Low concentration of DL-2-amino-5-phosphonovalerate induces epileptiform activity in guinea pig hippocampal slices

Epilepsia

Volumn 42, Issue 10, 2001, Pages 1228-1230

  Gorji, Ali ^a   Speckmann, Erwin Josef ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Electrophysiology; Glutamate; Hippocampus; Neuronal excitability; NMDA receptor hypofunction

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; CYCLOSPORIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENCYCLIDINE;

ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPILEPTIC DISCHARGE; EXTRACELLULAR SPACE; GUINEA PIG; HIPPOCAMPUS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; EPILEPSY; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; GUINEA PIGS; HIPPOCAMPUS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0035167173     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2001.01301.x     Document Type: Article

References (16)

1. 11C]ketamine and positron emission tomography in patients with medial temporal lobe epilepsy
2. Excitatory amino acid transmitters in epilepsy
3. Dose-dependent effects of phencyclidine on hippocampal CA1 neurons
4. Electrophysiological actions of phencyclidine in hippocampal slices from the rat
5. Phencyclidine (PCP) intoxication: Diagnosis in stages and algorithms of treatment
6. Neurological complications following liver transplantation
7. Electrophysiological effects of CsA on CA1 and CA3 regions of guinea pig hippocampal slices
8. Cyclosporin A and brain excitability studied in vitro
9. Cyclosporine induces epileptiform activity in an in vitro seizure model
10. Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus
11. Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus
12. Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of rats
13. Lowering of the potassium concentration induces epileptiform activity in the guinea pig hippocampal slices
14. Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
15. Phencyclidine actions measured intracellularly in hippocampal CA1 neurons
16. NMDA receptor hypofunction model of schizophrenia