Extracts of Pomelo Peels Prevent High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice through Activating the PPARα and GLUT4 Pathway

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Ding, Xiaobo ^a,b,c   Guo, Lu ^a   Zhang, Yu ^a   Fan, Shengjie ^a   Gu, Ming ^a   Lu, Yan ^a,b,c   Jiang, Dong ^d   Li, Yiming ^a   Huang, Cheng ^a   Zhou, Zhiqin ^b,c  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SOUTHWEST UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d Chongqing Academy of Agricultural Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CHOLESTEROL; CITRUS GRANDIS EXTRACT; FATTY ACID SYNTHASE; FLAVONOID; GLUCOSE; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PHENOL DERIVATIVE; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHEMICAL COMPOSITION; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; DRUG POTENCY; FAS GENE; FEMALE; FOOD INTAKE; GENE EXPRESSION; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUT4 GENE; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; LIPID BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIVER PARENCHYMA; METABOLIC DISORDER; MOUSE; NONHUMAN; PGC 1ALPHA GENE; PGC 1BETA GENE; PHYTOCHEMISTRY; PUMMELO; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; VARIETAS; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

ANIMALS; BODY WEIGHT; CITRUS; DIET, HIGH-FAT; EATING; FEMALE; GLUCOSE TRANSPORTER TYPE 4; METABOLIC DISEASES; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; PPAR ALPHA; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84885711125     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077915     Document Type: Article

References (43)

1. Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J, (2005) The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb 12: 295-300. doi:10.5551/jat.12.295. PubMed: 16394610.
2. Kersten S, Desvergne B, Wahli W, (2000) Roles of PPARs in health and disease. Nature 405: 421-424. doi:10.1038/35013000. PubMed: 10839530.
3. Lefebvre P, Chinetti G, Fruchart JC, Staels B, (2006) Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 116: 571-580. doi:10.1172/JCI27989. PubMed: 16511589.
4. Cleeman JI, (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285: 2486-2497. doi:10.1001/jama.285.19.2486. PubMed: 11368702.
5. Steiner G, (2001) Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomized study. Lancet 357: 905-910. doi:10.1016/S0140-6736(00)04209-4. PubMed: 11289345.
6. Goto T, Kim YI, Funakoshi K, Teraminami A, Uemura T, et al. (2011) Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARalpha-dependent and-independent pathways. Am J Physiol Endocrinol Metab 301: E1022-E1032. doi:10.1152/ajpendo.00061.2011. PubMed: 21862726.
7. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, et al. (2005) Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 54: 3358-3370. doi:10.2337/diabetes.54.12.3358. PubMed: 16306350.
8. Goto T, Kim YI, Takahashi N, Kawada T, (2013) Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors. Mol Nutr Food Res 57: 20-33. doi:10.1002/mnfr.201200522. PubMed: 23180608.
9. Suryawanshi JAS, (2011) An overview of Citrus aurantium used in treatment of various diseases. Afr J Plants Sci 5: 390-395.
10. Committee CP (2005) Chinese Pharmacopoeia. Beijing, PR China: Chemical Industry Press. p. pp. 1. p.
11. Kang SI, Shin HS, Kim HM, Hong YS, Yoon SA, et al. (2012) Immature Citrus sunki peel extract exhibits anti-obesity effects by beta-oxidation and lipolysis in high-fat diet-induced obese mice. Biol Pharm Bull 35: 223-230. doi:10.1248/bpb.35.223. PubMed: 22293353.
12. Mulvihill EE, Huff MW, (2012) Protection from metabolic dysregulation, obesity, and atherosclerosis by citrus flavonoids: activation of hepatic pgc1alpha-mediated fatty acid oxidation. PPAR Res: pp. 2012: 857142.
13. Ono E, Inoue J, Hashidume T, Shimizu M, Sato R, (2011) Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet. Biochem Biophys Res Commun 410: 677-681. doi:10.1016/j.bbrc.2011.06.055. PubMed: 21693102.
14. Shin H-S, Kang S-I, Ko H-C, Kim H-M, Hong Y-S, et al. (2011) Anti-inflammatory effect of the immature peel extract of Jinkyool (Citrus sunki Hort. ex Tanaka). Food Sci Biotechnol 20: pp. 1235-1241.
15. Tanaka T, Tanaka M, Kuno T, (2012) Cancer chemoprevention by citrus pulp and juices containing high amounts of beta-cryptoxanthin and hesperidin. J Biomed Biotechnol: pp. 2012: 516981.
16. Wu S-j, Ng C, Tzeng W, Ho K, Shyu YT, (2011) Functional antioxidant and tyrosinase inhibitory properties of extracts of Taiwanese pummelo (Citrus grandis Osbeck). Afr J Biotechnol 10: 7668-7674.
17. Yamada T, Hayasaka S, Shibata Y, Ojima T, Saegusa T, et al. (2011) Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study. J Epidemiol 21: 169-175. doi:10.2188/jea.JE20100084. PubMed: 21389640.
18. Lee YS, Cha BY, Saito K, Choi SS, Wang XX, et al. (2011) Effects of a Citrus depressa Hayata (shiikuwasa) extract on obesity in high-fat diet-induced obese mice. Phytomedicine 18: 648-654. doi:10.1016/j.phymed.2010.11.005. PubMed: 21216135.
19. Bok SH, Lee SH, Park YB, Bae KH, Son KH, et al. (1999) Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr 129: 1182-1185. PubMed: 10356084.
20. Park HJ, Jung UJ, Cho SJ, Jung HK, Shim S, et al. (2013) Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice. J Nutr Biochem 24: 419-427. doi:10.1016/j.jnutbio.2011.12.009. PubMed: 22694954.
21. Ding X, Fan S, Lu Y, Zhang Y, Gu M, et al. (2012) Citrus ichangensis peel extract exhibits anti-metabolic disorder effects by the inhibition of PPAR and LXR signaling in high-fat diet-induced C57BL/6 mouse. Evid Based Complement Alternat Med: pp. 2012,.
22. Galleano M, Calabro V, Prince PD, Litterio MC, Piotrkowski B, et al. (2012) Flavonoids and metabolic syndrome. Ann N Y Acad Sci 1259: 87-94. doi:10.1111/j.1749-6632.2012.06511.x. PubMed: 22758640.
23. Wang Y-C, Chuang Y-C, Hsu H-W, (2008) The flavonoid, carotenoid and pectin content in peels of citrus cultivated in Taiwan. Food Chem 106: 277-284. doi:10.1016/j.foodchem.2007.05.086.
24. Zarina Z, Tan S, (2013) Determination of flavonoids in Citrus grandis (Pomelo) peels and their inhibition activity on lipid peroxidation in fish tissue. Int. Food Res: pp. J 20: 313-317.
25. Hong HJ, Jin JY, Yang H, Kang WY, Kim DG, et al. (2010) Dangyuja (Citrus grandis Osbeck) peel improves lipid profiles and alleviates hypertension in rats fed a high-fat diet 26. Lab Animal Res. pp. pp. 361-367.
26. Do NL, (2010) Effect of pomelo (Citrus grandis (l). Osbeck) peel extract on lipid-carbohydrate metabolic enzymes and blood lipid, glucose parameters in experimental obese and diabetic mice. VNU J Sci Nat Sci Technol 26: 224-232.
27. Ramful D, Tarnus E, Rondeau P, Robert Da Silva C, Bahorun T, et al. (2010) Citrus fruit extracts reduce advanced glycation end products (AGEs)-and H2O2-induced oxidative stress in human adipocytes. J Agric Food Chem 58: 11119. doi:10.1021/jf102762s.
28. Folch J, Lees M, Sloane-Stanley G, (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509. PubMed: 13428781.
29. Zhang Y, Fan S, Hu N, Gu M, Chu C, et al. (2012) Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57Bl/6 mouse through the inhibition of PPARγ signaling. PPAR Res 2012, (2012).
30. Jang H-D, Chang K-S, Chang T-C, Hsu C-L, (2010) Antioxidant potentials of buntan pomelo (Citrus grandis Osbeck) and its ethanolic and acetified fermentation products. Food Chem 118: 554-558. doi:10.1016/j.foodchem.2009.05.020.
31. Raasmaja A, Lecklin A, Li XM, Zou J, Zhu GG, et al. (2013) A water-alcohol extract of Citrus grandis whole fruits has beneficial metabolic effects in the obese Zucker rats fed with high fat/high cholesterol diet. Food Chem 138: 1392-1399. doi:10.1016/j.foodchem.2012.09.140. PubMed: 23411259.
32. Huong DT, Takahashi Y, Ide T, (2006) Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids. Nutrition 22: 546-552. doi:10.1016/j.nut.2005.11.006. PubMed: 16483743.
33. Jung UJ, Kim HJ, Lee JS, Lee MK, Kim HO, et al. (2003) Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin Nutr 22: 561-568. doi:10.1016/S0261-5614(03)00059-1. PubMed: 14613759.
34. Jung UJ, Lee MK, Park YB, Kang MA, Choi MS, (2006) Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 38: 1134-1145. doi:10.1016/j.biocel.2005.12.002. PubMed: 16427799.
35. Sharma AK, Bharti S, Ojha S, Bhatia J, Kumar N, et al. (2011) Up-regulation of PPARgamma, heat shock protein-27 and-72 by naringin attenuates insulin resistance, beta-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. Br J Nutr 106: 1713-1723. doi:10.1017/S000711451100225X. PubMed: 21736771.
36. Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM, (2012) Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications 26: 483-490. doi:10.1016/j.jdiacomp.2012.06.001. PubMed: 22809898.
37. Roza JM, Xian-Liu Z, Guthrie N, (2007) Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Altern Ther Health Med 13: 44-48. PubMed: 17985810.
38. Demonty I, Lin Y, Zebregs YE, Vermeer MA, van der Knaap HC, et al. (2010) The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr 140: 1615-1620. doi:10.3945/jn.110.124735. PubMed: 20660284.
39. Hung JY, Hsu YL, Ko YC, Tsai YM, Yang CJ, et al. (2010) Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo. Lung Cancer 68: 366-374. doi:10.1016/j.lungcan.2009.08.013. PubMed: 19733932.
40. Singhal J, Nagaprashantha LD, Vatsyayan R, Ashutosh, Awasthi S, et al. (2012) Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer. Prev Res (Phila) 5: 473-483. doi:10.1158/1940-6207.CAPR-11-0318.
41. Hsu M-H, Sava Ü, Griffin KJ, Johnson EF, (2001) Identification of Peroxisome Proliferator-responsive Human Genes by Elevated Expression of the Peroxisome Proliferator-activated Receptor α in HepG2 Cells. J Biol Chem 276: 27950-27958. doi:10.1074/jbc.M100258200. PubMed: 11371553.
42. Peng P, Gao DM, Mohamed S, Chen J, Zhang J, et al. (2012) Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. Arch Biochem Biophyss 518: 61-70. doi:10.1016/j.abb.2011.11.026.
43. Lee YS, Cha BY, Choi SS, Choi BK, Yonezawa T, et al. (2013) Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J Nutr Biochem 24: 156-162. doi:10.1016/j.jnutbio.2012.03.014. PubMed: 22898571.