Metal-drug synergy: New ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

Journal of Biological Inorganic Chemistry

Volumn 18, Issue 7, 2013, Pages 779-790

  Iniguez, Eva ^a   Sánchez, Antonio ^b   Vasquez, Miguel A ^a   Martínez, Alberto ^c   Olivas, Joanna ^a   Sattler, Aaron ^d   Sánchez Delgado, Roberto A ^b   Maldonado, Rosa A ^a  

^a UNIVERSITY OF TEXAS AT EL PASO   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c NEW YORK CITY COLLEGE OF TECHNOLOGY   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Chagas disease; Ketoconazole; Leishmaniasis; Metal drug synergy; Ruthenium

Indexed keywords

[N6 RUTHENIUM(PARA CYMENE)CHLORIDE]2; [RUTHENIUM (N6 PARA CYMENE)(ACETYLACETONATE)(KETOCONAZOLE)] [BF4] 2 METAL COMPLEX; [RUTHENIUM(N6 PARA CYMENE) (2,2' BIPYRIDINE)(KETOCONAZOLE)] [BF4] 2 METAL COMPLEX; [RUTHENIUM(N6 PARA CYMENE)(ETHYLENEDIAMINE)(KETOCONAZOLE)] [BF4] 2 METAL COMPLEX; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; KETOCONAZOLE; RUTHENIUM CHLORIDE (2,2' BIPYRIDINE)(DIMETHYL SULFOXIDE) 3 KETOCONAZOLE METAL COMPLEX; RUTHENIUM CHLORIDE(DIMETHYL SULFOXIDE) 3 KETOCONAZOLE METAL COMPLEX; RUTHENIUM CHLORIDE(DIMETHYL SULFOXIDE)4; RUTHENIUM(N6 PARA CYMENE)CHLORIDE KETOCONAZOLE METAL COMPLEX; SODIUM[RUTHENIUM TETRACHLORIDE(DIMETHYL SULFOXIDE)2]; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; LD 50; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY ANALYSIS;

LEISHMANIA MAJOR; MURINAE; TRYPANOSOMA CRUZI;

ANIMALS; CELL LINE; HUMANS; KETOCONAZOLE; LEISHMANIA MAJOR; MICE; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84885610608     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-013-1024-2     Document Type: Article

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