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Volumn 21, Issue 7, 2008, Pages 876-884

Expression of VEGF-A/C, VEGF-R2, PDGF-α/β, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi-1 in Merkel cell carcinoma

Author keywords

Bmi 1; C kit; Mcl 1; Merkel cell carcinoma; Receptor tyrosine kinase; Targeted therapies

Indexed keywords

ANTIBODY; BMI1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA; PLATELET DERIVED GROWTH FACTOR BETA; PROTEIN MCL 1; STEM CELL FACTOR RECEPTOR; VASCULOTROPIN A; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 2;

EID: 46049097564     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.63     Document Type: Article
Times cited : (97)

References (71)
  • 1
    • 0033011983 scopus 로고    scopus 로고
    • Merkel cell carcinoma and melanoma: Etiological similarities and differences
    • Miller RW, Rabkin CS. Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol Biomarkers Prev 1999;8:153-158.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 153-158
    • Miller, R.W.1    Rabkin, C.S.2
  • 2
    • 0142213890 scopus 로고    scopus 로고
    • Epidemiology of primary Merkel cell carcinoma in the United States
    • Agelli M, Clegg LX. Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol 2003;49:832-841.
    • (2003) J Am Acad Dermatol , vol.49 , pp. 832-841
    • Agelli, M.1    Clegg, L.X.2
  • 3
    • 33745736931 scopus 로고    scopus 로고
    • Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): An overview on management
    • Veness MJ. Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): an overview on management. Australas J Dermatol 2006;47:160-165.
    • (2006) Australas J Dermatol , vol.47 , pp. 160-165
    • Veness, M.J.1
  • 4
    • 0642368569 scopus 로고    scopus 로고
    • High risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: A Trans-Tasman Radiation Oncology Group study - TROG 96:07
    • Poulsen M, Rischin D, Walpole E, et al. High risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group study - TROG 96:07. J Clin Oncol 2003;21:4371-4376.
    • (2003) J Clin Oncol , vol.21 , pp. 4371-4376
    • Poulsen, M.1    Rischin, D.2    Walpole, E.3
  • 5
    • 29244475354 scopus 로고    scopus 로고
    • Does chemotherapy improve survival in high risk stage I and II Merkel cell carcinoma of the skin?
    • Poulsen MG, Rischin D, Porter I, et al. Does chemotherapy improve survival in high risk stage I and II Merkel cell carcinoma of the skin? Int J Radiat Oncol Biol Phys 2006;64:114-119.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 114-119
    • Poulsen, M.G.1    Rischin, D.2    Porter, I.3
  • 6
    • 4043107081 scopus 로고    scopus 로고
    • Merkel cell carcinoma of the head and neck
    • Suarez C, Rodrigo JP, Ferlito A, et al. Merkel cell carcinoma of the head and neck. Oral Oncol 2004;40:773-779.
    • (2004) Oral Oncol , vol.40 , pp. 773-779
    • Suarez, C.1    Rodrigo, J.P.2    Ferlito, A.3
  • 7
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006;295:2516-2524.
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 8
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24:16-24.
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 9
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006;14:1329-1338.
    • (2006) Lancet , vol.14 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 10
    • 34247610583 scopus 로고    scopus 로고
    • Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor
    • DeMatteo RP, Maki RG, Singer S, et al. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor. Ann Surg 2007;245:347-352.
    • (2007) Ann Surg , vol.245 , pp. 347-352
    • DeMatteo, R.P.1    Maki, R.G.2    Singer, S.3
  • 11
    • 33747644456 scopus 로고    scopus 로고
    • Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung
    • Bobos M, Hytiroglou P, Kostopoulos I, et al. Immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol 2006;28:99-104.
    • (2006) Am J Dermatopathol , vol.28 , pp. 99-104
    • Bobos, M.1    Hytiroglou, P.2    Kostopoulos, I.3
  • 12
    • 28144462911 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in tumor angiogenesis and malignancies
    • Pradeep CR, Sunila ES, Kuttan G. Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in tumor angiogenesis and malignancies. Integr Cancer Ther 2005;4:315-321.
    • (2005) Integr Cancer Ther , vol.4 , pp. 315-321
    • Pradeep, C.R.1    Sunila, E.S.2    Kuttan, G.3
  • 13
    • 11444262478 scopus 로고    scopus 로고
    • C-kit expression in primary and metastatic Merkel cell carcinoma
    • Feinmesser M, Halpern M, Kaganovsky E, et al. C-kit expression in primary and metastatic Merkel cell carcinoma. Am J Dermatopathol 2004;26:458-462.
    • (2004) Am J Dermatopathol , vol.26 , pp. 458-462
    • Feinmesser, M.1    Halpern, M.2    Kaganovsky, E.3
  • 14
    • 1542611369 scopus 로고    scopus 로고
    • KIT receptor (CD117) expression in Merkel cell carcinoma
    • Strong S, Shalders K, Carr R, et al. KIT receptor (CD117) expression in Merkel cell carcinoma. Br J Dermatol 2004;150:384-385.
    • (2004) Br J Dermatol , vol.150 , pp. 384-385
    • Strong, S.1    Shalders, K.2    Carr, R.3
  • 15
    • 0035984735 scopus 로고    scopus 로고
    • CD117 (KIT receptor) expression in Merkel cell carcinoma
    • Su LD, Fullen DR, Lowe L, et al. CD117 (KIT receptor) expression in Merkel cell carcinoma. Am J Dermatopathol 2002;24:289-293.
    • (2002) Am J Dermatopathol , vol.24 , pp. 289-293
    • Su, L.D.1    Fullen, D.R.2    Lowe, L.3
  • 16
    • 33947511415 scopus 로고    scopus 로고
    • Merkel cell carcinoma: Evaluation of KIT (CD117) expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib mesylate
    • Swick BL, Ravdel L, Fitzpatrick JE, et al. Merkel cell carcinoma: evaluation of KIT (CD117) expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib mesylate. J Cutan Pathol 2007;34:324-329.
    • (2007) J Cutan Pathol , vol.34 , pp. 324-329
    • Swick, B.L.1    Ravdel, L.2    Fitzpatrick, J.E.3
  • 17
    • 0026352743 scopus 로고
    • Merkel cell carcinoma. Prognosis and management
    • Yiengpruksawan A, Coit DG, Thaler HT, et al. Merkel cell carcinoma. Prognosis and management. Arch Surg 1991;126:1514-1519.
    • (1991) Arch Surg , vol.126 , pp. 1514-1519
    • Yiengpruksawan, A.1    Coit, D.G.2    Thaler, H.T.3
  • 18
    • 0031822837 scopus 로고    scopus 로고
    • Tissue microarrays for high-throughput molecular profiling of tumor specimens
    • Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4:844-847.
    • (1998) Nat Med , vol.4 , pp. 844-847
    • Kononen, J.1    Bubendorf, L.2    Kallioniemi, A.3
  • 19
    • 0028896159 scopus 로고
    • bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
    • Sinicrope FA, Ruan SB, Cleary KR, et al. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 1995;15:237-241.
    • (1995) Cancer Res , vol.15 , pp. 237-241
    • Sinicrope, F.A.1    Ruan, S.B.2    Cleary, K.R.3
  • 20
    • 35349016886 scopus 로고    scopus 로고
    • TdT expression in Merkel cell carcinoma: Potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis
    • Sur M, Alardati H, Ross C, et al. TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007;20:1113-1120.
    • (2007) Mod Pathol , vol.20 , pp. 1113-1120
    • Sur, M.1    Alardati, H.2    Ross, C.3
  • 21
    • 33745813583 scopus 로고    scopus 로고
    • Immunohistochemical analysis of EGFR and HER-2 in patients with metastasizing melanoma, Merkel carcinoma and squamous cell carcinoma of the skin
    • Maubec E, Duvillard P, Velasco V, et al. Immunohistochemical analysis of EGFR and HER-2 in patients with metastasizing melanoma, Merkel carcinoma and squamous cell carcinoma of the skin. Ann Dermatol Venereol 2006;133:274-276.
    • (2006) Ann Dermatol Venereol , vol.133 , pp. 274-276
    • Maubec, E.1    Duvillard, P.2    Velasco, V.3
  • 22
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2000;411:355-365.
    • (2000) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 23
    • 0034213931 scopus 로고    scopus 로고
    • RTK mutations and human syndromes: When good receptors turn bad
    • Robertson SC, Tynan JA, Donoghue DJ. RTK mutations and human syndromes: when good receptors turn bad. Trends Genet 2000;16:265-271.
    • (2000) Trends Genet , vol.16 , pp. 265-271
    • Robertson, S.C.1    Tynan, J.A.2    Donoghue, D.J.3
  • 24
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000;103:211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 25
    • 0028903126 scopus 로고
    • Aberrant tyrosine phosphorylation in head and neck tumours and potentially premalignant tissues
    • Verschuur HP, Rijksen G, Slootweg PJ, et al. Aberrant tyrosine phosphorylation in head and neck tumours and potentially premalignant tissues. Acta Otolaryngol 1995;115:326-327.
    • (1995) Acta Otolaryngol , vol.115 , pp. 326-327
    • Verschuur, H.P.1    Rijksen, G.2    Slootweg, P.J.3
  • 26
    • 0036139884 scopus 로고    scopus 로고
    • Receptor tyrosine kinases as targets for anticancer drugs
    • Zwick E, Bange J, Ullrich A. Receptor tyrosine kinases as targets for anticancer drugs. Trends Mol Med 2002;8:17-23.
    • (2002) Trends Mol Med , vol.8 , pp. 17-23
    • Zwick, E.1    Bange, J.2    Ullrich, A.3
  • 27
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci 2005;109:227-241.
    • (2005) Clin Sci , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 28
    • 33748175142 scopus 로고    scopus 로고
    • Biology of platelet-derived growth factor and its involvement in disease
    • Alvarez RH, Kantarjian HM, Cortes JE. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006;81:1241-1257.
    • (2006) Mayo Clin Proc , vol.81 , pp. 1241-1257
    • Alvarez, R.H.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 29
    • 0026475653 scopus 로고
    • Expression of c-kit receptor in normal and transformed human nonlymphoid tissues
    • Natali PG, Nicotra MR, Sures I, et al. Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res 1992;52:6139-6143.
    • (1992) Cancer Res , vol.52 , pp. 6139-6143
    • Natali, P.G.1    Nicotra, M.R.2    Sures, I.3
  • 30
    • 0025718579 scopus 로고
    • Expression and functional role of the protooncogene c-kit in acute myeloblastic leukemia cells
    • Ikeda H, Kanakura Y, Tamaki T, et al. Expression and functional role of the protooncogene c-kit in acute myeloblastic leukemia cells. Blood 1991;78:2962-2968.
    • (1991) Blood , vol.78 , pp. 2962-2968
    • Ikeda, H.1    Kanakura, Y.2    Tamaki, T.3
  • 31
    • 0030069519 scopus 로고    scopus 로고
    • Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
    • Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res 1996;56:370-376.
    • (1996) Cancer Res , vol.56 , pp. 370-376
    • Krystal, G.W.1    Hines, S.J.2    Organ, C.P.3
  • 32
    • 0031791026 scopus 로고    scopus 로고
    • A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors
    • Nakahara M, Isozaki K, Hirota S, et al. A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors. Gastroenterology 1998;115:1090-1095.
    • (1998) Gastroenterology , vol.115 , pp. 1090-1095
    • Nakahara, M.1    Isozaki, K.2    Hirota, S.3
  • 33
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;11:125-134.
    • (2007) N Engl J Med , vol.11 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 34
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;24:2505-2512.
    • (2006) J Clin Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 35
    • 28044434570 scopus 로고    scopus 로고
    • A phase I study of BAY 43-9006 and gefitinib in patients with refractory or recurrent non-small-cell lung cancer (NSCLC)
    • Adjei AA, Mandrekar S, Marks RS, et al. A phase I study of BAY 43-9006 and gefitinib in patients with refractory or recurrent non-small-cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2005;23:3067.
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 3067
    • Adjei, A.A.1    Mandrekar, S.2    Marks, R.S.3
  • 36
    • 33645352823 scopus 로고    scopus 로고
    • Phase I trial of BAY 43-9006 (sorafenib) combined with dacarbazine (DTIC) in metastatic melanoma patients [abstract]
    • Eisen T, Ahmad T, Gore ME, et al. Phase I trial of BAY 43-9006 (sorafenib) combined with dacarbazine (DTIC) in metastatic melanoma patients [abstract]. Proc Am Soc Clin Oncol 2005;23:7508.
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 7508
    • Eisen, T.1    Ahmad, T.2    Gore, M.E.3
  • 37
    • 33846020023 scopus 로고    scopus 로고
    • Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib
    • Mross K, Steinbild S, Baas F, et al. Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib. Eur J Cancer 2007;43:55-63.
    • (2007) Eur J Cancer , vol.43 , pp. 55-63
    • Mross, K.1    Steinbild, S.2    Baas, F.3
  • 38
    • 33646381326 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis
    • Andersson J, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis. Gastroenterology 2006;130:1573-1581.
    • (2006) Gastroenterology , vol.130 , pp. 1573-1581
    • Andersson, J.1    Bumming, P.2    Meis-Kindblom, J.M.3
  • 39
    • 33745099617 scopus 로고    scopus 로고
    • An update on molecular genetics of gastrointestinal stromal tumours
    • Tornillo L, Terracciano LM. An update on molecular genetics of gastrointestinal stromal tumours. J Clin Pathol 2006;59:557-563.
    • (2006) J Clin Pathol , vol.59 , pp. 557-563
    • Tornillo, L.1    Terracciano, L.M.2
  • 40
    • 1642430704 scopus 로고    scopus 로고
    • Antisense oligonucleotide-based therapeutics for cancer
    • Dean NM, Bennett CF. Antisense oligonucleotide-based therapeutics for cancer. Oncogene 2003;22:9087-9096.
    • (2003) Oncogene , vol.22 , pp. 9087-9096
    • Dean, N.M.1    Bennett, C.F.2
  • 41
    • 4444365042 scopus 로고    scopus 로고
    • MCL-1 expression in B-cell non-Hodgkin's lymphomas
    • Cho-Vega JH, Rassidakis GZ, Admirand JH, et al. MCL-1 expression in B-cell non-Hodgkin's lymphomas. Hum Pathol 2004;35:1095-1100.
    • (2004) Hum Pathol , vol.35 , pp. 1095-1100
    • Cho-Vega, J.H.1    Rassidakis, G.Z.2    Admirand, J.H.3
  • 42
    • 20344371233 scopus 로고    scopus 로고
    • Antisense therapy for cancer
    • Gleave M, Monia BP. Antisense therapy for cancer. Nat Rev Cancer 2005;5:468-479.
    • (2005) Nat Rev Cancer , vol.5 , pp. 468-479
    • Gleave, M.1    Monia, B.P.2
  • 43
    • 0030807543 scopus 로고    scopus 로고
    • Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence
    • Ziegler A, Luedke GH, Fabbro D, et al. Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence. J Natl Cancer Inst 1997;89:1027-1036.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1027-1036
    • Ziegler, A.1    Luedke, G.H.2    Fabbro, D.3
  • 44
    • 0029043811 scopus 로고
    • Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo
    • Krajewski S, Bodrug S, Krajewska M, et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 1995;146:1309-1319.
    • (1995) Am J Pathol , vol.146 , pp. 1309-1319
    • Krajewski, S.1    Bodrug, S.2    Krajewska, M.3
  • 45
    • 33751080104 scopus 로고    scopus 로고
    • Mcl-1 is a relevant molecular target for antisense oligonucleotide strategies in gastric cancer cells
    • Wacheck V, Cejka D, Sieghart W, et al. Mcl-1 is a relevant molecular target for antisense oligonucleotide strategies in gastric cancer cells. Cancer Biol Ther 2006;5:1348-1354.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1348-1354
    • Wacheck, V.1    Cejka, D.2    Sieghart, W.3
  • 46
    • 0028965578 scopus 로고
    • The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
    • Yang T, Kozopas KM, Craig RW. The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J Cell Biol 1995;128:1173-1184.
    • (1995) J Cell Biol , vol.128 , pp. 1173-1184
    • Yang, T.1    Kozopas, K.M.2    Craig, R.W.3
  • 47
    • 0034071930 scopus 로고    scopus 로고
    • Functional analysis of the human MCL-1 gene
    • Akgul C, Turner PC, White MR, et al. Functional analysis of the human MCL-1 gene. Cell Mol Life Sci 2000;57:684-691.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 684-691
    • Akgul, C.1    Turner, P.C.2    White, M.R.3
  • 48
    • 0027480450 scopus 로고
    • MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
    • Kozopas KM, Yang T, Buchan HL, et al. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci USA 1993;90:3516-3520.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1    Yang, T.2    Buchan, H.L.3
  • 49
    • 0034743398 scopus 로고    scopus 로고
    • Rb, Mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer
    • Backus HH, van Riel JM, van Groeningen CJ, et al. Rb, Mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. Ann Oncol 2001;12:779-785.
    • (2001) Ann Oncol , vol.12 , pp. 779-785
    • Backus, H.H.1    van Riel, J.M.2    van Groeningen, C.J.3
  • 50
    • 0037030583 scopus 로고    scopus 로고
    • Expression of apoptotic regulators and their significance in cervical cancer
    • Chung TK, Cheung TH, Lo WK, et al. Expression of apoptotic regulators and their significance in cervical cancer. Cancer Lett 2004;180:63-68.
    • (2004) Cancer Lett , vol.180 , pp. 63-68
    • Chung, T.K.1    Cheung, T.H.2    Lo, W.K.3
  • 51
    • 0036659905 scopus 로고    scopus 로고
    • Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells
    • Derenne S, Monia B, Dean NM, et al. Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. Blood 2002;100:194-199.
    • (2002) Blood , vol.100 , pp. 194-199
    • Derenne, S.1    Monia, B.2    Dean, N.M.3
  • 52
    • 0037207516 scopus 로고    scopus 로고
    • Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression
    • Khoury JD, Medeiros LJ, Rassidakis GZ, et al. Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression. J Pathol 2001;199:90-97.
    • (2001) J Pathol , vol.199 , pp. 90-97
    • Khoury, J.D.1    Medeiros, L.J.2    Rassidakis, G.Z.3
  • 53
    • 0032928807 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers
    • Miyamoto Y, Hosotani R, Wada M, et al. Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers. Oncology 1999;56:73-82.
    • (1999) Oncology , vol.56 , pp. 73-82
    • Miyamoto, Y.1    Hosotani, R.2    Wada, M.3
  • 54
    • 28844437366 scopus 로고    scopus 로고
    • Mcl-1 overexpression in hepatocellular carcinoma: A potential target for antisense therapy
    • Sieghart W, Losert D, Strommer S, et al. Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy. J Hepatol 2006;44:151-157.
    • (2006) J Hepatol , vol.44 , pp. 151-157
    • Sieghart, W.1    Losert, D.2    Strommer, S.3
  • 55
    • 34548687035 scopus 로고    scopus 로고
    • mir-29 regulates Mcl-1 protein expression and apoptosis
    • Mott JL, Kobayashi S, Bronk SF, et al. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007;26:6133-6140.
    • (2007) Oncogene , vol.26 , pp. 6133-6140
    • Mott, J.L.1    Kobayashi, S.2    Bronk, S.F.3
  • 56
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the Bmi-1 proto-oncogene
    • van der Lugt NM, Domen J, Linders K, et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the Bmi-1 proto-oncogene. Genes Dev 1994;8:757-769.
    • (1994) Genes Dev , vol.8 , pp. 757-769
    • van der Lugt, N.M.1    Domen, J.2    Linders, K.3
  • 57
    • 0032076718 scopus 로고    scopus 로고
    • Polycombing the genome: PcG, trxG, and chromatin silencing
    • Pirrotta V. Polycombing the genome: PcG, trxG, and chromatin silencing. Cell 1998;93:333-336.
    • (1998) Cell , vol.93 , pp. 333-336
    • Pirrotta, V.1
  • 58
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and polycomb-group gene Bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, et al. The oncogene and polycomb-group gene Bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397:164-168.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3
  • 59
    • 18944407603 scopus 로고    scopus 로고
    • Mammary stem cells, self-renewal pathways, and carcinogenesis
    • Liu S, Dontu G, Wicha MS. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7:86-95.
    • (2005) Breast Cancer Res , vol.7 , pp. 86-95
    • Liu, S.1    Dontu, G.2    Wicha, M.S.3
  • 60
    • 33645297174 scopus 로고    scopus 로고
    • Hematopoietic stem cell senescence and long-term bone marrow injury
    • Wang Y, Schulte BA, Zhou D. Hematopoietic stem cell senescence and long-term bone marrow injury. Cell Cycle 2006;5:35-38.
    • (2006) Cell Cycle , vol.5 , pp. 35-38
    • Wang, Y.1    Schulte, B.A.2    Zhou, D.3
  • 61
    • 0037102196 scopus 로고    scopus 로고
    • The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells
    • Dimri GP, Martinez JL, Jacobs JJ, et al. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 2002;62:4736-4745.
    • (2002) Cancer Res , vol.62 , pp. 4736-4745
    • Dimri, G.P.1    Martinez, J.L.2    Jacobs, J.J.3
  • 62
    • 0035866814 scopus 로고    scopus 로고
    • BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas
    • Bea S, Tort F, Pinyol M, et al. BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res 2001;61:2409-2412.
    • (2001) Cancer Res , vol.61 , pp. 2409-2412
    • Bea, S.1    Tort, F.2    Pinyol, M.3
  • 63
    • 20444457518 scopus 로고    scopus 로고
    • Microarray analysis identifies a death-from cancer signature predicting therapy failure in patients with multiple types of cancer
    • Glinsky GV, Berezovska O, Glinskii AB. Microarray analysis identifies a death-from cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 2005;115:1503-1521.
    • (2005) J Clin Invest , vol.115 , pp. 1503-1521
    • Glinsky, G.V.1    Berezovska, O.2    Glinskii, A.B.3
  • 64
    • 0035877978 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B cell non-Hodgkin lymphoma
    • van Kemenade FJ, Raaphorst FM, Blokzijl T, et al. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B cell non-Hodgkin lymphoma. Blood 2001;97:3896-3901.
    • (2001) Blood , vol.97 , pp. 3896-3901
    • van Kemenade, F.J.1    Raaphorst, F.M.2    Blokzijl, T.3
  • 65
    • 0346094301 scopus 로고    scopus 로고
    • The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
    • Kim JH, Yoon SY, Kim CN, et al. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett 2004;203:217-224.
    • (2004) Cancer Lett , vol.203 , pp. 217-224
    • Kim, J.H.1    Yoon, S.Y.2    Kim, C.N.3
  • 66
    • 9244248707 scopus 로고    scopus 로고
    • Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer
    • Kim JH, Yoon SY, Jeong SH, et al. Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast 2004;13:383-388.
    • (2004) Breast , vol.13 , pp. 383-388
    • Kim, J.H.1    Yoon, S.Y.2    Jeong, S.H.3
  • 67
    • 33750296433 scopus 로고    scopus 로고
    • BMI-1: A protein expressed in stem cells, specialized cells and tumors of the gastrointestinal tract
    • Reinisch C, Kandutsch S, Uthman A, et al. BMI-1: a protein expressed in stem cells, specialized cells and tumors of the gastrointestinal tract. Histol Histopathol 2006;21:1143-1149.
    • (2006) Histol Histopathol , vol.21 , pp. 1143-1149
    • Reinisch, C.1    Kandutsch, S.2    Uthman, A.3
  • 68
    • 33745685884 scopus 로고    scopus 로고
    • Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    • Song LB, Zeng MS, Liao WT, et al. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res 2006;66:6225-6232.
    • (2006) Cancer Res , vol.66 , pp. 6225-6232
    • Song, L.B.1    Zeng, M.S.2    Liao, W.T.3
  • 69
    • 0035906853 scopus 로고    scopus 로고
    • The Bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
    • Vonlanthen S, Heighway J, Altermatt HJ, et al. The Bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer 2001;84:1372-1376.
    • (2001) Br J Cancer , vol.84 , pp. 1372-1376
    • Vonlanthen, S.1    Heighway, J.2    Altermatt, H.J.3
  • 70
    • 24044552961 scopus 로고    scopus 로고
    • Construction of antisense Bmi-1 expression plasmid and its inhibitory effect on K562 cells proliferation
    • Meng XX, Liu WH, Liu DD, et al. Construction of antisense Bmi-1 expression plasmid and its inhibitory effect on K562 cells proliferation. Chin Med J 2005;118:1346-1350.
    • (2005) Chin Med J , vol.118 , pp. 1346-1350
    • Meng, X.X.1    Liu, W.H.2    Liu, D.D.3
  • 71
    • 33644817605 scopus 로고    scopus 로고
    • When does the presence of the target predict response to the targeted agent?
    • Bergsland EK. When does the presence of the target predict response to the targeted agent? J Clin Oncol 2006;24:213-216.
    • (2006) J Clin Oncol , vol.24 , pp. 213-216
    • Bergsland, E.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.