New silver polypyridyl complexes: Synthesis, characterization and biological activity on Leishmania mexicana

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 8, 2006, Pages 600-604

  Navarro, Maribel ^a   Cisneros Fajardo, Efrén J ^a   Marchan, Edgar ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b UNIVERSIDAD DE ORIENTE   (Venezuela)

Author keywords

Antibiotic agents; Leishmania mexicana; Polypyridyl complexes, antileishmanial effects; Silver complexes, antileishmanial effects

Indexed keywords

ALBUMIN; DNA; LEISHMANIA MEXICANA EXTRACT; POLYPYRIDYL DERIVATIVE; PYRIDINE DERIVATIVE; SILVER NITRATE; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; HOST PARASITE INTERACTION; LEISHMANIA; LETHAL DOSE; LIGAND BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

EID: 33748486930     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296758     Document Type: Article

References (20)

1. Brown, R., Trypanosomiasis and Leishmaniasis, in: Critical Reports on Applied Chemistry, Chemotherapy of Tropical Diseases, M. Hooper (ed.). John Wiley & Sons, Chichester (1987)
2. World Health Organization. The World Health Report: Life in the 21st century. A vision for all. Report of the Director-General, pp. 44-51. WHO, Geneva (1998)
3. Olliaro, P., Bryceson, A., Practical Progress and New Drugs for Changing Patterns of Leishmaniasis. Parasitol. Today 9, 323 (1993)
4. Mbongo, N., Loiseau, P. M., Lawrence, F. et al., In vitro sensitivity of Leishmania donovani to organometallic derivates of pentamidine. Parasitol. Res. 83, 515 (1997)
5. Mbongo, N., Loiseau, P. M., Craciunescu, D. G.et al., Synergistic effect or Ir-(COT)- pentamidine alizarin red and pentamidine, amphotericin B, and paromomycin on Leishmania donovani. Acta Tropica 70, 239 (1998)
6. 2. J. Med. Chem. 36, 2041 (1993)
7. 6. J. Med. Chem. 40, 1937 (1997)
8. Sánchez-Delgado, R. A., Navarro, M., Lazardi, K. et al., Toward a Novel-based Chemotherapy against Tropical Diseases. 4. Synthesis and characterization of new metal-clotrimazole complexes and evaluation of their activity against Trypanosoma cruzi. Inorg. Chim. Acta 275-276, 528 (1998)
9. Navarro, M., Lehmann, T., Cisneros-Fajardo, E. J. et al., Toward a Novel-based Chemotherapy against Tropical Diseases. Part 5. Synthesis and characterization of new Ru(II) and Ru(III) clotrimazole and ketoconazole complexes and evaluation of their activity against Trypanosoma cruzi. Polyhedron 19, 2319 (2000)
10. Navarro, M., Cisneros-Fajardo, E. J., Lehmann, T. et al., Toward a Novel-based Chemotherapy against Tropical Diseases. Part 6. Synyhesis and characterization of new copper(II) and gold (I) clotrimazole and ketoconale complexes and evaluation of their activity against Trypanosoma cruzi. Inorg. Chem. 40, 6879 (2000)
11. Navarro, M., Cisneros-Fajardo, E., Fernandez-Mestre, M. et al., Design of Copper DNA Intercalators with Leishmanicidal Activity. J. Biol. Inorg. Chem 8, 401 (2003)
12. 4. J. Inorg. Biochem. 97, 364 (2003)
13. Farrell, N., Transition Metal Complexes as Drugs and Chemotherapeutic Agents, in: Catalysis by Metal Complexes, B. R. James, R. Ugo (eds.), Ch. 9 and references therein. Kluwer, Dordrecht (1989)
14. Abuskhuna, S., Briody, J., McCann, M. et al., Shyntesis, structure and anti-fugal activity of dimeric Ag(I) complexes containing bis-imidazole ligands. Polyhedron 23, 1249 (2004)
15. McCann, M., Coyle, B., McKay, S. et al., Metal complexes of 1,10-phenanthroline-5,6-dione after the susceptibility of the yeast Candida albicans to amphotericin B and miconazole. Biometals 17(4), 415 (2004)
16. Calderazo, F., Marchetti, F., Pampaloni, G. et al., Coordination properties of 1,10-phenantroline-5,6-dione towards group 4 and 5 metals in low and high oxidation states. J. Chem. Soc. Dalton Trans. 4389 (1999)
17. Dickeson, J. E., Summers, L. A., Derivates of 1,10-pheantroline-5,6- quinone. Aust. J. Chem. 23, 1023 (1970)
18. Marmur, J., A procedure for the isolation of deoxyribonucleic acid from micro-organisms. J. Mol. Biol. 3, 208 (1961)
19. Geary, W. J., Use of conductivity measurements in organic solvents for the characterization of coordination compounds. Coord. Chem. Rev. 7, 81 (1971)
20. Wilkinson, G., first ed. Comprehensive Coordination Chemistry, 1st ed., Vol. 5, Ch. 51. Pergamon Press, Oxford (1987)