA receptor NR2B subunit in cortical and subcortical areas of WAG/Rij rats

Synapse

Volumn 67, Issue 12, 2013, Pages 839-846

  Karimzadeh, Fariba ^a,b   Soleimani, Mansoureh ^c,d   Mehdizadeh, Mehdi ^c   Jafarian, Maryam ^a,b   Mohamadpour, Maliheh ^b   Kazemi, Hadi ^e   Joghataei, Mohammad Taghi ^c,d   Gorji, Ali ^b,f  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Shefa Neuroscience Research Centre   (Iran)

^c IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHAHED UNIVERSITY   (Iran)

^f UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Brain; Children seizures; Genetic models of epilepsy; Spike wave discharges

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; HIPPOCAMPAL CA1 REGION; IMMUNOHISTOCHEMISTRY; MALE; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SOMATOSENSORY CORTICAL LAYER;

BRAIN; CHILDREN SEIZURES; GENETIC MODELS OF EPILEPSY; SPIKE-WAVE DISCHARGES;

ANIMALS; BRAIN WAVES; CA1 REGION, HIPPOCAMPAL; EPILEPSY, ABSENCE; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SOMATOSENSORY CORTEX;

EID: 84885835684     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21687     Document Type: Article

References (51)

1. Bardoni R, Torsney C, Tong CK, Prandini M, MacDermott AB. 2004. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci 24:2774-2781.
2. Bast T, Wilson IA, Witter MP, Morris RGM. 2009. From rapid place learning to behavioral performance: a key role for the intermediate hippocampus. PLoS Biol 7:e1000089.
3. Beenhakker MP, Huguenard JR. 2009. Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron 62:612-632.
4. Bouwman BM, Suffczynski P, Midzyanovskaya IS, Maris E, van den Broek PL, van Rijn CM. 2007. The effects of vigabatrin on spike and wave discharges in WAG/Rij rats. Epilepsy Res 76:34-40.
5. Cao X, Cui Z, Feng R, Tang YP, Qin Z, Mei B, Tsien JZ. 2007. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Eur J Neurosci 25:1815-1822.
6. Chan KFY, Burnham WMI, Jia Z, Cortez MA, Snead OC. 2006. GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures. Eur J Pharmacol 541:64-72.
7. Clayton DA, Mesches MH, Alvarez E, Bickford PC, Browning MD. 2002. A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J Neurosci 22:3628-3637.
8. Coenen AM, Van Luijtelaar EL. 2003. Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats. Behav Genet 33:635-655.
9. Cui Z, Wang H, Tan Y, Zaia KA, Zhang S, Tsien JZ. 2004. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41:781-793.
10. D'Antuono M, Inaba Y, Biagini G, D'Arcangelo G, Tancredi V, Avoli M. 2006. Synaptic hyperexcitability of deep layer neocortical cells in a genetic model of absence seizures. Genes, brain, and behavior 5:73-84.
11. D'Arcangelo G, D'Antuono M, Biagini G, Warren R, Tancredi V, Avoli M. 2002. Thalamocortical oscillations in a genetic model of absence seizures. Eur J Neurosci 16:2383-2393.
12. Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C. 1998. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Progr Neurobiol 55:27-57.
13. Duguid IC, Smart TG. 2004. Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses. Nat Neurosci 7:525-533.
14. Finardi A, Gardoni F, Bassanini S, Lasio G, Cossu M, Tassi L, Caccia C, Taroni F, LoRusso G, Di Luca M, Battaglia G. 2006. NMDA receptor composition differs among anatomically diverse malformations of cortical development. J Neuropathol Exp Neurol 65:883-93.
15. Gorji A, Mittag C, Shahabi P, Seidenbecher T, Pape HC. 2011. Seizure-related activity of intralaminar thalamic neurons in a genetic model of absence epilepsy. Neurobiol Dis 43:266-274.
16. Gorji A, Speckmann EJ. 2001. Low concentration of DL-2-amino-5-phosphonovalerate induces epileptiform activity in guinea pig hippocampal slices. Epilepsia 42:1228-1230.
17. Huguenard JR, McCormick DA. 2007. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci 30:350-356.
18. Ingram EM, Tessler S, Bowery NG, Emson PC. 2000. Glial glutamate transporter mRNAs in the genetically absence epilepsy rat from Strasbourg. Mol Brain Res 75:96-104.
19. Kalia LV, Gingrich JR, Salter MW. 2004. Src in synaptic transmission and plasticity. Oncogene 23:8007-8016.
20. Koerner C, Danober L, Boehrer A, Marescaux C, Vergnes M. 1996. Thalamic NMDA transmission in a genetic model of absence epilepsy in rats. Epilepsy Res 25:11-19.
21. Kumlien E, Hartvig P, Valind S, Øye I, Tedroff J, Långström B. 2005. NMDA-receptor activity visualized with (S)-[N-methyl-11C] ketamine and positron emission tomography in patients with medial temporal lobe epilepsy. Epilepsia 40:30-37.
22. Luhmann HJ, Mittmann T, van Luijtelaar G, Heinemann U. 1995. Impairment of intracortical GABAergic inhibition in a rat model of absence epilepsy. Epilepsy Res 22:43-51.
23. Mandelbaum DE, Burack GD. 1997. The effect of seizure type and medication on cognitive and behavioral functioning in children with idiopathic epilepsy. Dev Med Child Neurol 39:731-735.
24. Marescaux C, Vergnes M, Bernasconi R. 1992. GABAB receptor antagonists: potential new anti-absence drugs. J Neural Transm Suppl 35:179.
25. Mathew SS, Hablitz JJ. 2011. Presynaptic NMDA receptors mediate IPSC potentiation at GABAergic synapses in developing rat neocortex. PLoS One 6:e17311.
26. Matta JA, Ashby MC, Sanz-Clemente A, Roche KW, Isaac JT. 2011. mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. Neuron 70:339-351.
27. Möddel G, Jacobson B, Ying Z, Janigro D, Bingaman W, González-Martínez J, Kellinghaus C, Prayson RA, Mohn AR, Gainetdinov RR, Caron MG, Koller BH. 1999. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98:427-436.
28. Mohn AR, Gainetdinov RR, Caron MG, Koller BH. 1999. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98:427-436.
29. Monnerie H, Hsu FC, Coulter DA, Le Roux PD. 2010. Role of the NR2A/2B subunits of the N-methyl-D-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro. Neuroscience 171:1075-1090.
30. Najm IM, Ying Z, Babb T, Mohamed A, Hadam J, LaPresto E, Wyllie E, Kotagal P, Bingaman W, Foldvary N, Morris H, Lüders HO. 2000. Epileptogenicity correlated with increased N-methyl-D-aspartate receptor subunit NR2A/B in human focal cortical dysplasia. Epilepsia 41:971-976.
31. Ngomba R, Biagioni F, Casciato S, Willems-van Bree E, Battaglia G, Bruno V, Nicoletti F, Van Luijtelaar E. 2005. The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology 49:89-103.
32. Ngomba R, Santolini I, Biagioni F, Molinaro G, Simonyi A, van Rijn C, D'Amore V, Mastroiacovo F, Olivieri G, Gradini R. 2011. Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology 60:1281-1291.
33. Nutt JG, Gunzler SA, Kirchhoff T, Hogarth P, Weaver JL, Krams M, Jamerson B, Menniti FS, Landen JW. 2008. Effects of a NR2B selective NMDA glutamate antagonist, CP-101, 606, on dyskinesia and Parkinsonism. Mov Disord 23:1860-1866.
34. Pavone A, Niedermeyer E. 2000. Absence seizures and the frontal lobe. Clin Electroencephalogr 31:153-156.
35. Paxinos G, Watson C. 1998. The rat brain in stereotaxic coordinates, 4th ed. New York: Academic Press.
36. Peeters B, Vossen J, Coenen A. 1990. Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats. Life Sci 47:523-529.
37. Pumain R, Louvel J, Gastard M, Kurcewicz I, Vergnes M. 1992. Responses to N-methyl-D-aspartate are enhanced in rats with petit mal-like seizures. J Neural Transm Suppl 35:97.
38. Sarkisova K, van Luijtelaar G. 2011. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression. Prog Neuropsychopharmacol Biol Psychiatry 35:854-76.
39. Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WHW. 1991. D, L-(Tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. Eur J Pharmacol 203:237-243.
40. Snead OC III. 1995. Basic mechanisms of generalized absence seizures. Ann Neurol 37:146-157.
41. Supcun B, Ghadiri MK, Zeraati M, Stummer W, Speckmann EJ, Gorji A. 2012. The effects of tetanic stimulation on plasticity of remote synapses in the hippocampus-perirhinal cortex-amygdala network. Synapse 66:965-974.
42. Swann JW, Le JT, Lam TT, Owens J, Mayer AT. 2007. The impact of chronic network hyperexcitability on developing glutamatergic synapses. Eur J Neurosci 26:975-991.
43. Talos DM, Kwiatkowski DJ, Cordero K, Black PM, Jensen FE. 2008. Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers. Ann Neurol 63:454-465.
44. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ. 1999. Genetic enhancement of learning and memory in mice. Nature 401:63-69.
45. van de Bovenkamp-Janssen MC, van der Kloet JC, van Luijtelaar G, Roubos EW. 2006. NMDA-NR1 and AMPA-GluR4 receptor subunit immunoreactivities in the absence epileptic WAG/Rij rat. Epilepsy Res 69:119-128.
46. van Luijtelaar G, Sitnikova E. 2006. Global and focal aspects of absence epilepsy: the contribution of genetic models. Neurosci Biobehav Rev 30:983-1003.
47. Wang YT, Salter MW. 1994. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369:233-235.
48. Williams D. 1950. New orientations in epilepsy. Br Med J 1:685-692.
49. Williams J, Sharp G, Lange B, Bates S, Griebel M, Spence G, Thomas P. 1996. The effects of seizure type, level of seizure control, and antiepileptic drugs on memory and attention skills in children with epilepsy. Dev Neuropsychol 12:241-253.
50. Zhang XH, Liu SS, Yi F, Zhuo M, Li BM. 2013. Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats. Mol Brain 6:13.
51. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM. 2005. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47:859-872.