The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 8, 2013, Pages 4615-4619

  Jiang, Wei ^a   Huang, Yong ^a   Wang, Jing Peng ^a   Yu, Xiao Yun ^a   Zhang, Lin Yi ^a  

^a Wenling City Chinese Medicine Hospital   (China)

Author keywords

Allicin; Apoptosis; Artesunate; Osteosarcoma cell line

Indexed keywords

ALLICIN; ANTIMALARIAL AGENT; ANTIOXIDANT; ARTEMISININ DERIVATIVE; ARTESUNATE; CASPASE; SULFINIC ACID DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; BONE TUMOR; CELL MOTION; CELL PROLIFERATION; DRUG EFFECT; DRUG POTENTIATION; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; HUMAN; IN VITRO STUDY; METABOLISM; MOUSE; NUDE MOUSE; OSTEOSARCOMA; PATHOLOGY; TUMOR CELL CULTURE;

ANIMALS; ANTIMALARIALS; ANTIOXIDANTS; APOPTOSIS; ARTEMISININS; BONE NEOPLASMS; CASPASES; CELL MOVEMENT; CELL PROLIFERATION; DRUG SYNERGISM; FEMALE; FLOW CYTOMETRY; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; OSTEOSARCOMA; SULFINIC ACIDS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 84885743909     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.8.4615     Document Type: Article

References (34)

1. Arditti FD, Rabinkov A, Miron T, et al (2005). Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate. Mol Cancer Ther, 4, 325-31.
2. Bacci G, Ferrari S, Bertoni F, et al (2000). Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report. J Clin Oncol, 18, 4016-27.
3. Bachmeier B, Fichtner I, Killian PH, et al (2011). Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. PLoS One, 6, e20550.
4. Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B (2010). Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. Nutr Cancer, 62, 947-57.
5. Benassi MS, Chiechi A, Ponticelli F, et al (2007). Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. Cancer Lett, 250, 194-205.
6. Berdelle N, Nikolova T, Quiros S, Efferth T, Kaina B (2011). Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells. Mol Cancer Ther, 10, 2224-33.
7. Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH (2012). Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol Rep, 28, 41-8.
8. Chano T, Mori K, Scotlandi K, et al (2004). Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. Oncol Rep, 11, 1257-63.
9. Cheng R, Li C, Li C, et al (2013). The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells. Invest Ophthalmol Vis Sci, 54, 3400-9.
10. Choeyprasert W, Natesirinilkul R, Charoenkwan P, Sittipreechacharn S (2013). Carboplatin and Doxorubicin in Treatment of Pediatric Osteosarcoma: A 9-year Single Institute Experience in the Northern Region of Thailand. Asian Pac J Cancer Prev, 14, 1101-6.
11. Du JH, Zhang HD, Ma ZJ, Ji KM (2010). Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo. Cancer Chemother Pharmacol, 65, 895-902.
12. Hamacher-Brady A, Stein HA, Turschner S, et al (2011). Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem, 286, 6587-601.
13. Hauben EI, Arends J, Vandenbroucke JP, et al (2003). Multiple primary malignancies in osteosarcoma patients. Incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma. Eur J Hum Genet, 11, 611-8.
14. Huang T, Gong WH, Li XC, et al (2012). Efficient killing effect of osteosarcoma cells by cinobufacini and cisplatin in combination. Asian Pac J Cancer Prev, 13, 2847-51.
15. Jiang Z, Chai J, Chuang HH, et al (2012). Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells. Anticancer Drugs, 23, 606-13.
16. Jin M, Shen X, Zhao C, et al (2013). In vivo study of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice. Drug Deliv, 20, 127-33.
17. Li LN, Zhang HD, Yuan SJ, et al (2007). Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/beta-catenin pathway. Int J Cancer, 121, 1360-5.
18. Li PC, Lam E, Roos WP, et al (2008). Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res, 68, 4347-51.
19. Li S, Xue F, Cheng Z, et al (2009). Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65. Int J Hematol, 90, 513-21.
20. Li T, Chen H, Yang Z, Liu XG, et al (2013). Evaluation of the immunosuppressive activity of artesunate in vitro and in vivo. Int Immunopharmacol, 16, 306-12.
21. Louis XL, Murphy R, Thandapilly SJ, Yu L, Netticadan T (2012). Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide. BMC Complement Altern Med, 12, 140.
22. Marina N, Gebhardt M, Teot L, Gorlick R (2004). Biology and therapeutic advances for pediatric osteosarcoma. Oncologist, 9, 422-41.
23. Meyers PA, Gorlick R, Heller G, et al (1998). Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol. J Clin Oncol, 16, 2452-8.
24. Miron T, Wilchek M, Shvidel L, Berrebi A, Arditti FD (2012). S-allyl derivatives of 6-mercaptopurine are highly potent drugs against human B-CLL through synergism between 6-mercaptopurine and allicin. Leuk Res, 36, 1536-40.
25. Mota TC, Cardoso PC, Gomes LM, et al (2011). In vitro evaluation of the genotoxic and cytotoxic effects of artesunate, an antimalarial drug, in human lymphocytes. Environ Mol Mutagen, 52, 590-4.
26. Oommen S, Anto RJ, Srinivas G, Karunagaran D (2004). Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol, 485, 97-103.
27. Padilla-Camberos E, Zaitseva G, Padilla C, Puebla AM (2010). Antitumoral activity of allicin in murine lymphoma L5178Y. Asian Pac J Cancer Prev, 11, 241-4.
28. Park SY, Cho SJ, Kwon HC, et al (2005). Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett, 224, 123-32.
29. Sertel S, Eichhorn T, Simon CH, et al (2010). Pharmacogenomic identification of c-Myc/Max-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines. Molecules, 15, 2886-910.
30. Wang Z, Liu Z, Cao Z, Li L (2012). Allicin induces apoptosis in EL-4 cells in vitro by activation of expression of caspase-3 and-12 and up-regulation of the ratio of Bax/Bcl-2. Nat Prod Res, 26, 1033-7.
31. Youns M, Efferth T, Reichling J, et al (2009). Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells. Biochem Pharmacol, 78, 273-83.
32. Zhang W, Ha M, Gong Y, et al (2010). Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncol Rep, 24, 1585-92.
33. Zhang ZM, Zhong N, Gao HQ, et al (2006). Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice. Chin Med J (Engl), 119, 422-5.
34. Zhou C, Pan W, Wang XP, Chen TS (2012). Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J Cell Physiol, 227, 3778-86.