Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo

Journal of Biological Chemistry

Volumn 288, Issue 41, 2013, Pages 29562-29572

  Maussang, David ^a   Mujić Delić, Azra ^a   Descamps, Francis J ^b   Stortelers, Catelijne ^b   Vanlandschoot, Peter ^b   Stigter Van Walsum, Marijke ^c   Vischer, Henry F ^a   Van Roy, Maarten ^b   Vosjan, Maria ^c   Gonzalez Pajuelo, Maria ^b   Van Dongen, Guus A M S ^c   Merchiers, Pascal ^b   Van Rompaey, Philippe ^b   Smit, Martine J ^a  

^a AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

^b ABLYNX NV   (Belgium)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL-CYCLE PROGRESSION; CHEMOKINE RECEPTORS; G PROTEIN COUPLED RECEPTORS; HEAD-AND-NECK CANCER; INVERSE AGONISTS; MEMBRANE-BOUND RECEPTORS; NATURALLY OCCURRING; THERAPEUTIC BENEFITS;

DISEASES; PATIENT TREATMENT;

TUMORS;

ANGIOGENIC PROTEIN; ANTINEOPLASTIC AGENT; BETA ARRESTIN 2; CHEMOKINE RECEPTOR CXCR7; CXCL1 CHEMOKINE; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY 8F11; NANOBODY; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VUF 11403;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; ARTIODACTYLA; BINDING AFFINITY; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CELL CYCLE PROGRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG ANTAGONISM; ENZYME INHIBITION; FEMALE; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TARGETING; TUMOR BIOPSY; TUMOR XENOGRAFT;

ANTIBODY ENGINEERING; CHEMOKINES; CXCR7; G PROTEIN-COUPLED RECEPTORS (GPCR); HEAD AND NECK CANCER; NANOBODIES; SIGNALING;

ANIMALS; ARRESTINS; BINDING, COMPETITIVE; CAMELIDS, NEW WORLD; CELL LINE, TUMOR; CHEMOKINE CXCL12; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HEK293 CELLS; HUMANS; MICE; MICE, NUDE; NIH 3T3 CELLS; RADIOLIGAND ASSAY; RECEPTORS, CXCR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE-DOMAIN ANTIBODIES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84885594077     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.498436     Document Type: Article

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